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MA35036B1 - Composés bis(fluoroalkyl)-1,4-benzodiazépinone - Google Patents

Composés bis(fluoroalkyl)-1,4-benzodiazépinone

Info

Publication number
MA35036B1
MA35036B1 MA36323A MA36323A MA35036B1 MA 35036 B1 MA35036 B1 MA 35036B1 MA 36323 A MA36323 A MA 36323A MA 36323 A MA36323 A MA 36323A MA 35036 B1 MA35036 B1 MA 35036B1
Authority
MA
Morocco
Prior art keywords
compounds
benzodiazepinone
fluoroalkyl
ch2ch2cf3
ch2cf3
Prior art date
Application number
MA36323A
Other languages
English (en)
Inventor
Claude Quesnelle
Soong-Hoon Kim
Francis Lee
Ashvinikumar Gavai
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45894701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35036(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA35036B1 publication Critical patent/MA35036B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSÉS DE FORMULE (I) OU LEURS PROMÉDICAMENTS ; DANS LAQUELLE R1 REPRÉSENTE CH2CF3 OU CH2CH2CF3 ; R2 REPRÉSENTE CH2CF3, CH2CH2CF3, OU CH2CH2CH2CF3 ; R3 REPRÉSENTE H OU CH3; CHAQUE RA REPRÉSENTE INDÉPENDAMMENT F, CL, -CN, -OCH3 ET/OU NHCH2CH2OCH3 ; ET Z VAUT ZÉRO, 1 OU 2. ELLE CONCERNE ÉGALEMENT DES PROCÉDÉS D'UTILISATION DE CES COMPOSÉS POUR INHIBER LE RÉCEPTEUR NOTCH, ET DES COMPOSITIONS PHARMACEUTIQUES COMPRENANT CES COMPOSÉS. CES COMPOSÉS SONT UTILES DANS LE TRAITEMENT, LA PRÉVENTION OU LE RALENTISSEMENT DE L'ÉVOLUTION DE MALADIES OU DE TROUBLES DANS DIVERS DOMAINES THÉRAPEUTIQUES, COMME LE TRAITEMENT DU CANCER.
MA36323A 2011-03-22 2012-03-22 Composés bis(fluoroalkyl)-1,4-benzodiazépinone MA35036B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161466238P 2011-03-22 2011-03-22
PCT/US2012/030021 WO2012129353A1 (fr) 2011-03-22 2012-03-22 Composés bis(fluoroalkyl)-1,4-benzodiazépinone

Publications (1)

Publication Number Publication Date
MA35036B1 true MA35036B1 (fr) 2014-04-03

Family

ID=45894701

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36323A MA35036B1 (fr) 2011-03-22 2012-03-22 Composés bis(fluoroalkyl)-1,4-benzodiazépinone

Country Status (32)

Country Link
US (2) US8629136B2 (fr)
EP (1) EP2688873B1 (fr)
JP (1) JP5873923B2 (fr)
KR (1) KR101948347B1 (fr)
CN (1) CN103717576B (fr)
AR (2) AR085471A1 (fr)
AU (1) AU2012230904B2 (fr)
BR (1) BR112013024059B1 (fr)
CA (1) CA2830902C (fr)
CL (1) CL2013002690A1 (fr)
CO (1) CO6771446A2 (fr)
CY (1) CY1116423T1 (fr)
DK (1) DK2688873T3 (fr)
EA (1) EA022530B1 (fr)
ES (1) ES2534080T3 (fr)
HR (1) HRP20150273T1 (fr)
IL (1) IL228534A (fr)
MA (1) MA35036B1 (fr)
MX (1) MX2013010420A (fr)
MY (1) MY161233A (fr)
PE (1) PE20140626A1 (fr)
PH (1) PH12013501738B1 (fr)
PL (1) PL2688873T3 (fr)
PT (1) PT2688873E (fr)
RS (1) RS53843B1 (fr)
SG (1) SG193555A1 (fr)
SI (1) SI2688873T1 (fr)
SM (1) SMT201500091B (fr)
TN (1) TN2013000372A1 (fr)
TW (1) TWI530489B (fr)
UY (1) UY33961A (fr)
WO (1) WO2012129353A1 (fr)

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AR129859A2 (es) 2024-10-02
BR112013024059B1 (pt) 2022-01-25
PE20140626A1 (es) 2014-05-30
DK2688873T3 (en) 2015-04-27
MY161233A (en) 2017-04-14
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WO2012129353A1 (fr) 2012-09-27
KR20140027956A (ko) 2014-03-07
US8822454B2 (en) 2014-09-02
JP2014511840A (ja) 2014-05-19
US20120245151A1 (en) 2012-09-27
AU2012230904B2 (en) 2016-03-31
BR112013024059A2 (pt) 2016-12-06
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EP2688873A1 (fr) 2014-01-29
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SI2688873T1 (sl) 2015-04-30
AU2012230904A1 (en) 2013-11-07
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