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MA30425B1 - ANTICORPS D'AFFINITE ELEVEE HUMAINS ET HUMANISES A FONCTION DE BLOCAGE ANTI-INTEGRINE a5ß1 AYANT UNE IMMUNOGENICITE REDUITE - Google Patents

ANTICORPS D'AFFINITE ELEVEE HUMAINS ET HUMANISES A FONCTION DE BLOCAGE ANTI-INTEGRINE a5ß1 AYANT UNE IMMUNOGENICITE REDUITE

Info

Publication number
MA30425B1
MA30425B1 MA31403A MA31403A MA30425B1 MA 30425 B1 MA30425 B1 MA 30425B1 MA 31403 A MA31403 A MA 31403A MA 31403 A MA31403 A MA 31403A MA 30425 B1 MA30425 B1 MA 30425B1
Authority
MA
Morocco
Prior art keywords
high affinity
human
antiintegrin
blockage
reduced immunogenicity
Prior art date
Application number
MA31403A
Other languages
English (en)
Inventor
Andreas Menrad
Joerg Willuda
Klaus Bosslet
Dieter Zopf
Heike Petrul
Stefan Steidl
Josef Prassler
Corinne Petit-Frere
Original Assignee
Bayer Schering Pharma Ag
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag, Morphosys Ag filed Critical Bayer Schering Pharma Ag
Publication of MA30425B1 publication Critical patent/MA30425B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES POLYPEPTIDES RECOMBINANTS HUMAINS OU HUMANISÉS QUI SE LIENT À L'INTÉGRINE A5ß1 AVEC UNE AFFINITÉ ÉLEVÉE ET QUI ONT UNE FONCTION DE BLOCAGE. L'INVENTION CONCERNE EN OUTRE DES APPLICATIONS DIAGNOSTIQUES ET PHARMACEUTIQUES DES POLYPEPTIDES
MA31403A 2006-05-24 2008-11-21 ANTICORPS D'AFFINITE ELEVEE HUMAINS ET HUMANISES A FONCTION DE BLOCAGE ANTI-INTEGRINE a5ß1 AYANT UNE IMMUNOGENICITE REDUITE MA30425B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06010779 2006-05-24

Publications (1)

Publication Number Publication Date
MA30425B1 true MA30425B1 (fr) 2009-05-04

Family

ID=38659612

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31403A MA30425B1 (fr) 2006-05-24 2008-11-21 ANTICORPS D'AFFINITE ELEVEE HUMAINS ET HUMANISES A FONCTION DE BLOCAGE ANTI-INTEGRINE a5ß1 AYANT UNE IMMUNOGENICITE REDUITE

Country Status (23)

