[go: up one dir, main page]

MA45887A1 - Cristal de dérivé de pyrido [3, 4-d] pyrimidine ou son solvate - Google Patents

Cristal de dérivé de pyrido [3, 4-d] pyrimidine ou son solvate

Info

Publication number
MA45887A1
MA45887A1 MA45887A MA45887A MA45887A1 MA 45887 A1 MA45887 A1 MA 45887A1 MA 45887 A MA45887 A MA 45887A MA 45887 A MA45887 A MA 45887A MA 45887 A1 MA45887 A1 MA 45887A1
Authority
MA
Morocco
Prior art keywords
crystal
pyrido
pyrimidine derivative
solvate
formula
Prior art date
Application number
MA45887A
Other languages
English (en)
Other versions
MA45887B1 (fr
Inventor
Hidetoshi Miyamoto
Tsuyoshi Mizuno
Gen Unoki
Yuki Miyazawa
Naoki Yajima
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of MA45887A1 publication Critical patent/MA45887A1/fr
Publication of MA45887B1 publication Critical patent/MA45887B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Walking Sticks, Umbrellas, And Fans (AREA)

Abstract

L'invention concerne un cristal d'un nouveau dérivé de pyrido [3, 4-d] pyrimidine ayant une excellente activité inhibitrice de cdk 4/6. L'invention concerne également un cristal d'un composé représenté par la formule (i). Dans la formule, r 1 représente un atome d'hydrogène ou un groupe alkyle en c 1-3 ; r 2 représente un atome d'hydrogène ou un groupe oxo ; l représente une liaison simple ou un groupe alkylène en c 1-3 ; et x représente ch ou n.
MA45887A 2016-11-28 2017-11-27 Cristal de dérivé de pyrido [3, 4-d] pyrimidine ou son solvate MA45887B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016229973 2016-11-28
PCT/JP2017/042437 WO2018097295A1 (fr) 2016-11-28 2017-11-27 Cristal de dérivé de pyrido [3, 4-d] pyrimidine ou son solvate

Publications (2)

Publication Number Publication Date
MA45887A1 true MA45887A1 (fr) 2020-11-30
MA45887B1 MA45887B1 (fr) 2021-04-30

Family

ID=62196036

Family Applications (1)

Application Number Title Priority Date Filing Date
MA45887A MA45887B1 (fr) 2016-11-28 2017-11-27 Cristal de dérivé de pyrido [3, 4-d] pyrimidine ou son solvate

Country Status (31)

Country Link
US (1) US11261182B2 (fr)
EP (1) EP3546456B1 (fr)
JP (2) JP6745905B2 (fr)
KR (1) KR102352637B1 (fr)
CN (1) CN109996800B (fr)
AU (1) AU2017364805B2 (fr)
CA (1) CA3041854C (fr)
CL (3) CL2019001420A1 (fr)
CO (1) CO2019005513A2 (fr)
CY (1) CY1125045T1 (fr)
DK (1) DK3546456T3 (fr)
EC (1) ECSP19037197A (fr)
ES (1) ES2905437T3 (fr)
HR (1) HRP20220065T1 (fr)
HU (1) HUE057706T2 (fr)
IL (1) IL266313B2 (fr)
LT (1) LT3546456T (fr)
MA (1) MA45887B1 (fr)
MX (1) MX382362B (fr)
MY (1) MY199852A (fr)
NZ (1) NZ752990A (fr)
PE (2) PE20250397A1 (fr)
PH (1) PH12019500905A1 (fr)
PL (1) PL3546456T3 (fr)
PT (1) PT3546456T (fr)
RS (1) RS63004B1 (fr)
SI (1) SI3546456T1 (fr)
TW (1) TWI755452B (fr)
UA (1) UA124273C2 (fr)
WO (1) WO2018097295A1 (fr)
ZA (1) ZA201902828B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2024006975A (es) * 2021-12-16 2024-08-27 Transthera Sciences Nanjing Inc Inhibidor de cdk9 y uso del mismo.
TW202521113A (zh) * 2023-09-27 2025-06-01 日商帝人製藥股份有限公司 類風濕性關節炎治療藥

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20063909B (en) 2002-01-22 2006-08-25 Warner Lambert Co 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES
ATE433967T1 (de) * 2003-01-17 2009-07-15 Warner Lambert Co 2-aminopyridin-substituierteheterocyclen als inhibitoren der zellulären proliferation
NZ544609A (en) 2003-07-11 2008-07-31 Warner Lambert Co Isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
PT2331547E (pt) 2008-08-22 2014-10-29 Novartis Ag Compostos de pirrolopirimidina como inibidores de cdk
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
SG11201601138PA (en) * 2013-08-23 2016-03-30 Neupharma Inc Certain chemical entities, compositions, and methods
GB201403536D0 (en) * 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
TR201819419T4 (tr) * 2014-05-29 2019-01-21 Taiho Pharmaceutical Co Ltd Yeni tetrahidropiridopirimidin bileşiği veya tuzu.
BR112017005511A2 (pt) 2014-09-17 2018-08-14 Celgene Quanticel Res Inc inibidores da histona-desmetilase.
RU2695337C2 (ru) * 2015-05-29 2019-07-23 Тейдзин Фарма Лимитед ПРОИЗВОДНОЕ ПИРИДО[3,4-d]ПИРИМИДИНА И ЕГО ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМАЯ СОЛЬ

Also Published As

Publication number Publication date
CY1125045T1 (el) 2023-03-24
RU2019116389A3 (fr) 2021-04-16
LT3546456T (lt) 2022-03-10
CL2021001448A1 (es) 2022-01-14
CA3041854A1 (fr) 2018-05-31
CL2021001447A1 (es) 2022-01-14
HRP20220065T1 (hr) 2022-04-15
HUE057706T2 (hu) 2022-05-28
JP7149980B2 (ja) 2022-10-07
IL266313B2 (en) 2023-12-01
MX2019005717A (es) 2019-08-12
EP3546456A4 (fr) 2020-04-29
AU2017364805A2 (en) 2019-10-24
RU2019116389A (ru) 2020-11-30
MA45887B1 (fr) 2021-04-30
CL2019001420A1 (es) 2019-08-30
PT3546456T (pt) 2022-02-28
PE20250397A1 (es) 2025-02-11
WO2018097295A1 (fr) 2018-05-31
PL3546456T3 (pl) 2022-05-02
PE20191133A1 (es) 2019-09-02
AU2017364805B2 (en) 2021-12-16
SI3546456T1 (sl) 2022-04-29
CN109996800A (zh) 2019-07-09
ES2905437T3 (es) 2022-04-08
JP6745905B2 (ja) 2020-08-26
MY199852A (en) 2023-11-25
RS63004B1 (sr) 2022-03-31
CO2019005513A2 (es) 2019-07-31
NZ752990A (en) 2025-08-29
JPWO2018097295A1 (ja) 2019-06-24
TWI755452B (zh) 2022-02-21
IL266313B1 (en) 2023-08-01
IL266313A (en) 2019-06-30
ZA201902828B (en) 2022-05-25
UA124273C2 (uk) 2021-08-18
BR112019009448A2 (pt) 2019-07-30
US20210276997A1 (en) 2021-09-09
CA3041854C (fr) 2025-05-13
CN109996800B (zh) 2021-11-19
JP2020121989A (ja) 2020-08-13
KR102352637B1 (ko) 2022-01-17
PH12019500905A1 (en) 2019-08-19
MX382362B (es) 2025-03-13
TW201833105A (zh) 2018-09-16
US11261182B2 (en) 2022-03-01
AU2017364805A1 (en) 2019-05-09
EP3546456B1 (fr) 2022-01-12
DK3546456T3 (da) 2022-03-07
EP3546456A1 (fr) 2019-10-02
KR20190067247A (ko) 2019-06-14
ECSP19037197A (es) 2019-06-30

Similar Documents

Publication Publication Date Title
PH12017502171A1 (en) PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
NO20062633L (no) Pyrazolderivater som proteinkinasemodulatorer
MA33851B1 (fr) Compose heterocyclique contenant de l'azote et fongicide agricole
EA200970510A1 (ru) Гетеромоноциклическое соединение и его применение
CY1124795T1 (el) Συνθεσεις και μεθοδοι για τη θεραπεια και προφυλαξη λοιμωξεων χειρουργικης θεσης
PE20190656A1 (es) Compuestos de tiazolo-piridina sustituida como inhibidores de malt1
MY197742A (en) Morphinan derivative
MX362940B (es) Nuevo derivado de nicotinamida o la sal del mismo.
PE20142081A1 (es) Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodo de uso de los mismos
MX389537B (es) Derivado de pirido[3,4-d]pirimidina y su sal farmacéuticamente aceptable.
EA200801828A3 (ru) Соединения 1,2,4,5- тетрагидро-3н-бензазепина, способ их получения и фармацевтические композиции, содержащие эти соединения
MX2024001202A (es) Derivados de heteroarilos biciclicos como inhibidores de ectonucleotido pirofosfatasa fosfodiesterasa 1
BRPI0408605A (pt) derivados de 8-perfluoralquil-6,7,8,9-tetrahidropirimido[1,2-a]piri midin-4-ona substituìdos
AR111684A1 (es) Compuestos plaguicidas bicíclicos
MA39707B1 (fr) Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens
EA201791816A1 (ru) Ингибиторы kv1.3 и их применение в медицине
PH12021551630A1 (en) Pyrimidine compound or salt thereof
AR065583A1 (es) Compuestos macrociclicos y composicion farmaceutica
MA45887A1 (fr) Cristal de dérivé de pyrido [3, 4-d] pyrimidine ou son solvate
AR047531A1 (es) Derivados 1h-tieno(2,3-c)pirazol utiles como inhibidores de quinasa
MX374576B (es) Derivado de 5h-pirrolo[2,3-d]pirimidin-6(7h)-ona novedoso.
PE20201148A1 (es) Compuestos biciclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias
AR123981A1 (es) Uso de derivados de ácido [(1,5-difenil-1h-pirazol-3-il)oxi]acético y sus sales, así como los agentes que los contienen, para la reducción de efectos fitotóxicos de agroquímicos, en especial de herbicidas, en plantas útiles o de cultivo
BR112018002403A2 (pt) composto, e, composição útil e método para tratar infecção de hiv
TH1901003128A (th) ผลึกของอนุพันธ์ไพริโด[3,4-d]ไพริมิดีนหรือโซลเวตของสิ่งนั้น