MA30352B1 - Pyridine [3,4-b] pyrazinones - Google Patents
Pyridine [3,4-b] pyrazinonesInfo
- Publication number
- MA30352B1 MA30352B1 MA31321A MA31321A MA30352B1 MA 30352 B1 MA30352 B1 MA 30352B1 MA 31321 A MA31321 A MA 31321A MA 31321 A MA31321 A MA 31321A MA 30352 B1 MA30352 B1 MA 30352B1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrazinones
- pyridine
- compounds
- methods
- synthesis
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical class OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
Abstract
Pyridine[3,4-b]pyrazinones Il est décrit des composés et des sels pharmaceutiquement acceptables des composés, lesdits composés ayant la structure de formule I : dans laquelle R2, R6A, R6B et R8 sont tels que définis dans la description. Des compositions pharmaceutiques, méthodes de traitement, procédés de synthèse et intermédiaires correspondants sont également décrits.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79397106P | 2006-04-21 | 2006-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30352B1 true MA30352B1 (fr) | 2009-04-01 |
Family
ID=38431249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA31321A MA30352B1 (fr) | 2006-04-21 | 2008-10-21 | Pyridine [3,4-b] pyrazinones |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US7902195B2 (fr) |
| EP (1) | EP2013208B1 (fr) |
| JP (1) | JP4436892B2 (fr) |
| KR (1) | KR101061328B1 (fr) |
| CN (1) | CN101454320B (fr) |
| AP (1) | AP2408A (fr) |
| AR (1) | AR060525A1 (fr) |
| AT (1) | ATE513831T1 (fr) |
| AU (1) | AU2007242555B2 (fr) |
| BR (1) | BRPI0710658A2 (fr) |
| CA (1) | CA2649775C (fr) |
| CR (1) | CR10327A (fr) |
| CU (1) | CU23777B7 (fr) |
| CY (1) | CY1111739T1 (fr) |
| DK (1) | DK2013208T3 (fr) |
| DO (1) | DOP2007000080A (fr) |
| EA (1) | EA014919B1 (fr) |
| EC (1) | ECSP088803A (fr) |
| ES (1) | ES2366239T3 (fr) |
| GT (1) | GT200700035A (fr) |
| HR (1) | HRP20110539T1 (fr) |
| IL (1) | IL194591A (fr) |
| MA (1) | MA30352B1 (fr) |
| ME (1) | MEP23808A (fr) |
| MX (1) | MX2008012456A (fr) |
| MY (1) | MY148583A (fr) |
| NL (1) | NL2000583C2 (fr) |
| NO (1) | NO20084129L (fr) |
| NZ (1) | NZ571540A (fr) |
| PA (1) | PA8724201A1 (fr) |
| PE (1) | PE20080192A1 (fr) |
| PL (1) | PL2013208T3 (fr) |
| RS (2) | RS20080484A (fr) |
| SI (1) | SI2013208T1 (fr) |
| SV (1) | SV2008003074A (fr) |
| TN (1) | TNSN08408A1 (fr) |
| TW (1) | TWI337609B (fr) |
| UA (1) | UA92637C2 (fr) |
| UY (1) | UY30291A1 (fr) |
| WO (1) | WO2007122466A1 (fr) |
| ZA (1) | ZA200808283B (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20110539T1 (hr) | 2006-04-21 | 2011-08-31 | Pfizer Products Inc. | PIRIDINO[3,4-b]PIRAZINONI |
| ES2544724T3 (es) * | 2006-12-12 | 2015-09-03 | Gilead Sciences, Inc. | Composición para tratar una hipertensión pulmonar |
| EA020372B1 (ru) | 2008-03-05 | 2014-10-30 | Мерк Патент Гмбх | Стимуляторы секреции инсулина - производные пиридопиразинонов, способы их получения и их применение для лечения диабета |
| WO2010041711A1 (fr) * | 2008-10-09 | 2010-04-15 | 杏林製薬株式会社 | Dérivé d'isoquinoléine et inhibiteur de la pde le comportant en tant qu’ingrédient actif |
| CN102686225A (zh) * | 2009-10-26 | 2012-09-19 | 西格诺药品有限公司 | 杂芳基化合物的合成和纯化方法 |
| MX346730B (es) | 2010-10-15 | 2017-03-30 | Gilead Sciences Inc | Composiciones y metodos para el tratamiento de la hipertension pulmonar. |
| JP5767393B2 (ja) | 2011-03-31 | 2015-08-19 | ファイザー・インク | 新規二環式ピリジノン |
| WO2012172449A1 (fr) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactames convenant comme inhibiteurs des bêta-sécrétases |
| JP6043355B2 (ja) | 2011-08-31 | 2016-12-14 | ファイザー・インク | ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物 |
| EP2852597B1 (fr) | 2012-05-04 | 2016-06-08 | Pfizer Inc | Composés d'hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitués par des hétérocycliques à titre d'inhibiteurs d'app, bace1 et bace2 |
| US9260455B2 (en) | 2012-09-20 | 2016-02-16 | Pfizer Inc. | Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| EP2931731A1 (fr) | 2012-12-11 | 2015-10-21 | Pfizer Inc. | Composés d'hexahydropyrano [3,4-d][1,3]thiazin-2-amine en tant qu'inhibiteurs de bace1 |
