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MX2007010272A - Inhibidores de moleculas pequenas de mdm2 y usos de los mismos. - Google Patents

Inhibidores de moleculas pequenas de mdm2 y usos de los mismos.

Info

Publication number
MX2007010272A
MX2007010272A MX2007010272A MX2007010272A MX2007010272A MX 2007010272 A MX2007010272 A MX 2007010272A MX 2007010272 A MX2007010272 A MX 2007010272A MX 2007010272 A MX2007010272 A MX 2007010272A MX 2007010272 A MX2007010272 A MX 2007010272A
Authority
MX
Mexico
Prior art keywords
mdm2
small molecule
molecule inhibitors
relates
inhibitors
Prior art date
Application number
MX2007010272A
Other languages
English (en)
Inventor
Shaomeng Wang
Zaneta Nikolovska-Coleska
Guoping Wang
Ke Ding
Yipin Lu
Su Qiu
Dongguang Qin
Sanjeev Kumar
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of MX2007010272A publication Critical patent/MX2007010272A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se refiere a moleculas pequenas que funcionan como inhibidores de la interaccion entre p53 y MDM2. La invencion tambien se refiere al uso de estos compuestos para inhibir el crecimiento celular, para inducir la muerte celular, para inducir el paro del ciclo celular, y/o para sensibilizar a las celulas a agentes adicionales.
MX2007010272A 2005-02-22 2006-02-22 Inhibidores de moleculas pequenas de mdm2 y usos de los mismos. MX2007010272A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65513505P 2005-02-22 2005-02-22
PCT/US2006/006221 WO2006091646A2 (en) 2005-02-22 2006-02-22 Small molecule inhibitors of mdm2 and uses thereof

Publications (1)

Publication Number Publication Date
MX2007010272A true MX2007010272A (es) 2008-03-12

Family

ID=36927977

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007010272A MX2007010272A (es) 2005-02-22 2006-02-22 Inhibidores de moleculas pequenas de mdm2 y usos de los mismos.

Country Status (11)

Country Link
EP (1) EP1856123B1 (es)
JP (2) JP5248866B2 (es)
KR (1) KR100944301B1 (es)
CN (2) CN102627649B (es)
AU (2) AU2006216780B8 (es)
BR (1) BRPI0609172A2 (es)
CA (2) CA2598690C (es)
EA (2) EA014445B1 (es)
MX (1) MX2007010272A (es)
NO (1) NO20074853L (es)
WO (1) WO2006091646A2 (es)

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Also Published As

Publication number Publication date
EA201001255A1 (ru) 2011-02-28
KR20070108917A (ko) 2007-11-13
AU2010202759B2 (en) 2012-07-19
CN102627649A (zh) 2012-08-08
EP1856123A4 (en) 2010-12-29
AU2006216780B8 (en) 2010-04-22
EP1856123A2 (en) 2007-11-21
CN102627649B (zh) 2015-03-25
NO20074853L (no) 2007-11-21
JP2012162550A (ja) 2012-08-30
CA2752738C (en) 2014-05-27
JP5248866B2 (ja) 2013-07-31
AU2006216780B2 (en) 2010-04-01
EA014445B1 (ru) 2010-12-30
CN101160314B (zh) 2012-05-23
AU2006216780A1 (en) 2006-08-31
CN101160314A (zh) 2008-04-09
EP1856123B1 (en) 2016-02-17
CA2598690A1 (en) 2006-08-31
WO2006091646A2 (en) 2006-08-31
JP2008531504A (ja) 2008-08-14
WO2006091646A3 (en) 2006-11-30
JP5638023B2 (ja) 2014-12-10
CA2752738A1 (en) 2006-08-31
EA200701771A1 (ru) 2008-06-30
KR100944301B1 (ko) 2010-02-24
AU2010202759A1 (en) 2010-07-22
CA2598690C (en) 2011-11-15
EA019566B1 (ru) 2014-04-30
BRPI0609172A2 (pt) 2010-02-23

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