[go: up one dir, main page]

MEP3208A - Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama - Google Patents

Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama

Info

Publication number
MEP3208A
MEP3208A MEP-32/08A MEP3208A MEP3208A ME P3208 A MEP3208 A ME P3208A ME P3208 A MEP3208 A ME P3208A ME P3208 A MEP3208 A ME P3208A
Authority
ME
Montenegro
Prior art keywords
modified
polypeptides
pharmacokinetic properties
chimeric polypeptides
modified chimeric
Prior art date
Application number
MEP-32/08A
Other languages
Bosnian (bs)
English (en)
Inventor
Nicholas J Papadopoulos
Samuel Davis
George D Yancopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22480568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP3208(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MEP3208A publication Critical patent/MEP3208A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
MEP-32/08A 1999-06-08 2000-05-23 Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama MEP3208A (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13813399P 1999-06-08 1999-06-08
PCT/US2000/014142 WO2000075319A1 (en) 1999-06-08 2000-05-23 Modified chimeric polypeptides with improved pharmacokinetic properties

Publications (1)

Publication Number Publication Date
MEP3208A true MEP3208A (xx) 2010-02-10

Family

ID=22480568

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-32/08A MEP3208A (xx) 1999-06-08 2000-05-23 Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama
MEP-2008-32A ME00024B (me) 1999-06-08 2000-05-23 Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2008-32A ME00024B (me) 1999-06-08 2000-05-23 Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama

Country Status (32)

