[go: up one dir, main page]

MA27305A1 - Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales - Google Patents

Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales

Info

Publication number
MA27305A1
MA27305A1 MA27914A MA27914A MA27305A1 MA 27305 A1 MA27305 A1 MA 27305A1 MA 27914 A MA27914 A MA 27914A MA 27914 A MA27914 A MA 27914A MA 27305 A1 MA27305 A1 MA 27305A1
Authority
MA
Morocco
Prior art keywords
diazabicyclo
derivatives
ene
hypertension
cardiovascular
Prior art date
Application number
MA27914A
Other languages
English (en)
Inventor
Olivier Bezencon
Daniel Bur
Walter Fischli
Lubos Remen
Sylvia Richard-Bildstein
Hans-Peter Weber
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29286070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27305(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA27305A1 publication Critical patent/MA27305A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA27914A 2002-04-29 2004-10-22 Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales MA27305A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP0204705 2002-04-29

Publications (1)

Publication Number Publication Date
MA27305A1 true MA27305A1 (fr) 2005-05-02

Family

ID=29286070

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27914A MA27305A1 (fr) 2002-04-29 2004-10-22 Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales

Country Status (26)

Country Link
US (2) US7427613B2 (fr)
EP (1) EP1501830B1 (fr)
JP (1) JP4041123B2 (fr)
KR (1) KR100783863B1 (fr)
CN (1) CN1649870A (fr)
AT (1) ATE527261T1 (fr)
AU (1) AU2003233963B2 (fr)
BR (1) BR0309498A (fr)
CA (1) CA2483241C (fr)
CL (1) CL2003002042A1 (fr)
CO (1) CO5631443A2 (fr)
EC (1) ECSP045378A (fr)
ES (1) ES2372931T3 (fr)
HR (1) HRP20041132A2 (fr)
IL (1) IL164767A0 (fr)
IS (1) IS7545A (fr)
MA (1) MA27305A1 (fr)
MX (1) MXPA04010608A (fr)
NO (1) NO20045042L (fr)
NZ (1) NZ536750A (fr)
PL (1) PL372141A1 (fr)
RU (1) RU2343153C2 (fr)
TW (1) TW200514786A (fr)
UA (1) UA80821C2 (fr)
WO (1) WO2003093267A1 (fr)
ZA (1) ZA200408283B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2521951A1 (fr) * 2003-04-28 2004-11-11 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine utilises comme inhibiteurs de la renine
WO2004096803A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives d'azabicyclononene
MXPA05011497A (es) * 2003-04-30 2005-12-15 Actelion Pharmaceuticals Ltd Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace).
US20060258648A1 (en) * 2003-04-30 2006-11-16 Olivier Bezencon 9-Azabicyclo'3.3.1 inon-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors
AU2004233577A1 (en) * 2003-05-02 2004-11-11 Actelion Pharmaceuticals Ltd. Diazabicyclononene derivatives
WO2004105762A1 (fr) * 2003-05-30 2004-12-09 Actelion Pharmaceuticals Ltd Utilisation medicale de derives de diazabicyclononene utilises comme inhibiteurs des proteases aspartiques parasites
US20080234305A1 (en) * 2003-10-09 2008-09-25 Olivier Bezencon Novel Tetrahydropyridine Derivatives
AU2004283821A1 (en) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd. Diazabicyclononene derivatives and their use as renin inhibitors
CN1930170A (zh) * 2003-10-23 2007-03-14 埃科特莱茵药品有限公司 二氮杂二环壬烯及四氢吡啶衍生物用作肾素抑制剂
AU2004295092A1 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd. Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain
WO2005054243A1 (fr) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et leur utilisation en tant qu'inhibiteurs de la renine
WO2006021403A1 (fr) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Dérivés du bicyclononène
WO2006021399A2 (fr) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Derives de bicyclononene
WO2006021401A2 (fr) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Derives de bicyclononene
AU2005276624B2 (en) * 2004-08-25 2011-09-29 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives as renin inhibitors
TW200634014A (en) * 2004-12-08 2006-10-01 Actelion Pharmaceuticals Ltd Novel diazabicyclononene derivative
WO2006063610A1 (fr) * 2004-12-17 2006-06-22 Actelion Pharmaceuticals Ltd Dérivés de diazabicyclononène substitués par des groupements hétéroaryle
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
EP1846407B1 (fr) * 2005-01-28 2011-06-29 Actelion Pharmaceuticals Ltd. Acide 7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylique cyclopropyl-(2,3-dimethylbenzyl)amide utilisé comme inhibiteur de la renine pour le traitement de l'hypertension
CA2608212A1 (fr) * 2005-05-27 2006-12-07 Actelion Pharmaceuticals Ltd Nouveaux derives d'amide d'acide piperidine carboxylique
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
EP2420491B1 (fr) 2005-12-30 2013-07-03 Novartis AG Dérivés de pipéridine 3,5-substitués en tant qu'inhibiteurs de rénine
JP2009526767A (ja) 2006-02-02 2009-07-23 アクテリオン ファーマシューティカルズ リミテッド 新規二級アミン
JP2009529033A (ja) * 2006-03-08 2009-08-13 アクテリオン ファーマシューティカルズ リミテッド 新規アミン
WO2008141462A1 (fr) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd. Nouveaux inhibiteurs de rhénine
BRPI0813900A2 (pt) 2007-06-25 2014-12-30 Novartis Ag Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina
WO2009023964A1 (fr) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Inhibiteurs de la rénine
BRPI0912388A2 (pt) 2008-05-05 2017-09-26 Merck Frosst Canada Ltd composto, forma cristalina, processo para preparar compostos, composição farmacêutica, e, uso de um composto, e, método para o tratamento ou profilaxia de doenças
CN109721613B (zh) * 2017-10-27 2021-07-30 四川科伦博泰生物医药股份有限公司 含季铵离子的大环酰胺化合物及其药物组合物和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
GB9020927D0 (en) 1990-09-26 1990-11-07 Beecham Group Plc Pharmaceuticals
US5268361A (en) * 1991-06-07 1993-12-07 Sri International Hydroxyazido derivatives and related compounds as renin inhibitors
US5374719A (en) * 1993-06-04 1994-12-20 Eli Lilly And Company Process for converting loracarbef dihydrate to loracarbef monohydrate
IL123293A (en) * 1995-09-07 2003-06-24 Hoffmann La Roche Piperidine derivatives, their preparation and pharmaceutical compositions containing them
WO1998039328A1 (fr) 1997-03-03 1998-09-11 F.Hoffmann-La Roche Ag 2,4,-diaminopyrimidines substitues
US20060223795A1 (en) * 2003-05-02 2006-10-05 Oliver Bezencon Novel diazabicyclononene derivatives
WO2005054243A1 (fr) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et leur utilisation en tant qu'inhibiteurs de la renine

Also Published As

Publication number Publication date
KR20040101546A (ko) 2004-12-02
NZ536750A (en) 2007-02-23
MXPA04010608A (es) 2004-12-13
US20050176700A1 (en) 2005-08-11
CL2003002042A1 (es) 2005-02-04
ECSP045378A (es) 2004-11-26
CA2483241C (fr) 2011-05-31
HRP20041132A2 (en) 2006-07-31
AU2003233963A1 (en) 2003-11-17
IL164767A0 (en) 2005-12-18
US20080312242A1 (en) 2008-12-18
CN1649870A (zh) 2005-08-03
BR0309498A (pt) 2005-02-15
EP1501830A1 (fr) 2005-02-02
TW200514786A (en) 2005-05-01
US7427613B2 (en) 2008-09-23
NO20045042L (no) 2004-11-19
ES2372931T3 (es) 2012-01-27
EP1501830B1 (fr) 2011-10-05
ZA200408283B (en) 2006-05-31
JP4041123B2 (ja) 2008-01-30
UA80821C2 (en) 2007-11-12
CA2483241A1 (fr) 2003-11-13
KR100783863B1 (ko) 2007-12-10
RU2004134320A (ru) 2005-08-27
JP2005527602A (ja) 2005-09-15
PL372141A1 (en) 2005-07-11
AU2003233963B2 (en) 2008-09-11
IS7545A (is) 2004-11-22
ATE527261T1 (de) 2011-10-15
CO5631443A2 (es) 2006-04-28
WO2003093267A1 (fr) 2003-11-13
RU2343153C2 (ru) 2009-01-10

Similar Documents

Publication Publication Date Title
MA27305A1 (fr) Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales
MA27556A1 (fr) Derives de phenylalanine comme inhibiteurs de la dipeptidyl peptidase pour le traitement ou la prevention du diabete
EA200300713A1 (ru) Производные бензимидазола и пиридилимидазола в качестве лигандов рецепторов гамма-аминомасляной кислоты
EP1784188A4 (fr) Derives de triazole accoles inhibiteurs de la dipeptidyl peptidase-iv utilises dans le traitement ou la prevention du diabete
NO20053645L (no) (4R)- og (4S)-diastereoisomerer av (2S)-2-[ 2-oksy-4-propylpyrrolidinyl]butanamid og farmasoytisk preparat inneholdende disse
ATE286500T1 (de) 1,2,3,4-tetrahydroisochinolin-derivate
MY140488A (en) Substituted oxazolidinones and their use in the field of blood coagulation
NO20051102L (no) Sulfonylamino-eddiksyre-derivater
TW200514772A (en) Novel tetrahydropyridine derivatives
MA30333B1 (fr) Aminotetrahydropyranes utiles en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete.
EP1490335A4 (fr) Inhibiteurs de la dipeptidyl peptidase beta-amino heterocycliques pour le traitement ou la prevention du diabete
WO2005032471A3 (fr) Inhibiteurs de type benzylether et benzylamino de beta-secretase pour le traitement de la maladie d'alzheimer
EP1721609A3 (fr) Dérivés de pyridylpyrimidine utilisés comme composés actifs contre des infections et des maladies à prions
BRPI0406801B8 (pt) derivados de tieno-pirimidinodiona e uso dos mesmos na modulação de doenças autoimunes
EP1689713A4 (fr) Inhibiteurs de benzylether et benzylamino de beta-secretase pour traiter la maladie d'alzheimer
MA30313B1 (fr) Amines secondaires en tant qu'inhibiteurs de la renine
MXPA05011496A (es) Derivados de azabiciclononeno.
WO2005030209A8 (fr) Derives de pyridine et leur utilisation comme antagonistes de l'urotensine ii
MA30292B1 (fr) Amines primaires comme inhibiteurs de la renine
MXPA05011497A (es) Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace).
MXPA04001773A (es) Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos.
ATE462703T1 (de) Bicyclononen-derivate als renin-inhibitoren
MA26734A1 (fr) Derives de 1-trifluoromethyl -4-hydroxy- 7-piperidinyl- aminomethylchromane, procede pour leur preparation et compositions pharmaceutiques les contenant
ATE406899T1 (de) Neutrale endopeptidase (nep) und humane lösliche endopeptidase (hsep) hemmer für die prophylaxe und behandlung von neurodegenerativen erkrankungen
TW200621774A (en) Bicyclononene derivatives