MA21896A1 - Procede de prepatration d'acides imidazolyl - alcenoiques . - Google Patents

Procede de prepatration d'acides imidazolyl - alcenoiques .

Info

Publication number: MA21896A1
Authority: MA; Morocco
Prior art keywords: prepatration; imidazolyl; alkenoic acids; angiotensin; antagonists
Prior art date: 1989-06-14

Application number

MA22145A

Other languages

English (en)

Inventor

Alan Finkelstein Joseph

Weinstock Joseph

Mecullock Kennan Richard

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-14

Filing date

1990-06-13

Publication date

1991-04-01

1990-06-13 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1991-04-01 Publication of MA21896A1 publication Critical patent/MA21896A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Polishing Bodies And Polishing Tools (AREA)
External Artificial Organs (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

MA22145A 1989-06-14 1990-06-13 Procede de prepatration d'acides imidazolyl - alcenoiques . MA21896A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36607989A	1989-06-14	1989-06-14
US50641290A	1990-04-06	1990-04-06

Publications (1)

Publication Number	Publication Date
MA21896A1 true MA21896A1 (fr)	1991-04-01

Family

ID=27003220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA22145A MA21896A1 (fr)	1989-06-14	1990-06-13	Procede de prepatration d'acides imidazolyl - alcenoiques .

Country Status (25)

