MC1365A1 - Derives du cyclohexene - Google Patents

Derives du cyclohexene

Info

Publication number: MC1365A1
Authority: MC; Monaco
Prior art keywords: group; general formula; compounds; compound; cyclohexene
Prior art date: 1980-01-29

Application number

MC811495A

Other languages

English (en)

French (fr)

Inventor

A Fischli

H Bruderer

R Pfister

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-01-29

Filing date

1981-01-26

Publication date

1981-10-23

1981-01-26 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1981-10-23 Publication of MC1365A1 publication Critical patent/MC1365A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

MC811495A 1980-01-29 1981-01-26 Derives du cyclohexene MC1365A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH72480A CH644580A5 (de)	1980-01-29	1980-01-29	Cyclohexen-derivate.

Publications (1)

Publication Number	Publication Date
MC1365A1 true MC1365A1 (fr)	1981-10-23

Family

ID=4193699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MC811495A MC1365A1 (fr)	1980-01-29	1981-01-26	Derives du cyclohexene

Country Status (32)

Country	Link
US (2)	US4336268A (sv)
EP (1)	EP0033156B1 (sv)
JP (1)	JPS56120650A (sv)
KR (6)	KR850000626B1 (sv)
AR (1)	AR227906A1 (sv)
AT (2)	ATE9895T1 (sv)
AU (1)	AU540697B2 (sv)
BR (1)	BR8100484A (sv)
CA (1)	CA1161064A (sv)
CH (1)	CH644580A5 (sv)
CS (6)	CS219941B2 (sv)
DE (2)	DE3166656D1 (sv)
DK (1)	DK15681A (sv)
ES (6)	ES8301200A1 (sv)
FI (1)	FI801147A7 (sv)
FR (1)	FR2479815A1 (sv)
GB (1)	GB2068373B (sv)
HU (1)	HU182280B (sv)
IE (1)	IE50885B1 (sv)
IL (1)	IL61961A (sv)
IT (1)	IT1135001B (sv)
LU (1)	LU83096A1 (sv)
MC (1)	MC1365A1 (sv)
NL (1)	NL8100403A (sv)
NO (1)	NO149958C (sv)
NZ (1)	NZ196086A (sv)
PH (1)	PH16098A (sv)
PT (1)	PT72415B (sv)
SE (1)	SE8100403L (sv)
YU (1)	YU332180A (sv)
ZA (1)	ZA81459B (sv)
ZW (1)	ZW31480A1 (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6372919B1 (en) *	2001-01-11	2002-04-16	Dov Pharmaceutical, Inc.	(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) *	2001-08-24	2003-05-27	Dov Pharmaceuticals Inc.	(−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20060173064A1 (en) *	2001-08-24	2006-08-03	Lippa Arnold S	(-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
US20080081834A1 (en)	2002-07-31	2008-04-03	Lippa Arnold S	Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US20070043100A1 (en)	2005-08-16	2007-02-22	Hagen Eric J	Novel polymorphs of azabicyclohexane
US20060100263A1 (en) *	2004-11-05	2006-05-11	Anthony Basile	Antipyretic compositions and methods
KR101733180B1 (ko)	2005-07-27	2017-05-08	뉴로반스, 인크.	신규 1-아릴-3-아자바이사이클로［3.1.0］헥산：제조 방법 및 신경 정신 질환 치료를 위한 용도
US20080045725A1 (en) *	2006-04-28	2008-02-21	Murry Jerry A	Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) *	2006-11-07	2012-03-20	Dov Pharmaceutical, Inc.	Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US20080269348A1 (en) *	2006-11-07	2008-10-30	Phil Skolnick	Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
EP2167083B1 (en) *	2007-06-06	2015-10-28	Euthymics Bioscience, Inc.	1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US9133159B2 (en)	2007-06-06	2015-09-15	Neurovance, Inc.	1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20140206740A1 (en)	2011-07-30	2014-07-24	Neurovance, Inc.	Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH249047A (de) *	1944-03-20	1947-05-31	Ag J R Geigy	Verfahren zur Darstellung eines basischen Esters einer 1-Aryl-cycloalkyl-1-carbonsäure.
CH249052A (de) *	1944-03-20	1947-05-31	Ag J R Geigy	Verfahren zur Darstellung eines basischen Amids einer 1-Aryl-cycloalkyl-1-carbonsäure.
US2647122A (en) *	1948-10-01	1953-07-28	Sterling Drug Inc	Tertiary amines and process of preparing them
US3109845A (en) *	1960-02-04	1963-11-05	Thomae Gmbh Dr K	1-cyclohexyl, 1-cyclohexenyl, 1-furyl, and 1-thienyl, tertiary amino substituted methanes
DE1518545A1 (de) *	1965-04-01	1970-01-15	Boehringer Mannheim Gmbh	Verfahren zur Herstellung neuer Phenylcyclohexylalkylamine und ihrer Salze
DE1518663A1 (de) *	1965-08-02	1969-12-18	Gruenenthal Chemie	Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3408396A (en) *	1965-10-22	1968-10-29	Colgate Palmolive Co	alpha-cyclohexyl-3, 4-disubstituted-phenyl acetamides
US3485873A (en) *	1966-12-21	1969-12-23	Sterling Drug Inc	N-benzyl-n-methyl-omega-phenyl-omega-cycloalkyl-lower-alkylamines
US3737451A (en) *	1970-09-23	1973-06-05	Sandoz Ag	Cis-3,4-diaryl-cyclopentylidene-and 1-cyclopentene-1-acetic acids and derivatives
US4053637A (en) *	1971-06-11	1977-10-11	Astra Lakemedal Aktiebolag	Compounds of diphenylcyclopentylamine type and methods for their uses
CA1130318A (en) *	1978-10-11	1982-08-24	Peter M. Muller	Cyclohexadiene derivatives