Country Link
EP (2) EP1544299B1 (xx)
JP (2) JP4723140B2 (xx)
KR (1) KR100659477B1 (xx)
CN (3) CN103349781B (xx)
AT (2) ATE417928T1 (xx)
AU (2) AU779303B2 (xx)
BE (1) BE2013C029I2 (xx)
BR (2) BRPI0011407B8 (xx)
CA (1) CA2376379C (xx)
CY (2) CY1108883T1 (xx)
CZ (2) CZ303656B6 (xx)
DE (2) DE60041159D1 (xx)
DK (2) DK1183353T3 (xx)
ES (2) ES2237429T3 (xx)
FR (1) FR13C0028I2 (xx)
HR (1) HRP20010908B1 (xx)
HU (3) HU230159B1 (xx)
IL (3) IL146890A0 (xx)
LT (1) LTC1183353I2 (xx)
LU (1) LU92195I2 (xx)
ME (2) MEP3208A (xx)
MX (1) MXPA01012630A (xx)
NO (4) NO330775B1 (xx)
NZ (1) NZ515913A (xx)
PL (1) PL208247B1 (xx)
PT (2) PT1183353E (xx)
RS (1) RS50073B (xx)
RU (1) RU2265661C2 (xx)
SK (1) SK287332B6 (xx)
UA (1) UA74146C2 (xx)
WO (1) WO2000075319A1 (xx)
ZA (1) ZA200110068B (xx)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710174B2 (en) 2001-09-13 2004-03-23 Isis Pharmaceuticals, Inc. Antisense inhibition of vascular endothelial growth factor receptor-1 expression
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
US6833349B2 (en) * 1999-06-08 2004-12-21 Regeneron Pharmaceuticals, Inc. Methods of treating inflammatory skin diseases
US7087411B2 (en) * 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
JP4669984B2 (ja) 2001-01-19 2011-04-13 ベジェニクス リミテッド 腫瘍画像化のターゲットとしてのF1t4(VEGFR−3)および抗腫瘍療法
US6734017B2 (en) 2001-09-28 2004-05-11 Isis Pharmaceuticals, Inc. Antisense modulation of vascular endothelial growth factor receptor-2 expression
US8183350B2 (en) 2002-05-04 2012-05-22 Acorda Therapeutics, Inc. Compositions and methods for promoting neuronal outgrowth
JP4730909B2 (ja) 2003-03-28 2011-07-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Vegf媒介性活性を遮断することにより糖尿病を処置する方法
JP2007532094A (ja) 2003-05-16 2007-11-15 アコーダ セラピューティクス、インク. Cns治療用のプロテオグリカン分解変異体
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
JP5399612B2 (ja) * 2003-05-16 2014-01-29 アコーダ セラピューティクス、インク. Cnsを治療するための融合タンパク質
EP1626989A2 (en) * 2003-05-28 2006-02-22 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection by using vegf antagonists
US7186699B2 (en) 2003-06-03 2007-03-06 Cell Genesys, Inc. Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
CA2519875C (en) * 2003-06-06 2014-01-14 Regeneron Pharmaceuticals, Inc. Method of tumor regression with vegf inhibitors
US7399612B2 (en) 2003-06-30 2008-07-15 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
AR046510A1 (es) * 2003-07-25 2005-12-14 Regeneron Pharma Composicion de un antagonista de vegf y un agente anti-proliferativo
US20050112061A1 (en) * 2003-08-06 2005-05-26 Jocelyn Holash Use of a VEGF antagonist in combination with radiation therapy
MXPA06013345A (es) 2004-05-18 2008-10-31 Acorda Therapeutics Inc Metodos para purificar condrointinasa y sus formulaciones estables.
KR100897379B1 (ko) * 2004-06-08 2009-05-14 쳉두 캉홍 바이오테크놀로지스 코. 리미티드 혈관신생-저해 키메릭 단백질 및 그 사용
WO2005123104A2 (en) 2004-06-10 2005-12-29 Regeneron Pharmaceuticals, Inc. Use of vegf inhibitors for the treatment of human cancer
EP1755645A2 (en) * 2004-06-18 2007-02-28 Regeneron Pharmaceuticals, Inc. Vegf inhibitors for the treatment of malignant pleural effusion
AU2005267741A1 (en) 2004-07-30 2006-02-09 Regeneron Pharmaceuticals, Inc. Methods of treating type I diabetes by blocking VEGF-mediated activity
ES2407859T3 (es) * 2004-09-13 2013-06-14 Genzyme Corporation Construcciones multiméricas.
FR2878749B1 (fr) * 2004-12-03 2007-12-21 Aventis Pharma Sa Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives
WO2006088650A2 (en) * 2005-02-02 2006-08-24 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a vegf inhibitor
EP1861116B1 (en) 2005-03-25 2015-09-16 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations
US7485295B2 (en) 2005-09-26 2009-02-03 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase ABCI mutants
CA2630839C (en) 2005-12-16 2017-01-17 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with dll4 antagonists
FR2895258B1 (fr) 2005-12-22 2008-03-21 Aventis Pharma Sa Combinaison comprenant de la combretastatine et des agents anticancereux
CN100502945C (zh) * 2006-03-31 2009-06-24 成都康弘生物科技有限公司 Vegf受体融合蛋白在治疗眼睛疾病中的应用
US8216575B2 (en) 2006-03-31 2012-07-10 Chengdu Kanghong Biotechnologies Co., Ltd. Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
DK2364691T3 (da) 2006-06-16 2013-07-01 Regeneron Pharma VEGF antagonist-formuleringer, der kan anvendes til intravitreal administration
JP5535633B2 (ja) 2006-09-29 2014-07-02 オンコメッド ファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
CA2666536C (en) 2006-10-10 2018-08-07 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
FR2918279B1 (fr) * 2007-07-05 2010-10-22 Aventis Pharma Sa Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan
CN101575379B (zh) * 2008-05-09 2012-05-30 上海抗体药物国家工程研究中心有限公司 可溶性vegfr双功能融合受体、其制备方法及用途
BRPI0921469B1 (pt) 2008-11-03 2022-01-18 Molecular Partners Ag Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica
CN101838329A (zh) * 2009-03-18 2010-09-22 嘉和生物药业有限公司 抗血管新生融合蛋白
ES2700450T3 (es) 2009-10-16 2019-02-15 Oncomed Pharm Inc Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensores
AR081361A1 (es) 2010-04-30 2012-08-29 Molecular Partners Ag Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
ES2652508T3 (es) 2010-08-06 2018-02-02 Genzyme Corporation Composiciones de antagonistas de VEGF y sus usos
JP6043629B2 (ja) * 2011-01-07 2016-12-14 中外製薬株式会社 抗体の物性を改善させる方法
SG191334A1 (en) 2011-01-13 2013-08-30 Regeneron Pharma Use of a vegf antagonist to treat angiogenic eye disorders
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
KR101397088B1 (ko) 2011-06-10 2014-05-19 강원대학교산학협력단 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물
JO3370B1 (ar) * 2011-11-10 2019-03-13 Regeneron Pharma طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
CN110078831A (zh) * 2011-12-01 2019-08-02 圆祥生命科技股份有限公司 补体和vegf途径的蛋白质抑制剂及其使用方法
CN103304668B (zh) * 2012-03-12 2015-10-28 江苏健德生物药业有限公司 Ultra-VEGF-trap免疫融合蛋白、其制备方法及其应用
ES2753135T3 (es) 2012-05-07 2020-04-07 Allergan Inc Método de tratamiento de DMAE en pacientes resistentes a terapia anti-VEGF
WO2014006113A1 (en) 2012-07-03 2014-01-09 Sanofi Method of treating cancer by effective amounts of aflibercept
AR093445A1 (es) 2012-11-14 2015-06-10 Regeneron Pharma Metodos para tratar el cancer de ovario con antagonistas de dll4
AU2014218318B2 (en) 2013-02-18 2018-02-15 Vegenics Pty Limited Ligand binding molecules and uses thereof
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
CN104193828B (zh) * 2013-09-12 2017-04-05 北京韩美药品有限公司 同时阻断her2和vegfr信号通路的重组融合蛋白
KR20160070164A (ko) 2013-11-05 2016-06-17 알러간, 인코포레이티드 항-vegf darpin으로 눈의 병태를 치료하는 방법
KR20170003973A (ko) 2014-05-12 2017-01-10 포르미콘 아게 Vegf 안타고니스트를 포함하는 사전충전형 플라스틱제 주사기
MX375557B (es) 2014-07-18 2025-03-06 Sanofi Sa Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer.
JP2016036322A (ja) * 2014-08-11 2016-03-22 日本化薬株式会社 血管新生因子と結合するキメラタンパク質
PL3230316T3 (pl) 2014-12-11 2022-05-02 Bayer Healthcare Llc Leczenie zwyrodnienia plamki żółtej związanego z wiekiem z małą aktywną zmianą neowaskularyzacji naczyniówki
GB201503453D0 (en) 2015-03-01 2015-04-15 Jain Arjun Endothelin-1"sponge"
TWI797060B (zh) 2015-08-04 2023-04-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
WO2017046140A1 (en) 2015-09-18 2017-03-23 Bayer Pharma Aktiengesellschaft Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
KR101936049B1 (ko) 2015-10-15 2019-01-08 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 생산방법
WO2017065559A1 (ko) 2015-10-15 2017-04-20 (주)알테오젠 Igg fc 도메인을 가지는 융합 단백질의 생산방법
KR102854749B1 (ko) 2015-11-18 2025-09-04 에스아이오2 메디컬 프로덕츠, 엘엘씨 안과 제제용 제약 패키지
AU2016358111B2 (en) 2015-11-18 2021-11-18 Sio2 Medical Products, Llc Pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist
WO2018218013A2 (en) 2017-05-24 2018-11-29 Sio2 Medical Products, Inc. Sterilizable pharmaceutical package for ophthalmic formulations
EP3377151A1 (en) 2015-11-18 2018-09-26 Formycon AG Pre-filled plastic syringe containing a vegf antagonist
CN108697792A (zh) * 2015-11-19 2018-10-23 珠海泰瑞尚生物医药科技有限公司 用于结合vegf的方法和组合物
CA3137326C (en) 2015-12-03 2024-01-23 Regeneron Pharmaceuticals, Inc. Use of vegf inhibitor to treat macular degeneration in a patient population
