MA21735A1 - Procede de production d'agents bis - aza -bicyclique s a activite anxiolytique ou antidepressive . - Google Patents

Procede de production d'agents bis - aza -bicyclique s a activite anxiolytique ou antidepressive .

Info

Publication number: MA21735A1
Authority: MA; Morocco
Prior art keywords: anxiolytic; aza; bicyclic; agents; producing bis
Prior art date: 1989-01-23

Application number

MA21996A

Other languages

English (en)

Inventor

Gene Michael Bright

Desai Kishor Amratral

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-23

Filing date

1990-01-22

Publication date

1990-10-01

1990-01-22 Application filed by Pfizer filed Critical Pfizer

1990-10-01 Publication of MA21735A1 publication Critical patent/MA21735A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

MA21996A 1989-01-23 1990-01-22 Procede de production d'agents bis - aza -bicyclique s a activite anxiolytique ou antidepressive . MA21735A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/000275 WO1990008148A1 (fr)	1989-01-23	1989-01-23	Agents anxiolytiques bis-aza-bicycliques
PCT/US1989/003811 WO1990008144A1 (fr)	1989-01-23	1989-09-01	Agents anxiolytiques bis-aza-bicycliques

Publications (1)

Publication Number	Publication Date
MA21735A1 true MA21735A1 (fr)	1990-10-01

Family

ID=22214801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA21996A MA21735A1 (fr)	1989-01-23	1990-01-22	Procede de production d'agents bis - aza -bicyclique s a activite anxiolytique ou antidepressive .

Country Status (38)