1980
- 1980-01-29 CH CH72480A patent/CH644580A5/de not_active IP Right Cessation
- 1980-04-10 FI FI801147A patent/FI801147A7/sv not_active Application Discontinuation
- 1980-12-11 CA CA000366550A patent/CA1161064A/en not_active Expired
- 1980-12-19 ZW ZW314/80A patent/ZW31480A1/xx unknown
- 1980-12-30 YU YU03321/80A patent/YU332180A/xx unknown
1981
- 1981-01-08 IT IT19047/81A patent/IT1135001B/it active
- 1981-01-14 DK DK15681A patent/DK15681A/da not_active Application Discontinuation
- 1981-01-19 CS CS817015A patent/CS219941B2/cs unknown
- 1981-01-19 CS CS817019A patent/CS219944B2/cs unknown
- 1981-01-19 CS CS817017A patent/CS220347B2/cs unknown
- 1981-01-19 CS CS81362A patent/CS219940B2/cs unknown
- 1981-01-19 CS CS817016A patent/CS219942B2/cs unknown
- 1981-01-19 CS CS817018A patent/CS219943B2/cs unknown
- 1981-01-20 PH PH25103A patent/PH16098A/en unknown
- 1981-01-22 NZ NZ196086A patent/NZ196086A/en unknown
- 1981-01-22 IL IL61961A patent/IL61961A/xx unknown
- 1981-01-22 ZA ZA00810459A patent/ZA81459B/xx unknown
- 1981-01-23 SE SE8100403A patent/SE8100403L/sv not_active Application Discontinuation
- 1981-01-23 AR AR284052A patent/AR227906A1/es active
- 1981-01-26 MC MC811495A patent/MC1365A1/fr unknown
- 1981-01-27 US US06/228,793 patent/US4336268A/en not_active Expired - Fee Related
- 1981-01-27 DE DE8181100576T patent/DE3166656D1/de not_active Expired
- 1981-01-27 DE DE19813102603 patent/DE3102603A1/de not_active Withdrawn
- 1981-01-27 EP EP81100576A patent/EP0033156B1/de not_active Expired
- 1981-01-27 LU LU83096A patent/LU83096A1/de unknown
- 1981-01-27 JP JP975781A patent/JPS56120650A/ja active Pending
- 1981-01-27 AT AT81100576T patent/ATE9895T1/de active
- 1981-01-27 FR FR8101480A patent/FR2479815A1/fr active Granted
- 1981-01-28 NO NO810297A patent/NO149958C/no unknown
- 1981-01-28 NL NL8100403A patent/NL8100403A/nl not_active Application Discontinuation
- 1981-01-28 PT PT72415A patent/PT72415B/pt unknown
- 1981-01-28 IE IE153/81A patent/IE50885B1/en unknown
- 1981-01-28 ES ES498866A patent/ES8301200A1/es not_active Expired
- 1981-01-28 BR BR8100484A patent/BR8100484A/pt unknown
- 1981-01-28 HU HU81178A patent/HU182280B/hu unknown
- 1981-01-28 GB GB8102555A patent/GB2068373B/en not_active Expired
- 1981-01-28 AT AT0035581A patent/AT376654B/de not_active IP Right Cessation
- 1981-01-28 KR KR1019810000259A patent/KR850000626B1/ko not_active Expired
- 1981-01-29 AU AU66719/81A patent/AU540697B2/en not_active Ceased
- 1981-10-29 ES ES506687A patent/ES506687A0/es active Granted
- 1981-10-29 ES ES506688A patent/ES506688A0/es active Granted
- 1981-10-29 ES ES506685A patent/ES8301883A1/es not_active Expired
- 1981-10-29 ES ES506686A patent/ES506686A0/es active Granted
- 1981-10-29 ES ES506684A patent/ES506684A0/es active Granted
1982
- 1982-03-24 US US06/361,290 patent/US4448991A/en not_active Expired - Fee Related
1984
- 1984-08-01 KR KR1019840004582A patent/KR840001552B1/ko not_active Expired
- 1984-08-01 KR KR1019840004581A patent/KR840001551B1/ko not_active Expired
- 1984-08-01 KR KR1019840004585A patent/KR840001554B1/ko not_active Expired
- 1984-08-01 KR KR1019840004584A patent/KR850000627B1/ko not_active Expired
- 1984-08-01 KR KR1019840004583A patent/KR840001553B1/ko not_active Expired

Also Published As

Publication number	Publication date
GB2068373B (en)	1983-11-30
ES8301884A1 (es)	1982-12-16
CS219940B2 (en)	1983-03-25
CS219941B2 (en)	1983-03-25
IL61961A0 (en)	1981-02-27
KR840001551B1 (ko)	1984-10-05
CS219943B2 (en)	1983-03-25
ES506686A0 (es)	1982-12-16
ES506685A0 (es)	1982-12-16
CS220347B2 (en)	1983-03-25
US4448991A (en)	1984-05-15
CS219942B2 (en)	1983-03-25
NL8100403A (nl)	1981-08-17
FI801147A7 (sv)	1981-01-01
CH644580A5 (de)	1984-08-15
PT72415A (en)	1981-02-01
JPS56120650A (en)	1981-09-22
IE810153L (en)	1981-07-29
ES8301883A1 (es)	1982-12-16
ZA81459B (en)	1982-02-24
KR850000627B1 (ko)	1985-05-06
KR850002003A (ko)	1985-04-10
ZW31480A1 (en)	1981-09-02
AT376654B (de)	1984-12-27
CA1161064A (en)	1984-01-24
GB2068373A (en)	1981-08-12
ATE9895T1 (de)	1984-11-15
KR840001553B1 (ko)	1984-10-05
KR840001554B1 (ko)	1984-10-05
EP0033156A2 (de)	1981-08-05
LU83096A1 (de)	1982-09-10
IL61961A (en)	1984-05-31
SE8100403L (sv)	1981-07-30
US4336268A (en)	1982-06-22
NO810297L (no)	1981-07-30
ES8400079A1 (es)	1983-10-16
PT72415B (en)	1982-07-26
NO149958C (no)	1984-07-25
ES498866A0 (es)	1982-12-01
HU182280B (en)	1983-12-28
ES8301200A1 (es)	1982-12-01
CS219944B2 (en)	1983-03-25
DK15681A (da)	1981-07-30
IT1135001B (it)	1986-08-20
NZ196086A (en)	1984-08-24
EP0033156B1 (de)	1984-10-17
ES506684A0 (es)	1983-10-16
FR2479815A1 (fr)	1981-10-09
AU540697B2 (en)	1984-11-29
ATA35581A (de)	1984-05-15
FR2479815B1 (sv)	1984-02-17
DE3102603A1 (de)	1981-12-10
KR840001552B1 (ko)	1984-10-05
PH16098A (en)	1983-06-24
KR830005105A (ko)	1983-07-23
NO149958B (no)	1984-04-16
EP0033156A3 (en)	1982-03-17
YU332180A (en)	1983-10-31
IE50885B1 (en)	1986-08-06
ES8301885A1 (es)	1982-12-16
DE3166656D1 (en)	1984-11-22
ES8301878A1 (es)	1982-12-16
ES506687A0 (es)	1982-12-16
BR8100484A (pt)	1981-08-18
IT8119047A0 (it)	1981-01-08
KR850000626B1 (ko)	1985-05-06
ES506688A0 (es)	1982-12-16
AU6671981A (en)	1981-08-06
AR227906A1 (es)	1982-12-30

