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MA29984B1 - Antagonistes du recepteur de crf et procedes correspondants - Google Patents

Antagonistes du recepteur de crf et procedes correspondants

Info

Publication number
MA29984B1
MA29984B1 MA29147A MA29147A MA29984B1 MA 29984 B1 MA29984 B1 MA 29984B1 MA 29147 A MA29147 A MA 29147A MA 29147 A MA29147 A MA 29147A MA 29984 B1 MA29984 B1 MA 29984B1
Authority
MA
Morocco
Prior art keywords
crf receptor
receptor antagonists
methods
crf
pharmaceutically acceptable
Prior art date
Application number
MA29147A
Other languages
English (en)
Inventor
Zhiyong Luo
Deborah Slee
John Edward Tellew
John Williams
Xiaohu Zhang
Original Assignee
Neurocrine Biosciences Inc
Sb Pharmco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc, Sb Pharmco Inc filed Critical Neurocrine Biosciences Inc
Publication of MA29984B1 publication Critical patent/MA29984B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Antagonistes du récepteur de CRF et méthodes les concernant Il est décrit des antagonistes du récepteur de CRF qui sont utiles dans le traitement de diverses affections, comprenant le traitement d'affections se manifestant par une hypersécrétion de CRF chez des animaux à sang chaud, telles qu'un ictus. Les antagonistes du récepteur de CRF de la présente invention ont la structure (I) suivante, et comprennent leurs stéréoisomères, leurs précurseurs médicamenteux et leurs sels pharmaceutiquement acceptables, structure dans laquelle R1, R2, R3, Y, Ar et H et sont tels que définis dans le présent mémoire. Il est décrit également des compositions contenant un antagoniste du récepteur de CRF en association avec un support pharmaceutiquement acceptable, ainsi que des méthodes pour leur utilisation.
MA29147A 2003-12-22 2006-06-27 Antagonistes du recepteur de crf et procedes correspondants MA29984B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53203103P 2003-12-22 2003-12-22

Publications (1)

Publication Number Publication Date
MA29984B1 true MA29984B1 (fr) 2008-12-01

Family

ID=34738733

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29147A MA29984B1 (fr) 2003-12-22 2006-06-27 Antagonistes du recepteur de crf et procedes correspondants

Country Status (19)

