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MA40437A - Méthodes de traitement du cancer faisant appel à des inhibiteurs de tigit et à des agents anticancéreux - Google Patents

Méthodes de traitement du cancer faisant appel à des inhibiteurs de tigit et à des agents anticancéreux

Info

Publication number
MA40437A
MA40437A MA040437A MA40437A MA40437A MA 40437 A MA40437 A MA 40437A MA 040437 A MA040437 A MA 040437A MA 40437 A MA40437 A MA 40437A MA 40437 A MA40437 A MA 40437A
Authority
MA
Morocco
Prior art keywords
cancer
methods
tigit inhibitors
treating cancer
agents
Prior art date
Application number
MA040437A
Other languages
English (en)
Inventor
Jane L Grogan
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55079055&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40437(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Publication of MA40437A publication Critical patent/MA40437A/fr

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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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Abstract

La présente invention concerne des méthodes consistant à administrer à l'individu une quantité efficace d'un agent qui diminue ou inhibe l'expression et/ou l'activité d'un tigit et d'un agent anticancéreux et/ou d'une thérapie anticancéreuse. L'invention concerne en outre des trousses comprenant un agent anticancéreux, un agent qui diminue ou inhibe l'expression et/ou l'activité d'un tigit, ou les deux, ainsi qu'un de leurs modes d'emploi.
MA040437A 2014-07-16 2015-07-16 Méthodes de traitement du cancer faisant appel à des inhibiteurs de tigit et à des agents anticancéreux MA40437A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462025394P 2014-07-16 2014-07-16

Publications (1)

Publication Number Publication Date
MA40437A true MA40437A (fr) 2017-05-24

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ID=55079055

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040437A MA40437A (fr) 2014-07-16 2015-07-16 Méthodes de traitement du cancer faisant appel à des inhibiteurs de tigit et à des agents anticancéreux

Country Status (19)