Country	Link
US (1)	US5122525A (fr)
EP (1)	EP0380217B1 (fr)
JP (1)	JPH0643427B2 (fr)
KR (1)	KR910009289B1 (fr)
CN (1)	CN1022186C (fr)
AP (1)	AP128A (fr)
AR (1)	AR246969A1 (fr)
AT (1)	ATE82574T1 (fr)
AU (1)	AU614214B2 (fr)
BA (1)	BA98302A (fr)
BG (1)	BG51046A3 (fr)
CA (1)	CA2008108C (fr)
CZ (1)	CZ277698B6 (fr)
DD (1)	DD291560A5 (fr)
DE (1)	DE69000467T2 (fr)
DK (1)	DK0380217T3 (fr)
EG (1)	EG19306A (fr)
ES (1)	ES2053094T3 (fr)
FI (1)	FI95381C (fr)
GR (1)	GR3006925T3 (fr)
HU (1)	HU215154B (fr)
IE (1)	IE62670B1 (fr)
IL (1)	IL93073A (fr)
IS (1)	IS1667B (fr)
MA (1)	MA21735A1 (fr)
MX (1)	MX19222A (fr)
MY (1)	MY104861A (fr)
NO (1)	NO175978C (fr)
NZ (1)	NZ232168A (fr)
OA (1)	OA10041A (fr)
PL (1)	PL163836B1 (fr)
PT (1)	PT92919B (fr)
RO (1)	RO110142B1 (fr)
RU (1)	RU2015977C1 (fr)
SK (1)	SK279339B6 (fr)
WO (2)	WO1990008148A1 (fr)
YU (1)	YU47554B (fr)
ZA (1)	ZA90430B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos
WO1992000075A1 (fr) *	1990-06-29	1992-01-09	Pfizer Inc.	Derives de pyridopyrazine utilises dans le traitement de l'abus et de la dependance de substances
CA2099563C (fr) *	1991-01-31	1998-09-29	Charles W. Murtiashaw	Preparation de (7s, trans)-2-(2-pyrimidinyl)-7-(hydroxymethyl)- octahydro-2h-pyrido[1,2-a]pyrazine
US5157034A (en) *	1991-02-27	1992-10-20	Pfizer Inc.	Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5185449A (en) *	1991-02-27	1993-02-09	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5326874A (en) *	1991-02-27	1994-07-05	Pfizer Inc.	Process for preparing trans-piperidine-2,5-dicarboxylates
US5311195A (en) *	1991-08-30	1994-05-10	Etak, Inc.	Combined relative and absolute positioning method and apparatus
BR9206541A (pt) *	1991-09-25	1995-04-25	Pfizer	Per-hidro-1h-pirido(1,2-a)pirazinas 2-substituídas neurolépticas
JP2753146B2 (ja) *	1992-06-16	1998-05-18	ファイザー・インコーポレーテッド	ビス−アザー二環式抗不安薬の製法および中間体
WO1994006794A1 (fr) *	1992-09-24	1994-03-31	National Institutes Of Health	Derives d'aralkyle diazabicycloalcane contre des troubles du systeme nerveux central
IL104506A (en) *	1993-01-25	1997-11-20	Israel State	Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) *	1993-08-20	1997-06-10	Pfizer Inc.	Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) *	1993-10-13	1995-10-03	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) *	1993-11-01	1999-06-20	Israel State	Controlled cryogenic contact system
US6231833B1 (en) *	1999-08-05	2001-05-15	Pfizer Inc	2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
MX9702350A (es) *	1994-09-30	1997-06-28	Pfizer	Derivados 2,7-sustituidos de octahidro-1h-pirido (1,2-a) pirazina.
WO1996010570A1 (fr) *	1994-09-30	1996-04-11	Pfizer Inc.	PERHYDRO-1H-PYRIDO[1,2-a] PYRAZINES DISUBSTITUEES EN 2,7 A ACTION NEUROLEPTIQUE
KR100286786B1 (ko) *	1995-12-21	2001-04-16	디. 제이. 우드, 스피겔 알렌 제이	2,7-치환된옥타하이드로-피롤로[1,2-에이]피라진유도체
CZ434998A3 (cs) *	1996-07-01	1999-11-17	Pfizer Inc.	Způsob výroby (7S,trans)-2-(2-pyrimidinyl)-7-(hydroxymethyl)oktahydro-2H-pyrido[1,2-a]-pyrazinu
PA8469101A1 (es) *	1998-04-09	2000-09-29	Pfizer Prod Inc	Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) *	1998-09-21	2000-11-11	Pfizer Prod Inc	Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) *	2000-07-31	2002-02-07	Coe Jotham Wadsworth	Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en)	2000-11-29	2003-12-30	Pfizer Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
AP2005003390A0 (en) *	2003-03-12	2005-09-30	Pfizer Prod Inc	Pyridyloxymethyl and benzisoxazole azabicyclic derivatives.
ATE418555T1 (de)	2003-04-09	2009-01-15	Biogen Idec Inc	A2a-adenosinrezeptorantagonisten
DK1689721T3 (da) *	2003-11-26	2010-09-20	Pfizer Prod Inc	Aminopyrazolderivater som GSK-3-ihibitorer
CA2566154A1 (fr) *	2004-05-27	2005-12-08	Warner-Lambert Company Llc	Combinaison therapeutique pour troubles d'hyperactivite avec deficit de l'attention
US7658206B2 (en)	2006-12-05	2010-02-09	Kohler Co.	Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3388128A (en) *	1965-09-03	1968-06-11	Allan R. Day	Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) *	1978-05-22	1980-01-08	Mead Johnson & Company	Buspirone anti-anxiety method
US4339579A (en) *	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) *	1982-05-07	1983-08-23	American Home Products Corporation	2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) *	1982-05-25	1983-11-08	American Home Products Corporation	4-Substituted-piperidino carboxamides
US4517187A (en) *	1982-10-18	1985-05-14	Pennwalt Corporation	1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) *	1984-03-15	1985-09-26	Bayer Ag, 5090 Leverkusen	Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) *	1986-02-17	1989-03-10	Acraf	Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
JP2668259B2 (ja) *	1988-02-18	1997-10-27	塩野義製薬株式会社	複素環化合物および抗潰瘍剤
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos

1989
- 1989-01-23 MX MX1922290A patent/MX19222A/es unknown
- 1989-01-23 WO PCT/US1989/000275 patent/WO1990008148A1/fr not_active Ceased
- 1989-09-01 RO RO148053A patent/RO110142B1/ro unknown
- 1989-09-01 WO PCT/US1989/003811 patent/WO1990008144A1/fr not_active Ceased
- 1989-09-01 HU HU40/90A patent/HU215154B/hu not_active IP Right Cessation
- 1989-12-13 IS IS3529A patent/IS1667B/is unknown
1990
- 1990-01-12 DK DK90300362.2T patent/DK0380217T3/da active
- 1990-01-12 ES ES90300362T patent/ES2053094T3/es not_active Expired - Lifetime
- 1990-01-12 EP EP90300362A patent/EP0380217B1/fr not_active Expired - Lifetime
- 1990-01-12 DE DE9090300362T patent/DE69000467T2/de not_active Expired - Fee Related
- 1990-01-12 AT AT90300362T patent/ATE82574T1/de not_active IP Right Cessation
- 1990-01-16 IL IL9307390A patent/IL93073A/en not_active IP Right Cessation
- 1990-01-18 BG BG090949A patent/BG51046A3/bg unknown
- 1990-01-19 MY MYPI90000101A patent/MY104861A/en unknown
- 1990-01-19 AR AR90315971A patent/AR246969A1/es active
- 1990-01-19 NZ NZ232168A patent/NZ232168A/xx unknown
- 1990-01-19 CA CA002008108A patent/CA2008108C/fr not_active Expired - Fee Related
- 1990-01-21 EG EG3290A patent/EG19306A/xx active
- 1990-01-22 CZ CS90299A patent/CZ277698B6/cs not_active IP Right Cessation
- 1990-01-22 AU AU48679/90A patent/AU614214B2/en not_active Ceased
- 1990-01-22 PT PT92919A patent/PT92919B/pt not_active IP Right Cessation
- 1990-01-22 PL PL90283395A patent/PL163836B1/pl not_active IP Right Cessation
- 1990-01-22 MA MA21996A patent/MA21735A1/fr unknown
- 1990-01-22 IE IE22590A patent/IE62670B1/en not_active IP Right Cessation
- 1990-01-22 CN CN90100291A patent/CN1022186C/zh not_active Expired - Fee Related
- 1990-01-22 DD DD90337249A patent/DD291560A5/de not_active IP Right Cessation
- 1990-01-22 AP APAP/P/1990/000158A patent/AP128A/en active
- 1990-01-22 SK SK299-90A patent/SK279339B6/sk unknown
- 1990-01-22 YU YU11190A patent/YU47554B/sh unknown
- 1990-01-22 KR KR1019900000701A patent/KR910009289B1/ko not_active Expired
- 1990-01-22 ZA ZA90430A patent/ZA90430B/xx unknown
- 1990-01-23 JP JP2013459A patent/JPH0643427B2/ja not_active Expired - Fee Related
- 1990-01-23 OA OA59727A patent/OA10041A/en unknown
1991
- 1991-07-09 US US07/721,537 patent/US5122525A/en not_active Expired - Lifetime
- 1991-07-22 RU SU915001279A patent/RU2015977C1/ru not_active IP Right Cessation
- 1991-07-22 NO NO912863A patent/NO175978C/no unknown
- 1991-07-22 FI FI913510A patent/FI95381C/fi not_active IP Right Cessation
1993
- 1993-01-28 GR GR930400172T patent/GR3006925T3/el unknown
1998
- 1998-03-30 BA BA980302A patent/BA98302A/bs unknown