Country	Link
EP (2)	EP0403159B1 (fr)
JP (1)	JPH0768223B2 (fr)
KR (1)	KR0165837B1 (fr)
CN (2)	CN1027504C (fr)
AT (2)	ATE250587T1 (fr)
CA (1)	CA2018438C (fr)
CY (1)	CY2232B1 (fr)
DE (3)	DE69033469T2 (fr)
DK (2)	DK0955294T3 (fr)
ES (2)	ES2142789T3 (fr)
FI (1)	FI102610B (fr)
GR (1)	GR3033452T3 (fr)
HU (1)	HU208537B (fr)
IE (2)	IE20000297A1 (fr)
IL (1)	IL94698A (fr)
LU (1)	LU90562I2 (fr)
MA (1)	MA21896A1 (fr)
NL (1)	NL300006I2 (fr)
NO (1)	NO175977C (fr)
NZ (1)	NZ233997A (fr)
PH (1)	PH27592A (fr)
PL (3)	PL166669B1 (fr)
PT (1)	PT94377B (fr)
SG (1)	SG52330A1 (fr)
ZW (1)	ZW9490A1 (fr)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5210079A (en) *	1988-01-07	1993-05-11	E. I. Du Pont De Nemours And Company	Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US5185351A (en) *	1989-06-14	1993-02-09	Smithkline Beecham Corporation	Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
US5449682A (en) *	1990-02-13	1995-09-12	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted benzyl element
PH30484A (en) *	1990-02-19	1997-05-28	Ciba Geigy	Acy compounds pharmaceutical composition containing said compound and method of use thereof
WO1992000067A2 (fr) *	1990-06-22	1992-01-09	E.I. Du Pont De Nemours And Company	Traitement de l'insuffisance renale chronique a l'aide d'imidazoles antagonistes des recepteurs d'angiotensine-ii
NZ238688A (en) *	1990-06-28	1992-05-26	Smithkline Beecham Corp	Substituted histidines: pharmaceutical compositions, preparation and uses thereof
NZ239161A (en) *	1990-07-31	1994-01-26	Smithkline Beecham Corp	Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
GB9027197D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
US5656650A (en) *	1990-12-14	1997-08-12	Smithkline Beecham Corp.	Angiotensin II receptor blocking compositions
ATE177634T1 (de) *	1990-12-14	1999-04-15	Smithkline Beecham Corp	Angiotensin-ii-rezeptor blockierende zusammensetzungen
GB9027209D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
GB9027198D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
US6034114A (en) *	1990-12-14	2000-03-07	Smithkline Beecham Plc	Medicament
GB9027210D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
US6028091A (en) *	1990-12-14	2000-02-22	Smithkline Beecham Plc	Medicament
GB9027199D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
GB9027212D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
GB9027211D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
GB9027208D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
US6025380A (en) *	1990-12-14	2000-02-15	Smithkline Beecham Plc	Medicament
GB9027201D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
AU9137791A (en) *	1990-12-14	1992-07-08	Smithkline Beecham Corporation	Imidazolyl-alkenoic acids
GB9027200D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
EP0505098A1 (fr) *	1991-03-19	1992-09-23	Merck & Co. Inc.	Dérivés d'imidazole ayant des groupes fonctionnels acides comme angiotensin II antagonistes
US5236928A (en) *	1991-03-19	1993-08-17	Merck & Co., Inc.	Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists
US5187179A (en) *	1991-03-22	1993-02-16	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted imidazo [1,2-b][1,2,4]triazole
US5128327A (en) *	1991-03-25	1992-07-07	Merck & Co., Inc.	Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
US5177074A (en) *	1991-03-26	1993-01-05	Merck & Co., Inc.	Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5252574A (en) *	1991-04-26	1993-10-12	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted thiophene or furan
US5198438A (en) *	1991-05-07	1993-03-30	Merck & Co., Inc.	Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5447949A (en) *	1991-05-15	1995-09-05	Smithkline Beecham Corporation	N-(heteroaryl) imidazolyl-alkenoic acids having angiotension II receptor antagonist activity
GB9110532D0 (en) *	1991-05-15	1991-07-03	Smithkline Beecham Corp	Chemical compounds
GB9110636D0 (en) *	1991-05-16	1991-07-03	Glaxo Group Ltd	Chemical compounds
US5175164A (en) *	1991-06-05	1992-12-29	Merck & Co., Inc.	Angiotensin ii antagonists incorporating a substituted indole or dihydroindole
DE4132632A1 (de) *	1991-10-01	1993-04-08	Bayer Ag	Substituierte imidazolyl-propensaeurederivate
DE4132631A1 (de) *	1991-10-01	1993-04-08	Bayer Ag	Imidazolyl-propensaeurederivate
DE4132633A1 (de) *	1991-10-01	1993-04-08	Bayer Ag	Cyclisch substituierte imidazolyl-propensaeurederivate
GB9121463D0 (en) *	1991-10-10	1991-11-27	Smithkline Beecham Corp	Medicament
US5322950A (en) *	1991-12-05	1994-06-21	Warner-Lambert Company	Imidazole with angiotensin II antagonist properties
US5389661A (en) *	1991-12-05	1995-02-14	Warner-Lambert Company	Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties
US5308853A (en) *	1991-12-20	1994-05-03	Warner-Lambert Company	Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties
US5240953A (en) *	1992-01-30	1993-08-31	Ortho Pharmaceutical Corporation	Substituted triazoles as angiotensin ii inhibitors
FR2687674B1 (fr) *	1992-02-07	1995-05-19	Roussel Uclaf	Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
DE4206041A1 (de) *	1992-02-27	1993-09-02	Bayer Ag	Sulfonylbenzyl-substituierte imidazolylpropensaeurederivate
DE4206045A1 (de) *	1992-02-27	1993-09-02	Bayer Ag	Sulfonylbenzyl substituierte pyridone
DE4206042A1 (de) *	1992-02-27	1993-09-02	Bayer Ag	Sulfonylbenzyl-substituierte imidazopyridine
DE4206043A1 (de) *	1992-02-27	1993-09-02	Bayer Ag	Sulfonylbenzyl-substituierte imidazole
US5364869A (en) *	1992-03-09	1994-11-15	Abbott Laboratories	Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists
DE4210787A1 (de) *	1992-04-01	1993-10-07	Bayer Ag	Cycloalkyl- und Heterocyclyl substituierte Imidazolylpropensäurederivate
