[go: up one dir, main page]

MX2009001840A - Procedimiento para la preparacion de derivados de acido 3-dihalometilpirazol-4-carboxilico. - Google Patents

Procedimiento para la preparacion de derivados de acido 3-dihalometilpirazol-4-carboxilico.

Info

Publication number
MX2009001840A
MX2009001840A MX2009001840A MX2009001840A MX2009001840A MX 2009001840 A MX2009001840 A MX 2009001840A MX 2009001840 A MX2009001840 A MX 2009001840A MX 2009001840 A MX2009001840 A MX 2009001840A MX 2009001840 A MX2009001840 A MX 2009001840A
Authority
MX
Mexico
Prior art keywords
acid derivatives
formula
dihalomethylpyrazole
preparing
carboxylic acid
Prior art date
Application number
MX2009001840A
Other languages
English (en)
Inventor
Sergii Pazenok
Norbert Lui
Arnd Neeff
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of MX2009001840A publication Critical patent/MX2009001840A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se refiere a un procedimiento para la preparación de derivados de ácido 3-dihalometilpirazol-4-carboxílico de fórmula (I) mediante la reacción de a-fluoroaminas de fórmula (III) en presencia de ácidos de Lewis con derivados de ácido acrílico de fórmula (II) hasta sales de vinamidinio de fórmula (IV) y su posterior reacción con hidrazinas, así como a las sales de vinamidinio de fórmula (IV) mismas. (Ver fórmulas I, II, III, IV, V, VI, VII).
MX2009001840A 2006-08-25 2007-08-22 Procedimiento para la preparacion de derivados de acido 3-dihalometilpirazol-4-carboxilico. MX2009001840A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006039909A DE102006039909A1 (de) 2006-08-25 2006-08-25 Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten
PCT/EP2007/007377 WO2008022777A2 (de) 2006-08-25 2007-08-22 Verfahren zum herstellen von 3-dihalomethyl-pyrazol-4-carbonsäurederivaten

Publications (1)

Publication Number Publication Date
MX2009001840A true MX2009001840A (es) 2009-03-03

Family

ID=39015935

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009001840A MX2009001840A (es) 2006-08-25 2007-08-22 Procedimiento para la preparacion de derivados de acido 3-dihalometilpirazol-4-carboxilico.

Country Status (16)

