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MA35716B1 - Formulations pharmaceutiques - Google Patents

Formulations pharmaceutiques

Info

Publication number
MA35716B1
MA35716B1 MA37033A MA37033A MA35716B1 MA 35716 B1 MA35716 B1 MA 35716B1 MA 37033 A MA37033 A MA 37033A MA 37033 A MA37033 A MA 37033A MA 35716 B1 MA35716 B1 MA 35716B1
Authority
MA
Morocco
Prior art keywords
pharmaceutical formulations
formulations
methylsulfonamido
propan
pyrimidin
Prior art date
Application number
MA37033A
Other languages
English (en)
Inventor
Rajinder Singh
Ping Li
Daya Verma
Yogita Krishnamachari
Xiaohong Shen
Hanchen Lee
Laychoo Tan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47501412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35716(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA35716B1 publication Critical patent/MA35716B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des formulations pharmaceutiques orales solides de (s)-méthyl(1-((4-(3-(5-chloro-2-fluoro-3-(méthylsulfonamido)phényl)-1-isopropyl-1h-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (composé a) et l'utilisation de ces formulations pour le traitement de maladies prolifératives, comme les maladies à tumeur solide.
MA37033A 2011-11-23 2014-05-15 Formulations pharmaceutiques MA35716B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161563229P 2011-11-23 2011-11-23
PCT/US2012/066185 WO2013078264A1 (fr) 2011-11-23 2012-11-21 Formulations pharmaceutiques

Publications (1)

Publication Number Publication Date
MA35716B1 true MA35716B1 (fr) 2014-12-01

Family

ID=47501412

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37033A MA35716B1 (fr) 2011-11-23 2014-05-15 Formulations pharmaceutiques

Country Status (38)

Country Link
US (4) US9387208B2 (fr)
EP (2) EP3449911B8 (fr)
JP (2) JP6216325B2 (fr)
KR (1) KR102091295B1 (fr)
CN (2) CN105708819B (fr)
AR (1) AR088936A1 (fr)
AU (1) AU2012340759C1 (fr)
BR (1) BR112014011981B8 (fr)
CA (1) CA2856406C (fr)
CL (1) CL2014001337A1 (fr)
CO (1) CO6940426A2 (fr)
CY (1) CY1121421T1 (fr)
DK (1) DK2782557T3 (fr)
EA (1) EA025389B1 (fr)
EC (1) ECSP23034537A (fr)
ES (2) ES2695099T3 (fr)
GT (1) GT201400100A (fr)
HR (1) HRP20181896T1 (fr)
HU (1) HUE040370T2 (fr)
IL (1) IL232305B (fr)
JO (1) JO3493B1 (fr)
LT (1) LT2782557T (fr)
MA (1) MA35716B1 (fr)
MX (1) MX353446B (fr)
MY (1) MY172729A (fr)
PE (1) PE20141994A1 (fr)
PH (1) PH12014501157B1 (fr)
PL (1) PL2782557T3 (fr)
PT (1) PT2782557T (fr)
RS (1) RS58048B1 (fr)
SG (1) SG11201401260QA (fr)
SI (1) SI2782557T1 (fr)
SM (1) SMT201800595T1 (fr)
TN (1) TN2014000145A1 (fr)
TW (1) TWI649098B (fr)
UA (1) UA115039C2 (fr)
WO (1) WO2013078264A1 (fr)
ZA (1) ZA201402418B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR077975A1 (es) 2009-08-28 2011-10-05 Irm Llc Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
AU2012335663B2 (en) 2011-11-11 2015-12-24 Array Biopharma Inc. Method of treating a proliferative disease
AR088936A1 (es) 2011-11-23 2014-07-16 Novartis Ag Formulaciones farmaceuticas
CR20170540A (es) 2015-06-04 2018-02-02 Pfizer Formas de dosificación solidas de palbociclib
RU2615986C1 (ru) * 2016-02-25 2017-04-12 Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") Замещенные метил (2-{ 4-[3-(3-метансульфониламино-2-фтор-5-хлор-фенил)-1Н-пиразол-4-ил]пиримидин-2-иламино} -этил)карбаматы, способ их получения и применения
US10449195B2 (en) 2016-03-29 2019-10-22 Shenzhen Pharmacin Co., Ltd. Pharmaceutical formulation of palbociclib and a preparation method thereof
BR112018074941A2 (pt) 2016-06-03 2019-03-12 Caponigro Giordano combinações farmacêuticas
CN106000220A (zh) * 2016-06-30 2016-10-12 东华大学 一种含化学试剂的有机溶剂崩解片的制备方法与应用
CN114306245A (zh) 2020-09-29 2022-04-12 深圳市药欣生物科技有限公司 无定形固体分散体的药物组合物及其制备方法
AU2021358394A1 (en) 2020-10-05 2023-04-13 Pierre Fabre Medicament Combination of encorafenib and binimetinib as adjuvant treatment for resected stage II melanoma
CN114557977A (zh) * 2022-02-16 2022-05-31 北京康立生医药技术开发有限公司 一种治疗肠癌的药物的制备方法、制剂及纯度分析方法
TR2022009483A2 (tr) * 2022-06-08 2023-12-21 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Palbosiklib içeren bir farmasötik bileşim.
WO2025003956A1 (fr) 2023-06-30 2025-01-02 Pfizer Inc. Formulations d'encorafénib à forte charge médicamenteuse
WO2025262137A1 (fr) * 2024-06-21 2025-12-26 Nanoform Finland Oyj Formulations comprenant de l'encorafénib nanométrique cristallin

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5475888A (en) 1977-11-29 1979-06-18 Jiyasuko Kk Surgical laser
US6391636B1 (en) 1994-05-31 2002-05-21 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
US6358932B1 (en) 1994-05-31 2002-03-19 Isis Pharmaceticals, Inc. Antisense oligonucleotide inhibition of raf gene expression
US6037136A (en) 1994-10-24 2000-03-14 Cold Spring Harbor Laboratory Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
WO1997008950A1 (fr) 1995-09-07 1997-03-13 Fuisz Technologies, Ltd. Systeme permettant de rendre biodisponibles des agents bioalterants sensiblement non solubles
US5717100A (en) 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
AR012634A1 (es) 1997-05-02 2000-11-08 Sugen Inc Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
WO1998052940A1 (fr) 1997-05-22 1998-11-26 G.D. Searle And Co. PYRAZOLES SUBSTITUES UTILISES COMME INHIBITEURS DE p38 KINASE
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US6204467B1 (en) 1998-03-24 2001-03-20 Ford Global Technologies, Inc. Method and apparatus for resistive welding
ME00275B (fr) 1999-01-13 2011-02-10 Bayer Corp DIPHENYLUREES A SUBSTITUANTS ω-CARBOXYARYLES, INHIBITRICES DE KINASE RAF
US6316435B2 (en) 1999-02-24 2001-11-13 Supergen, Inc. Combination therapy for lymphoproliferative diseases
AU782469B2 (en) * 1999-12-23 2005-08-04 Mayne Pharma International Pty Ltd Improved pharmaceutical compositions for poorly soluble drugs
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
ATE374753T1 (de) 2001-12-21 2007-10-15 Vernalis Cambridge Ltd 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
WO2004050068A1 (fr) * 2002-11-29 2004-06-17 Janssen Pharmaceutica N.V. Compositions pharmaceutiques comprenant un compose medicamenteux respectivement basique, tensioactif et base respectivement acide hydrosoluble et tolerable physiologiquement
EP1706400A1 (fr) 2004-01-09 2006-10-04 Novartis AG Derives de phenyl- 4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl¨-amine utilises comme inhibiteurs du recepteur igf-1r
EP1758892B1 (fr) 2004-06-10 2012-10-17 Irm Llc Composes et compositions utilises comme inhibiteurs de proteines kinases
EP1934185A1 (fr) 2005-08-12 2008-06-25 Synta Pharmaceuticals Corporation Composes pyrazoles modulant l'activite de la proteine hsp90
AU2006284053B2 (en) * 2005-08-22 2010-04-22 Novartis Ag Pharmaceutical compositions comprising a pH-dependent drug, a pH modifier and a retarding agent
EP1917258A2 (fr) 2005-08-26 2008-05-07 SmithKline Beecham Corporation Inhibiteurs de pyrimidinyl-pyrazole d'aurora kinases
PE20070427A1 (es) 2005-08-30 2007-04-21 Novartis Ag Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas
EP2024353A2 (fr) 2006-03-16 2009-02-18 Pfizer Products Inc. Pyrazoles
WO2007123892A2 (fr) 2006-04-17 2007-11-01 Arqule Inc. Inhibiteurs raf et leurs utilisations
KR101101675B1 (ko) 2006-10-02 2011-12-30 노파르티스 아게 단백질 키나제 억제제로서의 화합물 및 조성물
CN101522026A (zh) 2006-10-06 2009-09-02 Irm责任有限公司 蛋白激酶抑制剂及其应用方法
US20090022789A1 (en) * 2007-07-18 2009-01-22 Supernus Pharmaceuticals, Inc. Enhanced formulations of lamotrigine
CN101815712A (zh) 2007-08-01 2010-08-25 辉瑞有限公司 吡唑化合物及其作为raf抑制剂的用途
JP2011500649A (ja) * 2007-10-19 2011-01-06 アボット ゲーエムベーハー ウント カンパニー カーゲー Ｎ−アリール尿素系薬剤の固体分散体生成物
US8785486B2 (en) 2007-11-14 2014-07-22 Janssen Pharmaceuticals, Inc. Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
CN102015686B (zh) 2008-03-21 2014-07-02 诺华股份有限公司 杂环化合物及其用途
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
BRPI0916356B1 (pt) 2008-07-24 2022-08-23 Nerviano Medical Sciences S.R.L 3,4-diaril pirazois como inibidores da proteína quinase
BRPI0916713A2 (pt) 2008-07-28 2015-11-10 Gilead Science Inc compostos inibidores de histona desacetilase de cicloalquilideno e heterocicloalquilideno
MX2011003292A (es) 2008-09-29 2011-04-21 Boehringer Ingelheim Int Compuestos antiproliferativos.
DK2346495T4 (da) * 2008-10-07 2023-08-28 Kudos Pharm Ltd Farmaceutisk formulering 514
US20110293750A1 (en) 2008-11-11 2011-12-01 Yale University Activated wnt-beta-catenin signaling in melanoma
WO2010070060A1 (fr) 2008-12-19 2010-06-24 Nerviano Medical Sciences S.R.L. Pyrazoles bicycliques en tant qu'inhibiteurs de protéines kinases
AR075180A1 (es) * 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
WO2010100127A1 (fr) 2009-03-04 2010-09-10 Novartis Ag Dérivés d'imidazole disubstitués en tant que modulateurs de la protéine kinase raf
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
EP2443117B1 (fr) 2009-06-15 2016-03-23 Nerviano Medical Sciences S.r.l. Dérivés de pyrimidinylpyrrolopyridinone substitués, procédé pour leur préparation et leur utilisation en tant qu'inhibiteurs de kinase
KR101256018B1 (ko) 2009-08-20 2013-04-18 한국과학기술연구원 단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
AR077975A1 (es) 2009-08-28 2011-10-05 Irm Llc Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
US8242260B2 (en) 2009-08-28 2012-08-14 Novartis Ag Compounds and compositions as protein kinase inhibitors
CN102947290B (zh) 2010-01-27 2015-05-27 内尔维安诺医学科学有限公司 作为蛋白激酶抑制剂的3,4-二芳基吡唑的亚磺酰氨基衍生物
SG10201502484SA (en) 2010-03-30 2015-05-28 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
CN103153980B (zh) 2010-08-03 2015-12-16 内尔维安诺医学科学有限公司 吡唑并苯基苯磺酰胺化合物的衍生物及其作为抗肿瘤药的用途
PT2688572T (pt) 2011-03-21 2017-06-02 Valcuria Ab Composição farmacêutica com um inibidor de hdac e um esteroide e sua utilização
MX344580B (es) 2011-06-14 2016-12-20 Novartis Ag Combinacion de panobinostat y ruxolitinib en el tratamiento del cancer tal como una neoplasia mieloproliferativa.
AR088936A1 (es) 2011-11-23 2014-07-16 Novartis Ag Formulaciones farmaceuticas
CN104994850A (zh) 2012-11-08 2015-10-21 诺华股份有限公司 包含b-raf抑制剂和组蛋白脱乙酰基酶抑制剂的药物组合以及其在治疗增生性疾病中的用途

Also Published As

Publication number Publication date
DK2782557T3 (en) 2018-12-10
TW201328722A (zh) 2013-07-16
EA025389B1 (ru) 2016-12-30
BR112014011981B8 (pt) 2022-07-19
CA2856406A1 (fr) 2013-05-30
KR102091295B1 (ko) 2020-03-19
IL232305A0 (en) 2014-06-30
US20140309250A1 (en) 2014-10-16
IL232305B (en) 2019-06-30
US9763941B2 (en) 2017-09-19
NZ623628A (en) 2016-05-27
US9387208B2 (en) 2016-07-12
EP2782557B1 (fr) 2018-09-12
JO3493B1 (ar) 2020-07-05
CL2014001337A1 (es) 2014-10-24
LT2782557T (lt) 2018-12-27
SI2782557T1 (sl) 2019-02-28
ES2695099T3 (es) 2019-01-02
WO2013078264A1 (fr) 2013-05-30
GT201400100A (es) 2017-09-28
JP2015501808A (ja) 2015-01-19
BR112014011981A2 (pt) 2017-05-30
SG11201401260QA (en) 2014-07-30
RS58048B1 (sr) 2019-02-28
BR112014011981A8 (pt) 2018-07-31
PL2782557T3 (pl) 2019-03-29
US10561654B2 (en) 2020-02-18
TN2014000145A1 (en) 2015-09-30
CN103945831A (zh) 2014-07-23
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US10258622B2 (en) 2019-04-16
ZA201402418B (en) 2015-03-25
HRP20181896T1 (hr) 2019-02-22
PH12014501157A1 (en) 2014-08-11
US20190054086A1 (en) 2019-02-21
ECSP23034537A (es) 2023-08-31
EP2782557A1 (fr) 2014-10-01
MX2014006278A (es) 2014-07-09
US20170202837A1 (en) 2017-07-20
EP3449911B1 (fr) 2025-06-18
EA201491007A1 (ru) 2014-08-29
AU2012340759C1 (en) 2019-11-28
JP6216325B2 (ja) 2017-10-18
PT2782557T (pt) 2018-11-26
HUE040370T2 (hu) 2019-03-28
CA2856406C (fr) 2020-06-23
KR20140095500A (ko) 2014-08-01
PE20141994A1 (es) 2014-12-24
EP3449911B8 (fr) 2025-07-23
CO6940426A2 (es) 2014-05-09
AU2012340759A1 (en) 2014-05-29
JP2018035171A (ja) 2018-03-08
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UA115039C2 (uk) 2017-09-11
TWI649098B (zh) 2019-02-01
AR088936A1 (es) 2014-07-16
CN105708819A (zh) 2016-06-29
US20160279129A1 (en) 2016-09-29
SMT201800595T1 (it) 2019-01-11
PH12014501157B1 (en) 2014-08-11
MY172729A (en) 2019-12-11
HK1197024A1 (en) 2015-01-02
CY1121421T1 (el) 2020-05-29
BR112014011981B1 (pt) 2020-11-17
EP3449911A1 (fr) 2019-03-06
AU2012340759B2 (en) 2016-04-28

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