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MX2009003963A - Procedimiento para preparar difluorometilpirazolilcarboxilatos. - Google Patents

Procedimiento para preparar difluorometilpirazolilcarboxilatos.

Info

Publication number
MX2009003963A
MX2009003963A MX2009003963A MX2009003963A MX2009003963A MX 2009003963 A MX2009003963 A MX 2009003963A MX 2009003963 A MX2009003963 A MX 2009003963A MX 2009003963 A MX2009003963 A MX 2009003963A MX 2009003963 A MX2009003963 A MX 2009003963A
Authority
MX
Mexico
Prior art keywords
alkyl
phenyl
general formula
carboxylates
compound
Prior art date
Application number
MX2009003963A
Other languages
English (en)
Inventor
Thomas Grote
Michael Keil
Thomas Zierke
Michael Rack
Joachim Rheinheimer
Jochen Dietz
Sandra Loehr
Jan Klaas Lohmann
Sebastian Peer Smidt
Martin Sukopp
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of MX2009003963A publication Critical patent/MX2009003963A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/04—Esters of silicic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para preparar pirazol-4-ilcarboxilatos sustituidos con difluorometilo de la fórmula II (ver fórmula (I)) en donde R1 es alquilo C1-C8, cicloalquilo C3-C8, alcoxi C1-C4-alquilo C1-C4, etc.; y R2 es hidrógeno, alquilo C1-C4, bencilo o fenilo, en donde a) se hace reaccionar un compuesto de la fórmula general II (ver fórmula (II)) en donde X es flúor, cloro o bromo, R1 tiene uno de los significados previamente indicados y R4 es alquilo C1-C8, cicloalquilo C3-C8, alquenilo C2-C8, bencilo o fenilo, con un compuesto de silano de la fórmula general R3nSiCl(4-n), en donde n es 1, 2 ó 3 y los sustituyentes R3 están seleccionads, de modo independiente entre sí, de alquilo C1-C8 o fenilo, y con un metal, que está seleccionado entre los metales del grupo 1, 2, 3, 4 y 12 del sistema periódico y que presenta un potencial redox inferior a -0,7 V, referido a un electro de hidrógeno normal (a 25 ºC y 101,325 kPa); y b) la mezcla de reacción de la etapa a) se hace reaccionar con un compuesto de la formula general III R2HN-NH2 en donde R2 tiene uno de los significados previamente indicados.
MX2009003963A 2006-11-03 2007-11-02 Procedimiento para preparar difluorometilpirazolilcarboxilatos. MX2009003963A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06123461 2006-11-03
PCT/EP2007/061833 WO2008053043A1 (de) 2006-11-03 2007-11-02 Verfahren zur herstellung von difluormethylpyrazolylcarboxylaten

Publications (1)

Publication Number Publication Date
MX2009003963A true MX2009003963A (es) 2009-05-11

Family

ID=38050191

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003963A MX2009003963A (es) 2006-11-03 2007-11-02 Procedimiento para preparar difluorometilpirazolilcarboxilatos.

Country Status (21)