Country Link
US (1) US7939673B2 (es)
EP (1) EP2057126B1 (es)
JP (2) JP5511380B2 (es)
KR (1) KR101445326B1 (es)
CN (1) CN101506173B (es)
AT (1) ATE487702T1 (es)
BR (1) BRPI0715674B1 (es)
CA (1) CA2661407C (es)
DE (2) DE102006039909A1 (es)
DK (1) DK2057126T3 (es)
ES (1) ES2355309T3 (es)
IL (1) IL196894A (es)
MX (1) MX2009001840A (es)
RU (1) RU2470015C2 (es)
TW (1) TWI419880B (es)
WO (1) WO2008022777A2 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR066802A1 (es) 2007-06-01 2009-09-16 Basf Se Procedimiento para la preparacion de (3-dihalometil-1-metil- pirazol-4-il) carboxamidas n-susttituidas
EP2158185B1 (de) * 2007-06-15 2011-08-17 Basf Se Verfahren zur herstellung difluormethylsubstituierter pyrazolverbindungen
WO2009021987A1 (en) 2007-08-16 2009-02-19 Solvay (Société Anonyme) Process for the preparation of esters of 4-fluorosubstituted 3-oxo-alcanoic acids
EP2133341A1 (de) 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
EP2100883A1 (de) * 2008-03-10 2009-09-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4carbonsäure-Derivaten
ES2386940T3 (es) * 2008-05-02 2012-09-06 Basf Se Método para la preparación de ésteres halosustituidos de ácido 2-(aminometiliden)-3-oxobutírico
BRPI0911898A2 (pt) 2008-05-02 2015-10-13 Basf Se processo para preparar compostos, e, composto.
ES2525807T3 (es) 2008-05-05 2014-12-30 Basf Se Procedimiento de preparación de compuestos de pirazol sustituidos en las posiciones 1, 3, 4
CN102099343B (zh) 2008-07-21 2014-06-04 巴斯夫欧洲公司 制备1,3-二取代的吡唑羧酸酯的方法
GB0908435D0 (en) 2009-05-15 2009-06-24 Syngenta Ltd Processes
BR112012010486A2 (pt) 2009-11-05 2016-03-15 Basf Se processo para preparação de compostos 1-3 pirazol, processo para preparação de um acido pirazolcarboxilico da formula ia e processo para preparação de um composto da formula v
JP2013510112A (ja) 2009-11-05 2013-03-21 ビーエーエスエフ ソシエタス・ヨーロピア アミナールの調製方法及び１，３−二置換ピラゾール化合物を調製するためのその使用
CN103140477B (zh) 2010-04-23 2015-07-15 拜耳知识产权股份有限公司 制备5-氟-1-烷基-3-氟烷基-1h-吡唑-4-酰氯和酰氟的方法
BR112013032988A2 (pt) 2011-06-21 2016-08-16 Bayer Ip Gmbh método para a produção de pirazolilcarboxanilidas
EP2623496A1 (de) * 2012-02-01 2013-08-07 Bayer CropScience AG Verfahren zur Herstellung von 3,5-bis (fluoralkyl)-pyrazol-4-carbonsäure-Derivaten und 3,5-bis(fluoralkyl)-pyrazolen
ES2588386T3 (es) 2012-08-30 2016-11-02 Bayer Cropscience Ag Procedimiento de descarboxilación de derivados de ácido 3,5-bis(haloalquil)-pirazol-4-carboxílico
US8871947B2 (en) 2013-02-04 2014-10-28 KingChem LLC Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester
CN105408314B (zh) * 2013-05-22 2018-04-24 拜耳作物科学股份公司 从α,α-二卤代胺制备3,5-双(氟烷基)吡唑衍生物的方法
WO2014187774A1 (de) 2013-05-22 2014-11-27 Bayer Cropscience Ag Verfahren zur herstellung von 3,5-bis(fluoralkyl)-pyrazol-derivaten
TWI647215B (zh) * 2013-11-11 2019-01-11 德商拜耳作物科學股份有限公司 自α,α－二鹵胺製備３,５－雙鹵烷基吡唑衍生物之方法
US9139507B2 (en) 2013-12-09 2015-09-22 KingChem LLC. Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs
EP3015458A1 (en) 2014-11-03 2016-05-04 Bayer CropScience AG Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines
US9701640B2 (en) 2014-03-24 2017-07-11 Bayer Cropscience Aktiengesellschaft Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from α,α-dihaloamines and ketimines
EP3154947B1 (en) 2014-06-11 2018-03-28 Bayer CropScience Aktiengesellschaft Process for preparing 3,5-bis(haloalkyl)pyrazoles via acylation of ketimines
CN106458917B (zh) 2014-06-11 2019-04-12 拜耳作物科学股份公司 通过腙的酰化制备3,5-双(卤代烷基)吡唑衍生物的方法
CN104529899A (zh) * 2014-12-19 2015-04-22 浙江泰达作物科技有限公司 高区域选择性制备1-烷基-3-卤代烷基吡唑衍生物的方法
CN105541716B (zh) * 2015-03-26 2024-02-23 Ａｇｃ株式会社 吡唑衍生物的制造方法
US10407413B2 (en) * 2015-06-19 2019-09-10 Zhejiang Yongtai Technology Co., Ltd. Method for preparing pyrazolecarboxylic acid derivative, and intermediate thereof
KR20180021798A (ko) * 2015-06-26 2018-03-05 바이엘 크롭사이언스 악티엔게젤샤프트 α,α-디할로알킬아민 및 케트이민으로부터 할로알콕시- 및 할로알킬티오 그룹을 가지는 치환된 피라졸의 제조방법
EP3178813A1 (en) 2015-12-09 2017-06-14 Basf Se Method for preparing halogenated 3-oxocarboxylates carrying a 2-alkoxymethylidene or a 2-dialkylaminomethylidene group
BR112018014835A2 (pt) 2016-01-21 2018-12-18 Bayer Cropscience Ag processo para a preparação de quinolinas polifluoroalquiladas
KR102477317B1 (ko) 2016-09-21 2022-12-13 바이엘 크롭사이언스 악티엔게젤샤프트 3-플루오로알킬-5-피라졸카복실레이트 및 3-플루오로알킬-5-피라졸카복실산의 제조방법
WO2018234184A1 (en) 2017-06-22 2018-12-27 Bayer Aktiengesellschaft Process for the preparation of 2,3,4-trisubstituted quinolines
WO2019122164A1 (en) 2017-12-22 2019-06-27 Solvay Sa Process for the manufacture of pyrazole carboxylic derivatives and precursors thereof
EP3797099B1 (en) * 2018-05-21 2023-11-01 PI Industries Ltd. Method for preparing substituted heterocyclic compounds
TW202014410A (zh) 2018-06-18 2020-04-16 德商拜耳廠股份有限公司 二取代的５（３）－吡唑羧酸酯及由烯醇鹽與氟烷基胺基試劑（ｆａｒ）製備其之方法
JP6911143B2 (ja) 2018-11-07 2021-07-28 福建永晶科技股▲ふん▼有限公司Ｆｕｊｉａｎ Ｙｏｎｇｊｉｎｇ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ ピラゾール又はピリミジノンの新しい製造方法
CN110577503A (zh) * 2019-08-02 2019-12-17 宿迁市科莱博生物化学有限公司 一种卤素取代化合物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489624A (en) * 1992-12-01 1996-02-06 Minnesota Mining And Manufacturing Company Hydrophilic pressure sensitive adhesives
DE4302156A1 (de) * 1993-01-27 1994-07-28 Bayer Ag Verfahren zur Herstellung von Aminomethylenverbindungen
US5359089A (en) * 1993-12-22 1994-10-25 American Cyanamid Company Process for the preparation of 2,4,5-tribromopyrrole-3-carbonitrile
GB0101996D0 (en) * 2001-01-25 2001-03-14 Syngenta Participations Ag Organtic compounds
DE10161978A1 (de) * 2001-12-17 2003-06-26 Bayer Ag Verfahren zur Herstellung von 2-Halogenacyl-3-amino-acrylsäure-derivate
BR0308230B1 (pt) 2002-03-05 2014-05-20 Syngenta Participations Ag O-ciclopropil-carboxanilida, composição e método de controle ou prevenção de infestação de plantas cultivadas por microorganismos fitopatogênicos
DE10349500A1 (de) * 2003-10-23 2005-06-02 Bayer Cropscience Ag Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern
GB0415764D0 (en) * 2004-07-14 2004-08-18 Syngenta Participations Ag Chemical process
WO2006045504A1 (en) * 2004-10-21 2006-05-04 Syngenta Participations Ag Process for the preparation of pyrazoles
EP2158185B1 (de) * 2007-06-15 2011-08-17 Basf Se Verfahren zur herstellung difluormethylsubstituierter pyrazolverbindungen

