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MA31863B1 - Dérivés de pyrazole comme inhibiteurs de 5-lo - Google Patents

Dérivés de pyrazole comme inhibiteurs de 5-lo

Info

Publication number
MA31863B1
MA31863B1 MA32869A MA32869A MA31863B1 MA 31863 B1 MA31863 B1 MA 31863B1 MA 32869 A MA32869 A MA 32869A MA 32869 A MA32869 A MA 32869A MA 31863 B1 MA31863 B1 MA 31863B1
Authority
MA
Morocco
Prior art keywords
inhibitors
pyrazole derivatives
compounds
processes
formula
Prior art date
Application number
MA32869A
Other languages
Arabic (ar)
English (en)
Inventor
Edgardo Alvira
Matthew J Graneto
Margaret Lanahan Grapperhaus
Kaliappan Iyanar
Todd Michael Maddux
Matthew William Mahoney
Mark Alan Massa
Ray Kirby Sample
Michelle Ann Schmidt
Ronald Edward Seidel
Jon Gordon Selbo
Michael Brent Tollefson
Embse Richard Alan Vonder
Grace Mary Wagner
Scott Santford Woodard
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA31863B1 publication Critical patent/MA31863B1/fr

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)

Abstract

L'invention concerne des composés de formule (i), des procédés pour leur préparation, leur utilisation comme inhibiteurs de 5-lipoxygénase et des compositions pharmaceutiques les contenant.
MA32869A 2007-11-26 2010-05-26 Dérivés de pyrazole comme inhibiteurs de 5-lo MA31863B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US423607P 2007-11-26 2007-11-26
US426107P 2007-11-26 2007-11-26
US5549708P 2008-05-23 2008-05-23
PCT/IB2008/054873 WO2009069044A1 (fr) 2007-11-26 2008-11-20 Dérivés de pyrazole comme inhibiteurs de 5-lo

Publications (1)

Publication Number Publication Date
MA31863B1 true MA31863B1 (fr) 2010-11-01

Family

ID=40568336

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32869A MA31863B1 (fr) 2007-11-26 2010-05-26 Dérivés de pyrazole comme inhibiteurs de 5-lo

Country Status (28)

Country Link
US (1) US8097733B2 (fr)
EP (1) EP2225229A1 (fr)
JP (1) JP4718650B2 (fr)
KR (1) KR20100072090A (fr)
CN (1) CN101918392A (fr)
AP (1) AP2010005269A0 (fr)
AR (1) AR069743A1 (fr)
AU (1) AU2008331199A1 (fr)
BR (1) BRPI0819661A2 (fr)
CA (1) CA2705729C (fr)
CL (1) CL2008003495A1 (fr)
CO (1) CO6280402A2 (fr)
CR (1) CR11392A (fr)
DO (1) DOP2010000155A (fr)
EA (1) EA201000703A1 (fr)
EC (1) ECSP10010200A (fr)
IL (1) IL205602A0 (fr)
MA (1) MA31863B1 (fr)
MX (1) MX2010004604A (fr)
NI (1) NI201000089A (fr)
PA (1) PA8805301A1 (fr)
PE (1) PE20091069A1 (fr)
SV (1) SV2010003579A (fr)
TN (1) TN2010000231A1 (fr)
TW (1) TW200927098A (fr)
UY (1) UY31487A1 (fr)
WO (1) WO2009069044A1 (fr)
ZA (1) ZA201002758B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20125502B (en) 2008-05-23 2012-04-25 Novartis Ag Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
WO2011137363A1 (fr) * 2010-04-30 2011-11-03 Allergan, Inc. Nouveau traitement pour la dégénérescence maculaire liée à l'âge et la maladie ischémique oculaire associée à l'activation du complément par le ciblage de la 5-lipoxygénase
WO2011161615A1 (fr) 2010-06-24 2011-12-29 Ranbaxy Laboratories Limited Inhibiteurs de la 5-lipoxygénase
WO2015014446A1 (fr) * 2013-07-29 2015-02-05 Merck Patent Gmbh Dérivés de cyclopentane 1,3-disubstitutés
GB201403605D0 (en) * 2014-02-28 2014-04-16 Mologic Ltd Monitoring inflammation status
EP3299366B1 (fr) 2015-05-18 2020-09-09 Shenyang Sinochem Agrochemicals R&D Co., Ltd. Composés de pyrazole substitués contenant de la pyrimidine et procédé de préparation et utilisation de ceux-ci en tant que pesticides
CN111825678A (zh) * 2020-06-05 2020-10-27 连庆泉 一种卡马替尼的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254581A (en) 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
US5272173A (en) 1990-11-28 1993-12-21 Imperial Chemical Industries Plc 5-lipoxygenase inhibitors
IE913866A1 (en) 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
GB9300894D0 (en) 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
JP3400392B2 (ja) * 1994-10-18 2003-04-28 ファイザー製薬株式会社 ５−リポキシゲナーゼ阻害剤及び新規医薬組成物
US5883106A (en) 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
US6063928A (en) 1994-10-18 2000-05-16 Pfizer Inc 5-lipoxygenase inhibitors
SK281577B6 (sk) * 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
US6239285B1 (en) 1998-02-06 2001-05-29 Pfizer Inc Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
JP2009523820A (ja) 2006-01-23 2009-06-25 アミラ ファーマシューティカルス，インコーポレーテッド ５−リポキシゲナーゼの三環系抑制剤
US7674811B2 (en) 2006-03-14 2010-03-09 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
EP2097407A1 (fr) * 2006-11-27 2009-09-09 Pfizer Products Inc. Analogues du pyrazole

Also Published As

Publication number Publication date
CN101918392A (zh) 2010-12-15
UY31487A1 (es) 2009-07-17
ZA201002758B (en) 2011-06-29
TW200927098A (en) 2009-07-01
AP2010005269A0 (en) 2010-06-30
CA2705729A1 (fr) 2009-06-04
AU2008331199A1 (en) 2009-06-04
CA2705729C (fr) 2012-09-18
KR20100072090A (ko) 2010-06-29
TN2010000231A1 (fr) 2011-11-11
SV2010003579A (es) 2011-03-23
WO2009069044A1 (fr) 2009-06-04
MX2010004604A (es) 2010-08-04
DOP2010000155A (es) 2010-07-15
CL2008003495A1 (es) 2010-03-12
US8097733B2 (en) 2012-01-17
PE20091069A1 (es) 2009-07-19
PA8805301A1 (es) 2009-06-23
IL205602A0 (en) 2010-11-30
BRPI0819661A2 (pt) 2019-09-24
AR069743A1 (es) 2010-02-17
ECSP10010200A (es) 2010-06-29
EA201000703A1 (ru) 2010-12-30
EP2225229A1 (fr) 2010-09-08
CR11392A (es) 2010-05-28
JP4718650B2 (ja) 2011-07-06
JP2011504514A (ja) 2011-02-10
NI201000089A (es) 2010-10-05
US20090227634A1 (en) 2009-09-10
CO6280402A2 (es) 2011-05-20

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