Country Link
US (1) US8115012B2 (es)
EP (1) EP2086944B1 (es)
JP (1) JP5284266B2 (es)
KR (1) KR20090080108A (es)
CN (1) CN101535274B (es)
AR (1) AR063464A1 (es)
AT (1) ATE455105T1 (es)
AU (1) AU2007316081B2 (es)
BR (1) BRPI0718222A2 (es)
CA (1) CA2666746C (es)
DE (1) DE502007002646D1 (es)
DK (1) DK2086944T3 (es)
EA (1) EA017900B1 (es)
ES (1) ES2338281T3 (es)
IL (1) IL198288A0 (es)
MX (1) MX2009003963A (es)
PL (1) PL2086944T3 (es)
SI (1) SI2086944T1 (es)
UA (1) UA97498C2 (es)
WO (1) WO2008053043A1 (es)
ZA (1) ZA200903792B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8115012B2 (en) 2006-11-03 2012-02-14 Basf Se Process for preparing difluoromethylpyrazolyl carboxylates
AU2007338031B2 (en) * 2006-12-21 2012-08-16 Basf Se Process for preparing fluoromethyl-substituted heterocyclic compounds
UA99460C2 (ru) * 2007-06-01 2012-08-27 Басф Се Способ получения n-замещенных (3-дигалометил-1-метилпиразол-4-ил)карбоксамидов
WO2008152138A2 (de) * 2007-06-15 2008-12-18 Basf Se Verfahren zur herstellung difluormethylsubstituierter pyrazolverbindungen
UA99919C2 (ru) * 2007-07-12 2012-10-25 Басф Се Кристаллическая форма 3-(дифторметил)-метил-n-(3',4',5'-трифторо[1,1'-бифенил]-2-ил)-1h-пиразол-4-карбоксамида, способа ее получения, агент для защиты растений и способ борьбы с нежелательным ростом растения
CN101959840B (zh) 2008-02-29 2014-04-16 巴斯夫欧洲公司 制备2-烷氧基亚甲基-4,4-二氟-3-氧丁酸烷基酯的方法
EP2100883A1 (de) * 2008-03-10 2009-09-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten
US8586750B2 (en) * 2008-05-02 2013-11-19 Basf Se Method for the production of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters
BRPI0911898A2 (pt) * 2008-05-02 2015-10-13 Basf Se processo para preparar compostos, e, composto.
BRPI0911767A2 (pt) 2008-05-05 2015-07-28 Basf Se Processo, e, composto.
BRPI0912383A2 (pt) * 2008-05-08 2015-07-28 Basf Se Processo para preparar aril carboxamidas
EP2307384B1 (en) * 2008-07-21 2012-04-25 Basf Se Process for preparing 1,3-disubstituted pyrazolecarboxylic esters
GB0908435D0 (en) * 2009-05-15 2009-06-24 Syngenta Ltd Processes
BR112012010484A2 (pt) 2009-11-05 2016-03-15 Basf Se processo para preparar compostos da fórmula i, composto e processo para prepapar compostos de pirazol 1,3 dissubstituídos da fórmula vi.
BR112012010486A2 (pt) 2009-11-05 2016-03-15 Basf Se processo para preparação de compostos 1-3 pirazol, processo para preparação de um acido pirazolcarboxilico da formula ia e processo para preparação de um composto da formula v
GB201004301D0 (en) * 2010-03-15 2010-04-28 Syngenta Participations Ag Process
EP2595962B1 (en) 2010-07-23 2018-07-11 Solvay Sa Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids
WO2012025469A1 (en) 2010-08-24 2012-03-01 Solvay Sa Improved process for the preparation of esters of 1-h-pyrazole-4-carboxylic acids
US8987470B2 (en) * 2010-10-27 2015-03-24 Solvay Sa Process for the preparation of pyrazole-4-carboxamides
BR112013022613A2 (pt) 2011-03-07 2016-12-06 Basf Se processo para a preparação de um composto
EP2546229A1 (de) 2011-07-15 2013-01-16 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren zur Synthese von Aminobiphenylen
WO2013132006A1 (de) 2012-03-07 2013-09-12 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren zur synthese von aminobiphenylen unter verwendung von arylhydrazinen
EP2644593A1 (en) * 2012-03-30 2013-10-02 Solvay Sa Dialkoxymethyl oxobutyric acid esters, their manufacture and use
EP2671874B1 (en) 2012-06-06 2016-01-13 Solvay Sa Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids
TWI654180B (zh) 2012-06-29 2019-03-21 美商艾佛艾姆希公司 殺真菌之雜環羧醯胺
US8871947B2 (en) 2013-02-04 2014-10-28 KingChem LLC Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester
TWI596095B (zh) * 2013-03-13 2017-08-21 中外製藥股份有限公司 Dihydropyridazine-3,5-dione derivatives
EP2986594B1 (en) 2013-04-15 2017-05-17 E. I. du Pont de Nemours and Company Fungicidal amides
US9139507B2 (en) 2013-12-09 2015-09-22 KingChem LLC. Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs
WO2017054112A1 (zh) * 2015-09-28 2017-04-06 常州市卜弋科研化工有限公司 3-氟代烷基-1-甲基吡唑-4-羧酸的制备方法
CN108699004A (zh) * 2016-02-18 2018-10-23 索尔维公司 用于制造羧酰胺的方法
CN106279025B (zh) * 2016-08-15 2017-10-10 浙江永太科技股份有限公司 一种含吡唑环的二酯化合物及其制备方法
CN112041303A (zh) 2018-05-21 2020-12-04 Pi工业有限公司 制备取代的杂环化合物的方法
JP7064216B2 (ja) * 2019-02-27 2022-05-10 国立大学法人 東京大学 アルコキシビニリデン化合物の製造方法、ピラゾール化合物の製造方法
CN111116364B (zh) * 2019-12-30 2022-11-11 浙江本立科技股份有限公司 2-多卤代乙酰基-3-烷氧基丙烯酸酯的制备方法
WO2022233129A1 (en) 2021-05-05 2022-11-10 Fujian Yongjing Technology Co., Ltd New process for the synthesis of 5-fluoro-3- (difuoromethyl) -5-fluoro-1-methyl-1h-pyrazole-4-carboxylic acid derivatives and the free acid thereof
EP4396164A4 (en) * 2021-08-31 2025-12-03 Upl Ltd METHOD FOR THE PRODUCTION OF BIXAFEN
CN115160226A (zh) * 2022-07-19 2022-10-11 欧阳建峰 一种一步缩合法制备联苯吡菌胺的方法
CN119285548A (zh) * 2024-10-08 2025-01-10 湖南化工研究院有限公司 一种氟唑菌酰胺的制备方法

