MA41135B1 - Substituted benzamides 1,3-thiazol-2-yl - Google Patents
Substituted benzamides 1,3-thiazol-2-ylInfo
- Publication number
- MA41135B1 MA41135B1 MA41135A MA41135A MA41135B1 MA 41135 B1 MA41135 B1 MA 41135B1 MA 41135 A MA41135 A MA 41135A MA 41135 A MA41135 A MA 41135A MA 41135 B1 MA41135 B1 MA 41135B1
- Authority
- MA
- Morocco
- Prior art keywords
- thiazol
- compounds
- substituted benzamides
- prophylaxis
- disease
- Prior art date
Links
- 229940054066 benzamide antipsychotics Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- -1 1,3-thiazol-2-yl Chemical group 0.000 abstract 1
- 150000003936 benzamides Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001272 neurogenic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
La présente invention concerne des composés benzamide à substitution 1,3-thiazol-2-yl de formule générale (i) décrite et définie dans la description, des compositions pharmaceutiques et des associations comprenant lesdits composés et l'utilisation desdits composés pour la fabrication d'une composition pharmaceutique destinée au traitement ou à la prophylaxie d'une maladie, en particulier d'un trouble neurogène, en tant qu'agent unique ou en association avec d'autres principes actifs.The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (i) described and defined in the description, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for the manufacture of. a pharmaceutical composition intended for the treatment or prophylaxis of a disease, in particular of a neurogenic disorder, as a single agent or in combination with other active principles.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196954 | 2014-12-09 | ||
| PCT/EP2015/078765 WO2016091776A1 (en) | 2014-12-09 | 2015-12-07 | 1,3-thiazol-2-yl substituted benzamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA41135B1 true MA41135B1 (en) | 2021-10-29 |
Family
ID=52015966
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA41135A MA41135B1 (en) | 2014-12-09 | 2015-12-07 | Substituted benzamides 1,3-thiazol-2-yl |
| MA50674A MA50674B1 (en) | 2014-12-09 | 2015-12-07 | 1,3-Thiazol-2-yl substituted benzamides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA50674A MA50674B1 (en) | 2014-12-09 | 2015-12-07 | 1,3-Thiazol-2-yl substituted benzamides |
Country Status (42)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110256418B (en) * | 2014-12-09 | 2023-01-20 | 拜耳公司 | 1, 3-thiazol-2-yl substituted benzamides |
| TWI808055B (en) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Combination therapies of hdac inhibitors and pd-1 inhibitors |
| TWI794171B (en) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Combination therapies of hdac inhibitors and pd-l1 inhibitors |
| CN106588785A (en) * | 2016-12-02 | 2017-04-26 | 山东吉田香料股份有限公司 | Preparation method of acetylpyrazine |
| US10111883B1 (en) * | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
| HU231206B1 (en) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepines |
| JOP20200287A1 (en) | 2018-05-15 | 2020-11-09 | Bayer Ag | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| US20210220358A1 (en) * | 2018-05-15 | 2021-07-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| AU2019353424B2 (en) | 2018-10-05 | 2022-12-08 | Shionogi & Co., Ltd. | Medicine for treating chronic cough |
| CA3115939A1 (en) * | 2018-10-10 | 2020-04-16 | Bellus Health Cough Inc. | Treatment of pruritus with p2x3 antagonists |
