MA29634B1 - Heterocycles condenses avec la 1,4-dihydropyridine, procede pour preparer ceux-ci, utilisation et compositions contenant ceux-ci - Google Patents
Heterocycles condenses avec la 1,4-dihydropyridine, procede pour preparer ceux-ci, utilisation et compositions contenant ceux-ciInfo
- Publication number
- MA29634B1 MA29634B1 MA30580A MA30580A MA29634B1 MA 29634 B1 MA29634 B1 MA 29634B1 MA 30580 A MA30580 A MA 30580A MA 30580 A MA30580 A MA 30580A MA 29634 B1 MA29634 B1 MA 29634B1
- Authority
- MA
- Morocco
- Prior art keywords
- same
- dihydropyridine
- preparing
- compositions containing
- heterocycles
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La présente invention concerne des hétérocycles condensés avec la 1,4-dihydropyridine, un procédé pour préparer ceux-ci, l'utilisation et des compositions contenant ceux-ci. L'invention concerne des hétérocycles condensés avec la dihydropyridine substitués utiles pour le traitement d'une maladie cancéreuse, en particulier pour empêcher des cellules cancéreuses de se diviser. Ces composés agissent en tant qu'inhibiteurs des kinases Aurora A et/ou B.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05291558A EP1746097B1 (fr) | 2005-07-20 | 2005-07-20 | Héterocyles à fusion1,4-dihydropyridineprocédé de préparation, utilisation et compositions de celles-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA29634B1 true MA29634B1 (fr) | 2008-07-01 |
Family
ID=35510894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA30580A MA29634B1 (fr) | 2005-07-20 | 2008-01-16 | Heterocycles condenses avec la 1,4-dihydropyridine, procede pour preparer ceux-ci, utilisation et compositions contenant ceux-ci |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8163768B2 (fr) |
| EP (2) | EP1746097B1 (fr) |
| JP (2) | JP2009501778A (fr) |
| KR (1) | KR101286796B1 (fr) |
| CN (1) | CN101243087B (fr) |
| AR (1) | AR054845A1 (fr) |
| AT (2) | ATE455115T1 (fr) |
| AU (1) | AU2006273692B8 (fr) |
| BR (1) | BRPI0614002A2 (fr) |
| CA (1) | CA2615700C (fr) |
| CR (1) | CR9663A (fr) |
| CY (1) | CY1109964T1 (fr) |
| DE (1) | DE602005018911D1 (fr) |
| DK (1) | DK1746097T3 (fr) |
| DO (1) | DOP2006000175A (fr) |
| EA (1) | EA016815B1 (fr) |
| EC (1) | ECSP078062A (fr) |
| ES (1) | ES2339676T3 (fr) |
| HN (1) | HN2008000088A (fr) |
| HR (1) | HRP20100195T1 (fr) |
| IL (1) | IL188861A0 (fr) |
| MA (1) | MA29634B1 (fr) |
| MX (1) | MX2008000902A (fr) |
| MY (1) | MY148617A (fr) |
| NO (1) | NO20080831L (fr) |
| NZ (1) | NZ592766A (fr) |
| PE (2) | PE20100718A1 (fr) |
| PL (1) | PL1746097T3 (fr) |
| PT (1) | PT1746097E (fr) |
| RS (1) | RS51351B (fr) |
| SI (1) | SI1746097T1 (fr) |
| TN (1) | TNSN08020A1 (fr) |
| TW (1) | TWI386411B (fr) |
| UA (1) | UA98928C2 (fr) |
| UY (1) | UY29685A1 (fr) |
| WO (1) | WO2007012972A2 (fr) |
| ZA (1) | ZA200800542B (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2945535B1 (fr) * | 2009-05-18 | 2011-06-10 | Sanofi Aventis | Compose anticancereux et composition pharmaceutique le contenant |
| FR2967413A1 (fr) * | 2010-11-17 | 2012-05-18 | Sanofi Aventis | Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora. |
| TR201807023T4 (tr) | 2012-05-15 | 2018-06-21 | Novartis Ag | Abl1, abl2 ve bcr- abl1 aktivitesinin inhibe edilmesi için benzamid türevleri. |
| EP2861576B1 (fr) | 2012-05-15 | 2018-01-10 | Novartis AG | Dérivés de benzamide pour inhiber l'activité d'abl1, d'abl2 et de bcr-abl2 |
| EP2858988B1 (fr) | 2012-05-15 | 2018-02-28 | Novartis AG | Dérivés de benzamide pour inhiber l'activité d'abl1, d'abl2 et de bcr-abl2 |
| KR102190848B1 (ko) | 2012-05-15 | 2020-12-15 | 노파르티스 아게 | Abl1, abl2 및 bcr-abl1의 활성을 억제하기 위한 화합물 및 조성물 |
| CA2887701C (fr) | 2012-10-12 | 2020-12-15 | The Broad Institute, Inc. | Inhibiteurs de gsk3 et leurs procedes d'utilisation |
| AU2015360416A1 (en) | 2014-12-10 | 2017-06-08 | Massachusetts Institute Of Technology | Fused 1,3-azole derivatives useful for the treatment of proliferative diseases |
| CA2983314C (fr) | 2015-04-30 | 2024-11-12 | Memorial Sloan-Kettering Cancer Center | Analogues de la mitragynine et leurs utilisations |
| RU2619932C1 (ru) * | 2015-11-25 | 2017-05-22 | федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ |
| WO2017124087A1 (fr) | 2016-01-15 | 2017-07-20 | Memorial Sloan-Kettering Cancer Center | Composés antiparasitaires et leurs utilisations |
| CA3012846A1 (fr) | 2016-02-16 | 2017-08-24 | Massachusetts Institute Of Technology | Liants de max comme modulateurs de myc et leurs utilisations |
| CA3058198A1 (fr) | 2017-04-05 | 2018-10-11 | The Broad Institute, Inc. | Composes tricycliques en tant qu'inhibiteurs de glycogene synthase kinase 3 (gsk3) et leurs utilisations |
| WO2018209030A1 (fr) | 2017-05-12 | 2018-11-15 | Rti International | Diarylurées en tant que modulateurs allostériques de cb1 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002508324A (ja) * | 1997-12-13 | 2002-03-19 | ブリストル−マイヤーズ スクイブ カンパニー | サイクリン依存性キナーゼ阻害剤としてのピラゾロ［３，４−ｂ］ピリジンの使用 |
| JP2003529552A (ja) | 1999-11-19 | 2003-10-07 | アボット・ラボラトリーズ | 三環性ジヒドロピリミジンカリウムチャンネル開口剤 |
| US6538004B2 (en) | 2000-03-03 | 2003-03-25 | Abbott Laboratories | Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers |
| EP1259510B1 (fr) | 2000-03-03 | 2004-06-02 | Abbott Laboratories | Agents ouvrant les canaux potassium a base de dihydropyrazolone tricyclique et de dihydroisoxazolone tricyclique |
| CN1630656A (zh) | 2001-02-02 | 2005-06-22 | 三菱制药株式会社 | 二氢吡唑并吡啶化合物及其制药用途 |
| FR2823854A1 (fr) | 2001-04-18 | 2002-10-25 | Centre Nat Rech Scient | Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale |
| FR2825091B1 (fr) * | 2001-05-23 | 2003-07-04 | Servier Lab | Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7037902B2 (en) * | 2002-07-03 | 2006-05-02 | Receptron, Inc. | Affinity small molecules for the EPO receptor |
| SE0301371D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | New Compounds |
| BRPI0411364A (pt) * | 2003-06-13 | 2006-07-25 | Zentaris Gmbh | compostos tendo atividade inibidora de fosfatidilinositol 3-cinase e métodos de uso dos mesmos |
