[go: up one dir, main page]

MX2008016272A - Procesos de oxidacion mejorados con seguridad mejorada utiles en la fabricacion de moxidectina. - Google Patents

Procesos de oxidacion mejorados con seguridad mejorada utiles en la fabricacion de moxidectina.

Info

Publication number
MX2008016272A
MX2008016272A MX2008016272A MX2008016272A MX2008016272A MX 2008016272 A MX2008016272 A MX 2008016272A MX 2008016272 A MX2008016272 A MX 2008016272A MX 2008016272 A MX2008016272 A MX 2008016272A MX 2008016272 A MX2008016272 A MX 2008016272A
Authority
MX
Mexico
Prior art keywords
moxidectin
stabilised
manufacture
sibx
oxidation process
Prior art date
Application number
MX2008016272A
Other languages
English (en)
Inventor
Giuseppe Miraglia
Stefania Sapienza
Pasquale Massara
Marco Caraco
Jignesh Patel
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MX2008016272A publication Critical patent/MX2008016272A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona un proceso seguro y efectivo para la oxidación selectiva de un compuesto 5-O-protegido-LLF-2824 9-a para el compuesto 23-ceto correspondiente de la fórmula I (ver fórmula (I)) en donde R es un grupo protector. La presente invención también proporciona el uso de la oxidación selectiva proceso en la fabricación de moxidectina.
MX2008016272A 2006-06-22 2007-06-15 Procesos de oxidacion mejorados con seguridad mejorada utiles en la fabricacion de moxidectina. MX2008016272A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81572506P 2006-06-22 2006-06-22
PCT/US2007/014020 WO2007149305A2 (en) 2006-06-22 2007-06-15 Improved oxidation process with enhanced safety useful in the manufacture of moxidectin by means of stabilised 2-iodoxybenzoic acid (sibx)

Publications (1)

Publication Number Publication Date
MX2008016272A true MX2008016272A (es) 2009-01-15

Family

ID=36998058

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008016272A MX2008016272A (es) 2006-06-22 2007-06-15 Procesos de oxidacion mejorados con seguridad mejorada utiles en la fabricacion de moxidectina.

Country Status (12)

Country Link
US (1) US20080021093A1 (es)
EP (1) EP2044081A2 (es)
JP (1) JP2009541315A (es)
KR (1) KR20090018892A (es)
AU (3) AU2006100660B4 (es)
BR (1) BRPI0713609A2 (es)
CA (1) CA2650983A1 (es)
MX (1) MX2008016272A (es)
NZ (1) NZ548936A (es)
TW (1) TW200808809A (es)
WO (1) WO2007149305A2 (es)
ZA (1) ZA200810748B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ548936A (en) * 2006-06-22 2007-02-23 Wyeth Corp Selective oxidation of LL-F28249-alpha using o-iodoxybenzoic acid
CN103399115B (zh) * 2013-08-13 2015-03-04 河北圣雪大成制药有限责任公司 一种基于液相色谱仪检测莫西克汀含量的方法
CN104860961B (zh) * 2015-04-10 2017-08-04 新宇药业股份有限公司 一种制备5‑氧（对‑硝基苯甲酰）‑尼莫克汀的方法
CN111592553B (zh) * 2020-06-23 2022-09-02 江苏威凌生化科技有限公司 一种制备莫西克汀的方法
CN114591347B (zh) * 2022-03-29 2023-03-24 河北美荷药业有限公司 莫西菌素中间体及制备方法、莫西菌素的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988824A (en) * 1989-09-11 1991-01-29 Maulding Donald R Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds
FR2819808B1 (fr) * 2001-01-19 2003-04-18 Simafex Compositions stabilisees d'acide o-iodoxybenzoique et leur procede de preparation
US6762327B2 (en) * 2002-04-29 2004-07-13 Wyeth Selective oxidation process with enhanced safety
NZ548936A (en) * 2006-06-22 2007-02-23 Wyeth Corp Selective oxidation of LL-F28249-alpha using o-iodoxybenzoic acid

Also Published As

Publication number Publication date
EP2044081A2 (en) 2009-04-08
TW200808809A (en) 2008-02-16
WO2007149305A2 (en) 2007-12-27
AU2006100660A4 (en) 2006-09-07
WO2007149305A3 (en) 2008-02-14
AU2006203353B1 (en) 2007-12-13
US20080021093A1 (en) 2008-01-24
NZ548936A (en) 2007-02-23
JP2009541315A (ja) 2009-11-26
ZA200810748B (en) 2010-08-25
KR20090018892A (ko) 2009-02-24
CA2650983A1 (en) 2007-12-27
AU2006100660B4 (en) 2006-10-05
BRPI0713609A2 (pt) 2012-11-06
AU2006203353B8 (en) 2007-12-13
AU2007261596A1 (en) 2007-12-27

Similar Documents

Publication Publication Date Title
MX2008010921A (es) Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados.
TN2012000152A1 (en) Spiropiperidine compounds and pharmaceutical use thereof for treating diabetes
WO2009089537A3 (en) Anti-cancer compounds
MX2007004215A (es) Proceso para la sintesis de 4-(3-metansulfonilfenil)-1-n- propilpiperidina.
WO2008055814A3 (en) Process for the preparation of (s)-4-fluoromethyl-dihydro-furan-2-one
WO2008005565A3 (en) Antiviral phosphinate compounds
TN2012000248A1 (en) Novel spiropiperidine compounds
WO2009005677A3 (en) Antiviral compounds
WO2009005676A3 (en) Antiviral compounds
SG161145A1 (en) Photoacid generator containing aromatic ring
MX2009008781A (es) Derivados de ciclohexano espirociclicos.
UA95103C2 (ru) Замещенные арилсульфонамиды в качестве противовирусных средств
UY33325A (es) Purificación mediante adsorción de colorante caramelo
MX2012006026A (es) Derivados de acido 5-alquinil-tiofen-2-carboxilico y usos para tratamiento o prevencion de infecciones por flavivirus.
MX2008016272A (es) Procesos de oxidacion mejorados con seguridad mejorada utiles en la fabricacion de moxidectina.
UA103329C2 (ru) Соли соединений-ингибиторов вич
IL174469A0 (en) Rearranged pentanols, a method for the production thereof, and their use as antiphlogistics
NZ597866A (en) Therapeutic lactams
MY139797A (en) (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate
DE502005010342D1 (en) Substituierte cyclohexylessigsäure-derivate
MA31015B1 (fr) Procede de fabrication de 4.4'- (1-methyl-1,2-ethandiyl)-bis -(2,6-piperazindione)
UA98639C2 (en) Phosphodiesterase inhibitors
IL183104A0 (en) Method for production of candesartan
HU0402466D0 (en) Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
MX2009005579A (es) Quinazolinas sustituidas.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal