ZA977511B - Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides. - Google Patents

Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides.

Info

Publication number: ZA977511B
Authority: ZA; South Africa
Prior art keywords: pseudopeptides; antithrombotic; azacycloalkylalkanoyl peptides; peptides; antithrombotic azacycloalkylalkanoyl
Prior art date: 1996-08-21

Application number

ZA9707511A

Other languages

English (en)

Inventor

Scott I Klein

Bruce F Molino

Mark Czekaj

Charles J Gardner

Original Assignee

Rhone Poulenc Rorer Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-21

Filing date

1997-08-21

Publication date

1998-03-03

1997-08-21 Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma

1998-03-03 Publication of ZA977511B publication Critical patent/ZA977511B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA9707511A 1996-08-21 1997-08-21 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides. ZA977511B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/700,950 US5780590A (en)	1993-10-15	1996-08-21	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Publications (1)

Publication Number	Publication Date
ZA977511B true ZA977511B (en)	1998-03-03

Family

ID=24815484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9707511A ZA977511B (en)	1996-08-21	1997-08-21	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides.

Country Status (21)

Country	Link
US (1)	US5780590A (xx)
EP (1)	EP0929572A4 (xx)
JP (1)	JP2001501965A (xx)
KR (1)	KR20000035797A (xx)
CN (1)	CN1231671A (xx)
AP (1)	AP904A (xx)
AU (1)	AU722112B2 (xx)
BG (1)	BG103197A (xx)
BR (1)	BR9711205A (xx)
CA (1)	CA2263732A1 (xx)
EA (1)	EA001391B1 (xx)
HU (1)	HUP9903961A3 (xx)
IL (1)	IL128556A0 (xx)
NO (1)	NO990836L (xx)
NZ (1)	NZ334059A (xx)
OA (1)	OA10975A (xx)
PL (1)	PL331713A1 (xx)
SK (1)	SK14699A3 (xx)
UA (1)	UA48252C2 (xx)
WO (1)	WO1998017678A1 (xx)
ZA (1)	ZA977511B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6274705B1 (en)	1996-05-02	2001-08-14	Aventis Pharmaceuticals Products Inc.	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
EP0923553B1 (en) *	1996-08-21	2008-03-26	Aventis Pharmaceuticals Inc.	Stable non-hygroscopic crystalline form of n- n-n-(4-(piperidin-4-yl)butanoyl)-n-ethylglycyl compounds
WO1999019294A1 (en) *	1997-05-14	1999-04-22	Aventis Pharmaceuticals Products Inc. Legal/Patents	Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides
AP1057A (en) *	1997-10-10	2002-04-08	Aventis Pharmaceuticals Products Inc	Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides.
EP1155033A1 (en) *	1998-12-30	2001-11-21	Aventis Pharmaceuticals Products Inc.	Process for preparing a stable non-hygroscopic crystalline n-[n-[n-(piperdin-4-yl)butanoyl)-n-ethylglycyl]-(l)-aspartyl]-ss-cyclohexylalanine amide
US7200838B2 (en) *	2000-12-20	2007-04-03	National Instruments Corporation	System and method for automatically generating a graphical program in response to a state diagram
US7544681B2 (en)	2001-09-27	2009-06-09	Ramot At Tel Aviv University Ltd.	Conjugated psychotropic drugs and uses thereof
ES2400772T3 (es) *	2005-06-07	2013-04-12	Ramot At Tel Aviv University Ltd.	Sales novedosas de fármacos psicotrópicos conjugados y procedimientos para la preparación de las mismas
