MEP22708A - Solid oral compositions based on s-adenosyl methionine and/or nadh and process for obtaining them - Google Patents
Solid oral compositions based on s-adenosyl methionine and/or nadh and process for obtaining themInfo
- Publication number
- MEP22708A MEP22708A MEP-227/08A MEP22708A MEP22708A ME P22708 A MEP22708 A ME P22708A ME P22708 A MEP22708 A ME P22708A ME P22708 A MEP22708 A ME P22708A
- Authority
- ME
- Montenegro
- Prior art keywords
- nadh
- solid oral
- oral compositions
- compositions based
- calcium
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 3
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title 1
- 229960001570 ademetionine Drugs 0.000 title 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 3
- 239000000920 calcium hydroxide Substances 0.000 abstract 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 abstract 3
- 239000000292 calcium oxide Substances 0.000 abstract 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 2
- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 abstract 1
- 229940000681 5-hydroxytryptophan Drugs 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 abstract 1
- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 abstract 1
- 230000003001 depressive effect Effects 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000000395 magnesium oxide Substances 0.000 abstract 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003987 melatonin Drugs 0.000 abstract 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 abstract 1
- LDCYZAJDBXYCGN-UHFFFAOYSA-N oxitriptan Natural products C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 229940026510 theanine Drugs 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 abstract 1
- 229960002675 xylitol Drugs 0.000 abstract 1
- 235000010447 xylitol Nutrition 0.000 abstract 1
- 239000000811 xylitol Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000629A ITMI20060629A1 (it) | 2006-03-31 | 2006-03-31 | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
| PCT/IT2006/000610 WO2007113885A2 (en) | 2006-03-31 | 2006-08-08 | Solid oral compositions based on s-adenosyl methionine and/or nadh and process for obtaining them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP22708A true MEP22708A (en) | 2010-06-10 |
Family
ID=37327762
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2008-227A ME00115B (me) | 2006-03-31 | 2006-08-08 | Čvrste oralne kompozicije bazirane na s-adezonil metionin i/ili nadh i proces za njihovo dobijanje |
| MEP-227/08A MEP22708A (en) | 2006-03-31 | 2006-08-08 | Solid oral compositions based on s-adenosyl methionine and/or nadh and process for obtaining them |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2008-227A ME00115B (me) | 2006-03-31 | 2006-08-08 | Čvrste oralne kompozicije bazirane na s-adezonil metionin i/ili nadh i proces za njihovo dobijanje |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20090110729A1 (xx) |
| EP (1) | EP2007479B1 (xx) |
| JP (1) | JP5562632B2 (xx) |
| CN (1) | CN101415464B (xx) |
| AU (1) | AU2006341243B2 (xx) |
| BR (1) | BRPI0621556B8 (xx) |
| CA (1) | CA2645767C (xx) |
| DK (1) | DK2007479T3 (xx) |
| EA (1) | EA017895B1 (xx) |
| ES (1) | ES2774913T3 (xx) |
| HR (1) | HRP20200315T1 (xx) |
| HU (1) | HUE047955T2 (xx) |
| IL (1) | IL194254A (xx) |
| IT (1) | ITMI20060629A1 (xx) |
| ME (2) | ME00115B (xx) |
| MX (1) | MX2008012491A (xx) |
| NZ (1) | NZ571240A (xx) |
| PL (1) | PL2007479T3 (xx) |
| RS (2) | RS20080441A (xx) |
| SI (1) | SI2007479T1 (xx) |
| WO (1) | WO2007113885A2 (xx) |
| ZA (1) | ZA200808118B (xx) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090088404A1 (en) * | 2007-01-31 | 2009-04-02 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| GEP20156209B (en) | 2008-08-15 | 2015-01-12 | Aironvud Farmasiutikalz Ink | Linaclotide-containing formulations for oral administration |
| EP2189154A1 (en) | 2008-11-25 | 2010-05-26 | Gnosis S.p.A. | Effervescent tablets and mouth-soluble granulates of S-adenosyl methionine and process for the preparation thereof |
| IT1393331B1 (it) * | 2009-02-09 | 2012-04-20 | Graal S R L | Composizioni orosolubili e/o effervescenti contenenti almeno un sale di s-adenosilmetionina (same) |