| US9403846B2 (en) | 2012-12-19 | 2016-08-02 | Pfizer Inc. | Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| EP2956458B1 (fr) | 2013-02-13 | 2017-08-09 | Pfizer Inc | Composés hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitués par un hétéroaryle |
| US9233981B1 (en) | 2013-02-15 | 2016-01-12 | Pfizer Inc. | Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| CN105121439A (zh) | 2013-02-19 | 2015-12-02 | 辉瑞公司 | 作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物 |
| ES2742078T3 (es) | 2013-10-04 | 2020-02-13 | Pfizer | Piridonas bicíclicas novedosas como moduladores de gamma-secretasa |
| JO3466B1 (ar) * | 2013-12-20 | 2020-07-05 | Takeda Pharmaceuticals Co | مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6 |
| DK3126361T3 (da) | 2014-04-01 | 2020-01-02 | Pfizer | Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer |
| CR20160455A (es) | 2014-04-10 | 2016-12-16 | Pfizer | 2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4-d][1,3]TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILA |
| JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
| KR102061952B1 (ko) | 2014-08-06 | 2020-01-02 | 화이자 인코포레이티드 | 이미다조피리다진 화합물 |
| TN2017000342A1 (en) | 2015-02-03 | 2019-01-16 | Pfizer | Novel cyclopropabenzofuranyl pyridopyrazinediones |
| CR20170572A (es) | 2015-06-17 | 2018-03-20 | Pfizer | Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa |
| WO2017051276A1 (fr) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | N-[2-(2-amino-6,6-disubstitués-4,4a,5,6-tétrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl)-1,3-thiazol-4-yl]amides |
| WO2017051294A1 (fr) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | N-[2-(3-amino-2,5-diméthyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides utiles comme inhibiteurs de bace |
| WO2017051303A1 (fr) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | Dérivés de tétrahydropyrano[3,4-d] [1,3]oxazine et leur utilisation en tant qu'inhibiteurs de bace |
| SG11201806383TA (en) | 2016-02-23 | 2018-09-27 | Pfizer | 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds |
| PT3478679T (pt) | 2016-07-01 | 2021-06-30 | Pfizer | Derivados de 5,7-dihidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas |
| HUE060914T2 (hu) | 2017-06-22 | 2023-04-28 | Pfizer | Dihidro-pirrolo-piridin származékok |
| CN111182898B (zh) * | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| EP4219464A1 (fr) | 2018-03-23 | 2023-08-02 | Pfizer Inc. | Pipérazine azaspiro derivaves |
| WO2022182658A1 (fr) | 2021-02-23 | 2022-09-01 | Hoth Therapeutics, Inc. | Utilisation d'aprépitant pour le traitement de la maladie d'alzheimer |
| WO2024118524A1 (fr) | 2022-11-28 | 2024-06-06 | Cerevel Therapeutics, Llc | Composés d'azaindole et leur utilisation en tant qu'inhibiteurs de phosphodiestérase |
| WO2025145091A1 (fr) | 2023-12-29 | 2025-07-03 | Pfizer Inc. | Formes cristallines d'un modulateur muscarinique m4 du récepteur et méthodes de traitement de maladies |
| WO2025160132A1 (fr) * | 2024-01-23 | 2025-07-31 | Maplight Therapeutics, Inc. | Agonistes inverses de gpr6 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1361652A (fr) | 1963-06-21 | 1964-05-22 | Ciba Geigy | Procédé de préparation de diazines, entre autres de la 2-méthyl-6-hydroxy-7-morpholino-ptéridine |
| EP0556393B1 (fr) | 1990-11-06 | 2000-07-26 | Yamanouchi Pharmaceutical Co. Ltd. | Derive de pyrazine fusionnee |
| TW274550B (fr) | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
| JP2000154139A (ja) | 1998-09-16 | 2000-06-06 | Kyowa Hakko Kogyo Co Ltd | 縮環ピラジン誘導体 |
| US6369056B1 (en) | 1999-05-04 | 2002-04-09 | American Home Products Corporation | Cyclic urea and cyclic amide derivatives |
| US6465465B1 (en) * | 2000-03-14 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Process for the treatment of erectile dysfunction and product therefor |
| EP1364950A4 (fr) * | 2001-02-26 | 2005-03-09 | Tanabe Seiyaku Co | Derive de pyridopyrimidine ou naphthyridine |
| WO2002076954A1 (fr) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Composes utiles en tant qu'inhibiteurs de kinase pour le traitement de maladies hyperproliferantes |
| US20030114469A1 (en) * | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
