[go: up one dir, main page]

ZA969176B - Stable freeze-dried pharmaceutical formulation. - Google Patents

Stable freeze-dried pharmaceutical formulation.

Info

Publication number
ZA969176B
ZA969176B ZA9609176A ZA969176A ZA969176B ZA 969176 B ZA969176 B ZA 969176B ZA 9609176 A ZA9609176 A ZA 9609176A ZA 969176 A ZA969176 A ZA 969176A ZA 969176 B ZA969176 B ZA 969176B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical formulation
dried pharmaceutical
stable freeze
freeze
stable
Prior art date
Application number
ZA9609176A
Other languages
English (en)
Inventor
Colette Bouloumie
Thierry Breul
Laurence Colliere
Philippe Faure
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9484220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA969176(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ZA969176B publication Critical patent/ZA969176B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA9609176A 1995-11-03 1996-10-31 Stable freeze-dried pharmaceutical formulation. ZA969176B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9513022A FR2740686B1 (fr) 1995-11-03 1995-11-03 Formulation pharmaceutique lyophilisee stable

Publications (1)

Publication Number Publication Date
ZA969176B true ZA969176B (en) 1998-04-30

Family

ID=9484220

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9609176A ZA969176B (en) 1995-11-03 1996-10-31 Stable freeze-dried pharmaceutical formulation.

Country Status (31)

