[go: up one dir, main page]

TN2009000204A1 - Spirocetones servant d'inhibiteurs d'acetyl-coa-carboxylase - Google Patents

Spirocetones servant d'inhibiteurs d'acetyl-coa-carboxylase

Info

Publication number
TN2009000204A1
TN2009000204A1 TNP2009000204A TN2009000204A TN2009000204A1 TN 2009000204 A1 TN2009000204 A1 TN 2009000204A1 TN P2009000204 A TNP2009000204 A TN P2009000204A TN 2009000204 A TN2009000204 A TN 2009000204A TN 2009000204 A1 TN2009000204 A1 TN 2009000204A1
Authority
TN
Tunisia
Prior art keywords
spirocetones
carboxylase
coa
acetyl
inhibitors
Prior art date
Application number
TNP2009000204A
Other languages
English (en)
Inventor
Jeffrey Wayne Corbett
Richard Louis Elliott
Andrew Simon Bell
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TN2009000204A1 publication Critical patent/TN2009000204A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention propose des composés de formule (I) ou un sel pharmaceutiquement acceptable d'un tel composé, formule dans laquelle R1, R2, R3 R4, R5, R6, R7, R8 et R9 répondent aux définitions figurant dans le présent mémoire ; des compositions pharmaceutiques les contenant ; et leur utilisation dans le traitement de mammifères souffrant d'un état de surcharge pondérale.
TNP2009000204A 2006-11-29 2009-05-22 Spirocetones servant d'inhibiteurs d'acetyl-coa-carboxylase TN2009000204A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86177906P 2006-11-29 2006-11-29
PCT/IB2007/003639 WO2008065508A1 (fr) 2006-11-29 2007-11-16 Inhibiteurs de la spirocétoneacétyl-coa carboxylase

Publications (1)

Publication Number Publication Date
TN2009000204A1 true TN2009000204A1 (fr) 2010-10-18

Family

ID=39126209

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000204A TN2009000204A1 (fr) 2006-11-29 2009-05-22 Spirocetones servant d'inhibiteurs d'acetyl-coa-carboxylase

Country Status (23)

Country Link
US (1) US20090270435A1 (fr)
EP (1) EP2097420B1 (fr)
JP (1) JP2010511035A (fr)
KR (1) KR20090083956A (fr)
CN (1) CN101541809A (fr)
AP (1) AP2009004880A0 (fr)
AT (1) ATE552262T1 (fr)
AU (1) AU2007326950B2 (fr)
BR (1) BRPI0721053A2 (fr)
CA (1) CA2670422C (fr)
CO (1) CO6180424A2 (fr)
CR (1) CR10831A (fr)
EA (1) EA200900613A1 (fr)
EC (1) ECSP099371A (fr)
IL (1) IL198779A0 (fr)
MA (1) MA30932B1 (fr)
MX (1) MX2009005604A (fr)
NO (1) NO20091889L (fr)
RS (1) RS20090249A (fr)
SV (1) SV2009003281A (fr)
TN (1) TN2009000204A1 (fr)
WO (1) WO2008065508A1 (fr)
ZA (1) ZA200903268B (fr)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20081559A1 (es) * 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
JP5271917B2 (ja) * 2007-01-12 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション スピロクロマノン誘導体
CN100550853C (zh) * 2007-01-25 2009-10-14 华为技术有限公司 一种基于输出队列的流控实现方法及装置
DE102007028521A1 (de) * 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
ES2545231T3 (es) 2008-05-28 2015-09-09 Pfizer Inc. Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa
JP2011521940A (ja) * 2008-05-28 2011-07-28 ファイザー・インク ピラゾロスピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤
WO2010002010A1 (fr) * 2008-07-04 2010-01-07 Banyu Pharmaceutical Co.,Ltd. Nouveaux acides spirochromanone carboxyliques
US8110570B2 (en) 2008-07-14 2012-02-07 Cropsolution, Inc. Modulators of acetyl-coenzyme A carboxylase and methods of use thereof
DE102008038222A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh Indazol-5-carbonsäurehydrazid-derivate
EP2184276A1 (fr) 2008-11-07 2010-05-12 Universite Paul Cezanne Aix-Marseille Iii Procédé de préparation de nouvelles 1H-benzo(d) imidazol-2(3h)-ones substituées, de nouveaux intermédiaires et leur utilisation en tant qu'inhibiteurs de bace 1
EP2947082A1 (fr) * 2009-11-10 2015-11-25 Pfizer Inc INHIBITEURS DE N1-PYRAZOLOSPIROCÉTONE ACÉTYL-CoA CARBOXYLASE
WO2011058473A1 (fr) * 2009-11-10 2011-05-19 Pfizer Inc. Inhibiteurs de n2-pyrazolospirocétone acétyl-coa carboxylase
CA2792234C (fr) 2010-03-19 2014-05-27 Pfizer Inc. Derives de 2,3-dihydro-1h-inden-1-yl-2,7-diazaspiro[3.6]nonane et leur utilisation en tant qu'antagonistes ou agonistes inverses du recepteur de ghreline
WO2011140425A1 (fr) 2010-05-06 2011-11-10 Vertex Pharmaceuticals Incorporated Amides de chromène hétérocyclique-pipéridine spirocyclique utiles comme modulateurs des canaux ioniques
EP2582709B1 (fr) 2010-06-18 2018-01-24 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
HUE031616T2 (hu) 2010-09-30 2017-07-28 Pfizer N1-pirazol-spiroketon acetil-koenzim-A karboxiláz inhibítorok
AU2011322117B2 (en) 2010-10-29 2015-01-22 Pfizer Inc. N1/N2-lactam acetyl-CoA carboxylase inhibitors
PT2670752E (pt) 2011-02-02 2016-06-14 Vertex Pharma Piperidinamidas pirrolopirazina-espirocíclicas como moduladores de canais iónicos
CA2827311A1 (fr) * 2011-02-18 2012-08-23 Vertex Pharmaceuticals Incorporated Amides de piperidine spirocyclique chromanique en tant que modulateurs des canaux ioniques
CA2829803A1 (fr) 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Amides de piperidine spirocycliques morpholines utilises en tant que modulateurs de canaux ioniques
GEP20166474B (en) 2011-04-22 2016-05-10 Pfizer Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors
CN103702978B (zh) 2011-07-08 2018-03-06 拜耳知识产权有限责任公司 制备2‑氨基‑5‑氰基‑n,3‑二甲基苯甲酰胺的方法
CA2841757A1 (fr) 2011-07-15 2013-01-24 Etzer Darout Modulateurs de gpr 119
BR112014000288A2 (pt) 2011-07-22 2017-01-10 Pfizer moduladores do receptor de glucagon de quinolinila
ES2561105T3 (es) 2011-08-18 2016-02-24 Nippon Shinyaku Co., Ltd. Derivado heterocíclico como inhibidor de prostaglandina E sintasa microsómica (mPGES)
JP6043355B2 (ja) 2011-08-31 2016-12-14 ファイザー・インク ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
BR112014011254A2 (pt) 2011-11-11 2017-05-16 Pfizer 2-tiopirimidinonas
SG11201405477XA (en) 2012-04-06 2014-11-27 Pfizer Diacylglycerol acyltransferase 2 inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2852597B1 (fr) 2012-05-04 2016-06-08 Pfizer Inc Composés d'hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitués par des hétérocycliques à titre d'inhibiteurs d'app, bace1 et bace2
US9260455B2 (en) 2012-09-20 2016-02-16 Pfizer Inc. Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
EP2931731A1 (fr) 2012-12-11 2015-10-21 Pfizer Inc. Composés d'hexahydropyrano [3,4-d][1,3]thiazin-2-amine en tant qu'inhibiteurs de bace1
US9403846B2 (en) 2012-12-19 2016-08-02 Pfizer Inc. Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
EP2956458B1 (fr) 2013-02-13 2017-08-09 Pfizer Inc Composés hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitués par un hétéroaryle
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
