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MX2010002007A - Sulfonas ciclicas sustituidas por amino-bencilo utiles como inhibidores de bace. - Google Patents

Sulfonas ciclicas sustituidas por amino-bencilo utiles como inhibidores de bace.

Info

Publication number
MX2010002007A
MX2010002007A MX2010002007A MX2010002007A MX2010002007A MX 2010002007 A MX2010002007 A MX 2010002007A MX 2010002007 A MX2010002007 A MX 2010002007A MX 2010002007 A MX2010002007 A MX 2010002007A MX 2010002007 A MX2010002007 A MX 2010002007A
Authority
MX
Mexico
Prior art keywords
aminobenzyl
substituted cyclic
bace inhibitors
cyclic sulfones
sulfones useful
Prior art date
Application number
MX2010002007A
Other languages
English (en)
Inventor
Marina Tintelnot-Blomley
Rainer Machauer
Heinrich Rueeger
Jean-Michel Rondeau
Henrik Moebitz
Olivier Rogel
Emmanuelle Briard
Rainer Martin Lueoend
Siem Jacop Veenstra
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2010002007A publication Critical patent/MX2010002007A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a compuestos heterocíclicos novedosos de la fórmula: (ver fórmula I) en donde todas las variables son como se definen en la memoria descriptiva, en forma libre o en forma de sal, a su preparación, a su uso como medicamentos, y a medicamentos que los comprenden.
MX2010002007A 2007-08-23 2008-08-22 Sulfonas ciclicas sustituidas por amino-bencilo utiles como inhibidores de bace. MX2010002007A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07114881 2007-08-23
EP08160123 2008-07-10
PCT/EP2008/061030 WO2009024615A1 (en) 2007-08-23 2008-08-22 Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors

Publications (1)

Publication Number Publication Date
MX2010002007A true MX2010002007A (es) 2010-03-10

Family

ID=39789883

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002007A MX2010002007A (es) 2007-08-23 2008-08-22 Sulfonas ciclicas sustituidas por amino-bencilo utiles como inhibidores de bace.

Country Status (15)

Country Link
US (1) US20090054427A1 (es)
EP (1) EP2190833A1 (es)
JP (1) JP2010536831A (es)
KR (1) KR20100061805A (es)
CN (1) CN101835771A (es)
AR (1) AR068062A1 (es)
AU (1) AU2008290561A1 (es)
BR (1) BRPI0815673A2 (es)
CA (1) CA2697254A1 (es)
CL (1) CL2008002480A1 (es)
EA (1) EA201000340A1 (es)
MX (1) MX2010002007A (es)
PE (1) PE20090953A1 (es)
TW (1) TW200916097A (es)
WO (1) WO2009024615A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102076678A (zh) * 2008-07-10 2011-05-25 诺瓦提斯公司 作为bace抑制剂的具有氨基苄基取代基的环砜类化合物
WO2012009688A1 (en) 2010-07-16 2012-01-19 Rockefeller University Organic compounds
US9242943B2 (en) * 2011-01-18 2016-01-26 Siena Biotech S.P.A. 1,4 oxazines as BACE1 and/or BACE2 inhibitors
IN2014DN06580A (es) 2012-01-16 2015-05-22 Univ Rockefeller
JP6471100B2 (ja) 2013-02-12 2019-02-13 バック・インスティテュート・フォー・リサーチ・オン・エイジング Ｂａｃｅ仲介性ａｐｐプロセシングを調節するヒダントイン
CN106674264A (zh) * 2016-12-20 2017-05-17 苏州汉德创宏生化科技有限公司 (2,2,2‑三氟乙氧基)苯硼酸类化合物的合成方法
US11684622B2 (en) 2018-06-19 2023-06-27 Celecor Therapeutics, Inc. Deuterated RUC-4

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ326669A (en) * 1996-02-07 2001-05-25 Warner Lambert Co Thiopyran or pyran derivatives useful as pharmaceutical agents
NZ503980A (en) * 1997-12-16 2002-09-27 Warner Lambert Co 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (= gabapentin analogues), pharmaceuticals thereof, and their use in the treatment of neurological disorders
GB0602951D0 (en) * 2006-02-14 2006-03-29 Novartis Ag Organic Compounds

Also Published As

Publication number Publication date
AR068062A1 (es) 2009-11-04
WO2009024615A1 (en) 2009-02-26
TW200916097A (en) 2009-04-16
EP2190833A1 (en) 2010-06-02
BRPI0815673A2 (pt) 2015-02-18
KR20100061805A (ko) 2010-06-09
JP2010536831A (ja) 2010-12-02
EA201000340A1 (ru) 2010-08-30
CN101835771A (zh) 2010-09-15
PE20090953A1 (es) 2009-08-10
US20090054427A1 (en) 2009-02-26
CA2697254A1 (en) 2009-02-26
CL2008002480A1 (es) 2009-05-15
AU2008290561A1 (en) 2009-02-26

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Legal Events

Date Code Title Description
HH Correction or change in general
FA Abandonment or withdrawal