Country Link
US (9) US20170143825A1 (fr)
EP (1) EP3169363A4 (fr)
JP (4) JP2017522311A (fr)
KR (1) KR20170023081A (fr)
CN (1) CN107073108A (fr)
AU (1) AU2015289621A1 (fr)
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Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1539228B1 (fr) 2002-09-11 2010-12-29 Genentech, Inc. Nouvelles composition et methodes servant au traitement de maladies associees au systeme immunitaire
HUE036780T2 (hu) 2008-04-09 2018-07-30 Genentech Inc Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére
SI3485903T1 (sl) 2011-09-23 2023-02-28 Mereo Biopharma 5, Inc. Sredstva, ki vežejo VEGF/DLL4, in njihove uporabe
KR20220042248A (ko) 2013-07-16 2022-04-04 제넨테크, 인크. Pd-1 축 결합 길항제 및 tigit 억제제를 사용한 암을 치료하는 방법
JP6920194B2 (ja) 2014-08-19 2021-08-18 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 抗tigit抗体
EA039219B1 (ru) 2014-12-23 2021-12-20 Бристол-Майерс Сквибб Компани Антитела к tigit
PL3653221T3 (pl) 2015-02-19 2022-12-19 Compugen Ltd. Przeciwciała anty-pvrig i sposoby ich zastosowania
PT3283508T (pt) 2015-04-17 2021-06-21 Alpine Immune Sciences Inc Proteínas imuno modulatórias com afinidades afináveis
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit結合劑和彼之用途
WO2017011592A1 (fr) 2015-07-13 2017-01-19 Modular Genetics, Inc. Génération d'alcools acylés
WO2017030823A2 (fr) 2015-08-14 2017-02-23 Merck Sharp & Dohme Corp. Anticorps anti-tigit
WO2017053705A1 (fr) 2015-09-23 2017-03-30 Oncomed Pharmaceuticals, Inc. Méthodes et compositions pour le traitement du cancer
NZ739750A (en) 2015-09-25 2019-11-29 Genentech Inc Anti-tigit antibodies and methods of use
US10537633B2 (en) 2016-03-04 2020-01-21 Jn Biosciences Llc Antibodies to TIGIT
JP7527758B2 (ja) 2016-04-15 2024-08-05 アルパイン イミューン サイエンシズ インコーポレイテッド Cd80バリアント免疫調節タンパク質およびその使用
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
RU2765410C2 (ru) * 2016-11-30 2022-01-28 Онкомед Фармасьютикалс, Инк. Способы лечения рака, включающие связывающие tigit агенты
US10759855B2 (en) 2016-12-02 2020-09-01 Rigel Pharmaceuticals, Inc. Antigen binding molecules to TIGIT
AU2018243664B2 (en) * 2017-03-31 2024-02-01 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating T cell exhaustion by inhibiting or modulating T cell receptor signaling
TW202402800A (zh) 2017-05-01 2024-01-16 美商艾吉納斯公司 抗tigit抗體類和使用彼等之方法
US11225523B2 (en) 2017-06-01 2022-01-18 Compugen Ltd. Triple combination antibody therapies
WO2018229163A1 (fr) 2017-06-14 2018-12-20 King's College London Méthodes d'activation des lymphocytes t v delta 2 négatifs gamma delta
IL272227B2 (en) 2017-07-27 2025-09-01 iTeos Belgium SA Anti-tigit antibodies
MA50360A (fr) 2017-10-10 2020-08-19 Alpine Immune Sciences Inc Protéines immunomodulatrices de variants de ctla-4 et leurs utilisations
TWI816729B (zh) * 2017-12-30 2023-10-01 英屬開曼群島商百濟神州有限公司 抗tigit抗體及其作為治療和診斷的用途
EP3735417A1 (fr) 2018-01-03 2020-11-11 Alpine Immune Sciences, Inc. Protéines immunomodulatrices multi-domaine et leurs méthodes d'utilisation
EP3740508A4 (fr) 2018-01-15 2022-03-23 Nanjing Legend Biotech Co., Ltd. Anticorps et variants associés dirigés contre tigit
AU2019218516B2 (en) 2018-02-06 2021-10-21 I-Mab Biopharma (Hangzhou) Co., Ltd. Antibodies to T cell immunoreceptor with Ig and ITIM domains (TIGIT) and uses thereof
US20190247560A1 (en) 2018-02-13 2019-08-15 Gambro Lundia Ab Extracorporeal devices and methods of treating complement factor related diseases
CN112218891B (zh) 2018-03-13 2024-07-16 塔斯克疗法有限公司 抗-cd25抗体剂
CN111918873B (zh) 2018-03-27 2025-06-24 百时美施贵宝公司 使用紫外线信号实时监测滴度
JP2021521784A (ja) 2018-04-18 2021-08-30 ゼンコア インコーポレイテッド IL−15/IL−15RaFc融合タンパク質とPD−1抗原結合ドメインを含むPD−1標的化ヘテロダイマー融合タンパク質およびそれらの使用
IL278090B2 (en) 2018-04-18 2024-07-01 Xencor Inc Il-15/il-15rα heterodimeric fc fusion proteins and uses thereof
AU2019306628B2 (en) 2018-07-20 2024-11-14 Surface Oncology, LLC Anti-CD112R compositions and methods
CN112638944A (zh) 2018-08-23 2021-04-09 西进公司 抗tigit抗体
WO2020072821A2 (fr) 2018-10-03 2020-04-09 Xencor, Inc. Protéines de fusion fc hétérodimères d'il -12