ES2665153T3 (es) 2013-10-09 2018-04-24 Pfizer Inc. Antagonistas del receptor EP3 de prostaglandina
PE20161368A1 (es) 2014-03-17 2016-12-25 Pfizer Inhibidores de diacilglicerol aciltranferasa 2
ME03599B (fr) 2014-04-04 2020-07-20 Pfizer Composés bicycliques hétéroaryle ou aryle fusionnés et leur utilisation en tant qu'inhibiteurs irak4
CR20160455A (es) 2014-04-10 2016-12-16 Pfizer 2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4-d][1,3]TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILA
WO2016092413A1 (fr) 2014-12-10 2016-06-16 Pfizer Inc. Composés indoliques et indazoliques qui activent l'ampk
JP2017538769A (ja) 2014-12-22 2017-12-28 ファイザー・インク プロスタグランジンｅｐ３受容体の拮抗薬
AU2016257179A1 (en) 2015-05-05 2017-11-02 Pfizer Inc. 2-thiopyrimidinones
WO2016193844A1 (fr) 2015-05-29 2016-12-08 Pfizer Inc. Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de l'enzyme vanine-1
CR20170572A (es) 2015-06-17 2018-03-20 Pfizer Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa
WO2016203335A1 (fr) 2015-06-18 2016-12-22 Pfizer Inc. Nouvelles pyrido [2,3-b] pyrazinones utilisées en tant qu'inhibiteurs de bromodomaines de la famille bet
WO2017025849A1 (fr) 2015-08-13 2017-02-16 Pfizer Inc. Composés aryle ou hétéroaryle condensés bicycliques
AU2016311376B2 (en) 2015-08-27 2018-10-04 Pfizer Inc. Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
WO2017037567A1 (fr) 2015-09-03 2017-03-09 Pfizer Inc. Régulateurs de la frataxine
WO2017051303A1 (fr) 2015-09-24 2017-03-30 Pfizer Inc. Dérivés de tétrahydropyrano[3,4-d] [1,3]oxazine et leur utilisation en tant qu'inhibiteurs de bace
WO2017051276A1 (fr) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(2-amino-6,6-disubstitués-4,4a,5,6-tétrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl)-1,3-thiazol-4-yl]amides
WO2017051294A1 (fr) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-diméthyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides utiles comme inhibiteurs de bace
ES2871251T3 (es) 2015-12-29 2021-10-28 Pfizer 3-Azabiciclo[3.1.0]Hexanos sustituidos como inhibidores de la cetohexocinasa
CA3030381A1 (fr) 2016-07-14 2018-01-18 Pfizer Inc. Pyrimidine carboxamides utilisees comme inhibiteurs de l'enzyme vanin-1
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
WO2019133445A1 (fr) 2017-12-28 2019-07-04 Inception Ibd, Inc. Aminothiazoles utilisés en tant qu'inhibiteurs de vanin-1
CN108658938B (zh) * 2018-06-15 2021-03-23 上海现代制药股份有限公司 一种甲磺酸达比加群酯工艺杂质的合成方法
CN108774242B (zh) * 2018-08-22 2020-10-27 牡丹江医学院 一种防治冠心病的药物及其制备方法
MX2021002428A (es) 2018-08-31 2023-01-02 Pfizer Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas.
CN109400618B (zh) * 2018-11-09 2021-08-10 中国药科大学 一种色满衍生物及其制备方法和应用
WO2020102575A1 (fr) 2018-11-16 2020-05-22 Inception Ibd, Inc. Aminothiazoles hétérocycliques et leurs utilisations
CN109809992A (zh) * 2019-02-16 2019-05-28 安徽华胜医药科技有限公司 一种2-（2-氟-3-甲氧基苯基）-2-羟基乙酸乙酯的合成方法
ES3039586T3 (en) 2019-05-20 2025-10-22 Pfizer Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
CN110128347A (zh) * 2019-06-17 2019-08-16 韶远科技（上海)有限公司 一种1-甲基-1h-吲唑-6-甲酸的合成方法
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
MA58498B1 (fr) 2020-02-07 2024-08-30 Gasherbrum Bio, Inc. Agonistes hétérocycliques de glp-1
CN114437096B (zh) * 2020-11-06 2025-09-12 上海医药集团股份有限公司 一种螺杂环类化合物、其制备方法及应用
WO2023169456A1 (fr) 2022-03-09 2023-09-14 Gasherbrum Bio , Inc. Agonistes hétérocycliques de glp-1
US20250250269A1 (en) 2022-04-14 2025-08-07 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2024118524A1 (fr) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Composés d'azaindole et leur utilisation en tant qu'inhibiteurs de phosphodiestérase
WO2024125602A1 (fr) 2022-12-15 2024-06-20 Gasherbrum Bio, Inc. Sels et formes solides d'un composé ayant une activité agoniste de glp-1
WO2025036472A1 (fr) * 2023-08-16 2025-02-20 Pharmaengine, Inc. Inhibiteur de prmt5 mta-coopératif spirocyclique
WO2025133948A1 (fr) * 2023-12-21 2025-06-26 Pfizer Inc. Inhibiteurs de l'acétyl coa-carboxylase (acc)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
JP2001516330A (ja) * 1995-06-06 2001-09-25 メルク エンド カンパニー インコーポレーテッド アルファ１ａアドレナリンレセプターアンタゴニスト
AU2001289831A1 (en) * 2000-09-06 2002-03-22 Bayer Aktiengesellschaft Medicaments against viral infections
JPWO2004092179A1 (ja) * 2003-04-14 2006-07-06 日本曹達株式会社 スピロ誘導体、製造法および抗酸化薬
JP2005119987A (ja) * 2003-10-15 2005-05-12 Ajinomoto Co Inc アシルスルホンアミド誘導体
WO2006040329A1 (fr) * 2004-10-12 2006-04-20 Novo Nordisk A/S Composes spiro actifs du type a- hydroxysteroide deshydrogenase de type 1
JP2008540395A (ja) * 2005-05-03 2008-11-20 ファイザー・インク アミドレソルシノール化合物
MX2008000966A (es) * 2005-07-19 2008-03-26 Merck & Co Inc Nuevos derivados de espirocromanona.