Country Link
US (1) US20090081207A1 (fr)
EP (1) EP2032605A2 (fr)
JP (1) JP2009537158A (fr)
KR (1) KR20090027218A (fr)
CN (1) CN101495515A (fr)
AR (1) AR061107A1 (fr)
AU (1) AU2007253586A1 (fr)
BR (1) BRPI0711796A2 (fr)
CA (1) CA2652886A1 (fr)
CL (1) CL2007001488A1 (fr)
CR (1) CR10456A (fr)
DO (2) DOP20070101A (fr)
EA (1) EA200802348A1 (fr)
EC (1) ECSP088909A (fr)
MA (1) MA30425B1 (fr)
MX (1) MX2008014910A (fr)
NO (1) NO20085362L (fr)
PE (1) PE20080100A1 (fr)
TN (1) TNSN08469A1 (fr)
TW (1) TW200817433A (fr)
UY (1) UY30362A1 (fr)
WO (1) WO2007134876A2 (fr)
ZA (1) ZA200810850B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133250A2 (fr) 2005-10-31 2007-11-22 Austin Gurney Compositions et procédés de diagnostic et de traitement du cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
US20090220504A1 (en) 2006-03-21 2009-09-03 Anan Chuntharapai Combinatorial therapy
HRP20160308T1 (hr) 2007-09-26 2016-04-22 Genentech, Inc. Nova protutijela
EP2641612A1 (fr) * 2008-02-05 2013-09-25 Bristol-Myers Squibb Company Anticorps Alpha 5 - beta 1 et leurs utilisations
NZ592338A (en) 2008-09-26 2012-11-30 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
WO2010054212A1 (fr) * 2008-11-06 2010-05-14 Alexion Pharmaceuticals, Inc. Mise au point d’anticorps à immunogénicité réduite et méthodes de fabrication associées
WO2010072740A2 (fr) 2008-12-23 2010-07-01 Astrazeneca Ab Agents de liaison ciblés dirigés contre α5β1 et leurs applications
JP6051048B2 (ja) * 2009-03-25 2016-12-21 ジェネンテック， インコーポレイテッド 新規な抗α５β１抗体及びその使用
GB0918249D0 (en) 2009-10-19 2009-12-02 Respivert Ltd Compounds
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CA2794674A1 (fr) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Agents de liaison aux recepteurs frizzled et leurs utilisations
BR112013000452A2 (pt) * 2010-07-09 2020-02-11 Affibody Ab Polipeptídeo de ligação de albumina, proteína de fusão ou conjugado, polinucleotídeo, método para produzir um polipeptídeo, composição, método para a preparação de uma composição, e, método para aumentar a solubilidade de um composto
UY33337A (es) 2010-10-18 2011-10-31 Respivert Ltd DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS
EP2545905A1 (fr) 2011-07-11 2013-01-16 Britannia Pharmaceuticals Limited Nouvelle composition thérapeutique contenant de l'apomorphine en tant que principe actif
AU2013234081B2 (en) 2012-03-13 2017-02-02 Respivert Limited Crystalline PI3 kinase inhibitors
JP2015536933A (ja) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法
RU2681994C2 (ru) * 2012-12-26 2019-03-14 Онкосинерджи, Инк. КОМПОЗИЦИИ АНТИТЕЛА К ИНТЕГРИНУ β1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
ES2797901T3 (es) * 2015-06-28 2020-12-04 Allgenesis Biotherapeutics Inc Proteínas de fusión para la inhibición de angiogénesis
CN113557246B (zh) * 2019-07-24 2023-09-01 韩国基础科学支援研究院 靶向αvβ3整联蛋白的单域抗体
US11723955B1 (en) 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013495A (en) * 1994-10-21 2000-01-11 The Scripps Research Institute Methods of use for integrin B1C cell growth inhibitor
US6852318B1 (en) * 1998-05-08 2005-02-08 The Regents Of The University Of California Methods for detecting and inhibiting angiogenesis
US7285268B2 (en) * 2002-11-26 2007-10-23 Pdl Biopharma, Inc. Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
US7276589B2 (en) * 2002-11-26 2007-10-02 Pdl Biopharma, Inc. Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
RU2346701C2 (ru) * 2002-11-26 2009-02-20 ПиДиЭл БАЙОФАРМА ИНК. ХИМЕРНЫЕ И ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ ИНТЕГРИНА α5β1, КОТОРЫЕ МОДУЛИРУЮТ АНГИОГЕНЕЗ
KR20070009637A (ko) * 2004-03-24 2007-01-18 피디엘 바이오파르마 인코포레이티드 암 세포 증식을 억제하는 항α5β1 항체의 용도
US20090220504A1 (en) * 2006-03-21 2009-09-03 Anan Chuntharapai Combinatorial therapy

Also Published As

Publication number Publication date
UY30362A1 (es) 2008-01-02
DOP20070101A (es) 2007-12-30
AU2007253586A1 (en) 2007-11-29
JP2009537158A (ja) 2009-10-29
US20090081207A1 (en) 2009-03-26
TW200817433A (en) 2008-04-16
CA2652886A1 (fr) 2007-11-29
EP2032605A2 (fr) 2009-03-11
TNSN08469A1 (en) 2010-04-14
EA200802348A1 (ru) 2009-08-28
ZA200810850B (en) 2010-05-26
NO20085362L (no) 2009-02-23
BRPI0711796A2 (pt) 2011-12-06
KR20090027218A (ko) 2009-03-16
AR061107A1 (es) 2008-08-06
DOP2007000101A (es) 2007-12-31
CL2007001488A1 (es) 2008-01-04
CR10456A (es) 2009-02-26
WO2007134876A3 (fr) 2008-03-27
ECSP088909A (es) 2008-12-30
CN101495515A (zh) 2009-07-29
MX2008014910A (es) 2009-01-23
WO2007134876A2 (fr) 2007-11-29
PE20080100A1 (es) 2008-04-18
WO2007134876A8 (fr) 2009-07-02

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