MD503C2 - Derivaţi ai pentapeptidelor - Google Patents
Derivaţi ai pentapeptidelorInfo
- Publication number
- MD503C2 MD503C2 MD95-0391A MD950391A MD503C2 MD 503 C2 MD503 C2 MD 503C2 MD 950391 A MD950391 A MD 950391A MD 503 C2 MD503 C2 MD 503C2
- Authority
- MD
- Moldova
- Prior art keywords
- derivatives
- pentapeptyd
- dna synthesis
- independently
- under
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K7/067—Hemoregulatory peptides based on sequence Glp-Glu-Asp-Cys-Lys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Invenţia se referă la derivaţii pentapeptidelor, în special, la compuşii pentapeptidici, care manifestă o acţiune inhibitoare asupra sintezei ADN şi asupra vitezei mitotice în regenerarea ficatului, de asemenea asupra sintezei ADN şi creşterii liniei de celule maligne ale hepatomei in vitro şi in vivo.Derivaţii pentapeptidelor cu formula generală I:în care X1, X2 şi X3 fiecare reprezintă independent OH sau NH2, cu condiţia că X2 şi X3 ambii nu reprezintă NH2; sau X1 reprezintă OH; X2 reprezintă NH2 şi X3 reprezintă OH; sau X1, X2 şi X3 fiecare reprezintă independent OH.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO884054A NO884054D0 (no) | 1988-09-13 | 1988-09-13 | Nytt pentapeptid og fremgangsmaate for fremstilling derav. |
| PCT/NO1989/000093 WO1990002754A1 (en) | 1988-09-13 | 1989-09-12 | New pentapeptide and a process for the preparation thereof |
| SU914895028A RU2010799C1 (ru) | 1988-09-13 | 1991-03-12 | Производные пентапептидов |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD503B1 MD503B1 (ro) | 1996-03-29 |
| MD503C2 true MD503C2 (ro) | 1996-07-31 |
Family
ID=19891239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0391A MD503C2 (ro) | 1988-09-13 | 1994-12-29 | Derivaţi ai pentapeptidelor |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP0360481B1 (ro) |
| JP (1) | JPH04501710A (ro) |
| KR (1) | KR900701830A (ro) |
| CN (1) | CN1041158A (ro) |
| AT (1) | ATE102215T1 (ro) |
| AU (1) | AU623687B2 (ro) |
| DE (1) | DE68913411T2 (ro) |
| DK (1) | DK43891D0 (ro) |
| ES (1) | ES2062024T3 (ro) |
| FI (1) | FI911219A7 (ro) |
| HU (2) | HU206373B (ro) |
| LV (1) | LV10289B (ro) |
| MD (1) | MD503C2 (ro) |
| MY (1) | MY104912A (ro) |
| NO (2) | NO884054D0 (ro) |
| NZ (1) | NZ230625A (ro) |
| RU (1) | RU2010799C1 (ro) |
| WO (1) | WO1990002754A1 (ro) |
| ZA (1) | ZA896944B (ro) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620957A (en) * | 1989-07-14 | 1997-04-15 | Smithkline Beecham Corporation | Hemoregulatory peptides |
| TW222280B (ro) * | 1991-11-26 | 1994-04-11 | Smithkline Beecham Corp | |
| IL104323A0 (en) * | 1992-01-10 | 1993-05-13 | Smithkline Beecham Corp | Hemoregulatory peptides |
| EP1739091A1 (en) * | 1994-08-26 | 2007-01-03 | Novo Nordisk A/S | Trefoil peptide dimer |
| RU2297239C1 (ru) * | 2006-05-30 | 2007-04-20 | Общество С Ограниченной Ответственностью "Сиа Пептайдс" | Пептид, стимулирующий регенерацию ткани печени, фармацевтическая композиция на его основе и способ ее применения |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2591748A (en) | 1949-12-23 | 1952-04-08 | Hercules Powder Co Ltd | Amphoteric cellulose derivatives |
| FR2110268B1 (ro) | 1970-10-07 | 1976-06-04 | Minnesota Mining & Mfg | |
