[go: up one dir, main page]

ME03316B - Benzoksazinon amidi као modulatori mineralokorтikoidnog receptora - Google Patents

Benzoksazinon amidi као modulatori mineralokorтikoidnog receptora

Info

Publication number
ME03316B
ME03316B MEP-2019-19A MEP201919A ME03316B ME 03316 B ME03316 B ME 03316B ME P201919 A MEP201919 A ME P201919A ME 03316 B ME03316 B ME 03316B
Authority
ME
Montenegro
Prior art keywords
као
modulatorsokorтikoidnog
benzoksazinon
receptora
starches
Prior art date
Application number
MEP-2019-19A
Other languages
German (de)
English (en)
French (fr)
Inventor
Gavin O'mahony
Michael Kossenjans
Karl Edman
Johan Kajanus
Carl Anders Hogner
Philip Cornwall
Andrew Turner
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ME03316B publication Critical patent/ME03316B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/5381,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
MEP-2019-19A 2014-06-30 2015-06-26 Benzoksazinon amidi као modulatori mineralokorтikoidnog receptora ME03316B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462018790P 2014-06-30 2014-06-30
EP15736015.7A EP3160948B1 (en) 2014-06-30 2015-06-26 Benzoxazinone amides as mineralocorticoid receptor modulators
PCT/GB2015/051860 WO2016001631A1 (en) 2014-06-30 2015-06-26 Benzoxazinone amides as mineralocorticoid receptor modulators

Publications (1)

Publication Number Publication Date
ME03316B true ME03316B (me) 2019-10-20

Family

ID=53539739

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2019-19A ME03316B (me) 2014-06-30 2015-06-26 Benzoksazinon amidi као modulatori mineralokorтikoidnog receptora

Country Status (26)

Country Link
US (2) US10017502B2 (me)
EP (1) EP3160948B1 (me)
JP (1) JP6368383B2 (me)
KR (1) KR102012222B1 (me)
CN (1) CN106536491B (me)
AR (1) AR101036A1 (me)
AU (1) AU2015282450C1 (me)
CA (1) CA2953655C (me)
CY (1) CY1121596T1 (me)
DK (1) DK3160948T3 (me)
EA (1) EA029518B1 (me)
ES (1) ES2707726T3 (me)
HR (1) HRP20190147T1 (me)
HU (1) HUE042370T2 (me)
LT (1) LT3160948T (me)
ME (1) ME03316B (me)
MX (1) MX367404B (me)
PL (1) PL3160948T3 (me)
PT (1) PT3160948T (me)
RS (1) RS58274B1 (me)
SI (1) SI3160948T1 (me)
SM (1) SMT201900039T1 (me)
TR (1) TR201900659T4 (me)
TW (1) TWI677498B (me)
UY (1) UY36195A (me)
WO (1) WO2016001631A1 (me)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA029518B1 (ru) * 2014-06-30 2018-04-30 Астразенека Аб Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора
US11826376B2 (en) 2018-07-19 2023-11-28 Astrazeneca Ab Methods of treating heart failure with preserved ejection fraction employing dapagliflozin and compositions comprising the same
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用
JOP20200098A1 (ar) * 2019-08-30 2021-02-28 Astrazeneca Ab طرق علاج الفشل القلبي مع كسر قذفي منخفض بواسطة داباجليفلوزين
WO2022022865A1 (en) 2020-07-27 2022-02-03 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
CN114630682A (zh) 2020-07-27 2022-06-14 阿斯利康(瑞典)有限公司 用达格列净治疗慢性肾脏病的方法
WO2022262736A1 (zh) 2021-06-15 2022-12-22 正大天晴药业集团股份有限公司 苯并恶嗪酮类衍生物
TW202409023A (zh) 2022-07-14 2024-03-01 美商富曼西公司 除草苯并𠯤
CA3266292A1 (en) 2022-09-01 2024-03-07 Astrazeneca Ab COMBINATION OF SGLT2 INHIBITORS AND MINERALOCORTICOID RECEPTOR MODULATORS INTENDED FOR USE IN THE TREATMENT OF HEART DISEASE
CN120344508A (zh) * 2022-12-15 2025-07-18 正大天晴药业集团股份有限公司 苯并恶嗪酮类化合物的结晶及其制备
WO2025111184A1 (en) 2023-11-21 2025-05-30 Fmc Corporation Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1385835A1 (en) * 2001-04-23 2004-02-04 Astrazeneca AB Benzoxazinone derivatives for use in the treatment of angiogenesis
CA2510851A1 (en) * 2002-12-20 2004-07-08 Warner-Lambert Company Llc Benzoxazines and derivatives thereof as inhibitors of pi3ks
BRPI0513119A (pt) * 2004-07-14 2008-04-29 Ligand Pharm Inc compostos e métodos modulares de receptores intracelulares
CN101365696A (zh) * 2004-07-28 2009-02-11 Irm责任有限公司 作为类固醇激素核受体调节剂的化合物和组合物
PE20071164A1 (es) 2005-12-28 2008-01-11 Takeda Pharmaceutical Compuestos heterociclico fusionado como antagonista del receptor mineralocorticoide
TWI385161B (zh) 2006-02-02 2013-02-11 Mitsubishi Tanabe Pharma Corp 含氮雜雙環化合物
ATE537151T1 (de) 2006-10-31 2011-12-15 Pfizer Prod Inc Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
AU2008230115A1 (en) 2007-03-23 2008-10-02 Merck Sharp & Dohme Corp. Mineralocorticoid receptor modulators
CA2683059C (en) 2007-04-09 2012-09-25 Daiichi Sankyo Company, Limited Atropisomer of pyrrole derivative
JP5173653B2 (ja) * 2007-08-01 2013-04-03 田辺三菱製薬株式会社 医薬組成物
US8258131B2 (en) 2007-08-01 2012-09-04 Mitsubishi Tanabe Pharma Corporation Fused bicyclic compound
PE20091057A1 (es) 2007-12-19 2009-07-20 Lilly Co Eli Antagonistas del receptor mineralcorticoide y metodos de uso
CN102124003A (zh) * 2008-06-18 2011-07-13 阿斯利康(瑞典)有限公司 作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物
US20100094000A1 (en) 2008-09-03 2010-04-15 Takeda Pharmaceutical Company Limited Pyrazole compounds
WO2010098286A1 (ja) 2009-02-25 2010-09-02 第一三共株式会社 ミネラルコルチコイド受容体拮抗薬を含有する医薬
MX2011009506A (es) 2009-03-12 2011-09-28 Lilly Co Eli Antagonista del receptor mineralcorticoide y metodos de uso.
US20120022058A1 (en) 2009-04-10 2012-01-26 Pfizer Inc. 4,5-dihydro-1h-pyrazole compounds and their pharmaceutical uses
WO2011141846A2 (en) 2010-05-11 2011-11-17 Koninklijke Philips Electronics N.V. Lighting module
JP2013528598A (ja) 2010-05-11 2013-07-11 ファイザー・インク ミネラルコルチコイド受容体拮抗薬としてのモルホリン化合物
EP2594554A4 (en) 2010-07-13 2014-01-15 Dainippon Sumitomo Pharma Co BIARYLAMID DERIVATIVES BZW. PHARMACEUTICALLY PERMITTED SALT FROM THIS
WO2012064631A1 (en) 2010-11-10 2012-05-18 Boehringer Ingelheim International Gmbh Pyridyl ureas as mineralocorticoid receptor antagonists
EA029518B1 (ru) * 2014-06-30 2018-04-30 Астразенека Аб Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора

Also Published As

Publication number Publication date
MX2017000183A (es) 2017-04-25
EA029518B1 (ru) 2018-04-30
US9394291B2 (en) 2016-07-19
DK3160948T3 (en) 2019-02-18
JP2017522300A (ja) 2017-08-10
AU2015282450A1 (en) 2017-02-02
ES2707726T3 (es) 2019-04-04
EA201790046A1 (ru) 2017-08-31
CN106536491A (zh) 2017-03-22
MX367404B (es) 2019-08-20
KR102012222B1 (ko) 2019-10-21
PT3160948T (pt) 2019-02-01
UY36195A (es) 2016-01-08
TW201613909A (en) 2016-04-16
US20150376170A1 (en) 2015-12-31
LT3160948T (lt) 2019-02-11
TWI677498B (zh) 2019-11-21
JP6368383B2 (ja) 2018-08-01
SMT201900039T1 (it) 2019-02-28
KR20170021883A (ko) 2017-02-28
TR201900659T4 (tr) 2019-02-21
CY1121596T1 (el) 2020-05-29
CA2953655A1 (en) 2016-01-07
EP3160948A1 (en) 2017-05-03
RS58274B1 (sr) 2019-03-29
US10017502B2 (en) 2018-07-10
SI3160948T1 (sl) 2020-06-30
AU2015282450C1 (en) 2018-09-20
EP3160948B1 (en) 2018-10-24
AU2015282450B2 (en) 2018-05-10
US20170217945A1 (en) 2017-08-03
PL3160948T3 (pl) 2019-04-30
AR101036A1 (es) 2016-11-16
HRP20190147T1 (hr) 2019-03-22
CN106536491B (zh) 2018-12-18
WO2016001631A1 (en) 2016-01-07
CA2953655C (en) 2020-05-12
HUE042370T2 (hu) 2019-06-28

Similar Documents

Publication Publication Date Title
FIC20220017I1 (fi) Lonapegsomatropiini
DK3183051T3 (da) Væske-til-luftmembranenergivekslere
DK4242916T3 (da) Forstøver
DK3134402T3 (da) 4-amino-imidazoquinolinforbindelser
DK3006072T3 (da) Karadgang
DK3222714T3 (da) Phytasemutanter
DK3119396T3 (da) Muscarinreceptoragonister
DK3174483T3 (da) Hyporørkonstruktion
EP3230438C0 (en) N-GLYCOSYLATION
ME03316B (me) Benzoksazinon amidi као modulatori mineralokorтikoidnog receptora
DK3110442T3 (da) Modificerede meningokok-fhbp-polypeptider
MA41015A (fr) Hydrocyclone anti-boudinage
DK3183340T3 (da) Termolabile exonukleaser
DE112015001664A5 (de) Betätigungsaktuator
DE112015005041A5 (de) Gargerätevorrichtung
DK3110439T3 (da) Pcsk9-vacciner
DE102014000623A8 (de) Halbhohlnietelement
DK3009858T3 (da) Skyradar
DE202014005655U8 (de) llluminationsvorrichtung
DE112015001633A5 (de) Betätigungsaktuator
DK3447493T3 (da) Proteinrettede ortologer
DE112015005055A5 (de) Gargerätevorrichtung
DK3091875T3 (da) Vipbar taburet
FI20146001A (fi) Tahnatuubin puristin
DK3191825T3 (da) Kreatininbiosensor