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MX2009002121A - Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico. - Google Patents

Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico.

Info

Publication number
MX2009002121A
MX2009002121A MX2009002121A MX2009002121A MX2009002121A MX 2009002121 A MX2009002121 A MX 2009002121A MX 2009002121 A MX2009002121 A MX 2009002121A MX 2009002121 A MX2009002121 A MX 2009002121A MX 2009002121 A MX2009002121 A MX 2009002121A
Authority
MX
Mexico
Prior art keywords
snac
manufacture
hydroxybenzoyl
amino
formation
Prior art date
Application number
MX2009002121A
Other languages
English (en)
Inventor
William Elliott Bay
Yi Ren
Pingsheng Zhang
Joseph Norman Bernadino
George Frederick Klein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009002121A publication Critical patent/MX2009002121A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/04—Sodium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención describe métodos mejorados para la síntesis de ácido N-(8-[2-hidroxibenzoil]-amino)caprílico. Ciertos compuestos se han encontrado útiles para prevenir la formación de una impureza coloreada cuando se incluyen en una reacción de hidrólisis de éster. También se ha encontrado que la conducción de hidrólisis de éster en condiciones anaeróbicas minimiza la formación de la impureza de color. También se describen métodos mejorados para sintetizar la sal de sodio de ácido N-(8-[2-hidroxibenzoil]-amino)caprílico.
MX2009002121A 2006-09-07 2007-08-30 Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico. MX2009002121A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84277506P 2006-09-07 2006-09-07
PCT/EP2007/059037 WO2008028859A1 (en) 2006-09-07 2007-08-30 A process for the manufacture of snac (salcaprozate sodium)

Publications (1)

Publication Number Publication Date
MX2009002121A true MX2009002121A (es) 2009-05-20

Family

ID=38702068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002121A MX2009002121A (es) 2006-09-07 2007-08-30 Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico.

Country Status (12)

Country Link
US (3) US10875826B2 (es)
EP (1) EP2064175B1 (es)
JP (1) JP5021033B2 (es)
KR (1) KR101081149B1 (es)
CN (1) CN101506147B (es)
AU (1) AU2007293916B2 (es)
BR (1) BRPI0716539A2 (es)
CA (1) CA2662080C (es)
ES (1) ES2498519T3 (es)
IL (1) IL197014A (es)
MX (1) MX2009002121A (es)
WO (1) WO2008028859A1 (es)

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Also Published As

Publication number Publication date
WO2008028859A1 (en) 2008-03-13
KR20090060997A (ko) 2009-06-15
IL197014A0 (en) 2009-11-18
ES2498519T3 (es) 2014-09-24
EP2064175B1 (en) 2014-08-06
CA2662080C (en) 2012-07-17
AU2007293916A1 (en) 2008-03-13
CA2662080A1 (en) 2008-03-13
US20080064890A1 (en) 2008-03-13
US20200071263A1 (en) 2020-03-05
JP5021033B2 (ja) 2012-09-05
AU2007293916B2 (en) 2011-02-03
BRPI0716539A2 (pt) 2016-11-01
JP2010502667A (ja) 2010-01-28
EP2064175A1 (en) 2009-06-03
IL197014A (en) 2013-01-31
CN101506147B (zh) 2012-03-21
US10875826B2 (en) 2020-12-29
US20210070691A1 (en) 2021-03-11
CN101506147A (zh) 2009-08-12
KR101081149B1 (ko) 2011-11-07
US7544833B2 (en) 2009-06-09

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