MX2008000070A - Benzofuranone derivatives as nonsteroidal progesterone receptor modulators. - Google Patents
Benzofuranone derivatives as nonsteroidal progesterone receptor modulators.Info
- Publication number
- MX2008000070A MX2008000070A MX2008000070A MX2008000070A MX2008000070A MX 2008000070 A MX2008000070 A MX 2008000070A MX 2008000070 A MX2008000070 A MX 2008000070A MX 2008000070 A MX2008000070 A MX 2008000070A MX 2008000070 A MX2008000070 A MX 2008000070A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor modulators
- progesterone receptor
- well
- therapy
- benzofuranone derivatives
- Prior art date
Links
- 239000002379 progesterone receptor modulator Substances 0.000 title abstract 3
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title abstract 3
- ACZGCWSMSTYWDQ-UHFFFAOYSA-N 3h-1-benzofuran-2-one Chemical class C1=CC=C2OC(=O)CC2=C1 ACZGCWSMSTYWDQ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
Abstract
This invention relates to nonsteroidal progesterone receptor modulators of general formula (I), a process for their production, the use of progesterone receptor modulators for the production of pharmaceutical agents as well as pharmaceutical compositions that contain these compounds. The compounds according to the invention are suitable for therapy and prophylaxis of gynecological diseases, such as endometriosis, leiomyomas of the uterus, dysfunctional bleeding and dysmenorrhea, as well as for the therapy and prophylaxis of hormone-dependent tumors and for use for female birth control as well as for hormone replacement therapy.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005030294A DE102005030294A1 (en) | 2005-06-24 | 2005-06-24 | Nonsteroidal progesterone receptor modulators |
| PCT/EP2006/006532 WO2006136462A1 (en) | 2005-06-24 | 2006-06-22 | Benzofuranone derivatives as nonsteroidal progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008000070A true MX2008000070A (en) | 2008-03-19 |
Family
ID=36716643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008000070A MX2008000070A (en) | 2005-06-24 | 2006-06-22 | Benzofuranone derivatives as nonsteroidal progesterone receptor modulators. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1899315A1 (en) |
| JP (1) | JP2008543911A (en) |
| KR (1) | KR20080018275A (en) |
| CN (1) | CN101248056A (en) |
| AR (1) | AR057409A1 (en) |
| AU (1) | AU2006261049A1 (en) |
| BR (1) | BRPI0612305A2 (en) |
| CA (1) | CA2611900A1 (en) |
| CR (1) | CR9595A (en) |
| DE (1) | DE102005030294A1 (en) |
| DO (1) | DOP2006000150A (en) |
| EA (1) | EA200702604A1 (en) |
| EC (1) | ECSP078043A (en) |
| GT (1) | GT200600272A (en) |
| IL (1) | IL188022A0 (en) |
| MX (1) | MX2008000070A (en) |
| NO (1) | NO20080441L (en) |
| PE (1) | PE20070170A1 (en) |
| TW (1) | TW200738665A (en) |
| UY (1) | UY29626A1 (en) |
| WO (1) | WO2006136462A1 (en) |
| ZA (1) | ZA200800689B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY30805A1 (en) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS |
| DE102007032800A1 (en) * | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nonsteroidal progesterone receptor modulators |
| DE102007058747A1 (en) | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nonsteroidal progesterone receptor modulators |
| TWI477276B (en) * | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | Antiprogestin dosing regimens |
| MX363640B (en) | 2012-05-31 | 2019-03-28 | Repros Therapeutics Inc | Formulations and methods for vaginal delivery of antiprogestins. |
