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MA30395B1 - Dérivés de thiazolidinedione utilisés comme inhibiteurs des kinases PI3 - Google Patents

Dérivés de thiazolidinedione utilisés comme inhibiteurs des kinases PI3

Info

Publication number
MA30395B1
MA30395B1 MA31349A MA31349A MA30395B1 MA 30395 B1 MA30395 B1 MA 30395B1 MA 31349 A MA31349 A MA 31349A MA 31349 A MA31349 A MA 31349A MA 30395 B1 MA30395 B1 MA 30395B1
Authority
MA
Morocco
Prior art keywords
thiazolidinedione derivatives
kinases
inhibitors
derivatives used
relates
Prior art date
Application number
MA31349A
Other languages
English (en)
Inventor
Michael Gerard Darcy
Steven David Knight
Nicholas D Adams
Stanley J Schmidt
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA30395B1 publication Critical patent/MA30395B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

L'invention concerne une méthode pour inhiber l'activité/ la fonction de kinases PI3 en utilisant des dérivés de thiazolidinedione. La présente invention concerne également une méthode pour le traitement d'un ou plusieurs états pathologiques choisis entre: des troubles auto-immuns, des maladies inflammatoires, des maladies cardio-vasculaires, des maladies neurodégénératives, l'allergie, l'asthme, la pancréatite, l'insuffisance d'organes multiples, des maladies rénales, l'agrégation plaquettaire, le cancer, la motilité du sperme, le rejet d'un transplant, le rejet d'un greffon et des lésions pulmonaires par administration de dérivés de thiazolidinedione.
MA31349A 2006-04-11 2008-11-03 Dérivés de thiazolidinedione utilisés comme inhibiteurs des kinases PI3 MA30395B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79113406P 2006-04-11 2006-04-11

Publications (1)

Publication Number Publication Date
MA30395B1 true MA30395B1 (fr) 2009-05-04

Family

ID=38723938

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31349A MA30395B1 (fr) 2006-04-11 2008-11-03 Dérivés de thiazolidinedione utilisés comme inhibiteurs des kinases PI3

Country Status (19)

Country Link
US (1) US20090306074A1 (fr)
EP (1) EP2004189A2 (fr)
JP (1) JP2009533467A (fr)
KR (1) KR20080108611A (fr)
CN (1) CN101466377A (fr)
AR (1) AR060391A1 (fr)
AU (1) AU2007253956A1 (fr)
BR (1) BRPI0710004A2 (fr)
CA (1) CA2649224A1 (fr)
CL (1) CL2007000995A1 (fr)
CR (1) CR10354A (fr)
EA (1) EA200870426A1 (fr)
IL (1) IL194575A0 (fr)
MA (1) MA30395B1 (fr)
MX (1) MX2008013174A (fr)
NO (1) NO20084457L (fr)
PE (1) PE20080038A1 (fr)
TW (1) TW200815429A (fr)
WO (1) WO2007136940A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080255115A1 (en) * 2007-04-11 2008-10-16 Michael Gerard Darcy Thiazolidinedione derivatives as pi3 kinase inhibitors
PE20090717A1 (es) * 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
GB0801416D0 (en) * 2008-01-25 2008-03-05 Piramed Ltd Pharmaceutical compounds
JP2013505962A (ja) 2009-09-28 2013-02-21 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 組合せ
RU2458688C1 (ru) * 2011-06-23 2012-08-20 Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации Способ коррекции нарушений структурно-функциональных свойств эритроцитов и иммунного статуса у больных с острым панкреатитом
NZ700872A (en) 2012-03-26 2016-09-30 Nippon Chemiphar Co Prophylactic or therapeutic agent for giant cell tumors occurring in bone and soft tissue or for chondrosarcoma
JP6023630B2 (ja) * 2013-04-03 2016-11-09 株式会社ヤクルト本社 チアゾロン誘導体
JP6378918B2 (ja) * 2013-04-03 2018-08-22 株式会社ヤクルト本社 チアゾリジン誘導体又はその塩を有効成分とするＰｉｍ阻害剤
JP6527822B2 (ja) 2013-09-25 2019-06-05 日本ケミファ株式会社 骨・軟部に発生する巨細胞性腫瘍、軟骨肉腫または骨肉腫の予防、治療または転移の予防のための薬剤、動脈塞栓術用局所注入剤、および、人工骨
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
EP4302827A3 (fr) 2018-06-15 2024-03-13 JANSSEN Pharmaceutica NV Analogues de la rapamycine et leurs utilisations
MX2022006807A (es) 2019-12-05 2022-09-12 Anakuria Therapeutics Inc Análogos de rapamicina y usos de estos.

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CA2195559A1 (fr) * 1994-08-10 1996-02-22 Takashi Sohda Derives de la thiazolidindione, leur procede d'obtention et leurs utilisations
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6452014B1 (en) * 2000-12-22 2002-09-17 Geron Corporation Telomerase inhibitors and methods of their use
IL157740A0 (en) * 2001-03-07 2004-03-28 Incyte San Diego Inc Heterocyclic derivatives and pharmaceutical compositions containing the same
TWI223807B (en) * 2001-03-28 2004-11-11 Bayer Ag Optical data carrier comprising a merocyanine dye as light-absorbent compound in the information layer
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AU2003291613B2 (en) * 2002-04-30 2007-09-27 Merck & Co., Inc. Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers
US20040092561A1 (en) * 2002-11-07 2004-05-13 Thomas Ruckle Azolidinone-vinyl fused -benzene derivatives
AU2003255529B2 (en) * 2002-07-10 2008-11-20 Laboratoires Serono Sa Use of compounds for increasing spermatozoa motility
EA011807B1 (ru) * 2002-07-10 2009-06-30 Лаборатуар Сероно Са Азолидинонвинильные производные конденсированного бензола
EP1597255A1 (fr) * 2002-11-13 2005-11-23 Rigel Pharmaceuticals, Inc. Derives de rhodanine et compositions pharmaceutiques les contenant
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US20080255115A1 (en) * 2007-04-11 2008-10-16 Michael Gerard Darcy Thiazolidinedione derivatives as pi3 kinase inhibitors

Also Published As

Publication number Publication date
BRPI0710004A2 (pt) 2011-08-02
WO2007136940A2 (fr) 2007-11-29
US20090306074A1 (en) 2009-12-10
NO20084457L (no) 2009-01-07
CR10354A (es) 2008-10-29
AU2007253956A1 (en) 2007-11-29
MX2008013174A (es) 2008-10-21
CA2649224A1 (fr) 2007-11-29
JP2009533467A (ja) 2009-09-17
CL2007000995A1 (es) 2008-06-27
PE20080038A1 (es) 2008-02-22
IL194575A0 (en) 2009-08-03
TW200815429A (en) 2008-04-01
EP2004189A2 (fr) 2008-12-24
WO2007136940A3 (fr) 2008-12-04
EA200870426A1 (ru) 2009-04-28
AR060391A1 (es) 2008-06-11
KR20080108611A (ko) 2008-12-15
CN101466377A (zh) 2009-06-24

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