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MA33429B1 - Production de poliovirus à titres élevés pour la production de vaccins - Google Patents

Production de poliovirus à titres élevés pour la production de vaccins

Info

Publication number
MA33429B1
MA33429B1 MA34534A MA34534A MA33429B1 MA 33429 B1 MA33429 B1 MA 33429B1 MA 34534 A MA34534 A MA 34534A MA 34534 A MA34534 A MA 34534A MA 33429 B1 MA33429 B1 MA 33429B1
Authority
MA
Morocco
Prior art keywords
production
poliovirus
high quantity
vaccine
cells
Prior art date
Application number
MA34534A
Other languages
Arabic (ar)
English (en)
Inventor
John Alfred Lewis
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of MA33429B1 publication Critical patent/MA33429B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32651—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention concerne un procédé de production de poliovirus consistant à : a) fournir une culture cellulaire en suspension sans sérum, les cellules étant des cellules PER.C6, b) infecter lesdites cellules avec le poliovirus avec une densité cellulaire comprise entre 2 x 10
MA34534A 2009-07-16 2010-07-08 Production de poliovirus à titres élevés pour la production de vaccins MA33429B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27103809P 2009-07-16 2009-07-16
EP09165620 2009-07-16
PCT/EP2010/059796 WO2011006823A1 (fr) 2009-07-16 2010-07-08 Production de poliovirus à titres élevés pour la production de vaccins

Publications (1)

Publication Number Publication Date
MA33429B1 true MA33429B1 (fr) 2012-07-03

Family

ID=41412431

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34534A MA33429B1 (fr) 2009-07-16 2010-07-08 Production de poliovirus à titres élevés pour la production de vaccins

Country Status (32)

Country Link
US (4) US8546123B2 (fr)
EP (1) EP2454364B1 (fr)
JP (1) JP5845178B2 (fr)
KR (1) KR101548790B1 (fr)
CN (1) CN102482647B (fr)
AP (1) AP3140A (fr)
AR (1) AR077314A1 (fr)
AU (1) AU2010272685B2 (fr)
BR (1) BR112012000942B8 (fr)
CA (1) CA2763091C (fr)
CO (1) CO6491042A2 (fr)
CU (1) CU20120006A7 (fr)
DK (1) DK2454364T3 (fr)
EA (1) EA020563B1 (fr)
ES (1) ES2484093T3 (fr)
HR (1) HRP20140597T1 (fr)
IL (1) IL217465A (fr)
MA (1) MA33429B1 (fr)
MX (1) MX2011012648A (fr)
MY (1) MY183385A (fr)
NZ (1) NZ596880A (fr)
PE (1) PE20120571A1 (fr)
PL (1) PL2454364T3 (fr)
PT (1) PT2454364E (fr)
RS (1) RS53377B (fr)
SG (1) SG177655A1 (fr)
SI (1) SI2454364T1 (fr)
SM (1) SMT201400079B (fr)
TN (1) TN2011000628A1 (fr)
TW (1) TWI477606B (fr)
WO (1) WO2011006823A1 (fr)
ZA (1) ZA201108271B (fr)

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CN101472941B (zh) 2006-03-31 2017-08-08 沃弗-威斯康星校友研究基金会 用于疫苗的高滴度重组流感病毒
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
WO2010060719A1 (fr) 2008-11-03 2010-06-03 Crucell Holland B.V. Procédé pour la production de vecteurs adénoviraux
RS53377B (sr) 2009-07-16 2014-10-31 Crucell Holland B.V. Proizvodnja polio virusa u visokim titrima za proizvodnju vakcine
EP2493912B1 (fr) 2009-10-26 2020-07-29 Wisconsin Alumni Research Foundation Virus recombinants de la grippe de titre élevé à réplication améliorée dans les cellules vero
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
WO2013032942A1 (fr) 2011-08-26 2013-03-07 Yoshihiro Kawaoka Virus de la grippe ayant un segment génique pb2 mutant en tant que vaccins vivants atténués
CA2899928A1 (fr) * 2013-02-05 2014-08-14 University Of Georgia Research Foundation, Inc. Lignees cellulaires pour la production de virus et procedes d'utilisation
EP2863943B1 (fr) 2013-03-08 2016-07-13 Crucell Holland B.V. Vaccin anticoquelucheux acellulaire
CN105121634B (zh) 2013-03-13 2019-07-26 易木农麦克斯有限公司 具有提高的病毒生产能力的细胞系及其生产方法
KR20140112255A (ko) 2013-03-13 2014-09-23 고려대학교 산학협력단 바이러스 생산능이 증가된 세포주 및 그 제조방법
GB201305361D0 (en) 2013-03-25 2013-05-08 Univ Edinburgh Enhanced expression
RS57864B1 (sr) 2013-06-17 2018-12-31 De Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheid Welzijn En Spo Postupci za sprečavanje agregacije virusnih komponenti
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
US20160053281A1 (en) * 2013-08-15 2016-02-25 The University Court Of The University Of Edinburgh Enhanced Expression Of RNA Vectors
JP6783143B2 (ja) 2014-03-25 2020-11-11 テルモ ビーシーティー、インコーポレーテッド 培地の受動的補充
WO2015193324A1 (fr) 2014-06-17 2015-12-23 Crucell Holland B.V. Atténuation virale adaptée au froid (cava) et nouvelles souches de poliovirus atténuées
EP3159404B1 (fr) 2014-06-18 2019-07-17 ImmunoMax Co., Ltd. Procédé pour favoriser l'infection virale et augmenter la production de virus, en utilisant une lignée cellulaire présentant des fonctions perdues du gène bst2
WO2015196150A2 (fr) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations conférant une stabilité génétique à des gènes supplémentaires dans des virus de la grippe
US10294460B2 (en) 2014-07-24 2019-05-21 Janssen Vaccines & Prevention B.V. Process for the purification of poliovirus from cell cultures
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017004592A1 (fr) 2015-07-02 2017-01-05 Terumo Bct, Inc. Croissance cellulaire à l'aide de stimuli mécaniques
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
CA3014435C (fr) 2016-02-19 2023-04-18 Wisconsin Alumni Research Foundation (Warf) Replication amelioree du virus de la grippe b pour l'elaboration de vaccin
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US10372100B2 (en) * 2016-08-29 2019-08-06 Ge Healthcare Bio-Sciences Corp. Manufacturing system for biopharmaceutical products
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
CN107723279B (zh) * 2017-10-18 2020-11-10 成都远睿生物技术有限公司 一种缺陷型腺病毒AdC68-GP的培养方法
US11197926B2 (en) 2017-10-25 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
SG11202007503WA (en) * 2018-02-07 2020-09-29 Bharat Biotech Int Ltd A process for enterovirus purification and inactivation and vaccine compositions obtained thereof
JP7783047B2 (ja) 2018-08-07 2025-12-09 ウィスコンシン アルムニ リサーチ ファンデイション 組換えの生物学的に封じ込められたフィロウイルスワクチン
WO2020041311A1 (fr) 2018-08-20 2020-02-27 Wisconsin Alumni Research Foundation Vecteurs pour induire des réponses immunitaires à des épitopes non dominants dans la protéine hémagglutinine (ha)
EP3914295A2 (fr) 2019-01-23 2021-12-01 Yoshihiro Kawaoka Mutations conférant une stabilité génétique à des gènes supplémentaires dans des virus de la grippe
US11851648B2 (en) 2019-02-08 2023-12-26 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
WO2020223699A1 (fr) 2019-05-01 2020-11-05 Wisconsin Alumni Research Foundation (Warf) Réplication améliorée du virus de la grippe pour l'élaboration de vaccin
US20220175908A1 (en) 2019-05-16 2022-06-09 Janssen Vaccines & Prevention B.V. Methods for Inducing a Safe Immune Response Against Polio Virus
JP7627911B2 (ja) 2019-08-27 2025-02-07 ウィスコンシン アルムニ リサーチ ファンデイション 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス
US11739303B2 (en) 2020-01-24 2023-08-29 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized NA
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses

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RS53377B (sr) 2009-07-16 2014-10-31 Crucell Holland B.V. Proizvodnja polio virusa u visokim titrima za proizvodnju vakcine
KR20120070015A (ko) 2010-12-21 2012-06-29 (주)창조바이오텍 알파-피넨을 유효성분으로 포함하는 스쿠티카충 구제용 조성물

Also Published As

Publication number Publication date
BR112012000942B1 (pt) 2020-10-27
CN102482647B (zh) 2015-12-16
EA201270173A1 (ru) 2012-06-29
TWI477606B (zh) 2015-03-21
WO2011006823A1 (fr) 2011-01-20
HRP20140597T1 (hr) 2014-09-12
PT2454364E (pt) 2014-07-04
ES2484093T3 (es) 2014-08-11
US20140242670A1 (en) 2014-08-28
AU2010272685A1 (en) 2011-12-08
US20110027317A1 (en) 2011-02-03
AR077314A1 (es) 2011-08-17
CU20120006A7 (es) 2012-10-15
MX2011012648A (es) 2012-01-12
KR101548790B1 (ko) 2015-08-31
SMT201400079B (it) 2014-09-08
NZ596880A (en) 2013-10-25
US9022240B2 (en) 2015-05-05
EA020563B1 (ru) 2014-12-30
JP5845178B2 (ja) 2016-01-20
BR112012000942B8 (pt) 2021-05-25
RS53377B (sr) 2014-10-31
US20130273106A1 (en) 2013-10-17
PL2454364T3 (pl) 2014-09-30
DK2454364T3 (da) 2014-07-21
TW201118173A (en) 2011-06-01
IL217465A0 (en) 2012-02-29
CN102482647A (zh) 2012-05-30
US20130052224A1 (en) 2013-02-28
BR112012000942A2 (pt) 2016-03-15
TN2011000628A1 (en) 2013-05-24
IL217465A (en) 2016-05-31
KR20120033334A (ko) 2012-04-06
CA2763091A1 (fr) 2011-01-20
ZA201108271B (en) 2012-07-25
EP2454364A1 (fr) 2012-05-23
MY183385A (en) 2021-02-18
SG177655A1 (en) 2012-02-28
SI2454364T1 (sl) 2014-08-29
AP3140A (en) 2015-02-28
AU2010272685B2 (en) 2015-02-26
CO6491042A2 (es) 2012-07-31
JP2012532616A (ja) 2012-12-20
PE20120571A1 (es) 2012-06-06
US8546123B2 (en) 2013-10-01
HK1164922A1 (en) 2012-09-28
AP2012006075A0 (en) 2012-02-29
CA2763091C (fr) 2019-07-23
EP2454364B1 (fr) 2014-04-23

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