CA3116188A1 (fr) 2018-10-12 2020-04-16 Xencor, Inc. Proteines de fusion fc d'il-15/il-15ralpha ciblant pd-1 et utilisations dans des polytherapies faisant intervenir celles-ci
US11618776B2 (en) 2018-12-20 2023-04-04 Xencor, Inc. Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15RA and NKG2D antigen binding domains
US20220135619A1 (en) 2019-02-24 2022-05-05 Bristol-Myers Squibb Company Methods of isolating a protein
BR112021016923A2 (pt) * 2019-02-27 2021-11-03 Genentech Inc Métodos para tratar um paciente com câncer hematológico, métodos para tratar um paciente com mm recidivante ou refratário, métodos para tratar um paciente tendo um lnh recidivante ou refratário e kits
US20220249555A1 (en) * 2019-03-21 2022-08-11 Gamida Cell Ltd. Expanded nk cell fractions for transplantation in combination therapy
JP7645198B2 (ja) 2019-05-23 2025-03-13 ブリストル-マイヤーズ スクイブ カンパニー 細胞培養培地をモニターする方法
TWI760751B (zh) 2019-05-29 2022-04-11 美商美國禮來大藥廠 Tigit及pd-1/tigit-結合分子
CN112300279A (zh) * 2019-07-26 2021-02-02 上海复宏汉霖生物技术股份有限公司 针对抗cd73抗体和变体的方法和组合物
US11851466B2 (en) 2019-10-03 2023-12-26 Xencor, Inc. Targeted IL-12 heterodimeric Fc-fusion proteins
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
KR20220092584A (ko) 2019-11-05 2022-07-01 메르크 파텐트 게엠베하 항tigit 항체 및 이의 용도
WO2021113831A1 (fr) 2019-12-05 2021-06-10 Compugen Ltd. Anticorps anti-pvrig et anti-tigit pour élimination de tumeurs à base de cellules nk améliorées
CN112409450B (zh) * 2020-03-29 2023-01-24 郑州大学 TIGIT-IgV的亲和剂及其应用
CN114507284B (zh) * 2020-05-09 2023-05-26 华博生物医药技术(上海)有限公司 抗tigit的抗体、其制备方法和应用
MX2022015157A (es) 2020-06-02 2023-01-16 Arcus Biosciences Inc Anticuerpos para tigit.
MX2022015881A (es) 2020-06-18 2023-01-24 Genentech Inc Tratamiento con anticuerpos anti-tigit y antagonistas de union al eje de pd-1.
TW202216778A (zh) 2020-07-15 2022-05-01 美商安進公司 Tigit及cd112r阻斷
EP4225770A1 (fr) 2020-10-05 2023-08-16 Bristol-Myers Squibb Company Procédés pour concentrer des protéines
WO2022111612A1 (fr) * 2020-11-26 2022-06-02 信达生物制药(苏州)有限公司 Préparation comprenant un anticorps bispécifique anti-tigit/pd-1, son procédé de préparation et son utilisation
TW202304965A (zh) 2021-05-04 2023-02-01 美商艾吉納斯公司 抗tigit抗體、抗cd96抗體及其使用方法
TW202320848A (zh) 2021-07-28 2023-06-01 美商建南德克公司 治療癌症之方法及組成物
TW202321308A (zh) 2021-09-30 2023-06-01 美商建南德克公司 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法
CN114149489B (zh) * 2021-11-18 2023-12-15 厦门大学 一种靶向tigit的放射性标记化合物及其制备方法和应用
WO2023173011A1 (fr) 2022-03-09 2023-09-14 Bristol-Myers Squibb Company Expression transitoire de protéines thérapeutiques
WO2023198060A1 (fr) * 2022-04-12 2023-10-19 正大天晴药业集团股份有限公司 Association pharmaceutique d'inhibiteur de protéasome et d'anticorps anti-pd-1
CA3257760A1 (fr) 2022-06-07 2023-12-14 Genentech, Inc. Méthodes pronostiques et thérapeutiques pour le cancer
EP4658687A1 (fr) 2023-01-31 2025-12-10 University of Rochester Thérapie de blocage de point de contrôle immunitaire pour le traitement d'infections par staphylococcus aureus
EP4677119A1 (fr) 2023-03-06 2026-01-14 Genentech, Inc. Méthodes pronostiques et thérapeutiques contre le cancer du poumon non à petites cellules
WO2025174933A1 (fr) 2024-02-14 2025-08-21 Genentech, Inc. Méthodes de traitement du cancer du pancréas avec anticorps anti-pd-l1, anticorps anti-tigit, gemcitabine et nab-placlitaxel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008254951A1 (en) * 2007-05-14 2008-11-27 Biogen Idec Ma Inc. Single-chain Fc (ScFc) regions, binding polypeptides comprising same, and methods related thereto
HUE036780T2 (hu) * 2008-04-09 2018-07-30 Genentech Inc Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére
US20150322119A1 (en) * 2012-12-03 2015-11-12 Bristol-Myers Squibb Company Enhancing anti-cancer activity of immunomodulatory fc fusion proteins
CN104902913A (zh) * 2012-12-04 2015-09-09 昂科梅德制药有限公司 使用结合剂的免疫治疗

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US20240307534A1 (en) 2024-09-19
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US20250108111A1 (en) 2025-04-03
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