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MX2009005881A - Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida. - Google Patents

Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida.

Info

Publication number
MX2009005881A
MX2009005881A MX2009005881A MX2009005881A MX2009005881A MX 2009005881 A MX2009005881 A MX 2009005881A MX 2009005881 A MX2009005881 A MX 2009005881A MX 2009005881 A MX2009005881 A MX 2009005881A MX 2009005881 A MX2009005881 A MX 2009005881A
Authority
MX
Mexico
Prior art keywords
sup
reverse transcriptase
transcriptase inhibitors
nucleoside reverse
compounds
Prior art date
Application number
MX2009005881A
Other languages
English (en)
Inventor
Denis John Kertesz
Christine E Brotherton-Pleiss
Minmin Yang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009005881A publication Critical patent/MX2009005881A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos útiles par tratar una infección del VIH, o prevenir una infección de VIH, o para tratar el SIDA o el ARC. Los compuestos de la invención son de fórmula I, en donde R1, R2, R3, R4, R5a, R5b, R6a, R6b y X tienen los significados que se han definido en esta solicitud. Se describen también en la presente invención métodos para tratar una infección del VIH con los compuestos aquí definidos y composiciones farmacéuticas que contienen los compuestos. (ver fórmula (I)).
MX2009005881A 2006-12-13 2007-12-04 Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida. MX2009005881A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87467306P 2006-12-13 2006-12-13
PCT/EP2007/063224 WO2008071587A2 (en) 2006-12-13 2007-12-04 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
MX2009005881A true MX2009005881A (es) 2009-06-12

Family

ID=39381919

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005881A MX2009005881A (es) 2006-12-13 2007-12-04 Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida.

Country Status (17)

Country Link
US (1) US7998969B2 (es)
EP (1) EP2089384B1 (es)
JP (1) JP5415957B2 (es)
KR (1) KR101475091B1 (es)
CN (1) CN101553483B (es)
AR (1) AR064221A1 (es)
AU (1) AU2007332654B2 (es)
BR (1) BRPI0720436A2 (es)
CA (1) CA2671478C (es)
CL (1) CL2007003565A1 (es)
ES (1) ES2550152T3 (es)
IL (1) IL199152A (es)
MX (1) MX2009005881A (es)
PE (1) PE20081509A1 (es)
RU (1) RU2469032C2 (es)
TW (1) TW200833681A (es)
WO (1) WO2008071587A2 (es)

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Also Published As

Publication number Publication date
AR064221A1 (es) 2009-03-18
CN101553483A (zh) 2009-10-07
CL2007003565A1 (es) 2008-07-04
US20080146595A1 (en) 2008-06-19
WO2008071587A2 (en) 2008-06-19
CN101553483B (zh) 2013-04-17
RU2469032C2 (ru) 2012-12-10
AU2007332654B2 (en) 2013-06-20
ES2550152T3 (es) 2015-11-04
WO2008071587A3 (en) 2008-07-31
AU2007332654A1 (en) 2008-06-19
CA2671478A1 (en) 2008-06-19
PE20081509A1 (es) 2008-10-24
JP5415957B2 (ja) 2014-02-12
TW200833681A (en) 2008-08-16
KR101475091B1 (ko) 2014-12-22
EP2089384A2 (en) 2009-08-19
RU2009126624A (ru) 2011-01-20
CA2671478C (en) 2015-02-17
IL199152A (en) 2015-11-30
JP2010513240A (ja) 2010-04-30
EP2089384B1 (en) 2015-08-05
KR20090087512A (ko) 2009-08-17
BRPI0720436A2 (pt) 2014-01-07
US7998969B2 (en) 2011-08-16

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