Country Link
US (1) US7737154B2 (fr)
EP (1) EP1697374B1 (fr)
JP (1) JP4926720B2 (fr)
KR (1) KR20070009537A (fr)
CN (1) CN1938309B (fr)
AR (1) AR046967A1 (fr)
AU (1) AU2004309168B2 (fr)
BR (1) BRPI0417943A (fr)
CA (1) CA2550948A1 (fr)
IL (1) IL176350A0 (fr)
IS (1) IS8526A (fr)
MA (1) MA29984B1 (fr)
MY (1) MY143499A (fr)
NO (1) NO20063230L (fr)
NZ (1) NZ547990A (fr)
RU (1) RU2394035C2 (fr)
TW (1) TW200530242A (fr)
WO (1) WO2005063755A1 (fr)
ZA (1) ZA200604574B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
US8815599B2 (en) 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
JP2008517060A (ja) * 2004-10-19 2008-05-22 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド Ｃｒｆ受容体アンタゴニストおよびその製法
GB0519957D0 (en) 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
US8088779B2 (en) * 2005-09-30 2012-01-03 Smithkline Beecham (Cork) Limited Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists
AU2007297421B2 (en) 2006-09-20 2012-03-08 Eli Lilly And Company Thiazole pyrazolopyrimidines as CRF1 receptor antagonists
CA2662000C (fr) 2006-09-20 2013-01-08 Eli Lilly And Company Composes de thiophene pyrazolopyrimidine
KR100854679B1 (ko) * 2007-02-03 2008-08-27 김기형 심플 서비스 로케이션 프로토콜 네트워크 시스템 및 이를구성하는 에이전트.
EP2282998B1 (fr) * 2008-04-21 2014-09-10 Albemarle Corporation Procédés de production du n-alkylpyrazole
CN102753527B (zh) * 2010-02-02 2014-12-24 诺华股份有限公司 用作crf受体拮抗剂的环己基酰胺衍生物
WO2014060381A1 (fr) 2012-10-18 2014-04-24 Bayer Cropscience Ag Composés hétérocycliques pour la lutte contre les nuisibles
BR112015009751A2 (pt) 2012-10-31 2017-07-11 Bayer Cropscience Ag novos compostos heterocíclicos como pesticidas
US9856262B2 (en) * 2014-04-10 2018-01-02 Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. Analogues of 4H-pyrazolo[1,5-a] benzimidazole compound as PARP inhibitors
CN110996943A (zh) 2017-08-14 2020-04-10 云杉生物科学公司 促肾上腺皮质激素释放因子受体拮抗剂
KR20230092870A (ko) * 2020-07-27 2023-06-26 에스팜 바이오테크 피티와이 엘티디 화합물
KR20240023691A (ko) 2020-08-12 2024-02-22 스프루스 바이오사이언시스 인코포레이티드 다낭성 난소 증후군을 치료하기 위한 방법 및 조성물
US11708372B2 (en) 2021-11-19 2023-07-25 Spruce Biosciences, Inc. Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2168237T3 (es) * 1996-02-07 2007-04-01 Neurocrine Biosciences, Inc. Pirazolopirimidinas como antagonistas de receptores de crf.
PT915880E (pt) 1996-07-24 2007-12-31 Bristol Myers Squibb Pharma Co Azol triazinas e pirimidinas
US6060478A (en) 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6313124B1 (en) * 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
CN1227554A (zh) 1996-08-28 1999-09-01 辉瑞大药厂 取代的6,5－杂二环衍生物
CA2291709A1 (fr) * 1997-05-30 1998-12-03 Merck & Co., Inc. Nouveaux inhibiteurs d'angiogenese
ATE301657T1 (de) * 1998-01-28 2005-08-15 Bristol Myers Squibb Pharma Co Azolo-pyrimidine
WO2000059908A2 (fr) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines antagonistes de corticoliberine (crf)
CA2379633C (fr) 1999-09-30 2006-06-20 Neurogen Corporation Pyrazolo[1,5,-a]-1,5-pyrimidines et pyrazolo[1,5-a]-1,3,5-triazines amino substituees
CO5271670A1 (es) 1999-10-29 2003-04-30 Pfizer Prod Inc Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
MXPA03009938A (es) 2001-04-30 2005-09-07 Glaxo Group Ltd Pirimidinas fusionadas como antagonistas del factor liberador de corticotropina.
EP1395591B1 (fr) 2001-06-12 2008-06-04 Glaxo Group Limited Antagonistes du facteur de liberation de la corticotropine
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
ES2285409T3 (es) 2003-01-16 2007-11-16 Sb Pharmco Puerto Rico Inc Derivados pirrol(2,3-b)piridina sustituidos con heteroarilo como antagonistas del receptor de crf.
WO2004087707A1 (fr) 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Composes pyrazolopyrimidines et leur utilisation en medecine
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
US20070021429A1 (en) 2003-04-09 2007-01-25 Yves St-Denis Condensed n-heterocyclic compounds and their use as crf receptor antagonists
US20070293511A1 (en) 2003-12-22 2007-12-20 Sb Pharmco Puerto Rico Inc. And Neurocrine Biosciences, Inc., A Corporation Crf Receptor Antagonists and Methods
DE102004008807A1 (de) 2004-02-20 2005-09-08 Bayer Cropscience Ag Pyrazolopyrimidine
GB0519957D0 (en) 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
JP2008517060A (ja) 2004-10-19 2008-05-22 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド Ｃｒｆ受容体アンタゴニストおよびその製法
US8088779B2 (en) 2005-09-30 2012-01-03 Smithkline Beecham (Cork) Limited Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists

Also Published As

Publication number Publication date
CN1938309B (zh) 2011-11-09
RU2006126675A (ru) 2008-01-27
IS8526A (is) 2006-07-11
JP4926720B2 (ja) 2012-05-09
JP2007515472A (ja) 2007-06-14
RU2394035C2 (ru) 2010-07-10
BRPI0417943A (pt) 2007-04-17
EP1697374B1 (fr) 2012-08-29
AU2004309168B2 (en) 2009-04-23
WO2005063755A1 (fr) 2005-07-14
EP1697374A1 (fr) 2006-09-06
US7737154B2 (en) 2010-06-15
US20070287705A1 (en) 2007-12-13
AR046967A1 (es) 2006-01-04
CA2550948A1 (fr) 2005-07-14
TW200530242A (en) 2005-09-16
AU2004309168A1 (en) 2005-07-14
ZA200604574B (en) 2007-11-28
CN1938309A (zh) 2007-03-28
IL176350A0 (en) 2006-10-05
NZ547990A (en) 2010-04-30
KR20070009537A (ko) 2007-01-18
MY143499A (en) 2011-05-31
NO20063230L (no) 2006-09-12

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