US10576128B2 (en) 2016-01-26 2020-03-03 Formycon Ag Liquid formulation of a VEGF antagonist
JPWO2018070390A1 (ja) 2016-10-12 2019-08-22 第一三共株式会社 抗robo4抗体と他剤を含む組成物
EP3541365A1 (en) 2016-11-21 2019-09-25 Just Biotherapeutics, Inc. Aflibercept formulations and uses thereof
WO2018215580A1 (en) 2017-05-24 2018-11-29 Formycon Ag Method for sterilizing prefilled plastic syringes containing a vegf antagonist
US20200237997A1 (en) 2017-05-24 2020-07-30 Formycon Ag Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
TW201904610A (zh) 2017-06-14 2019-02-01 德商拜耳製藥公司 用於治療新生血管型青光眼之非抗體vegf拮抗劑
WO2019020777A1 (en) 2017-07-26 2019-01-31 Formycon Ag LIQUID FORMULATION OF A VEGF ANTAGONIST
CN111344410B (zh) 2017-08-17 2023-09-15 济世易为生物有限公司 从宿主细胞半乳糖凝集素和其他污染物中纯化糖基化蛋白的方法
KR102732284B1 (ko) 2017-11-20 2024-11-19 저스트-에보텍 바이오로직스, 아이엔씨. 등장화제로서 라이신 염을 함유하는 아플리베르셉트 제제 및 그것의 용도
CA3083472A1 (en) 2017-11-27 2019-05-31 4D Molecular Therapeutics Inc. Adeno-associated virus variant capsids and use for inhibiting angiogenesis
MX2020005166A (es) 2017-11-30 2020-09-03 Regeneron Pharma Uso de un antagonista de vegf para tratar trastornos oculares angiogenicos.
US11460452B2 (en) 2017-12-13 2022-10-04 Regeneron Pharmaceuticals, Inc. Devices and systems for chromatography column bed support management and related methods
EP4495136A3 (en) 2018-01-26 2025-04-23 The Regents of the University of California Methods and compositions for treatment of angiogenic disorders using anti-vegf agents
JP2021514656A (ja) 2018-03-02 2021-06-17 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. Il−6抗体ならびにその融合構築物およびコンジュゲート
TW202016125A (zh) * 2018-05-10 2020-05-01 美商再生元醫藥公司 用於定量及調節蛋白質黏度之系統與方法
LT4364724T (lt) 2018-05-10 2026-01-12 Regeneron Pharmaceuticals, Inc. Farmacinės formos, kurių sudėtyje yra didelės koncentracijos vegf receptoriaus sulietas baltymas
US11519020B2 (en) 2018-05-25 2022-12-06 Regeneron Pharmaceuticals, Inc. Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
CN111378044B (zh) 2018-12-28 2022-07-15 长春金赛药业有限责任公司 抗体融合蛋白、制备方法及其应用
US20220204920A1 (en) 2019-05-16 2022-06-30 Formycon Ag Method for reducing methionine oxidation in recombinant proteins
MX2022002355A (es) 2019-09-03 2022-04-06 Amgen Inc Dispositivo de inyeccion para suministro de farmacos y envase para el dispositivo de inyeccion.
AU2020348947B2 (en) 2019-09-16 2025-11-27 Amgen Inc. Method for external sterilization of drug delivery device
EP4041312A4 (en) 2019-10-10 2023-12-20 Kodiak Sciences Inc. METHOD FOR TREATING AN EYE DISORDER
JP2023502501A (ja) 2019-11-25 2023-01-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 眼内血管新生のための長時間作用型vegf阻害剤
AU2020398125C1 (en) 2019-12-06 2023-05-11 Regeneron Pharmaceuticals, Inc. Anti-VEGF protein compositions and methods for producing the same
JP2023505216A (ja) 2019-12-06 2023-02-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Vegfミニトラップおよびそれらの使用方法
AU2021226754A1 (en) 2020-02-24 2022-07-07 Amgen Inc. Containers and systems for use during external sterilization of drug delivery devices
AU2021268026A1 (en) 2020-05-08 2023-01-19 Regeneron Pharmaceuticals, Inc. VEGF traps and mini-traps and methods for treating ocular disorders and cancer
EP4329734A4 (en) 2021-04-26 2025-04-02 Celanese EVA Performance Polymers LLC Implantable device for the delayed release of a macromolecular drug compound
EP4145456A1 (en) 2021-09-06 2023-03-08 Bayer AG Prediction of a change related to a macular fluid
US20250002557A1 (en) 2021-11-24 2025-01-02 Suzhou Light Ferry Biomed. Co., Ltd Multi-specific ligand-binding molecules and applications thereof
KR102764987B1 (ko) * 2022-08-02 2025-02-12 주식회사 파노로스바이오사이언스 변형된 융합 단백질 및 이의 용도
WO2024056058A1 (zh) 2022-09-16 2024-03-21 齐鲁制药有限公司 一种稳定的高浓度自缓冲药物组合物
WO2025033876A1 (ko) * 2023-08-04 2025-02-13 주식회사 파노로스바이오사이언스 변형된 융합 단백질과 scFv의 결합체 및 이의 용도
WO2025213011A1 (en) 2024-04-05 2025-10-09 Amgen Inc. Method of assessing stopper movement in a drug delivery device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506466D0 (en) * 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US6100071A (en) * 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production

Also Published As

Publication number Publication date
DK1544299T3 (da) 2009-03-23
CA2376379A1 (en) 2000-12-14
JP5273746B2 (ja) 2013-08-28
DE60019415T2 (de) 2006-03-09
CY2013019I2 (el) 2015-11-04
PT1544299E (pt) 2009-03-18
HU230159B1 (hu) 2015-09-28
PL208247B1 (pl) 2011-04-29
IL146890A0 (en) 2002-08-14
BRPI0011407B1 (pt) 2018-09-25
SK17522001A3 (sk) 2003-04-01
EP1544299A1 (en) 2005-06-22
HUS1300052I1 (hu) 2016-08-29
CN1369009A (zh) 2002-09-11
HRP20010908B1 (en) 2006-05-31
AU779303B2 (en) 2005-01-13
ATE417928T1 (de) 2009-01-15
HK1043388A1 (en) 2002-09-13
CN101433715A (zh) 2009-05-20
CZ20014387A3 (cs) 2002-10-16
NO20016036D0 (no) 2001-12-10
JP4723140B2 (ja) 2011-07-13
NZ515913A (en) 2004-01-30
CN103349781B (zh) 2015-04-01
AU2005201365B2 (en) 2007-08-09
IL190234A0 (en) 2008-11-03
EP1183353A1 (en) 2002-03-06
BR0011407A (pt) 2002-04-02
ZA200110068B (en) 2002-12-06
ES2237429T3 (es) 2005-08-01
LTC1183353I2 (lt) 2023-02-27
MXPA01012630A (es) 2002-07-22
DE60019415D1 (de) 2005-05-19
HK1185798A1 (en) 2014-02-28
KR100659477B1 (ko) 2006-12-20
RU2265661C2 (ru) 2005-12-10
JP2011024595A (ja) 2011-02-10
EP1183353B1 (en) 2005-04-13
IL146890A (en) 2008-07-08
NO20016036L (no) 2002-02-08
NO332559B1 (no) 2012-10-29
HRP20010908A2 (en) 2005-04-30
NO2022060I1 (no) 2022-12-21
YU86901A (sh) 2004-05-12
HU229156B1 (en) 2013-09-30
BE2013C029I2 (xx) 2019-03-06
HK1132653A1 (en) 2010-03-05
BRPI0011407B8 (pt) 2021-05-25
ME00024B (me) 2010-02-10
DK1183353T3 (da) 2005-08-08
CA2376379C (en) 2007-08-07
PT1183353E (pt) 2005-06-30
UA74146C2 (uk) 2005-11-15
DE60041159D1 (de) 2009-01-29
KR20020019070A (ko) 2002-03-09
CN103349781A (zh) 2013-10-16
CZ303656B6 (cs) 2013-01-30
WO2000075319A1 (en) 2000-12-14
EP1544299B1 (en) 2008-12-17
LU92195I2 (fr) 2013-07-15
CN101433715B (zh) 2013-04-17
PL352246A1 (en) 2003-08-11
ATE293164T1 (de) 2005-04-15
FR13C0028I2 (fr) 2014-05-16
HUP0201515A2 (en) 2002-08-28
NO2013010I1 (no) 2013-06-17
CY2013019I1 (el) 2015-11-04
ES2319305T3 (es) 2009-05-06
AU2005201365A1 (en) 2005-04-28
HUP0201515A3 (en) 2004-12-28
CY1108883T1 (el) 2014-07-02
NO2013010I2 (no) 2013-05-15
FR13C0028I1 (fr) 2013-06-14
NO330775B1 (no) 2011-07-11
NO20100656L (no) 2002-02-08
SK287332B6 (sk) 2010-07-07
AU5040400A (en) 2000-12-28
CN100523187C (zh) 2009-08-05
CZ302689B6 (cs) 2011-09-07
LTPA2013009I1 (lt) 2013-06-25
JP2003501089A (ja) 2003-01-14
RS50073B (sr) 2009-01-22

