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MEP23808A - Pyridine[3,4-b]pyrazinones - Google Patents

Pyridine[3,4-b]pyrazinones

Info

Publication number
MEP23808A
MEP23808A MEP-238/08A MEP23808A MEP23808A ME P23808 A MEP23808 A ME P23808A ME P23808 A MEP23808 A ME P23808A ME P23808 A MEP23808 A ME P23808A
Authority
ME
Montenegro
Prior art keywords
compounds
pyrazinones
pyridine
disclosed
intermediates
Prior art date
Application number
MEP-238/08A
Other languages
Bosnian (bs)
English (en)
Unknown language (me)
Inventor
Robert O Hughes
Andrew Simon Bell
David Graham Brown
Dafydd Rhys Owen
Michael John Palmer
Christopher Phillips
David Louis Brown
Yvette Marlene Fobian
John Nicholas Freskos
Steven Edward Heasley
Eric Jon Jacobsen
Todd Michael Maddux
Brent Virgil Mischke
John Major Molyneaux
Joseph Blair Moon
Donald Joseph Rogier Jr
Michael Brent Tollefson
John Keith Walker
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MEP23808A publication Critical patent/MEP23808A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
MEP-238/08A 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones MEP23808A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79397106P 2006-04-21 2006-04-21
PCT/IB2007/001001 WO2007122466A1 (en) 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones

Publications (1)

Publication Number Publication Date
MEP23808A true MEP23808A (en) 2010-06-10

Family

ID=38431249

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-238/08A MEP23808A (en) 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones

Country Status (41)

Country Link
US (1) US7902195B2 (da)
EP (1) EP2013208B1 (da)
JP (1) JP4436892B2 (da)
KR (1) KR101061328B1 (da)
CN (1) CN101454320B (da)
AP (1) AP2408A (da)
AR (1) AR060525A1 (da)
AT (1) ATE513831T1 (da)
AU (1) AU2007242555B2 (da)
BR (1) BRPI0710658A2 (da)
CA (1) CA2649775C (da)
CR (1) CR10327A (da)
CU (1) CU23777B7 (da)
CY (1) CY1111739T1 (da)
DK (1) DK2013208T3 (da)
DO (1) DOP2007000080A (da)
EA (1) EA014919B1 (da)
EC (1) ECSP088803A (da)
ES (1) ES2366239T3 (da)
GT (1) GT200700035A (da)
HR (1) HRP20110539T1 (da)
IL (1) IL194591A (da)
MA (1) MA30352B1 (da)
ME (1) MEP23808A (da)
MX (1) MX2008012456A (da)
MY (1) MY148583A (da)
NL (1) NL2000583C2 (da)
NO (1) NO20084129L (da)
NZ (1) NZ571540A (da)
PA (1) PA8724201A1 (da)
PE (1) PE20080192A1 (da)
PL (1) PL2013208T3 (da)
RS (2) RS51885B (da)
SI (1) SI2013208T1 (da)
SV (1) SV2008003074A (da)
TN (1) TNSN08408A1 (da)
TW (1) TWI337609B (da)
UA (1) UA92637C2 (da)
UY (1) UY30291A1 (da)
WO (1) WO2007122466A1 (da)
ZA (1) ZA200808283B (da)