EP2051735B1 (en)	2006-07-17	2012-08-29	Ramot, at Tel Aviv University Ltd.	Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use treating pain and other cns disorders
US8207369B2 (en)	2008-02-11	2012-06-26	Ramot At Tel-Aviv University Ltd.	Conjugates for treating neurodegenerative diseases and disorders
AU2010329440A1 (en)	2009-12-09	2012-08-09	Bar-Ilan University	Methods of improving cognitive functions
CA2789654A1 (en)	2010-02-24	2011-09-01	Ramot At Tel-Aviv University Ltd.	Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same
US8916610B2 (en)	2010-09-22	2014-12-23	Ramot At Tel-Aviv University Ltd.	Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3821188A (en) *	1972-06-14	1974-06-28	American Home Prod	Proline and pyroglutamic acid containing tripeptides
GB8600263D0 (en) *	1985-01-22	1986-02-12	Ici America Inc	Peptide derivatives
US4683291A (en) *	1985-10-28	1987-07-28	Scripps Clinic And Research Foundation	Platelet binding inhibitors
FR2608160B1 (fr) *	1986-12-15	1989-03-31	Inst Nat Sante Rech Med	Nouveaux derives peptidiques et leur application notamment en therapeutique
US4857508A (en) *	1987-12-03	1989-08-15	Monsanto Company	Novel platelet-aggregation inhibitor peptide derivatives
US5037808A (en) *	1988-07-20	1991-08-06	Monsanto Co.	Indolyl platelet-aggregation inhibitors
US4992463A (en) *	1988-07-20	1991-02-12	Monsanto Company	Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
US4879313A (en) *	1988-07-20	1989-11-07	Mosanto Company	Novel platelet-aggregation inhibitors
US5023233A (en) *	1989-07-28	1991-06-11	Merck & Co., Inc.	Fibrinogen receptor antagonists
US4952562A (en) *	1989-09-29	1990-08-28	Rorer Pharmaceutical Corporation	Anti-thrombotic peptides and pseudopeptides
JPH05500954A (ja) *	1989-09-29	1993-02-25	ローヌ―プーラン　ローラー　インターナショナル（ホウルディングス）　インコーポレイテッド	抗血栓性ペプチド及び疑似ペプチド
US5051405A (en) *	1989-10-10	1991-09-24	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Anti-thrombotic peptides and pseudopeptides
US5053392A (en) *	1989-12-01	1991-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
US5086069A (en) *	1990-02-05	1992-02-04	Rorer Pharmaceutical Corporation	Anti-thrombotic peptide and pseudopeptide derivatives
CA2037153A1 (en) *	1990-03-09	1991-09-10	Leo Alig	Acetic acid derivatives
GB9007751D0 (en) *	1990-04-05	1990-06-06	Ciba Geigy Ag	Novel platelet-aggregation inhibitors
US5064814A (en) *	1990-04-05	1991-11-12	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Anti-thrombotic peptide and pseudopeptide derivatives
IL99538A0 (en) *	1990-09-27	1992-08-18	Merck & Co Inc	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
IL99539A0 (en) *	1990-09-27	1992-08-18	Merck & Co Inc	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
MX9201416A (es) *	1991-03-28	1992-10-01	Rhone Poulenc Rorer Int	Peptidos y pseudopeptidos antitromboticos.
AU661659B2 (en) *	1991-04-11	1995-08-03	Rhone-Poulenc Rorer International (Holdings) Inc.	Anti-thrombotic peptide and pseudopeptide derivatives
DE69213546T2 (de) *	1991-05-13	1997-02-27	Fujisawa Pharmaceutical Co	Neue Peptid-Verbindungen und Verfahren zur Herstellung davon
ATE199727T1 (de) *	1993-10-15	2001-03-15	Rhone Poulenc Rorer Pharma	Antithrombotisch wirkende azacycloalkyl-alkanoyl- peptide und-pseudopeptide