FR2689508B1 (fr) *	1992-04-01	1994-06-17	Fournier Ind & Sante	Derives de l'imidazole, leur procede de preparation et leur application en therapeutique.
DE4212796A1 (de) *	1992-04-16	1993-10-21	Bayer Ag	Propenoyl-imidazolderivate
DE4215588A1 (de) *	1992-05-12	1993-11-18	Bayer Ag	Biphenylmethyl-substituierte Pyridone
DE4215587A1 (de) *	1992-05-12	1993-11-18	Bayer Ag	Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone
DE4319041A1 (de) *	1992-10-23	1994-04-28	Bayer Ag	Trisubstituierte Biphenyle
WO1995029909A1 (fr) *	1994-04-29	1995-11-09	Pfizer Inc.	Nouveaux amides acycliques et cycliques utilises comme stimulateurs de la liberation des neurotransmetteurs
US20030004202A1 (en)	1997-04-28	2003-01-02	Smithkline Beecham Corporation	Endothelin receptor antagonists
AU3416995A (en) *	1994-09-02	1996-03-27	Smithkline Beecham Corporation	Endothelin receptor antagonists
WO1997022341A1 (fr) *	1995-12-21	1997-06-26	Smithkline Beecham Corporation	Antagonistes du recepteur d'endotheline
DE69624253T2 (de) *	1995-10-06	2003-08-07	Novartis Ag, Basel	Ati-rezeptorantagonisten zur verhinderung und behandlung des postischemischen nervenversagens und zum schutze ischemischer nieren
US6174910B1 (en)	1996-02-29	2001-01-16	Novartis Ag	AT1 receptor antagonist for the stimulation of apoptosis
AR011126A1 (es) *	1997-02-14	2000-08-02	Smithkline Beecham Corp	Procedimiento para preparar eprosartano y compuestos intermediarios.
ATE266631T1 (de)	1998-07-18	2004-05-15	Bayer Cropscience Ag	Imidamid-derivate
US6465502B1 (en)	1998-12-23	2002-10-15	Novartis Ag	Additional therapeutic use
ID29856A (id)	1998-12-23	2001-10-18	Novartis Ag	Penggunaan antagonis reseptor at-1 atau modulator reseptor at-2 untuk mengobati penyakit yang berkaitan dengan peningkatan reseptor-reseptor at-1 atau at-2
CN101011390A (zh)	1999-01-26	2007-08-08	诺瓦提斯公司	血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
AR033390A1 (es)	2000-08-22	2003-12-17	Novartis Ag	Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
SI1653950T1 (sl) *	2003-07-31	2008-06-30	Nicox Sa	Nitrooksi derivati losartana, valsatana, kandesartana, telmisartana, eprosartana in olmesartana kotblokatorji receptorja angiotenzina-II za zdravljenje kardiovaskularnih bolezni
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
GB0402262D0 (en)	2004-02-02	2004-03-10	Novartis Ag	Process for the manufacture of organic compounds
KR20070006774A (ko)	2004-03-17	2007-01-11	노파르티스 아게	치료에서 레닌 억제제의 용도
ES2384637T3 (es)	2004-10-08	2012-07-10	Novartis Ag	Uso de inhibidores de la renina para la prevención o el tratamiento de disfunción diastólica o insuficiencia cardiaca diastólica
RU2007115900A (ru)	2004-10-27	2008-11-10	Дайити Санкио Компани, Лимитед (Jp)	Производные бензола, имеющие 2 или более заместителей
EA200901140A1 (ru)	2007-03-01	2010-04-30	Пробиодруг Аг	Новое применение ингибиторов глутаминилциклазы
JP5667440B2 (ja)	2007-04-18	2015-02-12	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (fr)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
RU2453536C2 (ru) *	2007-10-22	2012-06-20	Оркид Рисерч Лабораториз Лимитед	Ингибиторы гистондезацетилазы
WO2009149279A2 (fr)	2008-06-04	2009-12-10	Synergy Pharmaceuticals Inc.	Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
AR072477A1 (es) *	2008-07-11	2010-09-01	Solvay Pharm Bv	Formulacion farmaceutica de eprosartan. uso.
CA2730603C (fr)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonistes de la guanylate cyclase utiles dans le traitement des affections gastro-intestinales, de l'inflammation gastro-intestinale, du cancer gastro-intestinal et d'autres affections
WO2011004384A2 (fr)	2009-06-05	2011-01-13	Glochem Industries Limited	Procédé de préparation déprosartan
CN102695546B (zh)	2009-09-11	2014-09-10	前体生物药物股份公司	作为谷氨酰胺酰环化酶抑制剂的杂环衍生物
US9181233B2 (en)	2010-03-03	2015-11-10	Probiodrug Ag	Inhibitors of glutaminyl cyclase
US8269019B2 (en)	2010-03-10	2012-09-18	Probiodrug Ag	Inhibitors
JP5945532B2 (ja)	2010-04-21	2016-07-05	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
US8530670B2 (en)	2011-03-16	2013-09-10	Probiodrug Ag	Inhibitors
US20130158080A1 (en)	2011-12-15	2013-06-20	Takeda Pharmaceuticals U.S.A., Inc.	Methods for treating hypertension in black patients
CN102584628B (zh) *	2011-12-30	2015-04-22	浙江外国语学院	一种n-羧甲基戊脒的合成方法
EP2970384A1 (fr)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Agonistes de la guanylate cyclase et leurs utilisations
WO2014151200A2 (fr)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions utiles pour le traitement de troubles gastro-intestinaux
AU2014274812B2 (en)	2013-06-05	2018-09-27	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase C, method of making and using same
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5671074A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
JPS5671073A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	Imidazole derivative
JPS58157768A (ja) *	1982-03-16	1983-09-19	Takeda Chem Ind Ltd	４−クロロ−２−フエニルイミダゾ−ル−５−酢酸誘導体
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs
CA1334092C (fr) *	1986-07-11	1995-01-24	David John Carini	Imidazoles bloquant les recepteurs de l'angiotensine ii
US4835154A (en) *	1987-06-01	1989-05-30	Smithkline Beckman Corporation	1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US4798843A (en) *	1987-07-09	1989-01-17	Smithkline Beckman Corporation	2-mercaproimidazole dopamine-β-hydroxylase inhibitors
CA1338238C (fr) *	1988-01-07	1996-04-09	David John Carini	Imidazoles bloquant les recepteurs de l'angiotensine ii et combinaisons de ces imidazoles avec des diuretiques et des anti-inflammatoires non steroidiens