-
2005
- 2005-07-20 ES ES05291558T patent/ES2339676T3/es not_active Expired - Lifetime
- 2005-07-20 SI SI200530964T patent/SI1746097T1/sl unknown
- 2005-07-20 DE DE602005018911T patent/DE602005018911D1/de not_active Expired - Lifetime
- 2005-07-20 RS RSP-2010/0159A patent/RS51351B/sr unknown
- 2005-07-20 EP EP05291558A patent/EP1746097B1/fr not_active Expired - Lifetime
- 2005-07-20 AT AT05291558T patent/ATE455115T1/de active
- 2005-07-20 PL PL05291558T patent/PL1746097T3/pl unknown
- 2005-07-20 DK DK05291558.4T patent/DK1746097T3/da active
- 2005-07-20 PT PT05291558T patent/PT1746097E/pt unknown
-
2006
- 2006-07-18 WO PCT/IB2006/002734 patent/WO2007012972A2/fr not_active Ceased
- 2006-07-18 PE PE2010000153A patent/PE20100718A1/es not_active Application Discontinuation
- 2006-07-18 PE PE2006000862A patent/PE20070212A1/es not_active Application Discontinuation
- 2006-07-18 ZA ZA200800542A patent/ZA200800542B/xx unknown
- 2006-07-18 AR ARP060103065A patent/AR054845A1/es not_active Application Discontinuation
- 2006-07-18 EP EP06808922A patent/EP1910366B1/fr active Active
- 2006-07-18 EA EA200800374A patent/EA016815B1/ru not_active IP Right Cessation
- 2006-07-18 MY MYPI20063429A patent/MY148617A/en unknown
- 2006-07-18 CN CN2006800303826A patent/CN101243087B/zh not_active Expired - Fee Related
- 2006-07-18 KR KR1020087003945A patent/KR101286796B1/ko not_active Expired - Fee Related
- 2006-07-18 AT AT06808922T patent/ATE521611T1/de not_active IP Right Cessation
- 2006-07-18 AU AU2006273692A patent/AU2006273692B8/en not_active Ceased
- 2006-07-18 JP JP2008522098A patent/JP2009501778A/ja not_active Withdrawn
- 2006-07-18 UA UAA200802146A patent/UA98928C2/ru unknown
- 2006-07-18 BR BRPI0614002-5A patent/BRPI0614002A2/pt not_active IP Right Cessation
- 2006-07-18 NZ NZ592766A patent/NZ592766A/xx not_active IP Right Cessation
- 2006-07-18 MX MX2008000902A patent/MX2008000902A/es active IP Right Grant
- 2006-07-18 CA CA2615700A patent/CA2615700C/fr not_active Expired - Fee Related
- 2006-07-19 TW TW095126453A patent/TWI386411B/zh not_active IP Right Cessation
- 2006-07-20 DO DO2006000175A patent/DOP2006000175A/es unknown
- 2006-07-20 UY UY29685A patent/UY29685A1/es unknown
-
2007
- 2007-12-27 EC EC2007008062A patent/ECSP078062A/es unknown
-
2008
- 2008-01-15 US US12/014,516 patent/US8163768B2/en active Active
- 2008-01-15 CR CR9663A patent/CR9663A/es unknown
- 2008-01-16 MA MA30580A patent/MA29634B1/fr unknown
- 2008-01-17 IL IL188861A patent/IL188861A0/en unknown
- 2008-01-18 TN TNP2008000020A patent/TNSN08020A1/en unknown
- 2008-01-21 HN HN2008000088A patent/HN2008000088A/es unknown
- 2008-02-15 NO NO20080831A patent/NO20080831L/no not_active Application Discontinuation
-
2010
- 2010-04-07 HR HR20100195T patent/HRP20100195T1/hr unknown
- 2010-04-09 CY CY20101100327T patent/CY1109964T1/el unknown
-
2012
- 2012-11-05 JP JP2012243375A patent/JP2013063987A/ja not_active Withdrawn
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