1996
- 1996-08-21 US US08/700,950 patent/US5780590A/en not_active Expired - Lifetime
1997
- 1997-08-15 WO PCT/US1997/014578 patent/WO1998017678A1/en not_active Ceased
- 1997-08-15 EA EA199900216A patent/EA001391B1/ru not_active IP Right Cessation
- 1997-08-15 HU HU9903961A patent/HUP9903961A3/hu unknown
- 1997-08-15 CN CN97198164A patent/CN1231671A/zh active Pending
- 1997-08-15 SK SK146-99A patent/SK14699A3/sk unknown
- 1997-08-15 IL IL12855697A patent/IL128556A0/xx unknown
- 1997-08-15 KR KR1019997001363A patent/KR20000035797A/ko not_active Ceased
- 1997-08-15 CA CA002263732A patent/CA2263732A1/en not_active Abandoned
- 1997-08-15 EP EP97938424A patent/EP0929572A4/en not_active Withdrawn
- 1997-08-15 NZ NZ334059A patent/NZ334059A/xx unknown
- 1997-08-15 UA UA99031553A patent/UA48252C2/uk unknown
- 1997-08-15 JP JP10519340A patent/JP2001501965A/ja not_active Ceased
- 1997-08-15 AP APAP/P/1999/001452A patent/AP904A/en active
- 1997-08-15 PL PL97331713A patent/PL331713A1/xx unknown
- 1997-08-15 BR BR9711205A patent/BR9711205A/pt not_active Application Discontinuation
- 1997-08-15 AU AU40749/97A patent/AU722112B2/en not_active Ceased
- 1997-08-21 ZA ZA9707511A patent/ZA977511B/xx unknown
1999
- 1999-02-15 OA OA9900033A patent/OA10975A/en unknown
- 1999-02-22 BG BG103197A patent/BG103197A/xx unknown
- 1999-02-22 NO NO990836A patent/NO990836L/no unknown

Also Published As

Publication number	Publication date
EP0929572A1 (en)	1999-07-21
KR20000035797A (ko)	2000-06-26
JP2001501965A (ja)	2001-02-13
HUP9903961A3 (en)	2000-12-28
US5780590A (en)	1998-07-14
IL128556A0 (en)	2000-01-31
OA10975A (en)	2001-11-01
EA001391B1 (ru)	2001-02-26
SK14699A3 (en)	2000-11-07
BR9711205A (pt)	1999-08-17
PL331713A1 (en)	1999-08-02
WO1998017678A1 (en)	1998-04-30
NZ334059A (en)	2000-01-28
UA48252C2 (uk)	2002-08-15
AU722112B2 (en)	2000-07-20
NO990836D0 (no)	1999-02-22
EP0929572A4 (en)	2001-09-12
AP9901452A0 (en)	1999-03-31
EA199900216A1 (ru)	1999-08-26
NO990836L (no)	1999-04-20
AU4074997A (en)	1998-05-15
HUP9903961A2 (hu)	2000-04-28
BG103197A (bg)	2000-05-31
CA2263732A1 (en)	1998-04-30
CN1231671A (zh)	1999-10-13
AP904A (en)	2000-11-24

Publication	Publication Date	Title
ZA971259B (en)	1997-12-04	Antimicrobial peptides and methods of use.
SG52974A1 (en)	1998-09-28	Compressor
EP0577775A4 (en)	1995-01-11	ANTI-THROMBOTIC PEPTIDES AND PSEUDOPEPTIDES.
EP0765165A4 (en)	1998-10-07	PREVENTED PEPTIDES
GB9609702D0 (en)	1996-07-10	Anticoagulant peptides
ZA977511B (en)	1998-03-03	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides.
ZA97283B (en)	1997-07-30	Isolated tyrosinase derived peptides and uses thereof
PL318017A1 (en)	1997-05-12	Peptides
GB9500601D0 (en)	1995-03-01	Modified peptides
GB9621338D0 (en)	1996-12-04	Compressor
ZA964825B (en)	1997-02-13	Collagen peptide fraction and its uses.
ZA965538B (en)	1997-12-29	Somatostatin peptides.
AU4967397A (en)	1998-06-10	Water-soluble peptides
ZA972186B (en)	1997-11-10	Lytic peptides.
TW428676U (en)	2001-04-01	Scrol compressor
GB9425380D0 (en)	1995-02-15	Peptides
GB9627114D0 (en)	1997-02-19	Multiple branch peptide constructions
EP0935608A4 (en)	2004-09-15	CYTOTOXIC PEPTIDES
GB9519511D0 (en)	1995-11-29	Peptides
GB9606272D0 (en)	1996-05-29	Gene and peptides
GB9613705D0 (en)	1996-08-28	Novel peptides
GB9425381D0 (en)	1995-02-15	Peptides
GB9608430D0 (en)	1996-06-26	Peptides
GB9625227D0 (en)	1997-01-22	Peptides
GB9612648D0 (en)	1996-08-21	Peptides