| CA3131312A1 (en) | 2019-02-25 | 2020-09-03 | Bellus Health Cough Inc. | Treatment with p2x3 modulators |
| PE20220171A1 (en) * | 2019-04-05 | 2022-01-28 | Syngenta Crop Protection Ag | DIAZINE-AMIDE COMPOUNDS ACTIVE AS PESTICIDES |
| EP3953343A1 (en) * | 2019-04-11 | 2022-02-16 | Syngenta Crop Protection AG | Pesticidally active diazine-amide compounds |
| EP3976609A1 (en) | 2019-05-31 | 2022-04-06 | Chiesi Farmaceutici S.p.A. | Pyridopyrimidines derivatives as p2x3 inhibitors |
| JP7641917B2 (en) | 2019-05-31 | 2025-03-07 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Aminoquinazoline Derivatives as P2X3 Inhibitors |
| EP3757103A1 (en) | 2019-06-27 | 2020-12-30 | Bayer AG | Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide for the treatment of neurogenic diseases |
| CN113082023B (en) * | 2019-12-23 | 2024-03-01 | 武汉朗来科技发展有限公司 | Drug combinations of P2X3 inhibitors and P2X4 inhibitors and their applications |
| CN114072399B (en) * | 2020-05-25 | 2024-11-29 | 中国医药研究开发中心有限公司 | Aromatic formamide compound and preparation method and medical application thereof |
| WO2022063205A1 (en) * | 2020-09-24 | 2022-03-31 | 中国医药研究开发中心有限公司 | Aryl formamide compound, preparation method for same, and medicinal uses thereof |
| JP7561978B2 (en) * | 2020-09-30 | 2024-10-04 | ヒューマンウェル ヘルスケア （グループ） カンパニー リミテッド | Benzamide compounds and their uses |
| CA3196335A1 (en) | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
| KR20230113536A (en) | 2020-11-27 | 2023-07-31 | 키에시 파르마슈티시 엣스. 피. 에이. | (aza)quinoline 4-amine derivatives as P2X3 inhibitors |
| US20240025880A1 (en) | 2020-11-27 | 2024-01-25 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| CN114591317A (en) * | 2020-12-04 | 2022-06-07 | 武汉人福创新药物研发中心有限公司 | P2X3 inhibitors and uses thereof |
| WO2022253945A1 (en) | 2021-06-04 | 2022-12-08 | Bayer Aktiengesellschaft | Pharmaceutical dosage forms comprising 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3r)-tetrahydrofuran-3-yloxy]-n-{(1r)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}-benzamide |
| WO2022253943A1 (en) | 2021-06-04 | 2022-12-08 | Bayer Aktiengesellschaft | Crystalline forms of 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3r)-tetrahydrofuran-3-yloxy]-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}-benzamide |
| CN116396285A (en) * | 2022-01-04 | 2023-07-07 | 上海华汇拓医药科技有限公司 | Preparation and Application of Deuterated Tetrahydrofuran Compounds |
| US12024285B1 (en) | 2022-03-10 | 2024-07-02 | Skypad Tech, Inc. | Modular mobility system including thrusters movably connected to a support structure |
| JP2025510348A (en) * | 2022-03-29 | 2025-04-14 | 人福医薬集団股▲分▼公司 | P2X3 inhibitor compounds and their salts, crystal polymorphs and uses |
| EP4640683A1 (en) * | 2022-12-22 | 2025-10-29 | Humanwell Healthcare (Group) Co., Ltd. | Method for preparing p2x3 inhibitor |
| AU2024274559A1 (en) | 2023-05-22 | 2026-01-22 | Chiesi Farmaceutici S.P.A. | Process and intermediates for the preparation of a p2x3 inhibitor |
| CN117777048B (en) * | 2023-09-25 | 2024-09-20 | 上海科利生物医药有限公司 | Preparation method of chiral 2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester |
| CN120227337A (en) * | 2023-12-29 | 2025-07-01 | 人福医药集团股份公司 | A solid dispersion of a P2X3 receptor antagonist and its preparation process |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2552804T3 (en) | 2005-05-04 | 2015-12-02 | Evotec Ag | Condensed heterocyclic compounds, and their compositions and uses |
