[go: up one dir, main page]

MA32400B1 - Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase - Google Patents

Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase

Info

Publication number
MA32400B1
MA32400B1 MA33438A MA33438A MA32400B1 MA 32400 B1 MA32400 B1 MA 32400B1 MA 33438 A MA33438 A MA 33438A MA 33438 A MA33438 A MA 33438A MA 32400 B1 MA32400 B1 MA 32400B1
Authority
MA
Morocco
Prior art keywords
substituted
isocoinolinase
isocoinolin
kinase inhibitors
kinase
Prior art date
Application number
MA33438A
Other languages
Arabic (ar)
English (en)
Inventor
Oliver Plettenburg
Katrin Lorenz
John Weston
Matthias Loehn
Heinz-Werner Kleemann
Olivier Duclos
Frédéric Jeannot
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA32400B1 publication Critical patent/MA32400B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

Cette invention concerne des isoquinolines et isoquinolinones substituées de formule (i) utilisées dans le traitement et/ou la prévention des maladies associées avec la rho-kinase et/ou la phosphorylation par l'intermédiaire de la rho-kinase de la phosphatase des chaînes légères de myosine, et des compositions contenant ces types de composés.
MA33438A 2008-06-24 2010-12-17 Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase MA32400B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290606 2008-06-24
PCT/EP2009/004421 WO2009156100A1 (fr) 2008-06-24 2009-06-19 Isoquinolines et isoquinolinones substituées utilisées comme inhibiteurs de rho-kinase

Publications (1)

Publication Number Publication Date
MA32400B1 true MA32400B1 (fr) 2011-06-01

Family

ID=40049863

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33438A MA32400B1 (fr) 2008-06-24 2010-12-17 Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase

Country Status (32)

Country Link
US (1) US8541449B2 (fr)
EP (1) EP2303846B1 (fr)
JP (1) JP5713893B2 (fr)
KR (1) KR101638326B1 (fr)
CN (1) CN102131784B (fr)
AR (1) AR072281A1 (fr)
AU (1) AU2009262517B2 (fr)
BR (1) BRPI0914696A2 (fr)
CA (1) CA2728137C (fr)
CO (1) CO6321250A2 (fr)
CR (1) CR11831A (fr)
DK (1) DK2303846T3 (fr)
DO (1) DOP2010000394A (fr)
EC (1) ECSP10010705A (fr)
ES (1) ES2541827T3 (fr)
HR (1) HRP20150726T1 (fr)
HU (1) HUE026617T2 (fr)
IL (1) IL210113A (fr)
MA (1) MA32400B1 (fr)
MX (1) MX2010013975A (fr)
MY (1) MY157330A (fr)
NZ (1) NZ590070A (fr)
PE (1) PE20110059A1 (fr)
PL (1) PL2303846T3 (fr)
PT (1) PT2303846E (fr)
RU (1) RU2538588C2 (fr)
SI (1) SI2303846T1 (fr)
SV (1) SV2010003772A (fr)
TW (1) TWI462907B (fr)
UY (1) UY31925A (fr)
WO (1) WO2009156100A1 (fr)
ZA (1) ZA201008119B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2728128C (fr) * 2008-06-24 2016-06-07 Sanofi-Aventis Isoquinolines et isoquinolinones a substitution en 6
EP2733141B1 (fr) 2011-07-15 2019-01-09 Shionogi & Co., Ltd. Dérivé d'azabenzimidazole possédant une activité activant l'ampk
WO2013113776A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
WO2013113788A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
WO2013113716A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
IN2014DN07220A (fr) 2012-02-03 2015-04-24 Basf Se
WO2013113720A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés de pyrimidine fongicides
CN104220428A (zh) 2012-02-03 2014-12-17 巴斯夫欧洲公司 杀真菌嘧啶化合物
WO2013113773A1 (fr) 2012-02-03 2013-08-08 Basf Se Composés fongicides de pyrimidine
US9738642B2 (en) 2013-09-19 2017-08-22 Bristol-Myers Squibb Company Triazolopyridine ether derivatives and their use in neurological and pyschiatric disorders
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3294871A1 (fr) 2015-05-12 2018-03-21 Platod Combinaison de caractéristiques pharmacologiques et microfluidiques pour production améliorée de plaquettes
JP6906105B2 (ja) * 2017-06-16 2021-07-21 成都先導薬物開発股▲ふん▼有限公司Ｈｉｔｇｅｎ Ｌｔｄ． Ｒｏｃｋを阻害する化合物及びその使用
CN109810174B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN110317169B (zh) * 2018-03-29 2022-06-03 复旦大学 一种1-取代异喹啉酮化合物及其制备方法
CA3236332A1 (fr) 2021-10-30 2023-05-04 Ziev B. Moses Traitements d'un dereglement de l'homeostasie cerebrale

