MA28602B1 - Pyridin-4-yl-ethynyl-imidazoles et pyrazoles en tant qu'antagonistes des recepteurs mglur5 - Google Patents

Pyridin-4-yl-ethynyl-imidazoles et pyrazoles en tant qu'antagonistes des recepteurs mglur5

Info

Publication number: MA28602B1
Authority: MA; Morocco
Prior art keywords: pyrazoles; imidazoles; ethynyl; pyridin; receptor antagonists
Prior art date: 2004-06-01

Application number

MA29482A

Other languages

English (en)

Inventor

Paul Spurr

Buettelmann Bernd

Maria Ceccarelli Simona

Jaeschke Georg

Kolczewski Sabine

Hugh Philip Porter Richard

Vieira Eric

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-01

Filing date

2006-11-22

Publication date

2007-05-02

2004-06-01 Priority claimed from PCT/EP2004/005881 external-priority patent/WO2004108701A1/fr

2006-11-22 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-05-02 Publication of MA28602B1 publication Critical patent/MA28602B1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

MA29482A 2004-06-01 2006-11-22 Pyridin-4-yl-ethynyl-imidazoles et pyrazoles en tant qu'antagonistes des recepteurs mglur5 MA28602B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/EP2004/005881 WO2004108701A1 (fr)	2003-06-05	2004-06-01	Derives d'imidazole utilises comme antagonistes du recepteur du glutamate
EP04021216		2004-09-07

Publications (1)

Publication Number	Publication Date
MA28602B1 true MA28602B1 (fr)	2007-05-02

Family

ID=35758209

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA29482A MA28602B1 (fr)	2004-06-01	2006-11-22	Pyridin-4-yl-ethynyl-imidazoles et pyrazoles en tant qu'antagonistes des recepteurs mglur5

Country Status (18)

Country	Link
US (2)	US20060030559A1 (fr)
JP (1)	JP4690395B2 (fr)
KR (2)	KR101057032B1 (fr)
AR (1)	AR054072A1 (fr)
BR (1)	BRPI0511678A (fr)
CR (1)	CR8742A (fr)
CY (1)	CY1108232T1 (fr)
DK (1)	DK1756086T3 (fr)
EA (1)	EA011722B1 (fr)
EC (1)	ECSP067039A (fr)
ES (1)	ES2307182T3 (fr)
HR (1)	HRP20080363T3 (fr)
IL (1)	IL179524A (fr)
MA (1)	MA28602B1 (fr)
NZ (1)	NZ551253A (fr)
PT (1)	PT1756086E (fr)
SI (1)	SI1756086T1 (fr)
TW (1)	TWI297683B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8329703B2 (en) *	2005-02-15	2012-12-11	Xtl Biopharmaceuticals Ltd.	Pyrazole compounds
US8334287B2 (en) *	2009-07-17	2012-12-18	Hoffmann-La Roche Inc.	Imidazoles
US20120040008A1 (en) *	2010-08-11	2012-02-16	Ashish Chatterji	Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20120039999A1 (en)	2010-08-11	2012-02-16	Ashish Chatterji	Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
EP3279216A4 (fr)	2015-04-01	2019-06-19	Chugai Seiyaku Kabushiki Kaisha	Procédé pour la production d'un hétéro-oligomère polypeptidique
US10941132B2 (en)	2016-01-05	2021-03-09	Hua Medicine (Shanghai) Ltd.	Pyrazole derivatives
KR102648875B1 (ko)	2016-03-30	2024-03-15	신탁시스 아베	성숙 뇌 손상의 치료에 사용하기 위한 ｍＧｌｕＲ５의 음성 알로스테릭 조절제
CN116056701A (zh)	2020-06-05	2023-05-02	诺埃玛制药公司	治疗结节硬化复合症的方法
MX2023001288A (es) *	2020-07-30	2023-04-28	Noema Pharma Ag	Metodos de tratamiento de la neuralgia del trigemino.