Similar Documents

Publication Publication Date Title
MEP3208A (xx) Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama
MXPA03006806A (es) Metodo para usar variante del receptor del factor de crecimiento celular endotelial vascular para tratar psoriasis y para mejorar curacion de heridas.
MXPA02000012A (es) Polipeptidos hibridos con propiedades farmacocineticas mejoradas.
AU2001291687A1 (en) Polyammonium-polysiloxane compounds, methods for the production and use thereof
IL146482A (en) Tek antagonists
MY120601A (en) C-21 modified epothilones
NO20001408L (no) Smal MWD, optimalisert etylen interpolymerblanding, fremgangsmÕte for fremstilling derav og gjenstander fremstilt derav
HK1042052A1 (zh) 内皮血管生长因子-2
WO2001000244A3 (en) METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES
AU2001278415A1 (en) Alpha-amylase mutants with altered stability
BG108494A (en) Pulmonary administration of chemically modified insulin
GEP20105118B (en) Anti-vegf antibodies
IL139702A0 (en) Hylbrid polypeptides with enhanced pharmacokinetic properties
HUP0203225A3 (en) Benzodiazepin derivatives, the production and use thereof
WO2002030465A3 (en) Compositions that inhibit proliferation of cancer cells
GB9918011D0 (en) 3-D sandwich preforms and method to provide the same
DK1065277T3 (da) Alfa-amylasemutanter
AU2580300A (en) Cloth for sportswear, use of said cloth in producing sportswear, and also said sportswear
AU2011501A (en) Benzimidazoles, production thereof and the use thereof as antithrombotic
WO2002058635A3 (en) Nicotine immunogens and antibodies and uses thereof
CU23070A3 (es) Reduccion de la capa fludizada de finos de laterita con reduccion de gases generados in situ.
EP1259530A4 (en) GENE 5 ASSOCIATED WITH DIFFERENTIATION OF MELANOMAS, PROMOTER, AND USE OF SAID GENE
AU4288300A (en) Unsupported flat linoleum structure and method of producing same
AU1816301A (en) Methods of increasing the redox ratio of iron in a glass article
IL147810A0 (en) Antitumor antibodies, proteins and uses thereof