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US5093347A (en) 1991-01-28 1992-03-03 Monsanto Company 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use
US5223526A (en) 1991-12-06 1993-06-29 Monsanto Company Pyrazole carboxanilide fungicides and use
IL111793A (en) * 1993-11-30 1998-12-06 Lilly Co Eli Process for preparing 2,2-Difluoroketene silyl acetals and alpha,alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid esters
HUP0301661A3 (en) * 2000-07-24 2003-11-28 Bayer Cropscience Ag Biphenyl carboxamides
DE10215292A1 (de) 2002-02-19 2003-08-28 Bayer Cropscience Ag Disubstitutierte Pyrazolylcarbocanilide
DE10351088A1 (de) 2003-10-31 2005-06-02 Bayer Cropscience Gmbh Verfahren zum Herstellen von fluormethyl-substituierten Heterocyclen
US20080108686A1 (en) 2004-06-18 2008-05-08 Basf Aktiengesellschaft N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides
JP5118043B2 (ja) 2005-09-16 2013-01-16 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト アミドの生成方法
US8115012B2 (en) 2006-11-03 2012-02-14 Basf Se Process for preparing difluoromethylpyrazolyl carboxylates
AU2007338031B2 (en) 2006-12-21 2012-08-16 Basf Se Process for preparing fluoromethyl-substituted heterocyclic compounds

Also Published As

Publication number Publication date
PL2086944T3 (pl) 2010-06-30
JP2010508333A (ja) 2010-03-18
ATE455105T1 (de) 2010-01-15
IL198288A0 (en) 2010-02-17
BRPI0718222A2 (pt) 2018-09-04
EP2086944A1 (de) 2009-08-12
AR063464A1 (es) 2009-01-28
JP5284266B2 (ja) 2013-09-11
AU2007316081B2 (en) 2012-04-26
EP2086944B1 (de) 2010-01-13
EA017900B1 (ru) 2013-04-30
EA200900607A1 (ru) 2009-10-30
UA97498C2 (ru) 2012-02-27
SI2086944T1 (sl) 2010-04-30
DK2086944T3 (da) 2010-05-03
US8115012B2 (en) 2012-02-14
CN101535274A (zh) 2009-09-16
KR20090080108A (ko) 2009-07-23
WO2008053043A1 (de) 2008-05-08
ZA200903792B (en) 2010-08-25
CA2666746A1 (en) 2008-05-08
ES2338281T3 (es) 2010-05-05
DE502007002646D1 (de) 2010-03-04
CN101535274B (zh) 2012-09-05
AU2007316081A1 (en) 2008-05-08
US20100069646A1 (en) 2010-03-18
CA2666746C (en) 2014-10-14

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