Also Published As

Publication number Publication date
CA2661407A1 (en) 2008-02-28
EP2057126B1 (de) 2010-11-10
JP5511380B2 (ja) 2014-06-04
WO2008022777A2 (de) 2008-02-28
ES2355309T3 (es) 2011-03-24
TWI419880B (zh) 2013-12-21
WO2008022777A3 (de) 2008-04-17
RU2470015C2 (ru) 2012-12-20
US20090326242A1 (en) 2009-12-31
DE502007005625D1 (de) 2010-12-23
JP2010501502A (ja) 2010-01-21
KR20090043580A (ko) 2009-05-06
CN101506173B (zh) 2012-05-30
CA2661407C (en) 2014-07-15
CN101506173A (zh) 2009-08-12
IL196894A (en) 2015-03-31
BRPI0715674B1 (pt) 2015-06-16
KR101445326B1 (ko) 2014-09-29
TW200817335A (en) 2008-04-16
IL196894A0 (en) 2009-11-18
JP2014001226A (ja) 2014-01-09
JP5805717B2 (ja) 2015-11-04
DK2057126T3 (da) 2011-02-28
EP2057126A2 (de) 2009-05-13
DE102006039909A1 (de) 2008-03-13
US7939673B2 (en) 2011-05-10
ATE487702T1 (de) 2010-11-15
WO2008022777A8 (de) 2009-04-09
BRPI0715674A2 (pt) 2013-07-09
RU2009110413A (ru) 2010-09-27

Similar Documents

Publication Publication Date Title
MX2009001840A (es) Procedimiento para la preparacion de derivados de acido 3-dihalometilpirazol-4-carboxilico.
NZ606001A (en) Derivatives of 1-amino-2-cyclobutylethylboronic acid
MY155478A (en) Process for the regioselective preparation of 1-alkyl-3-haloalkylpyrazole-4-carboxylic acid derivatives
NZ603268A (en) Process for synthesizing oxidized lactam compounds
UA102518C2 (ru) Способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой
MX2010001963A (es) Procedimiento para la preparacion de 4-aminobut-2-enolidos.
MY150280A (en) Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
NZ601805A (en) Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
PH12015501226A1 (en) Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing the same
MX2011009898A (es) Proceso para la obtencion de derivados de acido propionico.
PT2462098E (pt) Processos para a preparação de derivados de ácido 1-(2- halobifenil-4-il)-ciclopropanocarboxílico
MY150014A (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
MX2008012488A (es) Un proceso de acoplamiento para preparar intermedios de quinolona.
MX2012002818A (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.
MX337997B (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.
MY145611A (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
UA117849C2 (uk) Спосіб одержання 3-заміщених складних ефірів (індол-1-іл)-оцтової кислоти
WO2008092583A3 (de) Verfahren zum herstellen von dihaloacetessigsäurealkylestern
MX2013004193A (es) Procedimiento para la preparacion de derivados de acido 3-(6-amino-piridin-3-il)-2-acrilico.
MX2011010934A (es) Proceso para la preparacion de un ester del acido bifenil-2-il-carbamico.
MX2009008707A (es) Procedimiento para preparar fenilhidracinas sustituidas.
MY181791A (en) Process for the preparation of propionic acid derivatives
MX2009001508A (es) Un proceso novedoso para preparar ester de acido 3-amino-5-fluoro-4-dialcoxipentanoico.
MX2009006402A (es) Procedimiento para preparar benzofuran-2-carboxamidas.
MX2011009731A (es) Nuevo procedimiento de preparacion de compuestos de enaminocarbonilo.

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration