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MX2008000902A - Heterociclos de 1,4-dihidropiridina-condensados, proceso para preparar los mismos, uso y composiciones que los contienen. - Google Patents

Heterociclos de 1,4-dihidropiridina-condensados, proceso para preparar los mismos, uso y composiciones que los contienen.

Info

Publication number
MX2008000902A
MX2008000902A MX2008000902A MX2008000902A MX2008000902A MX 2008000902 A MX2008000902 A MX 2008000902A MX 2008000902 A MX2008000902 A MX 2008000902A MX 2008000902 A MX2008000902 A MX 2008000902A MX 2008000902 A MX2008000902 A MX 2008000902A
Authority
MX
Mexico
Prior art keywords
dihydropyridine
preparing
same
compositions containing
fused heterocycles
Prior art date
Application number
MX2008000902A
Other languages
English (en)
Inventor
Serge Mignani
Francois Clerc
Herve Minoux
Bruno Filoche-Romme
Cecile Combeau
Odile Angouillant-Boniface
Jacques Mauger
Jean-Christophe Carry
Anil Nair
Nina Ma
Kirsten Bjergarde
Laurent Schio
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of MX2008000902A publication Critical patent/MX2008000902A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Heterociclos de 1,4-dihidropiridina-condensados, proceso para preparacion de los mismos, uso y composiciones que los contienen. La invencion es acerca de heterociclos dihidropiridina-condensados sustituidos utiles para el tratamiento de la enfermedad del cancer, especialmente para prevenir que las celulas cancerigenas se dividan. Estos compuestos actuan como inhibidores de las quinasas Aurora A y/o B. Formula (I).
MX2008000902A 2005-07-20 2006-07-18 Heterociclos de 1,4-dihidropiridina-condensados, proceso para preparar los mismos, uso y composiciones que los contienen. MX2008000902A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05291558A EP1746097B1 (en) 2005-07-20 2005-07-20 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them
PCT/IB2006/002734 WO2007012972A2 (en) 2005-07-20 2006-07-18 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

Publications (1)

Publication Number Publication Date
MX2008000902A true MX2008000902A (es) 2008-03-26

Family

ID=35510894

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008000902A MX2008000902A (es) 2005-07-20 2006-07-18 Heterociclos de 1,4-dihidropiridina-condensados, proceso para preparar los mismos, uso y composiciones que los contienen.

Country Status (37)

Country Link
US (1) US8163768B2 (es)
EP (2) EP1746097B1 (es)
JP (2) JP2009501778A (es)
KR (1) KR101286796B1 (es)
CN (1) CN101243087B (es)
AR (1) AR054845A1 (es)
AT (2) ATE455115T1 (es)
AU (1) AU2006273692B8 (es)
BR (1) BRPI0614002A2 (es)
CA (1) CA2615700C (es)
CR (1) CR9663A (es)
CY (1) CY1109964T1 (es)
DE (1) DE602005018911D1 (es)
DK (1) DK1746097T3 (es)
DO (1) DOP2006000175A (es)
EA (1) EA016815B1 (es)
EC (1) ECSP078062A (es)
ES (1) ES2339676T3 (es)
HN (1) HN2008000088A (es)
HR (1) HRP20100195T1 (es)
IL (1) IL188861A0 (es)
MA (1) MA29634B1 (es)
MX (1) MX2008000902A (es)
MY (1) MY148617A (es)
NO (1) NO20080831L (es)
NZ (1) NZ592766A (es)
PE (2) PE20100718A1 (es)
PL (1) PL1746097T3 (es)
PT (1) PT1746097E (es)
RS (1) RS51351B (es)
SI (1) SI1746097T1 (es)
TN (1) TNSN08020A1 (es)
TW (1) TWI386411B (es)
UA (1) UA98928C2 (es)
UY (1) UY29685A1 (es)
WO (1) WO2007012972A2 (es)
ZA (1) ZA200800542B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945535B1 (fr) * 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) * 2010-11-17 2012-05-18 Sanofi Aventis Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
TR201807023T4 (tr) 2012-05-15 2018-06-21 Novartis Ag Abl1, abl2 ve bcr- abl1 aktivitesinin inhibe edilmesi için benzamid türevleri.
EP2861576B1 (en) 2012-05-15 2018-01-10 Novartis AG Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
EP2858988B1 (en) 2012-05-15 2018-02-28 Novartis AG Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
KR102190848B1 (ko) 2012-05-15 2020-12-15 노파르티스 아게 Abl1, abl2 및 bcr-abl1의 활성을 억제하기 위한 화합물 및 조성물
CA2887701C (en) 2012-10-12 2020-12-15 The Broad Institute, Inc. Gsk3 inhibitors and methods of use thereof
AU2015360416A1 (en) 2014-12-10 2017-06-08 Massachusetts Institute Of Technology Fused 1,3-azole derivatives useful for the treatment of proliferative diseases
CA2983314C (en) 2015-04-30 2024-11-12 Memorial Sloan-Kettering Cancer Center Mitragynine analogues and their uses
RU2619932C1 (ru) * 2015-11-25 2017-05-22 федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
WO2017124087A1 (en) 2016-01-15 2017-07-20 Memorial Sloan-Kettering Cancer Center Anti-parasitic compounds and uses thereof
CA3012846A1 (en) 2016-02-16 2017-08-24 Massachusetts Institute Of Technology Max binders as myc modulators and uses thereof
CA3058198A1 (en) 2017-04-05 2018-10-11 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof
WO2018209030A1 (en) 2017-05-12 2018-11-15 Rti International Diarylureas as cb1 allosteric modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508324A (ja) * 1997-12-13 2002-03-19 ブリストル−マイヤーズ スクイブ カンパニー サイクリン依存性キナーゼ阻害剤としてのピラゾロ［３，４−ｂ］ピリジンの使用
JP2003529552A (ja) 1999-11-19 2003-10-07 アボット・ラボラトリーズ 三環性ジヒドロピリミジンカリウムチャンネル開口剤
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
EP1259510B1 (en) 2000-03-03 2004-06-02 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
CN1630656A (zh) 2001-02-02 2005-06-22 三菱制药株式会社 二氢吡唑并吡啶化合物及其制药用途
FR2823854A1 (fr) 2001-04-18 2002-10-25 Centre Nat Rech Scient Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale
FR2825091B1 (fr) * 2001-05-23 2003-07-04 Servier Lab Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
SE0301371D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab New Compounds
BRPI0411364A (pt) * 2003-06-13 2006-07-25 Zentaris Gmbh compostos tendo atividade inibidora de fosfatidilinositol 3-cinase e métodos de uso dos mesmos