1990
- 1990-06-07 DE DE69033469T patent/DE69033469T2/de not_active Expired - Lifetime
- 1990-06-07 EP EP90306204A patent/EP0403159B1/fr not_active Expired - Lifetime
- 1990-06-07 ES ES90306204T patent/ES2142789T3/es not_active Expired - Lifetime
- 1990-06-07 DK DK99115614T patent/DK0955294T3/da active
- 1990-06-07 ES ES99115614T patent/ES2207091T3/es not_active Expired - Lifetime
- 1990-06-07 CA CA002018438A patent/CA2018438C/fr not_active Expired - Lifetime
- 1990-06-07 AT AT99115614T patent/ATE250587T1/de not_active IP Right Cessation
- 1990-06-07 DE DE2000175018 patent/DE10075018I2/de active Active
- 1990-06-07 SG SG1996002914A patent/SG52330A1/en unknown
- 1990-06-07 AT AT90306204T patent/ATE190051T1/de active
- 1990-06-07 EP EP99115614A patent/EP0955294B1/fr not_active Expired - Lifetime
- 1990-06-07 DE DE69034103T patent/DE69034103T2/de not_active Expired - Lifetime
- 1990-06-07 DK DK90306204T patent/DK0403159T3/da active
- 1990-06-08 NZ NZ233997A patent/NZ233997A/en unknown
- 1990-06-08 ZW ZW94/90A patent/ZW9490A1/xx unknown
- 1990-06-11 PH PH40649A patent/PH27592A/en unknown
- 1990-06-11 IL IL9469890A patent/IL94698A/en unknown
- 1990-06-12 PL PL90301863A patent/PL166669B1/pl unknown
- 1990-06-12 PL PL90301864A patent/PL166722B1/pl unknown
- 1990-06-12 PT PT94377A patent/PT94377B/pt not_active IP Right Cessation
- 1990-06-12 PL PL90285591A patent/PL165609B1/pl unknown
- 1990-06-13 IE IE20000297A patent/IE20000297A1/en unknown
- 1990-06-13 FI FI902970A patent/FI102610B/fi active IP Right Grant
- 1990-06-13 MA MA22145A patent/MA21896A1/fr unknown
- 1990-06-13 IE IE214090A patent/IE902140A1/en not_active IP Right Cessation
- 1990-06-13 NO NO902632A patent/NO175977C/no not_active IP Right Cessation
- 1990-06-14 JP JP2156627A patent/JPH0768223B2/ja not_active Expired - Lifetime
- 1990-06-14 CN CN90104438A patent/CN1027504C/zh not_active Expired - Lifetime
- 1990-06-14 HU HU903847A patent/HU208537B/hu unknown
- 1990-06-14 KR KR1019900008739A patent/KR0165837B1/ko not_active Expired - Lifetime
1993
- 1993-03-16 CN CN93103111A patent/CN1048159C/zh not_active Expired - Lifetime
2000
- 2000-04-05 LU LU90562C patent/LU90562I2/fr unknown
- 2000-05-16 NL NL300006C patent/NL300006I2/nl unknown
- 2000-05-19 GR GR20000401140T patent/GR3033452T3/el not_active IP Right Cessation
2001
- 2001-09-03 CY CY0100023A patent/CY2232B1/xx unknown