| EP2592070B1 (en) | 2006-06-29 | 2016-08-31 | F. Hoffmann-La Roche AG | Tetrazole-substituted arylamides |
| US8501933B2 (en) * | 2006-11-09 | 2013-08-06 | Roche Palo Alto Llc | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
| MX2009004900A (en) * | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Thiazole and oxazole-substituted arylamides. |
| EP2136639B1 (en) | 2007-04-02 | 2016-03-09 | Evotec AG | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
| US8076345B2 (en) | 2007-04-17 | 2011-12-13 | Evotec Ag | 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof |
| US20090099195A1 (en) | 2007-05-08 | 2009-04-16 | Astrazeneca Ab | Therapeutic Compounds 570 |
| US20090317360A1 (en) * | 2007-06-12 | 2009-12-24 | Genelabs Technologies, Inc. | Anti-viral inhibitors and methods of use |
| JP2011502148A (en) | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | P2X3 receptor antagonist for the treatment of pain |
| JP5552430B2 (en) | 2007-10-31 | 2014-07-16 | メルク・シャープ・アンド・ドーム・コーポレーション | P2X3 receptor antagonist for the treatment of pain |
| BRPI0821266B8 (en) | 2007-12-17 | 2023-02-07 | Hoffmann La Roche | TRIAZOL- SUBSTITUTED ARILAMIDE DERIVATIVES AND THEIR USE AND PHARMACEUTICAL COMPOSITION |
| JP5301561B2 (en) | 2007-12-17 | 2013-09-25 | エフ．ホフマン−ラ ロシュ アーゲー | Novel pyrazole-substituted arylamides |
| EP2234989B1 (en) | 2007-12-17 | 2014-08-13 | F. Hoffmann-La Roche AG | Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists |
| EP2234981B1 (en) | 2007-12-17 | 2016-03-30 | F. Hoffmann-La Roche AG | Novel imidazole-substituted arylamides |
| EP2262766B1 (en) | 2008-02-29 | 2015-11-11 | Evotec AG | Amide compounds, compositions and uses thereof |
| JP5608655B2 (en) | 2008-09-18 | 2014-10-15 | エヴォテック アーゲー | Modulator of P2X3 receptor activity |
| ES2534199T3 (en) | 2008-10-31 | 2015-04-20 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for pain management |
| EP2379518B1 (en) | 2008-12-16 | 2014-05-07 | F. Hoffmann-La Roche AG | Thiadiazole-substituted arylamides |
| CA2754654A1 (en) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel oxazolone and pyrrolidinone-substituted arylamides |
| CA2764956A1 (en) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel biphenyl and phenyl-pyridine amides |
| MX341133B (en) | 2010-01-13 | 2016-08-08 | Tempero Pharmaceuticals Inc * | Compounds and methods. |
| WO2013009810A1 (en) | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
| US9562041B2 (en) | 2012-05-16 | 2017-02-07 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| WO2014049488A1 (en) | 2012-09-28 | 2014-04-03 | Pfizer Inc. | Benzamide and heterobenzamide compounds |
| DK3381917T3 (en) | 2013-01-31 | 2021-10-18 | Bellus Health Cough Inc | IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF |
| US10183937B2 (en) * | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| CN110256418B (en) | 2014-12-09 | 2023-01-20 | 拜耳公司 | 1, 3-thiazol-2-yl substituted benzamides |
| US20210220358A1 (en) | 2018-05-15 | 2021-07-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| JOP20200287A1 (en) | 2018-05-15 | 2020-11-09 | Bayer Ag | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| EP3757103A1 (en) | 2019-06-27 | 2020-12-30 | Bayer AG | Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide for the treatment of neurogenic diseases |
-
2015
- 2015-12-07 CN CN201910653985.0A patent/CN110256418B/en not_active Expired - Fee Related
- 2015-12-07 LT LTEP19181710.5T patent/LT3587417T/en unknown
- 2015-12-07 HR HRP20220371TT patent/HRP20220371T1/en unknown