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CN106117213B (zh) * 2009-10-26 2022-03-18 西格诺药品有限公司 杂芳基化合物及其合成和纯化方法
CN103458690B (zh) 2010-10-15 2016-03-16 吉利德科学股份有限公司 治疗肺动脉高压的组合物和方法
ES2602794T3 (es) 2011-03-31 2017-02-22 Pfizer Inc Piridinonas bicíclicas novedosas
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WO2013030713A1 (en) 2011-08-31 2013-03-07 Pfizer Inc. Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
WO2013164730A1 (en) 2012-05-04 2013-11-07 Pfizer Inc. Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin- 2 -amine compounds as inhibitors of app, bace1 and bace 2.
EP2897964A1 (en) 2012-09-20 2015-07-29 Pfizer Inc. Alkyl-substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
CA2893256A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
JP6162820B2 (ja) 2012-12-19 2017-07-12 ファイザー・インク 炭素環式および複素環式置換ヘキサヒドロピラノ[3,4−d][1,3]チアジン−2−アミン化合物
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US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
SG11201505878UA (en) 2013-02-19 2015-09-29 Pfizer Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders
ES2742078T3 (es) 2013-10-04 2020-02-13 Pfizer Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
JO3466B1 (ar) * 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
CA2944308A1 (en) 2014-04-01 2015-10-08 Pfizer Inc. Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators
CN106459088A (zh) 2014-04-10 2017-02-22 辉瑞公司 2‑氨基‑6‑甲基‑4,4a,5,6‑四氢吡喃并[3,4‑d][1,3]噻嗪‑8a(8H)‑基‑1,3‑噻唑‑4‑基酰胺
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
ES2733502T3 (es) 2014-08-06 2019-11-29 Pfizer Compuestos de imidazopiridazina
DK3253755T3 (da) 2015-02-03 2020-09-28 Pfizer Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner
PL3310784T3 (pl) 2015-06-17 2021-03-08 Pfizer Inc. Związki tricykliczne i ich zastosowanie jako inhibitory fosfodiesterazy
WO2017051294A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
JP2018531924A (ja) 2015-09-24 2018-11-01 ファイザー・インク テトラヒドロピラノ[3,4−d][1,3]オキサジン誘導体、およびbace阻害剤としてのその使用
BR112018003489A2 (pt) 2015-09-24 2018-09-25 Pfizer n-[2-(2-amino-6,6-dissubstituído-4,4a,5,6-tetra-hidropirano[3,4-d][1,3]tiazin-8a(8h)-il)-1,3-tiazol-4-il]amidas
CN113332292A (zh) 2016-02-23 2021-09-03 辉瑞公司 6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物
PL3478679T3 (pl) 2016-07-01 2021-10-25 Pfizer Inc. Pochodne 5,7-dihydro-pirolopirydyny do leczenia chorób neurologicznych i neurodegeneracyjnych
DK3642202T3 (da) 2017-06-22 2023-01-30 Pfizer Dihydro-pyrrolo-pyridin-derivater
BR112019027717A2 (pt) * 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
AR115015A1 (es) 2018-03-23 2020-11-18 Pfizer Derivados de azaespiro piperazina
EP4297868A4 (en) 2021-02-23 2025-01-08 Hoth Therapeutics, Inc. USE OF APREPITANT TO TREAT ALZHEIMER'S
WO2024118524A1 (en) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Azaindole compounds and their use as phosphodiesterase inhibitors
WO2025145091A1 (en) 2023-12-29 2025-07-03 Pfizer Inc. Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases
WO2025160132A1 (en) * 2024-01-23 2025-07-31 Maplight Therapeutics, Inc. Gpr6 inverse agonists

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Also Published As

Publication number Publication date
CU23777B7 (es) 2012-02-15
HK1133875A1 (en) 2010-04-09
SV2008003074A (es) 2010-01-12
GT200700035A (es) 2008-02-05
AP2408A (en) 2012-05-30
CN101454320B (zh) 2012-12-19
HRP20110539T1 (hr) 2011-08-31
AU2007242555A1 (en) 2007-11-01
TWI337609B (en) 2011-02-21
UY30291A1 (es) 2007-11-30
CY1111739T1 (el) 2015-10-07
CN101454320A (zh) 2009-06-10
US20070249615A1 (en) 2007-10-25
AR060525A1 (es) 2008-06-25
ZA200808283B (en) 2009-11-25
TW200808794A (en) 2008-02-16
RS51885B (sr) 2012-02-29
EP2013208B1 (en) 2011-06-22
NZ571540A (en) 2010-10-29
CA2649775A1 (en) 2007-11-01
ECSP088803A (es) 2008-11-27
SI2013208T1 (sl) 2011-09-30
WO2007122466A1 (en) 2007-11-01
EA200801998A1 (ru) 2009-04-28
RS20080484A (sr) 2009-07-15
ES2366239T3 (es) 2011-10-18
DK2013208T3 (da) 2011-08-15
AU2007242555B2 (en) 2010-12-16
ATE513831T1 (de) 2011-07-15
TNSN08408A1 (fr) 2010-04-14
CU20080194A7 (es) 2011-03-21
KR101061328B1 (ko) 2011-08-31
NO20084129L (no) 2008-10-29
AP2008004640A0 (en) 2008-10-31
BRPI0710658A2 (pt) 2011-08-16
CA2649775C (en) 2011-05-31
PE20080192A1 (es) 2008-03-01
US7902195B2 (en) 2011-03-08
JP4436892B2 (ja) 2010-03-24
EP2013208A1 (en) 2009-01-14
EA014919B1 (ru) 2011-04-29
MA30352B1 (fr) 2009-04-01
PA8724201A1 (es) 2009-08-26
MY148583A (en) 2013-04-30
JP2009534368A (ja) 2009-09-24
NL2000583A1 (nl) 2007-10-23
IL194591A (en) 2012-07-31
CR10327A (es) 2008-10-21
MX2008012456A (es) 2008-10-10
KR20080110930A (ko) 2008-12-19
PL2013208T3 (pl) 2011-10-31
NL2000583C2 (nl) 2007-12-14
UA92637C2 (en) 2010-11-25
DOP2007000080A (es) 2007-11-15

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