| US8329208B2 (en) | 2009-07-28 | 2012-12-11 | Methylation Sciences International Srl | Pharmacokinetics of S-adenosylmethionine formulations |
| WO2012012902A1 (en) * | 2010-07-28 | 2012-02-02 | Msi Methylation Sciences Inc. | S-adenosylmethionine formulations with enhanced bioavailability |
| US20110027342A1 (en) * | 2009-07-28 | 2011-02-03 | Msi Methylation Sciences, Inc. | S-adenosylmethionine formulations with enhanced bioavailability |
| CA2770077A1 (en) * | 2009-08-06 | 2011-02-10 | Ironwood Pharmaceuticals, Inc. | Formulations comprising linaclotide |
| US8933030B2 (en) | 2010-02-17 | 2015-01-13 | Ironwwod Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| EP3626253B8 (en) | 2010-08-11 | 2022-04-20 | Ironwood Pharmaceuticals, Inc. | Stable formulations of linaclotide |
| EA201100309A1 (ru) * | 2011-03-03 | 2011-08-30 | Екофарм Патент Менеджмент Аг | Фармацевтическая композиция, стимулирующая биосинтез s-аденозилметионина, и пероральное лекарственное средство |
| TR201103625A1 (tr) * | 2011-04-14 | 2012-12-21 | Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ | Sefuroksim içeren tablet formülasyonu üretim prosesi. |
| MX347354B (es) | 2011-08-17 | 2017-04-24 | Ironwood Pharmaceuticals Inc | Tratamientos para trastornos gastrointestinales. |
| JP5877935B2 (ja) | 2012-10-17 | 2016-03-08 | メチレーション・サイエンシーズ・インターナショナル・ソサイアティーズ・ウィズ・リストリクティッド・ライアビリティＭｅｔｈｙｌａｔｉｏｎ Ｓｃｉｅｎｃｅｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓｒｌ | Ｓ−アデノシルメチオニンおよび没食子酸エステルを含む組成物 |
| ITMI20131906A1 (it) * | 2013-11-18 | 2015-05-19 | Gnosis Spa | Composizioni solide orali a lento rilascio |
| ES2775734T3 (es) | 2015-08-31 | 2020-07-28 | Nutramax Lab Inc | Composiciones que comprenden magnolia, felodendron, teanina y/o proteína de suero |
| IT202000006127A1 (it) * | 2020-03-23 | 2021-09-23 | Fmc S R L | Formulazione farmaceutica, dietetica e/o alimentare a base ademetionina e processo di realizzazione di detta formulazione |
| CN115708820B (zh) * | 2023-01-09 | 2023-06-02 | 广东科泰鼎润药业科技有限公司 | L-茶氨酸缓释制剂、双释放制剂、应用和药物 |
| AU2024274445A1 (en) | 2023-05-15 | 2025-11-27 | Bonafide Health, Llc | Sleep-improving compositions and methods of use |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3012943A (en) * | 1958-11-18 | 1961-12-12 | Nutrilite Products | Vitamin c concentrate |
| US3330729A (en) * | 1963-10-04 | 1967-07-11 | Goodrich Co B F | Sustained release tablet containing medicament admixed in a waterinsoluble acrylic acid cross-linked polymer and selected basic magnesium or calcium diluent |
| IE37913B1 (en) * | 1972-08-02 | 1977-11-09 | Bioresearch Sas | Salt of s-adenosyl-l-methionine |
| IE39517B1 (en) * | 1973-06-27 | 1978-10-25 | Bioresearch Sas | Double salts of s-adenosyl-l-methhionine |
| AR221676A1 (es) * | 1974-07-12 | 1981-03-13 | Bioresearch Sas | Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico |
| CA1187388A (en) * | 1978-09-20 | 1985-05-21 | American Monitor Corporation | Stabilization of working reagent solutions containing nadh, nadph, and/or enzymes, and the use of such stabilized reagents in enzymes or substrate assays |
| GB2064523B (en) * | 1979-12-04 | 1983-06-29 | Kanegafuchi Chemical Ind | Stable composition of s-adenosyl-l-methionine |
| US4394449A (en) * | 1980-02-13 | 1983-07-19 | Modrovich Ivan Endre | Stabilization of coenzymes in aqueous solution |
| IT1137640B (it) * | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| IT1139974B (it) * | 1981-09-11 | 1986-09-24 | Bioresearch Srl | Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo |
| JPS60181095A (ja) * | 1984-02-27 | 1985-09-14 | Nippon Zeon Co Ltd | Ｓ−アデノシル−ｌ−メチオニン含有組成物及びその製造法 |
| IT1173991B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Composizioni farmaceutiche comprendenti solfo-afenosil-l-metionina (same) particolarmente adatte per uso orale e per supposte |
| IT1173990B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
| US4870059A (en) * | 1985-11-27 | 1989-09-26 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Dehydration of hydrous matter with anhydrous maltose |