Also Published As

Publication number Publication date
RS20090249A (sr) 2010-06-30
CO6180424A2 (es) 2010-07-19
EP2097420A1 (fr) 2009-09-09
AU2007326950B2 (en) 2010-10-14
CN101541809A (zh) 2009-09-23
KR20090083956A (ko) 2009-08-04
CA2670422C (fr) 2011-09-06
AU2007326950A1 (en) 2008-06-05
SV2009003281A (es) 2010-08-17
CA2670422A1 (fr) 2008-06-05
EA200900613A1 (ru) 2009-10-30
MA30932B1 (fr) 2009-11-02
ATE552262T1 (de) 2012-04-15
IL198779A0 (en) 2010-02-17
EP2097420B1 (fr) 2012-04-04
NO20091889L (no) 2009-06-17
ECSP099371A (es) 2009-06-30
CR10831A (es) 2009-06-18
ZA200903268B (en) 2010-07-28
MX2009005604A (es) 2009-06-08
BRPI0721053A2 (pt) 2014-07-29
US20090270435A1 (en) 2009-10-29
AP2009004880A0 (en) 2009-06-30
WO2008065508A1 (fr) 2008-06-05
JP2010511035A (ja) 2010-04-08

Similar Documents

Publication Publication Date Title
TN2009000204A1 (fr) Spirocetones servant d'inhibiteurs d'acetyl-coa-carboxylase
TNSN08139A1 (fr) Composes therapeutiques
MA33832B1 (fr) Isoquinolinones et quinazolinones substituées
MA31419B1 (fr) Derives de pyridine
MA31963B1 (fr) Composes antagonistes du recepteur du glucagon, compositions contenant de tels composes et procedes d'utilisation
MA29672B1 (fr) [3.1.0] hétéroarylamides bicycliques servant d'inhibiteurs du transport de glycine de type I
MA49952B1 (fr) Dérivés de 3-(1-oxoisoindolin-2-yl)pipéridine-2,6-dione et leurs utilisations
MA31761B1 (fr) Nouveaux inhibiteurs de seh et leur utilisation
MA32171B1 (fr) Compose heterocyclique
TNSN07275A1 (fr) Derives de triazole substitues, servant d'antagonistes d'ocytocine
MA30539B1 (fr) Derives de piperazinyle utiles dans le traitement de maladies induites par le recepteur gpr38.
TNSN06109A1 (fr) Derives [3.1.0] bicycliques servant d'inhibiteurs du transporteur de glycine
TNSN08337A1 (fr) Piperidinoylpyrrolidines agonistes du recepteur de melanocortine de type 4
MA30232B1 (fr) Inhibiteurs de kinase bases sur l'hydantoine
MA27438A1 (fr) Piperazines heterocycliques substituees pour le traitement de la schizophrenie
NO20083207L (no) Inhibitorer av IAP
TNSN07022A1 (fr) Derives de pyridine
MA30911B1 (fr) Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine
MA27801A1 (fr) Nouveaux composes heterocycliques pour le traitement des affections inflammatoires et allergiques, leur procede de preparation et compositions pharmaceutiques les contenant
MA30999B1 (fr) Composés.
TNSN08137A1 (fr) Derives de carboxamides servant d'antagonistes des recepteurs muscariniques
EP1605936A4 (fr) Antagonistes du recepteur cgrp d'aryl spirohydantoine
MA28432B1 (fr) Antagonistes du recepteur de la chimiokine
PL1716152T3 (pl) Skondensowane związki heterocykliczne i ich zastosowanie jako antagonistów receptora metabotropowego do leczenia zaburzeń żołądkowo-jelitowych
MA30351B1 (fr) Composes de tetrahydropyridothienopyrimidine et leurs procedes d'utilisation