ME01916B - Novi spoj koristan u liječenju degenerativnih upalnih bolesti - Google Patents
Novi spoj koristan u liječenju degenerativnih upalnih bolestiInfo
- Publication number
- ME01916B ME01916B MEP-2014-132A MEP13214A ME01916B ME 01916 B ME01916 B ME 01916B ME P13214 A MEP13214 A ME P13214A ME 01916 B ME01916 B ME 01916B
- Authority
- ME
- Montenegro
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- intended
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 21
- 238000011282 treatment Methods 0.000 title claims 11
- 230000003412 degenerative effect Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 230000002265 prevention Effects 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 201000004681 Psoriasis Diseases 0.000 claims 6
- 230000004968 inflammatory condition Effects 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- 238000011321 prophylaxis Methods 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 208000005024 Castleman disease Diseases 0.000 claims 4
- 206010010356 Congenital anomaly Diseases 0.000 claims 4
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 4
- 208000034578 Multiple myelomas Diseases 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 206010052779 Transplant rejections Diseases 0.000 claims 4
- 210000000845 cartilage Anatomy 0.000 claims 4
- 230000008414 cartilage metabolism Effects 0.000 claims 4
- 230000036244 malformation Effects 0.000 claims 4
- 201000008265 mesangial proliferative glomerulonephritis Diseases 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 239000002585 base Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Claims (20)
1. Spoj, naznačen time što je u skladu s Formulom I: ili njegova farmaceutski prihvatljiva sol.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je u obliku slobodne baze.
3. Farmaceutski pripravak, naznačen time što sadrži farmaceutski prihvatljivu podlogu i farmaceutski djelotvornu količinu spoja, ili njegove farmaceutski prihvatljive soli, u skladu s patentnim zahtjevom 1 ili 2.
4. Farmaceutski pripravak u skladu s patentnim zahtjevom 3, naznačen time što je namijenjen oralnoj primjeni.
5. Farmaceutski pripravak u skladu s patentnim zahtjevom 3, naznačen time što je namijenjen primjeni injekcijom.
6. Farmaceutski pripravak u skladu s patentnim zahtjevom 3, naznačen time što je namijenjen topikalnoj primjeni.
7. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 3 do 6, naznačen time što sadrži dodatno terapijsko sredstvo.
8. Spoj, ili njegova farmaceutski prihvatljiva sol, u skladu s patentnim zahtjevom 1 ili 2, naznačen time što je namijenjen upotrebi kao medikament.
9. Spoj, ili njegova farmaceutski prihvatljiva sol, u skladu s patentnim zahtjevom 1 ili 2, naznačen time što je namijenjen upotrebi u liječenju, sprječavanju ili profilaksi upalnih stanja, autoimunih bolesti, proliferativnih bolesti, odbacivanja presadaka, bolesti koje uključuju poremećaj u metabolizmu hrskavice, prirođenih malformacija hrskavice, Castlemanove bolesti, multiplog mijeloma, psorijaze, Kaposijevog sarkoma ili mezangijskog proliferativnog glomerulonefritisa.
10. Upotreba spoja, ili njegove farmaceutski prihvatljive soli, u skladu s patentnim zahtjevom 1 ili 2, naznačena time što je spoj namijenjen pripravi medikamenta za liječenje, sprječavanje ili profilaksu upalnih stanja, autoimunih bolesti, proliferativnih bolesti, odbacivanja presadaka, bolesti koje uključuju poremećaj u metabolizmu hrskavice, prirođenih malformacija hrskavice, Castlemanove bolesti, multiplog mijeloma, psorijaze, Kaposijevog sarkoma ili mezangijskog proliferativnog glomerulonefritisa.
11. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 9, naznačen time što je namijenjen liječenju, sprječavanju ili profilaksi upalnog stanja.
12. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 11, naznačen time što je upalno stanje reumatoidni artritis.
13. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 9, naznačen time što je namijenjen liječenju, sprječavanju ili profilaksi sistemičnog eritematoznog lupusa.
14. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 9, naznačen time što je namijenjen liječenju, sprječavanju ili profilaksi psorijaze.
15. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 8, naznačen time što se spoj, ili njegova farmaceutski prihvatljiva sol, u skladu s patentnim zahtjevom 1 ili 2, primijenjuje u kombinaciji s dodatnim terapijskim sredstvom.