Also Published As

Publication number	Publication date
ATE250587T1 (de)	2003-10-15
KR0165837B1 (ko)	1999-02-18
CN1048038A (zh)	1990-12-26
NO175977B (no)	1994-10-03
DE10075018I2 (de)	2001-08-09
JPH0768223B2 (ja)	1995-07-26
DK0403159T3 (da)	2000-08-14
DE69034103T2 (de)	2004-07-15
PT94377A (pt)	1991-03-20
IE902140A1 (en)	1991-01-02
EP0955294B1 (fr)	2003-09-24
IE20000297A1 (en)	2000-12-13
FI902970A0 (fi)	1990-06-13
NL300006I2 (nl)	2000-10-02
HK1025315A1 (en)	2000-11-10
EP0955294A3 (fr)	2000-04-19
NL300006I1 (nl)	2000-07-03
EP0403159B1 (fr)	2000-03-01
HUT55011A (en)	1991-04-29
ES2142789T3 (es)	2000-05-01
EP0403159A3 (fr)	1991-12-27
SG52330A1 (en)	1998-09-28
PL285591A1 (en)	1991-03-25
DE10075018I1 (de)	2000-09-21
CN1079649A (zh)	1993-12-22
PH27592A (en)	1993-08-31
FI102610B1 (fi)	1999-01-15
PL166669B1 (pl)	1995-06-30
KR910000658A (ko)	1991-01-29
CN1048159C (zh)	2000-01-12
ES2207091T3 (es)	2004-05-16
PL166722B1 (pl)	1995-06-30
EP0403159A2 (fr)	1990-12-19
DE69034103D1 (de)	2003-10-30
IL94698A0 (en)	1991-04-15
HU903847D0 (en)	1990-11-28
IL94698A (en)	1994-07-31
PL165609B1 (pl)	1995-01-31
ZW9490A1 (en)	1990-10-31
NO175977C (no)	1995-01-11
HK1012384A1 (en)	1999-07-30
AU5690190A (en)	1991-01-10
HU208537B (en)	1993-11-29
CA2018438C (fr)	2000-08-08
LU90562I2 (fr)	2000-06-05
FI102610B (fi)	1999-01-15
DK0955294T3 (da)	2004-02-02
DE69033469T2 (de)	2000-09-07
DE69033469D1 (de)	2000-04-06
IE902140L (en)	1990-12-14
NO902632D0 (no)	1990-06-13
NZ233997A (en)	1991-04-26
PT94377B (pt)	1997-02-28
CN1027504C (zh)	1995-01-25
AU633322B2 (en)	1993-01-28
JPH03115278A (ja)	1991-05-16
CA2018438A1 (fr)	1990-12-14
CY2232B1 (en)	2003-04-18
EP0955294A2 (fr)	1999-11-10
NO902632L (no)	1990-12-17
ATE190051T1 (de)	2000-03-15
GR3033452T3 (en)	2000-09-29