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702600A1 (de) * 1977-01-22 1978-07-27 Thomae Gmbh Dr K Neue aminoalkoxyphenyl-derivate
FR2485537B2 (fr) 1977-04-13 1986-05-16 Anvar Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant
EP0541559A1 (fr) 1990-07-31 1993-05-19 E.I. Du Pont De Nemours And Company Equilibrage catalytique d'halocarbones selectionnes
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
GB9516709D0 (en) 1995-08-15 1995-10-18 Zeneca Ltd Medicament
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
SI0956865T2 (sl) 1996-08-12 2011-04-29 Mitsubishi Pharma Corp Zdravila, ki obsegajo inhibitor Rho-kinaze
JPH1087629A (ja) 1996-09-18 1998-04-07 Fujisawa Pharmaceut Co Ltd 新規イソキノリン誘導体、およびその医薬用途
EP1007525A1 (fr) 1997-08-29 2000-06-14 Zeneca Limited Derives aminometyl-oxo-oxazolidinyl-benzene
TW575567B (en) 1998-10-23 2004-02-11 Akzo Nobel Nv Serine protease inhibitor
GB9912701D0 (en) 1999-06-01 1999-08-04 Smithkline Beecham Plc Novel compounds
US6541456B1 (en) 1999-12-01 2003-04-01 Isis Pharmaceuticals, Inc. Antimicrobial 2-deoxystreptamine compounds
WO2001053288A1 (fr) * 2000-01-20 2001-07-26 Eisai Co., Ltd. Nouveaux composes de piperidine et medicaments contenant ces composes
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
US20040171533A1 (en) 2000-02-29 2004-09-02 Barbara Zehentner Methods and compositions for regulating adiopocytes
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
AR033517A1 (es) 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
GB0013060D0 (en) 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
AU2001296008A1 (en) 2000-10-27 2002-05-06 Takeda Chemical Industries Ltd. Process for preparing substituted aromatic compounds and intermediates therefor
EP1351936A1 (fr) 2001-01-15 2003-10-15 Glaxo Group Limited Derives aryle de piperidine et de piperazine comme inducteurs de l'expression du recepteur ldl
SE0101038D0 (sv) 2001-03-23 2001-03-23 Astrazeneca Ab Novel compounds
US20030095958A1 (en) 2001-04-27 2003-05-22 Bhisetti Govinda R. Inhibitors of bace
WO2002100833A1 (fr) * 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
GB0117899D0 (en) 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
ES2335092T3 (es) 2001-08-24 2010-03-22 Yale University Compuestos de piperazinona como agentes antitumorales y anticancer.
WO2003024450A1 (fr) 2001-09-20 2003-03-27 Eisai Co., Ltd. Methodes de traitement des maladies a prions
SE0104340D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New compounds
WO2004009555A1 (fr) 2002-07-22 2004-01-29 Asahi Kasei Pharma Corporation Derive d'isoquinoline 5-substituee
WO2004024717A1 (fr) 2002-09-12 2004-03-25 Kirin Beer Kabushiki Kaisha Derives d'isoquinoline d'inhibition des kinases et medicaments contenant ceux-ci
US20050014783A1 (en) 2003-05-29 2005-01-20 Schering Aktiengesellschaft Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy
EP1638939A2 (fr) 2003-06-24 2006-03-29 Neurosearch A/S Derives de noyaux aza et utilisation de ceux-ci comme inhibiteurs de la recapture des neurotransmetteurs monoaminergiques
EP1667982B1 (fr) 2003-09-23 2013-07-31 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique d'isoquinolinone
AU2004275720B2 (en) 2003-09-23 2008-04-24 Merck Sharp & Dohme Corp. Isoquinoline potassium channel inhibitors
US20050067037A1 (en) 2003-09-30 2005-03-31 Conocophillips Company Collapse resistant composite riser
EP1671962A1 (fr) 2003-10-10 2006-06-21 Ono Pharmaceutical Co., Ltd. Nouveau compose heterocyclique fondu et utilisation correspondante
JP2007008816A (ja) * 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
WO2005054202A1 (fr) 2003-11-25 2005-06-16 Eli Lilly And Company Derives de 7-phenyl-isoquinoline-5-sulfonylamino en tant qu'inhibiteurs de akt (proteine kinase b)
WO2005074535A2 (fr) 2004-01-30 2005-08-18 Eisai Co., Ltd. Inhibiteurs de cholinesterase pour des troubles de la colonne vertebrale
WO2005087226A1 (fr) 2004-03-05 2005-09-22 Eisai Co., Ltd. Traitement de cadasil avec des inhibiteurs de la cholinesterase
SE0400850D0 (sv) 2004-03-30 2004-03-31 Astrazeneca Ab Novel Compounds
US7517991B2 (en) * 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
ATE441641T1 (de) * 2005-06-28 2009-09-15 Sanofi Aventis Isochinolinderivate als inhibitoren von rho- kinase
ES2372067T3 (es) * 2005-07-26 2012-01-13 Sanofi Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa.
EP2385047B1 (fr) * 2005-07-26 2013-05-29 Sanofi Dérivés de l'isoquinoléine à substitution pipéridinyle
TW200745101A (en) 2005-09-30 2007-12-16 Organon Nv 9-Azabicyclo[3.3.1]nonane derivatives
US7618985B2 (en) * 2005-12-08 2009-11-17 N.V. Organon Isoquinoline derivatives
TW200738682A (en) 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives
US7893088B2 (en) * 2006-08-18 2011-02-22 N.V. Organon 6-substituted isoquinoline derivatives
CN101595094B (zh) * 2006-12-27 2013-02-20 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮衍生物
WO2008077552A1 (fr) * 2006-12-27 2008-07-03 Sanofi-Aventis Dérivés d'isoquinoline et d'isoquinolinone substitués
WO2008077553A1 (fr) * 2006-12-27 2008-07-03 Sanofi-Aventis Dérivés d'isoquinolone et d'isoquinolinone substitués par une cycloalkylamine
HRP20100705T1 (hr) * 2006-12-27 2011-01-31 Sanofi-Aventis Cikloalkilaminski supstituirani izokinolinski i izokinolinonski derivati
RU2455302C2 (ru) * 2006-12-27 2012-07-10 Санофи-Авентис ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ
DE602007013295D1 (de) 2006-12-27 2011-04-28 Sanofi Aventis Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren
JP5405316B2 (ja) * 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノリン誘導体

Also Published As

Publication number Publication date
HRP20150726T1 (hr) 2015-09-25
PT2303846E (pt) 2015-09-04
BRPI0914696A2 (pt) 2016-10-18
TW201010978A (en) 2010-03-16
NZ590070A (en) 2012-02-24
SV2010003772A (es) 2011-03-15
PL2303846T3 (pl) 2015-10-30
ES2541827T3 (es) 2015-07-27
DK2303846T3 (en) 2015-08-03
RU2538588C2 (ru) 2015-01-10
EP2303846B1 (fr) 2015-04-29
CA2728137C (fr) 2016-10-18
CN102131784B (zh) 2014-08-27
RU2011102456A (ru) 2012-07-27
HUE026617T2 (en) 2016-06-28
MX2010013975A (es) 2011-01-14
IL210113A0 (en) 2011-02-28
US20110190341A1 (en) 2011-08-04
ECSP10010705A (es) 2011-01-31
SI2303846T1 (sl) 2015-08-31
CA2728137A1 (fr) 2009-12-30
JP5713893B2 (ja) 2015-05-07
KR20110021922A (ko) 2011-03-04
UY31925A (es) 2010-01-29
CO6321250A2 (es) 2011-09-20
TWI462907B (zh) 2014-12-01
PE20110059A1 (es) 2011-02-15
HK1158644A1 (en) 2012-07-20
JP2011525511A (ja) 2011-09-22
CN102131784A (zh) 2011-07-20
AU2009262517B2 (en) 2014-01-09
DOP2010000394A (es) 2011-01-15
IL210113A (en) 2015-10-29
US8541449B2 (en) 2013-09-24
EP2303846A1 (fr) 2011-04-06
AR072281A1 (es) 2010-08-18
KR101638326B1 (ko) 2016-07-12
WO2009156100A1 (fr) 2009-12-30
MY157330A (en) 2016-05-31
CR11831A (es) 2011-03-18
AU2009262517A1 (en) 2009-12-30
ZA201008119B (en) 2011-07-27

Similar Documents

Publication Publication Date Title
MA32400B1 (fr) Isoquinoléines et isoquinolinones substituées en tant qu'inhibiteurs de rho-kinase
DK2125744T3 (da) Cycloalkylaminsubstituerede isochinolon- og isochinolinonderivater
MY150746A (en) Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
TNSN08039A1 (en) Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors
ATE554072T1 (de) Cycloalkylaminsubstituierte isochinolinderivate
TN2009000273A1 (en) New substituted isoquinoline and isoquinolinone derivatives
MY146037A (en) Isoquinoline derivatives as inhibitors of rho-kinase
MY155279A (en) Substituted isoquinoline and isoquinolinone derivatives
TNSN08038A1 (en) Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors
MY154767A (en) Cycloalkyamine substituted isoquinoline and isoquinolinone derivatives
EA201600002A1 (ru) Производные пролекарства замещенных триазолопиридинов
MA32399B1 (fr) Isoquinoléines et isoquinoléinones 6-substituées.
MY153756A (en) Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors
TN2010000589A1 (en) Substituted dsoquinolines and isoquinodlinones as rho kinase inhibitors
EA202091923A1 (ru) Замещенные трициклические соединения как ингибиторы fgfr
ECSP10010706A (es) Isoquinolinas e isoquinolinonas 6-sustituidas
CY1116829T1 (el) Υποκατεστημενες ισοκινολινες και ισοκινολινονες ως αναστολεις κινασης rho
NI201000217A (es) Quinolinas e isoquinolinas 6 - sustituidas.
TN2010000588A1 (en) Substituted isoquinolines and isoquinolinones
CY1114847T1 (el) ΔΙ- ΚΑΙ ΠΟΛΥΚΥΚΛΙΚΕΣ ΙΣΟΚΙΝΟΛΙΝΕΣ ΚΑΙ ΠΑΡΑΓΩΓΑ ΙΣΟΚΙΝΟΛΙΝΩΝ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ rho ΚΙΝΑΣΗΣ