| WO2014070517A1 (en) | 2012-11-02 | 2014-05-08 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19723722A1 (en) * | 1997-05-30 | 1998-12-10 | Schering Ag | Nonsteroidal progestogens |
| US6358948B1 (en) * | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| HK1043788A1 (en) * | 1999-05-04 | 2002-09-27 | American Home Products Corporation | Tetracyclic progesterone receptor modulator compounds and methods |
| CA2472746A1 (en) * | 2002-01-14 | 2003-07-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof |
| HRP20040923A2 (en) * | 2002-03-11 | 2004-12-31 | Schering Ag | 5-{2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino}-phtalide and related compounds with progesterone receptor modulating activity for use in fertility control and hormone replacement therapy |
| DE10346939A1 (en) * | 2003-10-06 | 2005-05-19 | Schering Ag | New arylalkanol derivatives used for treating e.g. respiratory diseases, joint diseases, vascular inflammations, skin disorders, kidney and liver diseases and neurological diseases |
-
2005
- 2005-06-24 DE DE102005030294A patent/DE102005030294A1/en not_active Ceased
-
2006
- 2006-06-22 MX MX2008000070A patent/MX2008000070A/en not_active Application Discontinuation
- 2006-06-22 KR KR1020087001789A patent/KR20080018275A/en not_active Withdrawn
- 2006-06-22 CA CA002611900A patent/CA2611900A1/en not_active Abandoned
- 2006-06-22 AU AU2006261049A patent/AU2006261049A1/en not_active Abandoned
- 2006-06-22 EP EP06762405A patent/EP1899315A1/en not_active Withdrawn
- 2006-06-22 EA EA200702604A patent/EA200702604A1/en unknown
- 2006-06-22 CN CNA2006800306699A patent/CN101248056A/en active Pending
- 2006-06-22 WO PCT/EP2006/006532 patent/WO2006136462A1/en not_active Ceased
- 2006-06-22 JP JP2008517445A patent/JP2008543911A/en active Pending
- 2006-06-22 BR BRPI0612305-8A patent/BRPI0612305A2/en not_active Application Discontinuation
- 2006-06-23 TW TW095122741A patent/TW200738665A/en unknown
- 2006-06-26 PE PE2006000732A patent/PE20070170A1/en not_active Application Discontinuation
- 2006-06-26 GT GT200600272A patent/GT200600272A/en unknown
- 2006-06-26 UY UY29626A patent/UY29626A1/en not_active Application Discontinuation
- 2006-06-26 DO DO2006000150A patent/DOP2006000150A/en unknown
- 2006-06-27 AR ARP060102752A patent/AR057409A1/en unknown
-
2007
- 2007-12-10 IL IL188022A patent/IL188022A0/en unknown
- 2007-12-14 CR CR9595A patent/CR9595A/en not_active Application Discontinuation
- 2007-12-21 EC EC2007008043A patent/ECSP078043A/en unknown
-
2008
- 2008-01-23 NO NO20080441A patent/NO20080441L/en not_active Application Discontinuation
- 2008-01-23 ZA ZA200800689A patent/ZA200800689B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL188022A0 (en) | 2008-03-20 |
| BRPI0612305A2 (en) | 2010-11-03 |
| CA2611900A1 (en) | 2006-12-28 |
| CN101248056A (en) | 2008-08-20 |
| ECSP078043A (en) | 2008-01-23 |
| CR9595A (en) | 2008-05-05 |
| KR20080018275A (en) | 2008-02-27 |
| WO2006136462A1 (en) | 2006-12-28 |
| PE20070170A1 (en) | 2007-03-02 |
| AU2006261049A1 (en) | 2006-12-28 |
| JP2008543911A (en) | 2008-12-04 |
| GT200600272A (en) | 2007-08-20 |
| DE102005030294A1 (en) | 2007-01-04 |
| AR057409A1 (en) | 2007-12-05 |
| ZA200800689B (en) | 2009-07-29 |
| UY29626A1 (en) | 2007-01-31 |
| EA200702604A1 (en) | 2008-06-30 |
| DOP2006000150A (en) | 2006-12-31 |
| NO20080441L (en) | 2008-03-07 |
| EP1899315A1 (en) | 2008-03-19 |
| TW200738665A (en) | 2007-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |