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MX2008000072A - Non-steroidal progesterone receptor modulators. - Google Patents

Non-steroidal progesterone receptor modulators.

Info

Publication number
MX2008000072A
MX2008000072A MX2008000072A MX2008000072A MX2008000072A MX 2008000072 A MX2008000072 A MX 2008000072A MX 2008000072 A MX2008000072 A MX 2008000072A MX 2008000072 A MX2008000072 A MX 2008000072A MX 2008000072 A MX2008000072 A MX 2008000072A
Authority
MX
Mexico
Prior art keywords
receptor modulators
progesterone receptor
therapy
prophylaxis
steroidal progesterone
Prior art date
Application number
MX2008000072A
Other languages
Spanish (es)
Inventor
Peter Droescher
Alexander Hillisch
Norbert Schmees
Wolfgang Schwede
Ulrike Fuhrmann
Carsten Moeller
Anja Schmidt
Ulrich Bothe
Guenter Kaufmann
Lothar Sobek
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MX2008000072A publication Critical patent/MX2008000072A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to non-steroidal progesterone receptor modulators of the general formula (I), a process for their preparation, the use of the progesterone receptor modulators for producing medicaments, and pharmaceutical compositions comprising these compounds. The compounds according to the invention are suitable for the therapy and prophylaxis of gynaecological disorders such as endometriosis, leiomyomas of the uterus, dysfunctional (bleeding )and dysmenorrhoea, and for the therapy and prophylaxis of hormone-dependent tumours and for use for female fertility control and for hormone replacement therapy.
MX2008000072A 2005-06-24 2006-06-22 Non-steroidal progesterone receptor modulators. MX2008000072A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030292A DE102005030292A1 (en) 2005-06-24 2005-06-24 Nonsteroidal progesterone receptor modulators
PCT/EP2006/006531 WO2006136461A2 (en) 2005-06-24 2006-06-22 Non-steroidal progesterone receptor modulators

Publications (1)

Publication Number Publication Date
MX2008000072A true MX2008000072A (en) 2008-03-24

Family

ID=37199176

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008000072A MX2008000072A (en) 2005-06-24 2006-06-22 Non-steroidal progesterone receptor modulators.

Country Status (22)

Country Link
EP (1) EP1902049A2 (en)
JP (1) JP2008543910A (en)
KR (1) KR20080030622A (en)
CN (1) CN101248066A (en)
AR (1) AR054519A1 (en)
AU (1) AU2006261048A1 (en)
BR (1) BRPI0611903A2 (en)
CA (1) CA2611897A1 (en)
CR (1) CR9598A (en)
DE (1) DE102005030292A1 (en)
DO (1) DOP2006000148A (en)
EA (1) EA200702524A1 (en)
EC (1) ECSP078044A (en)
GT (1) GT200600271A (en)
IL (1) IL188021A0 (en)
MX (1) MX2008000072A (en)
NO (1) NO20080440L (en)
PE (1) PE20070125A1 (en)
TW (1) TW200740778A (en)
UY (1) UY29624A1 (en)
WO (1) WO2006136461A2 (en)
ZA (1) ZA200800690B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (en) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS
DE102007032800A1 (en) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nonsteroidal progesterone receptor modulators
DE102007058747A1 (en) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nonsteroidal progesterone receptor modulators
WO2010002075A1 (en) * 2008-07-02 2010-01-07 Pharmacostech Co., Ltd. Methods for preparing amide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19856475A1 (en) * 1998-11-27 2000-05-31 Schering Ag Nonsteroidal anti-inflammatories
EP1344776A1 (en) * 2002-03-11 2003-09-17 Schering Aktiengesellschaft 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders
CA2531060A1 (en) * 2003-07-01 2005-01-13 Schering Aktiengesellschaft Heterocyclically-substitued pentanol derivatives, process for their production and their use as anti-inflammatory agents

Also Published As

Publication number Publication date
PE20070125A1 (en) 2007-02-14
BRPI0611903A2 (en) 2010-10-05
TW200740778A (en) 2007-11-01
JP2008543910A (en) 2008-12-04
UY29624A1 (en) 2007-01-31
CR9598A (en) 2008-04-09
ZA200800690B (en) 2009-09-30
IL188021A0 (en) 2008-03-20
DOP2006000148A (en) 2007-07-15
GT200600271A (en) 2007-02-05
CN101248066A (en) 2008-08-20
AU2006261048A1 (en) 2006-12-28
EP1902049A2 (en) 2008-03-26
AR054519A1 (en) 2007-06-27
CA2611897A1 (en) 2006-12-28
DE102005030292A1 (en) 2007-01-11
WO2006136461A2 (en) 2006-12-28
WO2006136461A3 (en) 2007-03-15
KR20080030622A (en) 2008-04-04
EA200702524A1 (en) 2008-06-30
NO20080440L (en) 2008-03-25
ECSP078044A (en) 2008-01-23

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal