MX2009008270A - Polipeptido novedoso que tiene actividad anti-tumoral. - Google Patents
Polipeptido novedoso que tiene actividad anti-tumoral.Info
- Publication number
- MX2009008270A MX2009008270A MX2009008270A MX2009008270A MX2009008270A MX 2009008270 A MX2009008270 A MX 2009008270A MX 2009008270 A MX2009008270 A MX 2009008270A MX 2009008270 A MX2009008270 A MX 2009008270A MX 2009008270 A MX2009008270 A MX 2009008270A
- Authority
- MX
- Mexico
- Prior art keywords
- tumor activity
- amino acid
- acid sequence
- polypeptide
- novel polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 210000002889 endothelial cell Anatomy 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un polipéptido novedoso que tiene actividad anti-tumoral a través de la inducción de la apoptosis de la célula endotelial y el uso del mismo; más particularmente, la presente invención se refiere a un método para inducir la apoptosis de la célula endotelial, y para prevenir o tratar el cáncer, que comprende administrar a un sujeto que necesita del mismo una cantidad efectiva de (a) un polipéptido aislado que tiene la secuencia de aminoácidos de SEQ ID NO: 9, o la secuencia de aminoácidos que tiene al menos 90% de homología de secuencia con la secuencia de aminoácidos de SEQ ID NO: 9, o (b) un polinucleótido aislado que codifica el polipéptido de (a).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89870807P | 2007-02-01 | 2007-02-01 | |
| PCT/KR2008/000621 WO2008094012A1 (en) | 2007-02-01 | 2008-02-01 | Novel polypeptide having anti-tumor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009008270A true MX2009008270A (es) | 2009-08-12 |
Family
ID=39674265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009008270A MX2009008270A (es) | 2007-02-01 | 2008-02-01 | Polipeptido novedoso que tiene actividad anti-tumoral. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110124582A1 (es) |
| EP (1) | EP2121739A4 (es) |
| JP (1) | JP2010526527A (es) |
| KR (1) | KR20090111320A (es) |
| AU (1) | AU2008211884A1 (es) |
| CA (1) | CA2676640A1 (es) |
| MX (1) | MX2009008270A (es) |
| WO (1) | WO2008094012A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006211730A1 (en) * | 2005-02-01 | 2006-08-10 | Imagene Co., Ltd. | Method for stimulation collagen synthesis and/or KGF expression |
| MX2008009493A (es) * | 2006-01-23 | 2008-10-03 | Imagene Co Ltd | Peptido novedoso y uso del mismo. |
| WO2010099477A2 (en) | 2009-02-27 | 2010-09-02 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| EP3255146B1 (en) | 2009-03-16 | 2019-05-15 | Pangu Biopharma Limited | Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities |
| EP2509625B1 (en) | 2009-12-11 | 2015-01-28 | Atyr Pharma, Inc. | Histidyl trna synthetases for reducing inflammation |
| CA2804424C (en) | 2010-07-12 | 2021-03-30 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| CA2873852A1 (en) | 2011-06-08 | 2012-12-13 | Indiana University Research And Technology Corporation | Monoclonal antibody and antigens for diagnosing and treating lung disease and injury |
| US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
| CN104220461A (zh) | 2011-12-29 | 2014-12-17 | Atyr医药公司 | 天冬氨酰-tRNA合成酶-FC缀合物 |
| CN104334196B (zh) | 2012-02-16 | 2018-04-10 | Atyr 医药公司 | 用于治疗自身免疫疾病和炎性疾病的组氨酰‑tRNA合成酶 |
| JP6397479B2 (ja) | 2013-03-15 | 2018-09-26 | エータイアー ファーマ， インコーポレイテッド | ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート |
| CN110536694A (zh) | 2017-04-20 | 2019-12-03 | Atyr 医药公司 | 用于治疗肺部炎症的组合物和方法 |
| KR102292069B1 (ko) * | 2020-10-19 | 2021-08-20 | 대한민국 | 돌돔 인지질분해효소 유래의 항균 펩타이드를 유효성분으로 함유하는 암 치료용 약학적 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155214A (en) * | 1984-03-05 | 1992-10-13 | The Salk Institute For Biological Studies | Basic fibroblast growth factor |
| US5556645A (en) * | 1990-01-12 | 1996-09-17 | Bockman; Richard | Methods of enhancing wound healing and tissue repair |
| US5981606A (en) * | 1991-03-01 | 1999-11-09 | Warner-Lambert Company | Therapeutic TGF-beta-wound healing compositions and methods for preparing and using same |
| US5641867A (en) * | 1993-09-29 | 1997-06-24 | The Trustees Of Columbia University In The City Of New York | Antibody which specifically binds to endothelial-monocyte activating polypeptide II |
| US6391311B1 (en) * | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
| US6800286B1 (en) * | 1998-08-19 | 2004-10-05 | The Regents Of The University Of Colorado | Chimeric fibroblast growth factor proteins, nucleic acid molecules, and uses thereof |
| WO2000029620A1 (en) * | 1998-11-13 | 2000-05-25 | Children's Hospital Of Los Angeles | Methods of facilitating vascular growth |
| AU5114000A (en) * | 2000-06-14 | 2001-12-24 | Imagene Co., Ltd. | P43 anti-tumor therapeutic agent and three dimensional structure of its cytokinedomain |
| KR100405919B1 (ko) * | 2001-06-05 | 2003-11-14 | 주식회사 이매진 | ｐ43의 Ｎ-말단 펩타이드를 유효성분으로 하는 면역증강용 약학조성물 |
| KR100515016B1 (ko) * | 2002-07-22 | 2005-09-15 | 재단법인서울대학교산학협력재단 | ｐ43을 유효성분으로 하는 창상 치료용 약학적 조성물 |
| AU2006211730A1 (en) * | 2005-02-01 | 2006-08-10 | Imagene Co., Ltd. | Method for stimulation collagen synthesis and/or KGF expression |
| MX2008009493A (es) * | 2006-01-23 | 2008-10-03 | Imagene Co Ltd | Peptido novedoso y uso del mismo. |
-
2008
- 2008-02-01 AU AU2008211884A patent/AU2008211884A1/en not_active Abandoned
- 2008-02-01 WO PCT/KR2008/000621 patent/WO2008094012A1/en not_active Ceased
- 2008-02-01 EP EP08712277A patent/EP2121739A4/en not_active Withdrawn
- 2008-02-01 MX MX2009008270A patent/MX2009008270A/es not_active Application Discontinuation
- 2008-02-01 KR KR1020097016040A patent/KR20090111320A/ko not_active Ceased
- 2008-02-01 JP JP2009548159A patent/JP2010526527A/ja active Pending
- 2008-02-01 CA CA002676640A patent/CA2676640A1/en not_active Abandoned
-
2010
- 2010-08-11 US US12/854,843 patent/US20110124582A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010526527A (ja) | 2010-08-05 |
| KR20090111320A (ko) | 2009-10-26 |
| EP2121739A4 (en) | 2010-03-10 |
| EP2121739A1 (en) | 2009-11-25 |
| CA2676640A1 (en) | 2008-08-07 |
| AU2008211884A1 (en) | 2008-08-07 |
| US20110124582A1 (en) | 2011-05-26 |
| WO2008094012A1 (en) | 2008-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |