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MA30988B1 - Composes destines a inhiber la progression mitotique - Google Patents

Composes destines a inhiber la progression mitotique

Info

Publication number
MA30988B1
MA30988B1 MA31985A MA31985A MA30988B1 MA 30988 B1 MA30988 B1 MA 30988B1 MA 31985 A MA31985 A MA 31985A MA 31985 A MA31985 A MA 31985A MA 30988 B1 MA30988 B1 MA 30988B1
Authority
MA
Morocco
Prior art keywords
compounds
mitotic progression
inhibiting mitotic
cancer
treatment
Prior art date
Application number
MA31985A
Other languages
English (en)
Inventor
Christopher F Claiborne
Todd B Sells
Stephen G Stroud
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39315133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30988(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of MA30988B1 publication Critical patent/MA30988B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS REPRÉSENTÉS PAR LA FORMULE GÉNÉRALE (I), AINSI QUE DES PROCÉDÉS DESTINÉS AU TRAITEMENT DU CANCER. L'INVENTION CONCERNE PLUS PARTICULIÈREMENT DE PUISSANTS INHIBITEURS DE LA KINASE AURORA A, DES COMPOSITIONS PHARMACEUTIQUES COMPRENANT LES COMPOSÉS, AINSI QUE DES PROCÉDÉS D'UTILISATION DE CES COMPOSÉS POUR LE TRAITEMENT DU CANCER.
MA31985A 2006-11-16 2009-06-12 Composes destines a inhiber la progression mitotique MA30988B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85934006P 2006-11-16 2006-11-16

Publications (1)

Publication Number Publication Date
MA30988B1 true MA30988B1 (fr) 2009-12-01

Family

ID=39315133

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31985A MA30988B1 (fr) 2006-11-16 2009-06-12 Composes destines a inhiber la progression mitotique

Country Status (34)

Country Link
US (7) US8026246B2 (fr)
EP (4) EP2086981B1 (fr)
JP (3) JP5102839B2 (fr)
KR (2) KR101342014B1 (fr)
CN (2) CN101547924B (fr)
AR (1) AR064246A1 (fr)
AT (1) ATE556076T1 (fr)
AU (1) AU2007322046B2 (fr)
BR (1) BRPI0718803B8 (fr)
CA (1) CA2669680C (fr)
CL (1) CL2007003244A1 (fr)
CR (3) CR10782A (fr)
CY (1) CY1112828T1 (fr)
DK (2) DK2497772T3 (fr)
EA (1) EA015779B1 (fr)
ES (3) ES2537451T3 (fr)
GE (1) GEP20125459B (fr)
HR (2) HRP20120490T1 (fr)
IL (1) IL198690A0 (fr)
MA (1) MA30988B1 (fr)
MX (3) MX2009004670A (fr)
MY (1) MY153243A (fr)
NO (1) NO343338B1 (fr)
NZ (3) NZ611898A (fr)
PH (1) PH12012502057B1 (fr)
PL (2) PL2497772T3 (fr)
PT (2) PT2497772E (fr)
RS (2) RS53788B1 (fr)
SG (2) SG176443A1 (fr)
SI (2) SI2086981T1 (fr)
TW (1) TWI401255B (fr)
UA (1) UA94129C2 (fr)
WO (1) WO2008063525A1 (fr)
ZA (1) ZA200903279B (fr)

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WO2010065134A1 (fr) * 2008-12-05 2010-06-10 Millennium Pharmaceuticals, Inc. 5, 7-dihydro- 6h-pyrimido [ 5, 4-d] [ 1 ] benzazépin-6-thiones utilisées en tant qu'inhibiteurs de plk
MX2011006725A (es) 2008-12-22 2011-09-15 Millennium Pharm Inc Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20.
JO3635B1 (ar) * 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
JO3434B1 (ar) * 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
CN104031049A (zh) * 2010-02-19 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂的结晶形式
US20120107304A1 (en) 2010-04-27 2012-05-03 Boehringer Ingelheim International Gmbh Combination therapy in treatment of oncological and fibrotic diseases
WO2011161031A1 (fr) * 2010-06-22 2011-12-29 Glaxosmithkline Llc Composés de benzotriazolodiazépine inhibiteurs de bromodomaines
AR086656A1 (es) * 2011-06-03 2014-01-15 Millennium Pharm Inc Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a
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US9724354B2 (en) 2013-03-22 2017-08-08 Millennium Pharmaceuticals, Inc. Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
WO2015085289A1 (fr) 2013-12-06 2015-06-11 Millennium Pharmaceuticals, Inc. Combinaison d'inhibiteurs de kinase aurora et d'anticorps anti-cd30
CA2972076A1 (fr) * 2014-12-23 2016-06-30 Millennium Pharmaceuticals, Inc. Combinaison d'inhibiteurs de raf et d'inhibiteurs de kinases aurora
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
CA2997769A1 (fr) 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Sulfonamides heterocycliques tricycliques contraints en tant qu'agents anti-cancereux
CN108349961B (zh) 2015-09-09 2022-02-18 西奈山伊坎医学院 杂环受限三环磺酰胺作为抗癌试剂
US11340215B2 (en) 2016-02-26 2022-05-24 Japanese Foundation For Cancer Research Screening method of anticancer agent focused on function of HP1 and evaluation system
CN109195593A (zh) 2016-03-15 2019-01-11 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
JP6188986B1 (ja) * 2017-03-23 2017-08-30 株式会社ノエビア 時計遺伝子発現量調整剤及びエラスチン産生促進剤
WO2019195658A1 (fr) 2018-04-05 2019-10-10 Dana-Farber Cancer Institute, Inc. Niveaux sting comme biomarqueur pour l'immunothérapie du cancer
WO2020049208A1 (fr) 2018-09-09 2020-03-12 Fundacio Privada Institut De Recerca De La Sida - Caixa Aurora cinasa comme cible pour traiter, prévenir ou soigner une infection par vih ou le sida
US20220305048A1 (en) 2019-08-26 2022-09-29 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling
WO2023196959A1 (fr) 2022-04-07 2023-10-12 Eli Lilly And Company Procédé de fabrication d'un inhibiteur de kras g12c
WO2023196887A1 (fr) 2022-04-08 2023-10-12 Eli Lilly And Company Méthode de traitement comprenant des inhibiteurs de kras g12c et des inhibiteurs d'aurora a
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WO2025245045A1 (fr) 2024-05-21 2025-11-27 The Regents Of The University Of California Méthodes de traitement du cancer du poumon

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CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها

Also Published As

Publication number Publication date
EP2086981B1 (fr) 2012-05-02
ES2537451T3 (es) 2015-06-08
US20240400567A1 (en) 2024-12-05
US9765076B2 (en) 2017-09-19
CA2669680C (fr) 2012-04-10
EP2944639A1 (fr) 2015-11-18
JP5452811B2 (ja) 2014-03-26
US20110312943A1 (en) 2011-12-22
EP2086981A1 (fr) 2009-08-12
PT2497772E (pt) 2015-02-05
RS52313B (sr) 2012-12-31
JP5102839B2 (ja) 2012-12-19
TWI401255B (zh) 2013-07-11
CR10782A (es) 2009-06-24
KR101110458B1 (ko) 2012-03-13
PL2497772T3 (pl) 2015-05-29
KR20110113210A (ko) 2011-10-14
JP2014055166A (ja) 2014-03-27
US9988384B2 (en) 2018-06-05
EA015779B1 (ru) 2011-12-30
ATE556076T1 (de) 2012-05-15
BRPI0718803B1 (pt) 2020-11-17
NZ597252A (en) 2013-06-28
SG10201503350TA (en) 2015-06-29
KR20090091173A (ko) 2009-08-26
CN103483343A (zh) 2014-01-01
ES2528793T3 (es) 2015-02-12
AR064246A1 (es) 2009-03-25
SG176443A1 (en) 2011-12-29
CR20140544A (es) 2015-01-12
NZ611898A (en) 2015-01-30
SI2497772T1 (sl) 2015-03-31
CN101547924B (zh) 2013-09-25
BRPI0718803A2 (pt) 2013-12-03
MX2009004670A (es) 2009-05-15
PT2086981E (pt) 2012-06-20
EP2497773A1 (fr) 2012-09-12
CN101547924A (zh) 2009-09-30
GEP20125459B (en) 2012-03-26
RS53788B1 (sr) 2015-06-30
IL198690A0 (en) 2010-02-17
HRP20120490T1 (hr) 2012-07-31
NZ577042A (en) 2012-03-30
US11958855B2 (en) 2024-04-16
US8026246B2 (en) 2011-09-27
US20110312942A1 (en) 2011-12-22
MY153243A (en) 2015-01-29
AU2007322046A1 (en) 2008-05-29
DK2086981T3 (da) 2012-08-06
KR101342014B1 (ko) 2013-12-19
EP2944639B1 (fr) 2017-01-04
US20190031662A1 (en) 2019-01-31
CN103483343B (zh) 2016-06-01
US10836766B2 (en) 2020-11-17
UA94129C2 (ru) 2011-04-11
CL2007003244A1 (es) 2008-04-04
US20080167292A1 (en) 2008-07-10
CY1112828T1 (el) 2016-02-10
CR20140154A (es) 2014-07-23
EP2497772B1 (fr) 2014-10-29
MX343391B (es) 2016-11-04
ES2384123T3 (es) 2012-06-29
NO20091864L (no) 2009-06-15
AU2007322046B2 (en) 2012-04-05
JP2012006965A (ja) 2012-01-12
HK1217699A1 (en) 2017-01-20
EP2497772A1 (fr) 2012-09-12
EP2497773B1 (fr) 2015-02-25
US20210214361A1 (en) 2021-07-15
NO343338B1 (no) 2019-02-04
TW200829589A (en) 2008-07-16
JP2010510215A (ja) 2010-04-02
EA200970486A1 (ru) 2009-10-30
DK2497772T3 (en) 2015-01-19
PL2086981T3 (pl) 2012-09-28
PH12012502057A1 (en) 2015-09-14
HRP20150047T1 (en) 2015-03-13
ZA200903279B (en) 2010-07-28
MX348568B (es) 2017-06-20
BRPI0718803B8 (pt) 2021-05-25
WO2008063525A1 (fr) 2008-05-29
CA2669680A1 (fr) 2008-05-29
US20150166545A1 (en) 2015-06-18
HK1175777A1 (en) 2013-07-12
PH12012502057B1 (en) 2018-10-24
HK1134672A1 (en) 2010-05-07
SI2086981T1 (sl) 2012-12-31
HK1175778A1 (en) 2013-07-12

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