Publication	Publication Date	Title
EP0202164B1 (fr)	1989-02-08	Dérivés de (benzoyl-4 pipéridino)-2 phenyl-1 alcanols, leur préparation et leur application en thérapeutique
FR2545482A1 (fr)	1984-11-09	Derives de phenethanolamine
FR2503702A1 (fr)	1982-10-15	Nouveaux cycloalcane-amides a substituants adjacents, doues de proprietes analgesiques et compositions pharmaceutiques les contenant
BE851310A (fr)	1977-08-10	Nouveaux derives de la tetrahydro-equinocandine b
MC1365A1 (fr)	1981-10-23	Derives du cyclohexene
SK22793A3 (en)	1993-07-07	New process for preparimg formoterol and related compounds
EP0332528A1 (fr)	1989-09-13	Dérivés d'isoindolinone, leurs procédés de préparation et les médicaments les contenant
MC1706A1 (fr)	1986-09-22	Dérivés de tétrahydronaphtalène
EP0025727B1 (fr)	1984-03-28	Dérivés de l'indole, procédé pour leur préparation et médicaments les contenant
BE1009852A3 (fr)	1997-10-07	Derives 1-[2(vinyl-substitues)]-3-4-dihydro-5h-2,3-benzodiazepine.
CA2000091A1 (fr)	1990-04-04	Derives de la benzoxazolinone, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
BE1000039A4 (fr)	1987-12-15	Nouvelles 8 alpha-acylamino-ergolines, leur preparation et leur utilisation comme medicaments.
FR2643634A1 (fr)	1990-08-31	Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2662442A1 (fr)	1991-11-29	Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant.
MC1357A1 (fr)	1981-08-10	Derives de 2,3-indoledione
CA2046292A1 (en)	1991-06-08	Bicyclic amino-substituted compounds
EP1196403B1 (fr)	2005-11-09	N-aralkyl amines cycliques antipsychotiques
EP0074903A2 (fr)	1983-03-23	Dérivés d'amino-2 tétrahydro-1,2,3,4 naphtalène, leur préparation et leur application en thérapeutique
EP0322263B1 (fr)	1994-03-30	Carbamates tricycliques, leur procédé de préparation et leur application en thérapeutique
FR2669030A1 (fr)	1992-05-15	Nouveaux derives d'imidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP1960387B1 (fr)	2011-11-02	Derives de isoquinoline et benzo[h]isoquinoline, leur preparation et leur utilisation en therapeutique en tant qu antagonistes du recepteur de l histamine h3
EP0869952B1 (fr)	2001-09-19	Derives de 5-naphtalen-1-y1-1,3-dioxanes, leur preparation et leur application en therapeutique
MC1287A1 (fr)	1980-07-22	Derives de cyclohexadiene
CH682322A5 (sv)	1993-08-31
CA1183849A (fr)	1985-03-12	¬alkyl- et alcenyl-3 piperidyl-4)-2 ethyl\|-3 indoles et leur utilisation comme medicaments

Legal Events

Date	Code	Title	Description
1986-12-12	YP	Annual fee paid