| US7067658B2 (en) | 2002-09-30 | 2006-06-27 | Bristol-Myers Squibb Company | Pyridino and pyrimidino pyrazinones |
| WO2005040337A2 (fr) | 2003-05-20 | 2005-05-06 | The Regents Of The University Of California | Procedes permettant de lier des agents a des plaques $g(b)-amyloides |
| DE602004026053D1 (fr) | 2003-06-26 | 2010-04-29 | Merck Sharp & Dohme | |
| DE102004033670A1 (de) | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| EP1833803A4 (fr) | 2005-01-03 | 2009-08-05 | Myriad Genetics Inc | Composes pharmaceutiques constituant des activateurs de caspases et des inducteurs d'apoptose et utilisation de ces composes |
| WO2006126082A2 (fr) * | 2005-05-24 | 2006-11-30 | Pharmacia & Upjohn Company Llc | Pyridine [3,4-b] pyrazinones |
| WO2007022638A1 (fr) | 2005-08-26 | 2007-03-01 | Methylgene Inc. | Inhibiteurs d'analogues de benzodiazepine et de benzopiperazine de l'histone deacetylase |
| WO2007112347A1 (fr) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Inhibiteurs de la dipeptidyl peptidase |
| HRP20110539T1 (hr) | 2006-04-21 | 2011-08-31 | Pfizer Products Inc. | PIRIDINO[3,4-b]PIRAZINONI |
-
2007
- 2007-04-10 HR HR20110539T patent/HRP20110539T1/hr unknown
- 2007-04-10 CA CA2649775A patent/CA2649775C/fr not_active Expired - Fee Related
- 2007-04-10 EA EA200801998A patent/EA014919B1/ru not_active IP Right Cessation
- 2007-04-10 PL PL07734320T patent/PL2013208T3/pl unknown
- 2007-04-10 ES ES07734320T patent/ES2366239T3/es active Active
- 2007-04-10 DK DK07734320.0T patent/DK2013208T3/da active
- 2007-04-10 JP JP2009505983A patent/JP4436892B2/ja not_active Expired - Fee Related
- 2007-04-10 BR BRPI0710658-0A patent/BRPI0710658A2/pt not_active IP Right Cessation
- 2007-04-10 RS RSP-2008/0484A patent/RS20080484A/sr unknown
- 2007-04-10 SI SI200730675T patent/SI2013208T1/sl unknown
- 2007-04-10 EP EP07734320A patent/EP2013208B1/fr active Active
- 2007-04-10 NZ NZ571540A patent/NZ571540A/en not_active IP Right Cessation
- 2007-04-10 WO PCT/IB2007/001001 patent/WO2007122466A1/fr not_active Ceased
- 2007-04-10 CN CN2007800198932A patent/CN101454320B/zh not_active Expired - Fee Related
- 2007-04-10 MX MX2008012456A patent/MX2008012456A/es active IP Right Grant
- 2007-04-10 RS RS20110363A patent/RS51885B/sr unknown
- 2007-04-10 ME MEP-238/08A patent/MEP23808A/xx unknown
- 2007-04-10 KR KR1020087028465A patent/KR101061328B1/ko not_active Expired - Fee Related
- 2007-04-10 MY MYPI20084131A patent/MY148583A/en unknown
- 2007-04-10 AP AP2008004640A patent/AP2408A/xx active
- 2007-04-10 AU AU2007242555A patent/AU2007242555B2/en not_active Ceased
- 2007-04-10 AT AT07734320T patent/ATE513831T1/de active
- 2007-04-11 NL NL2000583A patent/NL2000583C2/nl not_active IP Right Cessation
- 2007-04-18 AR ARP070101657A patent/AR060525A1/es not_active Application Discontinuation
- 2007-04-18 UY UY30291A patent/UY30291A1/es not_active Application Discontinuation
- 2007-04-19 GT GT200700035A patent/GT200700035A/es unknown
- 2007-04-19 PE PE2007000483A patent/PE20080192A1/es not_active Application Discontinuation
- 2007-04-20 DO DO2007000080A patent/DOP2007000080A/es unknown
- 2007-04-20 TW TW096114037A patent/TWI337609B/zh not_active IP Right Cessation
- 2007-04-20 US US11/737,966 patent/US7902195B2/en not_active Expired - Fee Related
- 2007-04-20 PA PA20078724201A patent/PA8724201A1/es unknown
- 2007-10-04 UA UAA200812397A patent/UA92637C2/ru unknown
-
2008
- 2008-09-29 NO NO20084129A patent/NO20084129L/no not_active Application Discontinuation
- 2008-09-29 ZA ZA200808283A patent/ZA200808283B/xx unknown
- 2008-09-30 CR CR10327A patent/CR10327A/es unknown
- 2008-10-07 IL IL194591A patent/IL194591A/en not_active IP Right Cessation
- 2008-10-08 EC EC2008008803A patent/ECSP088803A/es unknown
- 2008-10-17 CU CU20080194A patent/CU23777B7/es active IP Right Grant
- 2008-10-17 TN TNP2008000408A patent/TNSN08408A1/fr unknown
- 2008-10-21 SV SV2008003074A patent/SV2008003074A/es unknown
- 2008-10-21 MA MA31321A patent/MA30352B1/fr unknown
-
2011
- 2011-07-25 CY CY20111100731T patent/CY1111739T1/el unknown
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