16. Farmaceutski pripravak u skladu s patentnim zahtjevom 7, naznačen time što je dodatno terapijsko sredstvo sredstvo za liječenje, sprječavanje ili profilaksu upalnih stanja, autoimunih bolesti, proliferativnih bolesti, odbacivanja presadaka, bolesti koje uključuju poremećaj u metabolizmu hrskavice, prirođenih malformacija hrskavice, Castlemanove bolesti, multiplog mijeloma, psorijaze, Kaposijevog sarkoma ili mezangijskog proliferativnog glomerulonefritisa.
17. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 15, naznačen time što je dodatno terapijsko sredstvo sredstvo za liječenje, sprječavanje upalnih stanja, autoimunih bolesti, proliferativnih bolesti, odbacivanja presadaka, bolesti koje uključuju poremećaj u metabolizmu hrskavice, prirođenih malformacija hrskavice, Castlemanove bolesti, multiplog mijeloma, psorijaze, Kaposijevog sarkoma ili mezangijskog proliferativnog glomerulonefritisa.
18. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 15, naznačen time što se spoj, ili njegovu farmaceutski prihvatljivu sol, suprimijenjuje s drugim terapijskim sredstvom za liječenje i/ili sprječavanje sistemičnog eritematoznog lupusa.
19. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 15, naznačen time što se spoj, ili njegovu farmaceutski prihvatljivu sol, suprimijenjuje s drugim terapijskim sredstvom za liječenje i/ili sprječavanje psorijaze.
20. Spoj, ili njegova farmaceutski prihvatljiva sol, namijenjen upotrebi u skladu s patentnim zahtjevom 15, naznačen time što se spoj, ili njegovu farmaceutski prihvatljivu sol, suprimijenjuje s drugim terapijskim sredstvom za liječenje i/ili sprječavanje reumatoidnog artritisa.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22068509P | 2009-06-26 | 2009-06-26 | |
| US29818810P | 2010-01-25 | 2010-01-25 | |
| EP10728648.6A EP2445912B1 (en) | 2009-06-26 | 2010-06-25 | Novel compound useful for the treatment of degenerative and inflammatory diseases |
| PCT/EP2010/059067 WO2010149771A1 (en) | 2009-06-26 | 2010-06-25 | Novel compound useful for the treatment of degenerative and inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01916B true ME01916B (me) | 2015-05-20 |
Family
ID=42340530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2014-132A ME01916B (me) | 2009-06-26 | 2010-06-25 | Novi spoj koristan u liječenju degenerativnih upalnih bolesti |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US8796457B2 (me) |
| EP (2) | EP2792677B1 (me) |
| JP (1) | JP5486084B2 (me) |
| KR (1) | KR101712561B1 (me) |
| CN (1) | CN102459261B (me) |
| AR (1) | AR077221A1 (me) |
| AU (1) | AU2010264635B2 (me) |
| BR (1) | BRPI1014759A2 (me) |
| CA (1) | CA2765988C (me) |
| CL (1) | CL2011003276A1 (me) |
| CO (1) | CO6491039A2 (me) |
| CR (1) | CR20110673A (me) |
| CY (1) | CY1119711T1 (me) |
| DK (2) | DK2445912T3 (me) |
| DO (1) | DOP2011000378A (me) |
| EA (1) | EA020111B1 (me) |
| ES (2) | ES2519170T3 (me) |
| HR (2) | HRP20141057T1 (me) |
| HU (1) | HUE034205T2 (me) |
| IL (1) | IL216618A (me) |
| JO (1) | JO3030B1 (me) |
| LT (1) | LT2792677T (me) |
| MA (1) | MA33447B1 (me) |
| ME (1) | ME01916B (me) |
| MX (1) | MX2011013451A (me) |
| NZ (1) | NZ596836A (me) |
| PE (1) | PE20120494A1 (me) |
| PL (2) | PL2445912T3 (me) |
| PT (2) | PT2445912E (me) |
| RS (1) | RS53617B1 (me) |
| SG (1) | SG177359A1 (me) |
| SI (2) | SI2792677T1 (me) |
| SM (2) | SMT201700333T1 (me) |
| TW (1) | TWI469981B (me) |
| UY (1) | UY32741A (me) |
| WO (1) | WO2010149771A1 (me) |
| ZA (1) | ZA201109502B (me) |
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| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| WO2012142160A1 (en) * | 2011-04-12 | 2012-10-18 | Rigel Pharmaceuticals, Inc. | Methods for inhibiting allograft rejection |