Also Published As

Publication number Publication date
EA016815B1 (ru) 2012-07-30
BRPI0614002A2 (pt) 2011-03-01
ATE521611T1 (de) 2011-09-15
TWI386411B (zh) 2013-02-21
US20080261969A1 (en) 2008-10-23
UA98928C2 (ru) 2012-07-10
CR9663A (es) 2008-02-21
DK1746097T3 (da) 2010-05-25
HN2008000088A (es) 2011-05-31
EP1746097B1 (en) 2010-01-13
CN101243087B (zh) 2013-07-24
TNSN08020A1 (en) 2009-07-14
IL188861A0 (en) 2008-04-13
ATE455115T1 (de) 2010-01-15
EP1746097A1 (en) 2007-01-24
AU2006273692B2 (en) 2012-11-22
KR20080026658A (ko) 2008-03-25
CA2615700C (en) 2013-06-18
CY1109964T1 (el) 2014-09-10
NO20080831L (no) 2008-04-03
ECSP078062A (es) 2008-01-23
HRP20100195T1 (hr) 2010-05-31
CN101243087A (zh) 2008-08-13
PL1746097T3 (pl) 2010-06-30
PE20070212A1 (es) 2007-03-21
SI1746097T1 (sl) 2010-05-31
JP2009501778A (ja) 2009-01-22
US8163768B2 (en) 2012-04-24
TW200740812A (en) 2007-11-01
RS51351B (sr) 2011-02-28
EA200800374A1 (ru) 2008-08-29
UY29685A1 (es) 2007-02-28
AU2006273692A8 (en) 2012-12-13
AU2006273692A1 (en) 2007-02-01
AU2006273692B8 (en) 2012-12-13
MA29634B1 (fr) 2008-07-01
PT1746097E (pt) 2010-04-15
MY148617A (en) 2013-05-15
NZ592766A (en) 2012-12-21
JP2013063987A (ja) 2013-04-11
EP1910366B1 (en) 2011-08-24
ES2339676T3 (es) 2010-05-24
ZA200800542B (en) 2010-02-24
WO2007012972A2 (en) 2007-02-01
KR101286796B1 (ko) 2013-07-17
CA2615700A1 (en) 2007-02-01
AR054845A1 (es) 2007-07-18
PE20100718A1 (es) 2010-10-20
WO2007012972A3 (en) 2007-04-05
DE602005018911D1 (de) 2010-03-04
EP1910366A2 (en) 2008-04-16
DOP2006000175A (es) 2007-03-31

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