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US3033199A (en) *	1959-10-13	1962-05-08	Jacobs Clifford Roy	Closure for protective device
US3045022A (en)	1960-04-07	1962-07-17	Reilly Tar & Chem Corp	Process of preparing ethynylpyridines
US3303199A (en)	1963-07-15	1967-02-07	Geigy Chem Corp	Certain imidazolone derivatives and process for making same
US3341548A (en) *	1964-04-29	1967-09-12	Hoffmann La Roche	Nitroimidazoles and their preparation
DE2035905A1 (de)	1970-07-20	1972-02-03	Chemische Fabrik Stockhausen & Cie.,4150Krefeld	Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (fr) *	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
US4508560A (en)	1981-11-11	1985-04-02	Ciba Geigy Corporation	Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use
US4711962A (en) *	1984-10-18	1987-12-08	Stauffer Chemical Company	Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
WO1991000277A1 (fr)	1989-06-30	1991-01-10	E.I. Du Pont De Nemours And Company	Imidazoles substitues
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
ID28529A (id)	1997-08-14	2001-05-31	Hoffmann La Roche	Vinileter heterosiklik untuk gangguan neurologi
EP1214303A1 (fr) *	1999-08-31	2002-06-19	Merck & Co., Inc.	Composes heterocycliques et procedes d'utilisation de ceux-ci
PL357433A1 (en)	1999-10-15	2004-07-26	F.Hoffmann-La Roche Ag	Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
IL136553A0 (en)	2000-06-05	2001-06-14	Compugen Ltd	SPLICE VARIANT OF mGluR
EP1303495B1 (fr)	2000-07-24	2010-05-26	Krenitsky Pharmaceuticals, Inc.	5-alkynyle pyrimidines substituees avec activite neurotrophique
CZ20031795A3 (cs) *	2000-12-04	2004-01-14	F. Hoffmann-La Roche Ag	Fenylethenylové nebo fenylethynylové deriváty jako antagonisté glutamátového receptoru
EP1238586A1 (fr)	2001-03-09	2002-09-11	Basf Aktiengesellschaft	2-alkynyl-pyri(mi)dines herbicides
US6596731B2 (en)	2001-03-27	2003-07-22	Hoffmann-La Roche Inc.	Substituted imidazo[1,2-A] pyridine derivatives
CA2462289C (fr)	2001-10-04	2010-02-23	Nicholas D. Cosford	Composes de tetrazole substitues par heteroaryle, modulateurs du recepteur-5 metabotropique du glutamate
US20030187026A1 (en)	2001-12-13	2003-10-02	Qun Li	Kinase inhibitors
JP2005516950A (ja)	2001-12-19	2005-06-09	メルク　エンド　カムパニー　インコーポレーテッド	代謝型グルタミン酸受容体−５のヘテロアリール置換イミダゾールモジュレータ
US20070060618A1 (en)	2002-10-24	2007-03-15	Merck & Co., Inc.	Alkyne derivatives as tracers for metabotropic glutamate receptor binding
ITMI20030151A1 (it)	2003-01-30	2004-07-31	Recordati Ind Chimica E Farma Ceutica S P A	Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
TWI292318B (en)	2003-03-10	2008-01-11	Hoffmann La Roche	Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en)	2003-06-05	2007-11-12	Hoffmann La Roche	Imidazole derivatives as glutmate receptor antagonists
US7531529B2 (en)	2003-06-05	2009-05-12	Roche Palo Alto Llc	Imidazole derivatives
US7091222B2 (en) *	2003-07-03	2006-08-15	Hoffmann-La Roche Inc.	Imidazole derivatives
US7452909B2 (en) *	2003-09-04	2008-11-18	Hoffman-La Roche Inc.	Imidazole derivatives
DE102004032567A1 (de)	2004-07-05	2006-03-02	Grünenthal GmbH	Substituierte 1-Propiolyl-piperazine

2005
- 2005-05-23 HR HR20080363T patent/HRP20080363T3/xx unknown
- 2005-05-23 JP JP2007513776A patent/JP4690395B2/ja not_active Expired - Fee Related
- 2005-05-23 KR KR1020087022221A patent/KR101057032B1/ko not_active Expired - Fee Related
- 2005-05-23 BR BRPI0511678-3A patent/BRPI0511678A/pt not_active Application Discontinuation
- 2005-05-23 ES ES05744719T patent/ES2307182T3/es not_active Expired - Lifetime
- 2005-05-23 KR KR1020067025236A patent/KR100907108B1/ko not_active Expired - Fee Related
- 2005-05-23 EA EA200602154A patent/EA011722B1/ru not_active IP Right Cessation
- 2005-05-23 NZ NZ551253A patent/NZ551253A/en not_active IP Right Cessation
- 2005-05-23 PT PT05744719T patent/PT1756086E/pt unknown
- 2005-05-23 DK DK05744719T patent/DK1756086T3/da active
- 2005-05-23 SI SI200530280T patent/SI1756086T1/sl unknown
- 2005-05-27 AR ARP050102179A patent/AR054072A1/es unknown
- 2005-05-27 TW TW094117351A patent/TWI297683B/zh not_active IP Right Cessation
- 2005-05-31 US US11/141,547 patent/US20060030559A1/en not_active Abandoned
2006
- 2006-11-09 CR CR8742A patent/CR8742A/es unknown
- 2006-11-22 MA MA29482A patent/MA28602B1/fr unknown
- 2006-11-23 IL IL179524A patent/IL179524A/en not_active IP Right Cessation
- 2006-11-28 EC EC2006007039A patent/ECSP067039A/es unknown
2008
- 2008-07-31 CY CY20081100804T patent/CY1108232T1/el unknown
2009
- 2009-11-05 US US12/613,089 patent/US8293916B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20060030559A1 (en)	2006-02-09
KR20080089523A (ko)	2008-10-06
HRP20080363T3 (hr)	2008-09-30
EA011722B1 (ru)	2009-04-28
HK1105972A1 (zh)	2008-02-29
DK1756086T3 (da)	2008-08-04
PT1756086E (pt)	2008-08-08
IL179524A0 (en)	2007-05-15
JP2008500979A (ja)	2008-01-17
ES2307182T3 (es)	2008-11-16
BRPI0511678A (pt)	2008-01-08
ECSP067039A (es)	2006-12-29
CR8742A (es)	2007-08-28
US20100048569A1 (en)	2010-02-25
TW200609222A (en)	2006-03-16
IL179524A (en)	2012-04-30
KR20070021231A (ko)	2007-02-22
CY1108232T1 (el)	2014-02-12
JP4690395B2 (ja)	2011-06-01
KR101057032B1 (ko)	2011-08-16
US8293916B2 (en)	2012-10-23
TWI297683B (en)	2008-06-11
AR054072A1 (es)	2007-06-06
SI1756086T1 (sl)	2008-08-31
KR100907108B1 (ko)	2009-07-09
EA200602154A1 (ru)	2007-06-29
NZ551253A (en)	2010-07-30

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ITMN20040005A1 (it)	2004-06-01	Erogatore d'acqua estraibile
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