Also Published As

Publication number	Publication date
WO1990008148A1 (fr)	1990-07-26
HU215154B (hu)	2000-09-28
NO175978B (no)	1994-10-03
GR3006925T3 (fr)	1993-06-30
OA10041A (en)	1996-10-14
AU4867990A (en)	1990-07-26
NO175978C (no)	1995-01-11
SK279339B6 (sk)	1998-10-07
HUT63163A (en)	1993-07-28
NO912863L (no)	1991-07-22
RU2015977C1 (ru)	1994-07-15
RO110142B1 (ro)	1995-10-30
IE900225L (en)	1990-07-23
ATE82574T1 (de)	1992-12-15
EP0380217A1 (fr)	1990-08-01
AP9000158A0 (en)	1990-01-31
CN1044464A (zh)	1990-08-08
ZA90430B (en)	1991-08-28
EG19306A (en)	1995-01-31
WO1990008144A1 (fr)	1990-07-26
MX19222A (es)	1993-12-01
CN1022186C (zh)	1993-09-22
EP0380217B1 (fr)	1992-11-19
FI95381C (fi)	1996-01-25
IL93073A (en)	1994-05-30
BA98302A (bs)	2001-09-14
KR910009289B1 (ko)	1991-11-09
CZ277698B6 (en)	1993-03-17
AR246969A1 (es)	1994-10-31
DE69000467T2 (de)	1993-04-01
YU47554B (sh)	1995-10-03
PT92919A (pt)	1990-07-31
PL163836B1 (pl)	1994-05-31
CA2008108A1 (fr)	1990-07-23
PT92919B (pt)	1995-12-29
JPH02233681A (ja)	1990-09-17
IE62670B1 (en)	1995-03-08
CS29990A3 (en)	1992-11-18
AP128A (en)	1991-03-20
FI913510A0 (fi)	1991-07-22
NZ232168A (en)	1991-08-27
IS3529A7 (is)	1990-07-24
KR900011774A (ko)	1990-08-02
YU11190A (sh)	1993-05-28
NO912863D0 (no)	1991-07-22
AU614214B2 (en)	1991-08-22
ES2053094T3 (es)	1994-07-16
BG51046A3 (bg)	1993-01-15
DK0380217T3 (da)	1992-12-14
DE69000467D1 (de)	1992-12-24
MY104861A (en)	1994-06-30
DD291560A5 (de)	1991-07-04
US5122525A (en)	1992-06-16
JPH0643427B2 (ja)	1994-06-08
FI95381B (fi)	1995-10-13
CA2008108C (fr)	1995-08-08
IS1667B (is)	1997-11-14

Publication	Publication Date	Title
MA21735A1 (fr)	1990-10-01	Procede de production d'agents bis - aza -bicyclique s a activite anxiolytique ou antidepressive .
MA22481A1 (fr)	1992-12-31	Procede de preparation d'acides imidazolyl - alcenoiques .
MA21610A1 (fr)	1990-04-01	Procede de production de composes triazoliques .
DE69008969D1 (de)	1994-06-23	System zum Hervorrufen von Elektroenzephalogramm-Signalen.
FR2582294B1 (fr)	1992-09-25	Procede de production d'alumine-beta
FR2593513B1 (fr)	1991-07-26	Procede de production d'essence
FR2656300B1 (fr)	1993-06-11	Procede de production de phenol.
FR2593175B1 (fr)	1988-05-13	Procede de production de 3-phenyl-4-cyanopyrroles.
FR2561238B1 (fr)	1987-06-12	Procede de production de diphenylamines ou de n,n'-diphenyl-phenylenediamines
MA21812A1 (fr)	1990-12-31	Procede de preparation de derives de dipeptides a activite inhibitrice d'enzymes .
FR2668951B1 (fr)	1994-07-22	Procede d'activation de catalyseurs d'hydrocraquage.
MA21122A1 (fr)	1988-07-01	Procede de preparation de derives d'acides aminocarboxyliques bicycliques .
FR2678625B1 (fr)	1995-07-07	Procede de production d'acetate de cellulose.
MA22151A1 (fr)	1991-12-31	Procede de production d'azabenzimidazoles
IT1230769B (it)	1991-10-29	Processo catalitico per la produzione di ossime.
BR8800160A (pt)	1988-08-30	Processo para a producao de 2,2',4,4',6,6'-hexanitro estilbeno
MA21849A1 (fr)	1990-12-31	Procede de fabrication d'alkyl - ethoxy - carboxylates .
FR2682303B1 (fr)	1995-04-28	Catalyseur d'hydrogenation et procede de production de ce catalyseur.
FR2662438B1 (fr)	1993-10-29	Procede de production d'alkylbenzenes utilisant des catalyseurs a base de zeolithe y desaluminee.
FR2625194B1 (fr)	1990-05-04	Procede de production d'aldehydes aromatiques
OA09798A (fr)	1994-04-15	"Procédé de désalcoolisation".
FR2643647B1 (fr)	1991-06-21	Procede microbiologique d'obtention de methylcetones
MA21966A1 (fr)	1991-07-01	Procede de production de tetrathiocarbonates .
FR2595714B1 (fr)	1990-05-18	Procede perfectionne de production d'interleukine-0
MA21132A1 (fr)	1988-07-01	Derive d'oxadiazolone , son procede de production et herbicide le contenant .