ZA9895B - Substituted bis-acridines and related compounds as ccr5 receptor antagonists antiinflammatory agents and antiviral agents - Google Patents

Substituted bis-acridines and related compounds as ccr5 receptor antagonists antiinflammatory agents and antiviral agents

Info

Publication number: ZA9895B
Authority: ZA; South Africa
Prior art keywords: agents; acridines; receptor antagonists; related compounds; substituted bis
Prior art date: 1997-01-08

Application number

ZA9895A

Other languages

English (en)

Inventor

William E Bondinell

Valerie A Reader

Thomas Wen Fu Ku

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-08

Filing date

1998-01-07

Publication date

1998-07-08

1998-01-07 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1998-07-08 Publication of ZA9895B publication Critical patent/ZA9895B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C07D219/12—Amino-alkylamino radicals attached in position 9

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Virology (AREA)
Dermatology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Transplantation (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA9895A 1997-01-08 1998-01-07 Substituted bis-acridines and related compounds as ccr5 receptor antagonists antiinflammatory agents and antiviral agents ZA9895B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3514897P	1997-01-08	1997-01-08

Publications (1)

Publication Number	Publication Date
ZA9895B true ZA9895B (en)	1998-07-08

Family

ID=21880954

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9895A ZA9895B (en)	1997-01-08	1998-01-07	Substituted bis-acridines and related compounds as ccr5 receptor antagonists antiinflammatory agents and antiviral agents

Country Status (9)

Country	Link
US (2)	US6242459B1 (xx)
EP (1)	EP0979078A4 (xx)
JP (1)	JP2001509152A (xx)
AR (1)	AR011057A1 (xx)
AU (1)	AU6020898A (xx)
CA (1)	CA2276525A1 (xx)
CO (1)	CO4920243A1 (xx)
WO (1)	WO1998030218A1 (xx)
ZA (1)	ZA9895B (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6025154A (en)	1995-06-06	2000-02-15	Human Genome Sciences, Inc.	Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6743594B1 (en)	1995-06-06	2004-06-01	Human Genome Sciences, Inc.	Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6514987B1 (en) *	1997-01-06	2003-02-04	Cerus Corporation	Frangible compounds for pathogen inactivation
ZA985542B (en)	1997-07-03	1999-04-07	Smithkline Beecham Corp	Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents
CN1279668A (zh)	1997-11-18	2001-01-10	帝人株式会社	环胺衍生物及其作为药物的用途
EP1179341B1 (en)	1999-05-18	2005-11-09	Teijin Limited	Remedies or preventives for diseases in association with chemokines
WO2000076982A1 (en) *	1999-06-16	2000-12-21	University Of Iowa Research Foundation	Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
CA2378499A1 (en)	1999-08-04	2001-02-15	Teijin Limited	Cyclic amine ccr3 antagonists
ATE346042T1 (de) *	1999-12-08	2006-12-15	Teijin Ltd	Zyklische aminverbindungen als ccr5-rezeptor antagonisten
US6410566B1 (en)	2000-05-16	2002-06-25	Teijin Limited	Cyclic amine derivatives and their use as drugs
JP2004510706A (ja)	2000-07-07	2004-04-08	キャンサー・リサーチ・テクノロジー・リミテッド	治療用アクリドン及びアクリジン化合物
US7175988B2 (en)	2001-02-09	2007-02-13	Human Genome Sciences, Inc.	Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7393934B2 (en)	2001-12-21	2008-07-01	Human Genome Sciences, Inc.	Human G-protein chemokine receptor (CCR5) HDGNR10
AU2003207646C1 (en) *	2002-01-22	2008-09-18	Vanderbilt University	Treating stress response with chemokine receptor CCR5 modulators
WO2004005464A2 (en) *	2002-07-02	2004-01-15	Uab Research Foundation	Compounds promoting delivery of genes
CA2559809A1 (en)	2004-03-12	2005-11-10	Human Genome Sciences, Inc.	Antibodies against human g-protein chemokine receptor (ccr5) hdgnr10
US20080108586A1 (en) *	2006-09-06	2008-05-08	Incyte Corporation	Combination therapy for human immunodeficiency virus infection
WO2013024022A1 (en)	2011-08-12	2013-02-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for treatment of pulmonary hypertension
US10149830B2 (en)	2016-06-03	2018-12-11	Cushing Academy	Pharmaceutical agents and methods relating thereto
CN115443133B (zh)	2020-02-19	2024-02-20	伊契洛夫科技有限公司	改进的抗抑郁疗法
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
WO2024119148A1 (en) *	2022-12-02	2024-06-06	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Topoisomerase iii (top3) inhibitors and antiviral compounds based on bisacridines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2503899A (en) *	1945-08-29	1950-04-11	Dow Chemical Co	Diacridyl diamine derivatives
FR2314165A1 (fr)	1975-06-13	1977-01-07	Anvar	Nouveaux bis (anthryl-9) alcanes et leur preparation
FR2588259B1 (fr)	1985-10-04	1988-01-22	Aix Marseille Universite	Bis-acridiniques monopontes et bis-acridiniques bipontes
JPH0688924B2 (ja)	1986-05-28	1994-11-09	ダイセル化学工業株式会社	光記憶材料
DE4014421A1 (de) *	1990-05-05	1991-11-07	Merck Patent Gmbh	Aminosaeurederivate
JPH04226467A (ja)	1990-09-13	1992-08-17	Ricoh Co Ltd	電子写真感光体の疲労回復方法
ES2107557T3 (es) *	1991-12-10	1997-12-01	Shionogi & Co	Derivado de acido hidroxamico a base de sulfonamida aromatica.
DE4405378A1 (de) *	1994-02-19	1995-08-24	Merck Patent Gmbh	Adhäsionsrezeptor-Antagonisten

