ZA97991B - Novel cyclic amino acids as pharmaceutical agents. - Google Patents
Novel cyclic amino acids as pharmaceutical agents.Info
- Publication number
- ZA97991B ZA97991B ZA9700991A ZA97991A ZA97991B ZA 97991 B ZA97991 B ZA 97991B ZA 9700991 A ZA9700991 A ZA 9700991A ZA 97991 A ZA97991 A ZA 97991A ZA 97991 B ZA97991 B ZA 97991B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- amino acids
- cyclic amino
- pharmaceutical agents
- date
- Prior art date
Links
- -1 cyclic amino acids Chemical class 0.000 title abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1127896P | 1996-02-07 | 1996-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA97991B true ZA97991B (en) | 1997-08-15 |
Family
ID=21749660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9700991A ZA97991B (en) | 1996-02-07 | 1997-02-06 | Novel cyclic amino acids as pharmaceutical agents. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5929088A (fr) |
| EP (1) | EP0888325B1 (fr) |
| JP (1) | JP2000511877A (fr) |
| KR (1) | KR19990082349A (fr) |
| AT (1) | ATE218135T1 (fr) |
| AU (1) | AU720628B2 (fr) |
| BR (1) | BR9707366A (fr) |
| CA (1) | CA2244708A1 (fr) |
| CZ (1) | CZ296052B6 (fr) |
| DE (1) | DE69712877T2 (fr) |
| DK (1) | DK0888325T3 (fr) |
| EA (1) | EA001534B1 (fr) |
| ES (1) | ES2176668T3 (fr) |
| HU (1) | HUP9901074A3 (fr) |
| IL (1) | IL125562A (fr) |
| NO (1) | NO983612L (fr) |
| NZ (1) | NZ326669A (fr) |
| PL (1) | PL328432A1 (fr) |
| PT (1) | PT888325E (fr) |
| SK (1) | SK282665B6 (fr) |
| WO (1) | WO1997029101A1 (fr) |
| ZA (1) | ZA97991B (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100491282B1 (ko) | 1996-07-24 | 2005-05-24 | 워너-램버트 캄파니 엘엘씨 | 통증 치료용 이소부틸가바 및 그의 유도체 |
| ATE239695T1 (de) * | 1997-09-18 | 2003-05-15 | Warner Lambert Co | Stereoselektive verfahren zur herstellung von gabapentinanalogen |
| DE19751062A1 (de) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
| US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
| AU759392B2 (en) * | 1997-12-16 | 2003-04-10 | Warner-Lambert Company | 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
| WO2001072311A1 (fr) * | 2000-03-28 | 2001-10-04 | Delorenzo Robert J | Inhibition d'un nouveau courant de lesion calcique se formant dans les neurones lors d'une lesion, afin de prevenir la mort des cellules neuronales |
| US6900192B2 (en) | 2000-10-06 | 2005-05-31 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| WO2002028881A1 (fr) | 2000-10-06 | 2002-04-11 | Xenoport, Inc. | Composes derives d'acide biliaire assurant des concentrations systemiques prolongees de medicaments apres administration par voie orale |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| EP1412324A4 (fr) | 2001-06-11 | 2004-09-29 | Xenoport Inc | Conjugues d'amino acides permettant d'obtenir des concentrations systemiques soutenues d'analogues du gaba |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| ES2296956T5 (es) | 2001-06-11 | 2011-07-12 | Xenoport, Inc. | Profármacos de análogos de gaba, composiciones y sus usos. |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| AU2002316231A1 (en) | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| WO2003080588A1 (fr) | 2002-03-20 | 2003-10-02 | Xenoport | Promedicaments 1-(acyloxy)-alkyle cyclique d'analogues de l'acide gamma-aminobutyrique, leurs compositions et leurs utilisations |
| US7183259B2 (en) | 2002-05-17 | 2007-02-27 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
| US20040092498A1 (en) * | 2002-08-16 | 2004-05-13 | David Blakemore | Substituted glycine derivatives for use as medicaments |
| AU2003297927A1 (en) | 2002-12-11 | 2004-06-30 | Xenoport, Inc. | Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof |
| CA2451267A1 (fr) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Utilisations pharmaceutiques de ligands alpha2delta |
| PT1572173E (pt) | 2002-12-13 | 2010-05-10 | Warner Lambert Co | Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior |
| WO2005025562A1 (fr) | 2003-09-11 | 2005-03-24 | Xenoport, Inc. | Traitement et/ou prevention de l'incontinence urinaire et promedicaments des analogues gaba |
| WO2005025675A1 (fr) | 2003-09-12 | 2005-03-24 | Pfizer Limited | Associations comprenant des ligands alpha-2-delta et des inhibiteurs du recaptage de la serotonine et de la noradrenaline |
| CN1871021B (zh) | 2003-09-17 | 2010-07-28 | 什诺波特有限公司 | 用gaba类似物的前药治疗或预防多动腿综合征 |
| PL1677767T3 (pl) | 2003-10-14 | 2011-12-30 | Xenoport Inc | Krystaliczna postać analogu kwasu gamma-aminomasłowego |
| DK1691811T3 (da) | 2003-12-11 | 2014-10-20 | Sunovion Pharmaceuticals Inc | Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression |
| WO2006050514A1 (fr) | 2004-11-04 | 2006-05-11 | Xenoport, Inc. | Formes posologiques orales a liberation prolongee d'un promedicament du nom de gabapentine |
| ES2367881T3 (es) | 2006-12-22 | 2011-11-10 | Recordati Ireland Limited | Politerapia para trastornos de las vías urinarias inferiores con ligandos a2d y los aine. |
| MX2010002007A (es) * | 2007-08-23 | 2010-03-10 | Novartis Ag | Sulfonas ciclicas sustituidas por amino-bencilo utiles como inhibidores de bace. |
| EP2250148B1 (fr) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Forme cristalline de sels de calcium d'acide (3s)-aminomethyl-5-methyl-hexanoique et ses procedes d'utilisation |
| WO2009094577A2 (fr) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Formes mésophasiques de précurseurs d'acide (3s)-aminométhyl-5-méthyl-hexanoïque et procédés d'utilisation |
| JP5291123B2 (ja) | 2008-01-25 | 2013-09-18 | ゼノポート，インコーポレイティド | （３ｓ）−アミノメチル−５−ヘキサン酸プロドラッグの結晶形態及びその使用 |
| CA2740087C (fr) | 2008-10-08 | 2019-07-23 | Kyphia Pharmaceuticals, Inc. | Conjugues gaba et procedes d'utilisation de ceux-ci |
| WO2010084797A1 (fr) * | 2009-01-21 | 2010-07-29 | 第一三共株式会社 | Composé contenant un hétéroatome |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| HUE047629T2 (hu) | 2013-01-28 | 2020-05-28 | Lopez Hector L | Eljárások ß-alanin tolerancia, farmakodinamika és hatékonyság javítására és azok alkalmazása |
| CN114621119A (zh) | 2018-05-14 | 2022-06-14 | 昌郁医药公司 | 萘普生和普瑞巴林的1-(酰氧基)-烷基氨基甲酸酯药物缀合物的结晶形式 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| KR970010173B1 (ko) * | 1991-07-09 | 1997-06-21 | 닛뽕소다 가부시끼가이샤 | 함헤테로 시클로헥산디온 유도체, 그의 제조방법 및 제초제 |
| US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
| GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
| US5527194A (en) * | 1994-02-02 | 1996-06-18 | Brunswick Corporation | Thrust sensor for marine drives |
| US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| US5760006A (en) * | 1997-06-23 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating psoriasis |
-
1997
- 1997-01-02 EP EP97901385A patent/EP0888325B1/fr not_active Expired - Lifetime
- 1997-01-02 CA CA002244708A patent/CA2244708A1/fr not_active Abandoned
- 1997-01-02 IL IL12556297A patent/IL125562A/en not_active IP Right Cessation
- 1997-01-02 DK DK97901385T patent/DK0888325T3/da active
- 1997-01-02 PT PT97901385T patent/PT888325E/pt unknown
- 1997-01-02 AT AT97901385T patent/ATE218135T1/de not_active IP Right Cessation
- 1997-01-02 EA EA199800682A patent/EA001534B1/ru not_active IP Right Cessation
- 1997-01-02 DE DE69712877T patent/DE69712877T2/de not_active Expired - Fee Related
- 1997-01-02 JP JP09528505A patent/JP2000511877A/ja not_active Abandoned
- 1997-01-02 KR KR1019980706079A patent/KR19990082349A/ko not_active Ceased
- 1997-01-02 AU AU15295/97A patent/AU720628B2/en not_active Ceased
- 1997-01-02 BR BR9707366A patent/BR9707366A/pt not_active Application Discontinuation
- 1997-01-02 CZ CZ19982452A patent/CZ296052B6/cs not_active IP Right Cessation
- 1997-01-02 WO PCT/US1997/000255 patent/WO1997029101A1/fr not_active Ceased
- 1997-01-02 ES ES97901385T patent/ES2176668T3/es not_active Expired - Lifetime
- 1997-01-02 US US09/077,053 patent/US5929088A/en not_active Expired - Fee Related
- 1997-01-02 SK SK1067-98A patent/SK282665B6/sk unknown
- 1997-01-02 HU HU9901074A patent/HUP9901074A3/hu unknown
- 1997-01-02 PL PL97328432A patent/PL328432A1/xx unknown
- 1997-01-02 NZ NZ326669A patent/NZ326669A/en unknown
- 1997-02-06 ZA ZA9700991A patent/ZA97991B/xx unknown
-
1998
- 1998-08-06 NO NO983612A patent/NO983612L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU720628B2 (en) | 2000-06-08 |
| PT888325E (pt) | 2002-10-31 |
| WO1997029101A1 (fr) | 1997-08-14 |
| IL125562A0 (en) | 1999-03-12 |
| EA199800682A1 (ru) | 1999-02-25 |
| IL125562A (en) | 2001-08-08 |
| EP0888325B1 (fr) | 2002-05-29 |
| KR19990082349A (ko) | 1999-11-25 |
| JP2000511877A (ja) | 2000-09-12 |
| DE69712877D1 (de) | 2002-07-04 |
| HUP9901074A3 (en) | 2001-08-28 |
| DE69712877T2 (de) | 2002-11-14 |
| ATE218135T1 (de) | 2002-06-15 |
| EA001534B1 (ru) | 2001-04-23 |
| PL328432A1 (en) | 1999-02-01 |
| NZ326669A (en) | 2001-05-25 |
| SK106798A3 (en) | 1999-07-12 |
| CZ296052B6 (cs) | 2005-12-14 |
| CZ245298A3 (cs) | 1998-11-11 |
| DK0888325T3 (da) | 2002-09-16 |
| HUP9901074A2 (hu) | 2001-04-28 |
| NO983612D0 (no) | 1998-08-06 |
| ES2176668T3 (es) | 2002-12-01 |
| US5929088A (en) | 1999-07-27 |
| EP0888325A1 (fr) | 1999-01-07 |
| NO983612L (no) | 1998-10-06 |
| BR9707366A (pt) | 1999-07-20 |
| CA2244708A1 (fr) | 1997-08-14 |
| SK282665B6 (sk) | 2002-11-06 |
| AU1529597A (en) | 1997-08-28 |
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