| US4704365A (en) * | 1986-02-24 | 1987-11-03 | Abbott Laboratories | Composition and method for stabilization of dinucleotides |
| JPH0291018A (ja) * | 1988-09-27 | 1990-03-30 | Farval Ag | 湿気に対して安定な固形バルプロ酸製剤とその製造法 |
| US6451341B1 (en) * | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
| IT1243859B (it) * | 1990-10-23 | 1994-06-28 | Bioresearch Spa | Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids. |
| US5332727A (en) * | 1993-04-29 | 1994-07-26 | Birkmayer U.S.A. | Stable, ingestable and absorbable NADH and NADPH therapeutic compositions |
| GB2341798B (en) * | 1998-09-25 | 2001-03-14 | Brian Whittle Associates Ltd | Nutritional and pharmaceutical compositions comprising desiccants |
| IT1318535B1 (it) * | 2000-05-25 | 2003-08-27 | Chementecno Srl | Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina. |
| US20030069202A1 (en) * | 2000-06-02 | 2003-04-10 | Kern Kenneth Norman | Compositions, kits, and methods for promoting defined health benefits |
| US20020132780A1 (en) * | 2001-01-12 | 2002-09-19 | Heisey Matthew Thomas | Low carbohydrate compositions, kits thereof, and methods of use |
| JP4346311B2 (ja) * | 2001-04-27 | 2009-10-21 | 京都薬品工業株式会社 | 発泡性坐剤の保存方法 |
| WO2002102823A1 (en) | 2001-06-14 | 2002-12-27 | Orchid Chemicals & Pharmaceuticals Limited | Stable salts of s-adenosyl-l-methionine (same) and the process for their preparation |
| CN100436466C (zh) * | 2001-08-10 | 2008-11-26 | 株式会社林原生物化学研究所 | 海藻糖或麦芽糖醇和金属离子化合物的缔合物 |
| ITMI20012462A1 (it) * | 2001-11-22 | 2003-05-22 | Gnosis Srl | Processo per la preparazione di compresse comprendenti s-adenosilmetionina |
| US20040131805A1 (en) * | 2002-06-20 | 2004-07-08 | Merical Rick L. | Films having a desiccant material incorporated therein and methods of use and manufacture |
| EP1671636A4 (en) * | 2003-09-22 | 2009-05-27 | Nisshin Kyorin Pharmaceutical | IMPROVED FIXED 5-AMINOSALICYLIC ACID PREPARATION AND STORAGE METHOD FOR TREATING THEREOF |
| US20070298108A1 (en) * | 2004-03-01 | 2007-12-27 | Peter Svete | Pharmaceutical Formulation |
| CN1663567A (zh) * | 2004-03-05 | 2005-09-07 | 罗靖 | 复方甲硫氨酸维生素b1冻干粉针制剂及其制备方法 |
| US8263574B2 (en) * | 2004-09-29 | 2012-09-11 | James L. Schaller, P.A. | Topical formulations for the treatment of depression with S adenosyl methionine |
| ITRM20050344A1 (it) | 2005-06-30 | 2007-01-01 | Luca Maria De | Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi. |
| EP3219304A4 (en) * | 2014-11-10 | 2018-05-16 | Showa Denko K.K. | Moisturizing agent |
-
2006
- 2006-03-31 IT IT000629A patent/ITMI20060629A1/it unknown
- 2006-08-08 HU HUE06780609A patent/HUE047955T2/hu unknown
- 2006-08-08 ZA ZA200808118A patent/ZA200808118B/xx unknown
- 2006-08-08 NZ NZ571240A patent/NZ571240A/en not_active IP Right Cessation
- 2006-08-08 RS RSP-2008/0441A patent/RS20080441A/sr unknown
- 2006-08-08 MX MX2008012491A patent/MX2008012491A/es active IP Right Grant
- 2006-08-08 AU AU2006341243A patent/AU2006341243B2/en active Active
- 2006-08-08 RS RS20200221A patent/RS59995B1/sr unknown
- 2006-08-08 PL PL06780609T patent/PL2007479T3/pl unknown
- 2006-08-08 JP JP2009502342A patent/JP5562632B2/ja active Active
- 2006-08-08 CA CA2645767A patent/CA2645767C/en active Active
- 2006-08-08 DK DK06780609.1T patent/DK2007479T3/da active
- 2006-08-08 ES ES06780609T patent/ES2774913T3/es active Active
- 2006-08-08 BR BRPI0621556A patent/BRPI0621556B8/pt active IP Right Grant
- 2006-08-08 ME MEP-2008-227A patent/ME00115B/me unknown
- 2006-08-08 WO PCT/IT2006/000610 patent/WO2007113885A2/en not_active Ceased
- 2006-08-08 SI SI200632369T patent/SI2007479T1/sl unknown
- 2006-08-08 ME MEP-227/08A patent/MEP22708A/xx unknown
- 2006-08-08 HR HRP20200315TT patent/HRP20200315T1/hr unknown
- 2006-08-08 CN CN2006800541063A patent/CN101415464B/zh active Active
- 2006-08-08 EP EP06780609.1A patent/EP2007479B1/en active Active
- 2006-08-08 EA EA200802095A patent/EA017895B1/ru unknown
-
2008
- 2008-09-22 IL IL194254A patent/IL194254A/en active IP Right Grant
- 2008-09-29 US US12/240,002 patent/US20090110729A1/en not_active Abandoned
-
2015
- 2015-05-21 US US14/718,789 patent/US10471088B2/en active Active
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