1998
- 1998-01-05 AR ARP980100032A patent/AR011057A1/es unknown
- 1998-01-07 CO CO98000422A patent/CO4920243A1/es unknown
- 1998-01-07 ZA ZA9895A patent/ZA9895B/xx unknown
- 1998-01-08 JP JP53117498A patent/JP2001509152A/ja active Pending
- 1998-01-08 EP EP98903437A patent/EP0979078A4/en not_active Withdrawn
- 1998-01-08 US US09/341,171 patent/US6242459B1/en not_active Expired - Fee Related
- 1998-01-08 CA CA002276525A patent/CA2276525A1/en not_active Abandoned
- 1998-01-08 WO PCT/US1998/000489 patent/WO1998030218A1/en not_active Ceased
- 1998-01-08 AU AU60208/98A patent/AU6020898A/en not_active Abandoned
2001
- 2001-04-11 US US09/833,044 patent/US20010031763A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20010031763A1 (en)	2001-10-18
WO1998030218A1 (en)	1998-07-16
EP0979078A1 (en)	2000-02-16
US6242459B1 (en)	2001-06-05
EP0979078A4 (en)	2000-06-21
CA2276525A1 (en)	1998-07-16
AR011057A1 (es)	2000-08-02
CO4920243A1 (es)	2000-05-29
AU6020898A (en)	1998-08-03
JP2001509152A (ja)	2001-07-10

Publication	Publication Date	Title
ZA9895B (en)	1998-07-08	Substituted bis-acridines and related compounds as ccr5 receptor antagonists antiinflammatory agents and antiviral agents
HU9603525D0 (en)	1997-02-28	Vironectin receptor antagonists
IL125658A0 (en)	1999-04-11	Ccr-3 receptor antagonists
IL133235A0 (en)	2001-03-19	1-Amino-alkylcyclohexane nmda receptor antagonists
EP0912175A4 (en)	1999-09-08	FIBRINOGENIC RECEPTOR ANTAGONISTS
AU6267198A (en)	1998-09-08	Amides as npy5 receptor antagonists
EP1000031A4 (en)	2001-08-16	VITRONECTIN RECEPTOR ANTAGONISTS
IL130760A0 (en)	2001-01-28	Vitronectin receptor antagonists
EP1007051A4 (en)	2001-08-29	INTEGRIN RECEPTOR ANTAGONISTS
SG80041A1 (en)	2001-04-17	Muscarinic receptor antagonists
EP0885213A4 (en)	1999-04-28	FIBRINOGEN RECEPTOR ANTAGONISTS
PL341114A1 (en)	2001-03-26	Antagonists of thrombosin receptors
IL135189A0 (en)	2001-05-20	Vitronectin receptor antagonist
IL135028A0 (en)	2001-05-20	Vitronectin receptor antagonists
IL135188A0 (en)	2001-05-20	Vitronectin receptor antagonist
PL335100A1 (en)	2000-04-10	Oxazolynones as antagonists of 5ht2a receptor
EP1027337A4 (en)	2002-04-03	Integrin receptor Antagonist
GB9820014D0 (en)	1998-11-04	Receptor antagonists and uses thereof
PL330708A1 (en)	1999-05-24	Derivatives of indolydine useful as antagonists of 5-ht-2c receptor
PL338453A1 (en)	2000-11-06	2-acylaminopropanoamines as antagonists of the tachykinin receptor
PL338456A1 (en)	2000-11-06	2-acylaminopropanoamines as antagonists of the tachykinin receptor
AU6826498A (en)	1998-10-12	Endotholin receptor antagonists
ID22978A (id)	1999-12-23	Antagonis reseptor endotelin
ZA981206B (en)	1999-03-26	Use of NMDA receptor antagonist
ZA986620B (en)	1999-01-25	Fibrinogen receptor antagonist