- 2015-12-07 UA UAA201707107A patent/UA120382C2/en unknown
- 2015-12-07 EA EA201791261A patent/EA032312B1/en not_active IP Right Cessation
- 2015-12-07 RS RS20211014A patent/RS62227B1/en unknown
- 2015-12-07 CR CR20170242A patent/CR20170242A/en unknown
- 2015-12-07 JO JOP/2015/0301A patent/JOP20150301B1/en active
- 2015-12-07 PL PL15804824T patent/PL3230281T3/en unknown
- 2015-12-07 CR CR20210108A patent/CR20210108A/en unknown
- 2015-12-07 PT PT191817105T patent/PT3587417T/en unknown
- 2015-12-07 PL PL19181710T patent/PL3587417T3/en unknown
- 2015-12-07 WO PCT/EP2015/078765 patent/WO2016091776A1/en not_active Ceased
- 2015-12-07 MA MA41135A patent/MA41135B1/en unknown
- 2015-12-07 UY UY0001036422A patent/UY36422A/en active IP Right Grant
- 2015-12-07 HU HUE15804824A patent/HUE055290T2/en unknown
- 2015-12-07 PT PT158048249T patent/PT3230281T/en unknown
- 2015-12-07 PE PE2021001723A patent/PE20220253A1/en unknown
- 2015-12-07 KR KR1020177018575A patent/KR102548799B1/en active Active
- 2015-12-07 LT LTEP15804824.9T patent/LT3230281T/en unknown
- 2015-12-07 JP JP2017530625A patent/JP6544665B2/en not_active Expired - Fee Related
- 2015-12-07 SG SG10202012274RA patent/SG10202012274RA/en unknown
- 2015-12-07 SG SG11201704717VA patent/SG11201704717VA/en unknown
- 2015-12-07 DK DK15804824.9T patent/DK3230281T3/en active
- 2015-12-07 CN CN201580075714.1A patent/CN107207507B/en not_active Expired - Fee Related
- 2015-12-07 MX MX2020005909A patent/MX387478B/en unknown
- 2015-12-07 SI SI201531643T patent/SI3230281T1/en unknown
- 2015-12-07 PE PE2017000984A patent/PE20180227A1/en unknown
- 2015-12-07 CU CU2017000077A patent/CU24411B1/en unknown
- 2015-12-07 BR BR112017012327-4A patent/BR112017012327B1/en not_active IP Right Cessation
- 2015-12-07 CA CA2969952A patent/CA2969952A1/en active Pending
- 2015-12-07 NZ NZ761161A patent/NZ761161A/en unknown
- 2015-12-07 RS RS20220250A patent/RS63014B1/en unknown
- 2015-12-07 HU HUE19181710A patent/HUE058009T2/en unknown
- 2015-12-07 US US15/534,855 patent/US10174016B2/en active Active
- 2015-12-07 TN TN2017000244A patent/TN2017000244A1/en unknown
- 2015-12-07 ES ES19181710T patent/ES2908822T3/en active Active
- 2015-12-07 HR HRP20211002TT patent/HRP20211002T1/en unknown
- 2015-12-07 DK DK19181710.5T patent/DK3587417T3/en active
- 2015-12-07 MX MX2017007658A patent/MX377651B/en active IP Right Grant
- 2015-12-07 SI SI201531781T patent/SI3587417T1/en unknown
- 2015-12-07 MA MA50674A patent/MA50674B1/en unknown
- 2015-12-07 MY MYPI2017702127A patent/MY192690A/en unknown
- 2015-12-07 AU AU2015359626A patent/AU2015359626B2/en not_active Ceased
- 2015-12-07 EP EP15804824.9A patent/EP3230281B1/en active Active
- 2015-12-07 KR KR1020237021217A patent/KR20230098368A/en not_active Withdrawn
- 2015-12-07 EA EA201891120A patent/EA034273B1/en not_active IP Right Cessation
- 2015-12-07 EP EP19181710.5A patent/EP3587417B9/en active Active
- 2015-12-07 ES ES15804824T patent/ES2882952T3/en active Active
- 2015-12-08 TW TW110100512A patent/TWI780562B/en not_active IP Right Cessation
- 2015-12-08 TW TW104141168A patent/TWI716371B/en not_active IP Right Cessation
- 2015-12-09 AR ARP150104007A patent/AR102948A1/en unknown
-
2017
- 2017-06-05 IL IL25266517A patent/IL252665B/en active IP Right Grant
- 2017-06-08 PH PH12017501079A patent/PH12017501079A1/en unknown
- 2017-06-09 CO CONC2017/0005742A patent/CO2017005742A2/en unknown
- 2017-06-09 SV SV2017005461A patent/SV2017005461A/en unknown
