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MA33198B1 - Anticorps anti-her di-spécifiques - Google Patents

Anticorps anti-her di-spécifiques

Info

Publication number
MA33198B1
MA33198B1 MA34255A MA34255A MA33198B1 MA 33198 B1 MA33198 B1 MA 33198B1 MA 34255 A MA34255 A MA 34255A MA 34255 A MA34255 A MA 34255A MA 33198 B1 MA33198 B1 MA 33198B1
Authority
MA
Morocco
Prior art keywords
antibodies
specific antibodies
relates
egfr
specific anti
Prior art date
Application number
MA34255A
Other languages
Arabic (ar)
English (en)
Inventor
Germaine Fuh
Gabriele Schaefer
Lauric Haber
Mark X Sliwkowski
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MA33198B1 publication Critical patent/MA33198B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)

Abstract

La présente invention concerne des anticorps anti-HER, comprenant des anticorps anti-HER multi-spécifiques, des compositions les comprenant et des procédés d'utilisation de ces anticorps. L'invention concerne également des anticorps anti-EGFR/HER3 multi-spécifiques moins toxiques que les antagonistes traditionnels de l'EGFR.
MA34255A 2009-03-20 2010-03-19 Anticorps anti-her di-spécifiques MA33198B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21056209P 2009-03-20 2009-03-20
PCT/US2010/028023 WO2010108127A1 (fr) 2009-03-20 2010-03-19 Anticorps anti-her di-spécifiques

Publications (1)

Publication Number Publication Date
MA33198B1 true MA33198B1 (fr) 2012-04-02

Family

ID=42111063

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34255A MA33198B1 (fr) 2009-03-20 2010-03-19 Anticorps anti-her di-spécifiques

Country Status (27)

Country Link
US (4) US8597652B2 (fr)
EP (2) EP3088420A1 (fr)
JP (2) JP5624114B2 (fr)
KR (3) KR20150036824A (fr)
CN (2) CN102356092B (fr)
AR (1) AR075896A1 (fr)
AU (1) AU2010226453B2 (fr)
BR (1) BRPI1006215A2 (fr)
CA (1) CA2755640C (fr)
CL (1) CL2011002304A1 (fr)
CO (1) CO6430487A2 (fr)
CR (1) CR20110496A (fr)
EC (1) ECSP11011338A (fr)
ES (1) ES2572728T3 (fr)
HK (1) HK1205155A1 (fr)
IL (2) IL214827A (fr)
MA (1) MA33198B1 (fr)
MX (1) MX2011009729A (fr)
MY (1) MY152068A (fr)
NZ (1) NZ594665A (fr)
PE (1) PE20120539A1 (fr)
RU (2) RU2504553C2 (fr)
SG (2) SG174378A1 (fr)
TW (3) TWI461211B (fr)
UA (1) UA106070C2 (fr)
WO (1) WO2010108127A1 (fr)
ZA (1) ZA201106127B (fr)

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EP2408817A1 (fr) 2012-01-25
HK1205155A1 (en) 2015-12-11
HK1165809A1 (en) 2012-10-12
RU2013146469A (ru) 2015-04-27
EP3088420A1 (fr) 2016-11-02
BRPI1006215A2 (pt) 2019-09-24
TW201544123A (zh) 2015-12-01
CO6430487A2 (es) 2012-04-30
KR101362522B1 (ko) 2014-02-14
US20100255010A1 (en) 2010-10-07
RU2011142281A (ru) 2013-04-27
KR20110117256A (ko) 2011-10-26
TW201036637A (en) 2010-10-16
US20140193414A1 (en) 2014-07-10
US9327035B2 (en) 2016-05-03
JP2012521196A (ja) 2012-09-13
EP2408817B1 (fr) 2016-03-16
ECSP11011338A (es) 2011-10-31
KR20150036824A (ko) 2015-04-07
MY152068A (en) 2014-08-15
TWI461211B (zh) 2014-11-21
US8597652B2 (en) 2013-12-03
ES2572728T3 (es) 2016-06-02
SG174378A1 (en) 2011-10-28
US20120121596A1 (en) 2012-05-17
TW201438739A (zh) 2014-10-16
CA2755640A1 (fr) 2010-09-23
US20140056899A1 (en) 2014-02-27
RU2504553C2 (ru) 2014-01-20
MX2011009729A (es) 2011-10-14
CN102356092B (zh) 2014-11-05
JP5624114B2 (ja) 2014-11-12
NZ594665A (en) 2013-08-30
IL214827A0 (en) 2011-11-30
CA2755640C (fr) 2018-05-22
CL2011002304A1 (es) 2012-04-09
AU2010226453B2 (en) 2013-11-21
AU2010226453A1 (en) 2011-09-08
CN104447995A (zh) 2015-03-25
CR20110496A (es) 2011-12-06
UA106070C2 (uk) 2014-07-25
KR20130080871A (ko) 2013-07-15
ZA201106127B (en) 2014-03-26
JP2014158481A (ja) 2014-09-04
AR075896A1 (es) 2011-05-04
SG10201402742YA (en) 2014-08-28
PE20120539A1 (es) 2012-05-12
CN102356092A (zh) 2012-02-15
IL233563A0 (en) 2014-08-31

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