| SG10201914052TA (en) * | 2011-10-11 | 2020-03-30 | Sanofi Biotechnology | Compositions for the treatment of rheumatoid arthritis and methods of using same |
| TWI589299B (zh) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
| PE20150187A1 (es) * | 2012-06-22 | 2015-02-27 | Galapagos Nv | Aminotriazolopiridina para uso en tratamiento de inflamacion y composiciones farmaceuticas de la misma |
| CN105745209B (zh) | 2013-09-05 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 三唑并吡啶化合物、组合物及其使用方法 |
| EP3318565B1 (en) | 2013-12-05 | 2021-04-14 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides |
| GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| KR102747428B1 (ko) * | 2015-04-13 | 2024-12-27 | 알파시그마 에스.피.에이. | 심혈관 질환의 치료 방법 |
| US11414413B2 (en) | 2016-07-26 | 2022-08-16 | Suzhou Longbiotech Pharmaceuticals Co., Ltd. | Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof |
| US11427581B2 (en) | 2018-01-31 | 2022-08-30 | Zhuhai United Laboratories Co., Ltd. | JAK inhibitor and use thereof |
| MX2021002422A (es) | 2018-08-29 | 2021-07-15 | Regeneron Pharma | Métodos y composiciones para el tratamiento de sujetos que padecen artritis reumatoide. |
| TW202521583A (zh) | 2019-01-31 | 2025-06-01 | 法商賽諾菲生物技術公司 | 用於治療幼年原發性關節炎之組成物及方法 |
| CA3137909A1 (en) | 2019-04-24 | 2020-10-29 | Sanofi Biotechnology | Methods of diagnosis and treatment of rheumatoid arthritis |
| US12297279B2 (en) | 2019-06-04 | 2025-05-13 | Sanofi Biotechnology | Compositions and methods for treating pain in subjects with rheumatoid arthritis |
| CN111072655B (zh) * | 2019-12-30 | 2021-12-10 | 深圳市坤健创新药物研究院 | 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用 |
| AU2021276656A1 (en) | 2020-05-19 | 2022-11-24 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| US11596612B1 (en) | 2022-03-08 | 2023-03-07 | PTC Innovations, LLC | Topical anesthetics |
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| DE60016384T2 (de) | 1999-01-29 | 2005-12-01 | Chugai Seiyaku K.K. | Chondrogonese promotoren und indolin-2-on derivate |
| EP1391211A1 (en) | 2001-04-27 | 2004-02-25 | Chugai Seiyaku Kabushiki Kaisha | Chondrogenesis promoters |
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| CA2487679A1 (en) * | 2002-05-30 | 2003-12-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of jak and cdk2 protein kinases |
| BRPI0407384A (pt) | 2003-02-14 | 2006-02-21 | Pfizer Prod Inc | piridinas-triazóis como compostos antiinflamatórios |
| US20050222171A1 (en) | 2004-01-22 | 2005-10-06 | Guido Bold | Organic compounds |
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| WO2006018735A2 (en) | 2004-08-18 | 2006-02-23 | Pharmacia & Upjohn Company Llc | Triazolopyridine compounds |
| MX2007004179A (es) | 2004-10-07 | 2007-06-07 | Warner Lambert Co | Derivados de triazolpiridina como agentes antibacterianos. |
| GB0515026D0 (en) | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
| BRPI0716239A2 (pt) * | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
| TW200904816A (en) | 2007-06-05 | 2009-02-01 | Takeda Pharmaceutical | Fused heterocycle derivatives and use thereof |
| EP2178868A1 (en) | 2007-07-18 | 2010-04-28 | Novartis Ag | Bicyclic heteroaryl compounds and their use as kinase inhibitors |
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| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
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| WO2010010189A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
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| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
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2010
- 2010-05-31 JO JOP/2010/0179A patent/JO3030B1/ar active
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