- 2017-06-09 DO DO2017000137A patent/DOP2017000137A/en unknown
- 2017-06-09 CL CL2017001488A patent/CL2017001488A1/en unknown
- 2017-06-09 NI NI201700073A patent/NI201700073A/en unknown
- 2017-06-09 EC ECIEPI201736253A patent/ECSP17036253A/en unknown
- 2017-11-21 US US15/820,429 patent/US10202369B2/en active Active
-
2018
- 2018-08-08 DO DO2018000182A patent/DOP2018000182A/en unknown
- 2018-11-13 JP JP2018212898A patent/JP6647371B2/en not_active Expired - Fee Related
- 2018-11-15 US US16/192,314 patent/US10472354B2/en active Active
-
2019
- 2019-09-19 IL IL269468A patent/IL269468B/en active IP Right Grant
- 2019-09-19 IL IL269467A patent/IL269467B/en active IP Right Grant
- 2019-09-25 IL IL269661A patent/IL269661B/en active IP Right Grant
- 2019-10-01 US US16/589,838 patent/US11142523B2/en not_active Expired - Fee Related
-
2020
- 2020-06-07 IL IL275183A patent/IL275183B/en active IP Right Grant
- 2020-08-13 AR ARP200102296A patent/AR119761A2/en not_active Application Discontinuation
-
2021
- 2021-06-14 IL IL283979A patent/IL283979B/en unknown
- 2021-08-20 CY CY20211100750T patent/CY1124486T1/en unknown
- 2021-09-09 US US17/470,459 patent/US20230053411A1/en not_active Abandoned
-
2022
- 2022-03-15 CY CY20221100217T patent/CY1125083T1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA41135B1 (en) | Substituted benzamides 1,3-thiazol-2-yl | |
| MA40523A (en) | 2- (MORPHOLIN-4-YL) -1,7-NAPHTHYRIDINES | |
| MA35422B1 (en) | Amine-substituted imidazopyridazines | |
| MA45020A (en) | AROMATIC SULPHONAMIDE DERIVATIVES | |
| MA45782B1 (en) | Modulators of the cxcr7 piperidine receptor | |
| MA35193B1 (en) | Halogeno-1,3-alkyl oxazines as inhibitors of bace1 and / or bace2 | |
| MA47217A (en) | N - ((HET) ARYLMETHYL) HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMATIC KALLICREIN INHIBITORS | |
| MA35246B1 (en) | 1,3-oxazines as inhibitors of bace1 and / or bace2 | |
| MA40955B1 (en) | 2-amino-6- (difluoromethyl) -5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors | |
| MA39225A1 (en) | 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines used as bace1 inhibitors in the treatment of alzheimer's disease | |
| MA39219A1 (en) | New lrrk2 Kinase Inhibitor Compounds Used to Treat Parkinson's, Alzheimer's and Amyotrophic Lateral Sclerosis | |
| MA38661A1 (en) | Heteroaromatic compounds and their use as d1 dopamine ligands | |
| MA38556A1 (en) | Inhibitors of bace1 | |
| MA47082B1 (en) | Aromatic carboxylic acid amides as bradykinin b1 receptor antagonists | |
| MA40875A (en) | 2,4-DIAMINO-QUINOLEIN SUBSTITUTED AS NEW ANTI-CANCER AGENTS | |
| MA38810A1 (en) | Inhibitors of rorc2 related methods of use | |
| EA201590066A1 (en) | DIFTORGEXAHYDROCYCLOPENTAXOXASYNYLES AND DIFTORGEXAHYDROBENZOXASYNYLES AS BETA SECRETASE INHIBITORS | |
| MA39337A1 (en) | Modulators of pyrazines of gpr6 | |
| MA38679A1 (en) | Cxcr7 receiver modulators | |
| MA43913A (en) | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC M1 RECEPTOR | |
| EA201992804A1 (en) | AMINOGLYCOSIDE DERIVATIVES AND THEIR APPLICATION IN TREATMENT OF GENETIC DISEASES | |
| MA43553B1 (en) | 2-(MORPHOLIN-4-YL)-1,7-NAPHTHYRIDINES | |
| MA38774A1 (en) | Substituted pyrazolo-pyridinamines inhibitors of mknk1 kinase for use in hyperproliferative and / or angiogenesis disorders. | |
| MA38642A1 (en) | Pharmaceutical compositions of substituted triazolopyridine compounds for use as anticancer agents | |
| MA38364A1 (en) | Substituted imidazopyridazine compounds |