| US4237253A (en) | 1977-04-21 | 1980-12-02 | L'oreal | Copolymers, their process of preparation, and cosmetic compounds containing them |
| NO860752L (no) * | 1985-06-26 | 1986-12-29 | Bio Tech As | Pentapeptider med cellevekstregulerende virkning og fremgangsmaate for fremstilling derav. |
| GB8626539D0 (en) * | 1986-11-06 | 1986-12-10 | Nycomed As | Peptide compounds |
-
1988
- 1988-09-13 NO NO884054A patent/NO884054D0/no unknown
-
1989
- 1989-09-11 CN CN89107061A patent/CN1041158A/zh active Pending
- 1989-09-12 DE DE68913411T patent/DE68913411T2/de not_active Expired - Fee Related
- 1989-09-12 KR KR1019900700995A patent/KR900701830A/ko not_active Withdrawn
- 1989-09-12 NZ NZ230625A patent/NZ230625A/xx unknown
- 1989-09-12 WO PCT/NO1989/000093 patent/WO1990002754A1/en not_active Ceased
- 1989-09-12 MY MYPI89001244A patent/MY104912A/en unknown
- 1989-09-12 AT AT89309237T patent/ATE102215T1/de not_active IP Right Cessation
- 1989-09-12 ES ES89309237T patent/ES2062024T3/es not_active Expired - Lifetime
- 1989-09-12 EP EP89309237A patent/EP0360481B1/en not_active Expired - Lifetime
- 1989-09-12 AU AU42240/89A patent/AU623687B2/en not_active Ceased
- 1989-09-12 HU HU9057Q patent/HU206373B/hu not_active IP Right Cessation
- 1989-09-12 HU HU895790A patent/HU895790D0/hu unknown
- 1989-09-12 EP EP89910214A patent/EP0434722A1/en active Pending
- 1989-09-12 FI FI911219A patent/FI911219A7/fi not_active Application Discontinuation
- 1989-09-12 JP JP1509645A patent/JPH04501710A/ja active Pending
- 1989-09-12 ZA ZA896944A patent/ZA896944B/xx unknown
-
1991
- 1991-03-08 NO NO91910933A patent/NO910933L/no unknown
- 1991-03-12 DK DK91438A patent/DK43891D0/da not_active Application Discontinuation
- 1991-03-12 RU SU914895028A patent/RU2010799C1/ru active
-
1993
- 1993-06-15 LV LVP-93-590A patent/LV10289B/xx unknown
-
1994
- 1994-12-29 MD MD95-0391A patent/MD503C2/ro active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Brevet nr.WO 87/00180, Int. Cl. C 07 K 7/06, 1987. * |
| Ян Эрик Паульсен, Карл-Л. Рейхельт, Анна К. Петерсен, Purification and characterization of a growth inhibitory hepatic peptide, apreliminary note, Virehows Arch B. 54, 152-154, 1987. * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010799C1 (ru) | 1994-04-15 |
| EP0360481B1 (en) | 1994-03-02 |
| FI911219A0 (fi) | 1991-03-12 |
| NO910933D0 (no) | 1991-03-08 |
| HU206373B (en) | 1992-10-28 |
| NO910933L (no) | 1991-03-08 |
| ZA896944B (en) | 1990-06-27 |
| AU4224089A (en) | 1990-04-02 |
| DK43891A (da) | 1991-03-12 |
| DE68913411D1 (de) | 1994-04-07 |
| JPH04501710A (ja) | 1992-03-26 |
| EP0434722A1 (en) | 1991-07-03 |
| HUT58766A (en) | 1992-03-30 |
| FI911219A7 (fi) | 1991-03-12 |
| CN1041158A (zh) | 1990-04-11 |
| NZ230625A (en) | 1991-06-25 |
| AU623687B2 (en) | 1992-05-21 |
| ATE102215T1 (de) | 1994-03-15 |
| MD503B1 (ro) | 1996-03-29 |
| KR900701830A (ko) | 1990-12-04 |
| LV10289B (en) | 1995-04-20 |
| DK43891D0 (da) | 1991-03-12 |
| LV10289A (lv) | 1994-10-20 |
| HU895790D0 (en) | 1991-11-28 |
| DE68913411T2 (de) | 1994-06-23 |
| EP0360481A1 (en) | 1990-03-28 |
| MY104912A (en) | 1994-06-30 |
| WO1990002754A1 (en) | 1990-03-22 |
| ES2062024T3 (es) | 1994-12-16 |
| NO884054D0 (no) | 1988-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20110312 |