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BR9711205A - Composto - Google Patents

Composto

Info

Publication number
BR9711205A
BR9711205A BR9711205A BR9711205A BR9711205A BR 9711205 A BR9711205 A BR 9711205A BR 9711205 A BR9711205 A BR 9711205A BR 9711205 A BR9711205 A BR 9711205A BR 9711205 A BR9711205 A BR 9711205A
Authority
BR
Brazil
Prior art keywords
compound
Prior art date
Application number
BR9711205A
Other languages
English (en)
Inventor
Scott I Klein
Bruce F Molito
Mark Czekaj
Charles J Gardner
Original Assignee
Rhone Poulenc Rorer Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma
Publication of BR9711205A publication Critical patent/BR9711205A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR9711205A 1996-08-21 1997-08-15 Composto BR9711205A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/700,950 US5780590A (en) 1993-10-15 1996-08-21 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
PCT/US1997/014578 WO1998017678A1 (en) 1996-08-21 1997-08-15 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Publications (1)

Publication Number Publication Date
BR9711205A true BR9711205A (pt) 1999-08-17

Family

ID=24815484

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9711205A BR9711205A (pt) 1996-08-21 1997-08-15 Composto

Country Status (21)

Country Link
US (1) US5780590A (pt)
EP (1) EP0929572A4 (pt)
JP (1) JP2001501965A (pt)
KR (1) KR20000035797A (pt)
CN (1) CN1231671A (pt)
AP (1) AP904A (pt)
AU (1) AU722112B2 (pt)
BG (1) BG103197A (pt)
BR (1) BR9711205A (pt)
CA (1) CA2263732A1 (pt)
EA (1) EA001391B1 (pt)
HU (1) HUP9903961A3 (pt)
IL (1) IL128556A0 (pt)
NO (1) NO990836L (pt)
NZ (1) NZ334059A (pt)
OA (1) OA10975A (pt)
PL (1) PL331713A1 (pt)
SK (1) SK14699A3 (pt)
UA (1) UA48252C2 (pt)
WO (1) WO1998017678A1 (pt)
ZA (1) ZA977511B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274705B1 (en) 1996-05-02 2001-08-14 Aventis Pharmaceuticals Products Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
DE69738601T2 (de) * 1996-08-21 2009-04-30 Aventis Pharmaceuticals Inc. Stabile, nicht-hygroskopische, kristalline form von n-än-n(4-(piperidin-4-yl)butanoyl)-n-ethylglycyl verbindungen
WO1999019294A1 (en) * 1997-05-14 1999-04-22 Aventis Pharmaceuticals Products Inc. Legal/Patents Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides
BR9814068A (pt) * 1997-10-10 2000-09-26 Aventis Pharm Prod Inc Processos para preparar um composto de pseudotetrapeptìdeo, para preparar um peptìdeo substituìdo por ciclo-hexilmetila, para preparar um amido peptìdeo, para preparar um composto de aspartame protegido, para preparar um dipeptìdeo substituìdo por ciclo-hexilmetila, para preparar um composto ácido substituìdo por azaeterociclila, e, composto de pseudotetrapeptìdeo
WO2000040601A1 (en) * 1998-12-30 2000-07-13 Aventis Pharmaceuticals Products Inc. Process for preparing a stable non-hygroscopic crystalline n-[n-[n- piperdin- 4-yl)butanoyl)- n.ethylglycyl]- (l)-aspartyl] -ss-cyclohexylalanine amide
US7200838B2 (en) * 2000-12-20 2007-04-03 National Instruments Corporation System and method for automatically generating a graphical program in response to a state diagram
US7544681B2 (en) 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
CA2610838A1 (en) * 2005-06-07 2006-12-14 Ramot At Tel Aviv University Ltd. Novel salts of conjugated psychotropic drugs and processes of preparing same
US8222296B2 (en) 2006-07-17 2012-07-17 Ramot At Tel-Aviv University Ltd. Conjugates comprising a GABA- or glycine compound, pharmaceutical compositions and combinations thereof and their use in treating CNS disorders
US8207369B2 (en) 2008-02-11 2012-06-26 Ramot At Tel-Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
US8975251B2 (en) 2009-12-09 2015-03-10 Bar-Ilan University Methods of improving cognitive functions
JP2013520488A (ja) 2010-02-24 2013-06-06 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド ペルフェナジン−ｇａｂａのトリメシラート塩の結晶性形態物及びその製法方法
WO2012038963A1 (en) 2010-09-22 2012-03-29 Ramot At Tel-Aviv University Ltd. An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821188A (en) * 1972-06-14 1974-06-28 American Home Prod Proline and pyroglutamic acid containing tripeptides
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
FR2608160B1 (fr) * 1986-12-15 1989-03-31 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US4992463A (en) * 1988-07-20 1991-02-12 Monsanto Company Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
JPH05500954A (ja) * 1989-09-29 1993-02-25 ローヌ―プーラン　ローラー　インターナショナル（ホウルディングス）　インコーポレイテッド 抗血栓性ペプチド及び疑似ペプチド
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
US5086069A (en) * 1990-02-05 1992-02-04 Rorer Pharmaceutical Corporation Anti-thrombotic peptide and pseudopeptide derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
GB9007751D0 (en) * 1990-04-05 1990-06-06 Ciba Geigy Ag Novel platelet-aggregation inhibitors
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
EP0584066A4 (en) * 1991-04-11 1994-10-12 Rhone Poulenc Rorer Int Anti-thrombotic peptide and pseudopeptide derivatives.
ATE142641T1 (de) * 1991-05-13 1996-09-15 Fujisawa Pharmaceutical Co Neue peptid-verbindungen und verfahren zur herstellung davon
CA2174097C (en) * 1993-10-15 2002-06-04 Scott I. Klein Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Also Published As

Publication number Publication date
EP0929572A4 (en) 2001-09-12
CA2263732A1 (en) 1998-04-30
HUP9903961A3 (en) 2000-12-28
OA10975A (en) 2001-11-01
AP9901452A0 (en) 1999-03-31
EA199900216A1 (ru) 1999-08-26
AP904A (en) 2000-11-24
EP0929572A1 (en) 1999-07-21
KR20000035797A (ko) 2000-06-26
EA001391B1 (ru) 2001-02-26
WO1998017678A1 (en) 1998-04-30
JP2001501965A (ja) 2001-02-13
US5780590A (en) 1998-07-14
HUP9903961A2 (hu) 2000-04-28
PL331713A1 (en) 1999-08-02
CN1231671A (zh) 1999-10-13
BG103197A (bg) 2000-05-31
ZA977511B (en) 1998-03-03
NZ334059A (en) 2000-01-28
IL128556A0 (en) 2000-01-31
UA48252C2 (uk) 2002-08-15
NO990836D0 (no) 1999-02-22
NO990836L (no) 1999-04-20
SK14699A3 (en) 2000-11-07
AU722112B2 (en) 2000-07-20
AU4074997A (en) 1998-05-15

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Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
FA8 Dismissal: dismissal - article 36, par. 1 of industrial property law