Country Link
US (1) US6284277B1 (xx)
EP (1) EP0858325B1 (xx)
JP (1) JP3357376B2 (xx)
KR (1) KR100367752B1 (xx)
CN (1) CN1124844C (xx)
AR (1) AR004255A1 (xx)
AT (1) ATE221374T1 (xx)
AU (1) AU713383B2 (xx)
BR (1) BR9611367A (xx)
CA (1) CA2234140C (xx)
CZ (1) CZ287178B6 (xx)
DE (1) DE69622735T2 (xx)
DK (1) DK0858325T3 (xx)
EE (1) EE04293B1 (xx)
ES (1) ES2180805T3 (xx)
FR (1) FR2740686B1 (xx)
IL (1) IL124214A (xx)
IS (1) IS1967B (xx)
MX (1) MX9803344A (xx)
MY (1) MY116578A (xx)
NO (1) NO322582B1 (xx)
NZ (1) NZ321616A (xx)
PL (1) PL186284B1 (xx)
PT (1) PT858325E (xx)
RU (1) RU2163801C2 (xx)
SK (1) SK283031B6 (xx)
TR (1) TR199800782T2 (xx)
TW (1) TW442295B (xx)
UA (1) UA60297C2 (xx)
WO (1) WO1997017064A1 (xx)
ZA (1) ZA969176B (xx)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6197787B1 (en) * 1997-03-03 2001-03-06 Sanofi-Synthelabo Pharmaceutical formulations containing poorly soluble drug substances
JP4939680B2 (ja) * 1997-05-27 2012-05-30 武田薬品工業株式会社 固形製剤
FR2764800B1 (fr) * 1997-06-23 1999-09-10 Sanofi Sa Composition pharmaceutique solide contenant des derives de benzofuranne
SE9702680D0 (sv) * 1997-07-11 1997-07-11 Astra Pharma Prod New formulation
DE19754324A1 (de) * 1997-12-08 1999-06-10 Byk Gulden Lomberg Chem Fab Neue Darreichungsform enthaltend einen säurelabilen Wirkstoff
DK1037607T3 (da) 1997-12-08 2004-06-21 Altana Pharma Ag Hidtil ukendt suppositoriumsform, der omfatter en syrelabil aktiv forbindelse
GB9804013D0 (en) * 1998-02-25 1998-04-22 Sanofi Sa Formulations
FR2781227B1 (fr) * 1998-07-20 2002-02-22 Sanofi Sa Procede pour la preparation du sel potassique du lintitript
FR2782455B3 (fr) * 1998-08-20 2000-09-15 Sanofi Sa Composition pharmaceutique injectable a base d'un sel pharmaceutiquement acceptable du clopidogrel ou de ticlopidine
US6898762B2 (en) 1998-08-21 2005-05-24 United Video Properties, Inc. Client-server electronic program guide
FR2787329B1 (fr) * 1998-12-17 2001-02-09 Aventis Pharma Sa Nouvelle application therapeutique des heparines de bas poids moleculaire
ATE294571T1 (de) * 1999-03-03 2005-05-15 Lilly Co Eli Echinocandin pharmazeutische zusammensetzungen
ES2204548T3 (es) 1999-03-03 2004-05-01 Eli Lilly And Company Complejos de equinocandina/carbohidrato.
FR2793685B1 (fr) * 1999-05-19 2001-08-24 Promindus Actions Promotionnel Compositions pharmaceutiques, destinees a l'administration par voie orale de phloroglucinol et leur preparation
FR2805539B1 (fr) * 2000-02-25 2005-06-10 Oreal Compositions de teinture des fibres keratiniques contenant des derives d'indolizine et procede de teinture
US7962414B1 (en) 2000-05-11 2011-06-14 Thomson Licensing Method and system for controlling and auditing content/service systems
US6716884B1 (en) 2000-05-19 2004-04-06 Promindus (Actions Promotionnelles Dans L'industrie Et Le Commerce) Pharmaceutical compositions for oral administration of phloroglucinol and preparation thereof
EP1310252A4 (en) 2000-08-18 2009-06-10 Takeda Pharmaceutical INJECTIONS
PL203300B1 (pl) * 2000-10-31 2009-09-30 Akad Medyczna Stabilna postać farmaceutyczna leku przeciwnowotworowego oraz sposób wytwarzania stabilnej postaci farmaceutycznej leku przeciwnowotworowego
MY137726A (en) * 2000-11-22 2009-03-31 Nycomed Gmbh Freeze-dried pantoprazole preparation and pantoprazole injection
EP1336408A4 (en) * 2000-11-24 2005-01-19 Yamanouchi Pharma Co Ltd WATER-SOLVENT LIQUID MEDICAMENT FOR INHALATION
ES2234451T1 (es) * 2001-11-14 2005-07-01 Teva Pharmaceutical Industries Ltd. Formas cristalinas y amorfas de losartan potasio y procedimiento para su preparacion.
EP1453826A1 (en) * 2001-12-10 2004-09-08 Dr. Reddy's Laboratories Ltd. Amorphous form of 2-n-butyl-3-[[2-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4'] non-1-en-4-one
BRPI0307802B8 (pt) 2002-02-22 2021-05-25 Merck Sharp & Dohme formulação farmacêutica compreendendo temozolomida, processo para a produção da mesma, bem como artigo fabricado contendo pó liofilizado compreendendo temozolomida
US20040022842A1 (en) * 2002-06-03 2004-02-05 Mebiopharm Co., Ltd. Liposome preparations containing oxaliplatin
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
GB2393181A (en) * 2002-09-19 2004-03-24 Cipla Ltd Amorphous clopidogrel
DK1549638T3 (da) 2002-10-03 2008-01-21 Hoffmann La Roche Indol-3-carboxamider som glucokinase (GK) aktivatorer
WO2004050085A1 (en) * 2002-12-03 2004-06-17 F. Hoffmann-La Roche Ag Aminoalkoxyindoles as 5-ht6-receptor ligands for the treatment of cns-disorders
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
GB0304636D0 (en) * 2003-02-28 2003-04-02 Britannia Pharmaceuticals Ltd Pharmaceutical composition for nasal delivery
RU2238728C1 (ru) * 2003-05-06 2004-10-27 Открытое акционерное общество "Новосибхимфарм" Способ получения раствора никотиновой кислоты для инъекций
DE602004030781D1 (de) * 2003-05-07 2011-02-10 Eisai R&D Man Co Ltd Gefriergetrocknetes präparat mit methylcobalamin und verfahren zu seiner herstellung
CZ300795B6 (cs) * 2003-09-02 2009-08-12 Pliva-Lachema A. S. Farmaceutická kompozice a zpusob její výroby
JP2007504177A (ja) * 2003-09-02 2007-03-01 プリヴァ−ラケマ，エー．エス． 医薬組成物、その製造方法及び治療上の使用
MY141763A (en) * 2003-09-18 2010-06-30 Novartis Ag Pharmaceutical products comprising bisphosphonates
CA2550811C (en) * 2003-12-24 2012-05-01 Jane Hirsh Temperature-stable formulations, and methods of development thereof
US20050255161A1 (en) * 2004-05-10 2005-11-17 Servet Buyuktimkin Method for the long term stabilization of labile compounds at room temperature in pharmaceutical preparations containing water
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US20060275331A1 (en) * 2004-08-31 2006-12-07 Borek Zaludek Pharmaceutical composition, method of manufacturing and therapeutic use thereof
EP2592075B1 (en) * 2004-11-02 2015-04-29 Northwestern University Pyridazine compounds for the treatment of inflammatory diseases
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US20070026026A1 (en) * 2005-08-01 2007-02-01 David Delmarre Oral liquid losartan compositions
EP1787641A1 (de) * 2005-11-22 2007-05-23 Helm AG Tazobactam-Piperacillin-Lyophilisat
US20080108664A1 (en) * 2005-12-23 2008-05-08 Liu Belle B Solid-state form of AMG 706 and pharmaceutical compositions thereof
WO2007103711A2 (en) * 2006-03-01 2007-09-13 Dr. Reddy's Laboratories Ltd. Polymorphic forms of rimonabant
WO2007146652A1 (en) * 2006-06-06 2007-12-21 Threshold Pharmaceuticals, Inc. Unit dose form of glufosfamide
US20070287734A1 (en) * 2006-06-09 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted pyrazole compounds with cannabinoid receptor activity
AR063606A1 (es) 2006-11-07 2009-02-04 Acambis Inc Estabilizacion de vacunas mediante liofilizacion
US20100062066A1 (en) * 2006-11-14 2010-03-11 Acusphere, Inc Formulations of Tetrahydropyridine Antiplatelet Agents for Parenteral or Oral Administration
US8765690B2 (en) * 2007-04-05 2014-07-01 Threshold Pharmaceuticals, Inc. Treatment of cancer with glufosfamide in patients not receiving insulin therapy
GB0715285D0 (en) * 2007-08-06 2007-09-12 Britannia Pharmaceuticals Ltd Improvements in or relating to powdered medicaments for nasal delivery
RU2370258C2 (ru) * 2007-11-16 2009-10-20 Закрытое Акционерное Общество "Биокад" Фармацевтическая композиция для парентеральной доставки в форме лиофилизата и способ ее получения
PL2112155T3 (pl) 2008-04-25 2011-03-31 Sandoz Ag Wodorosiarczan (VI) 2-acetoksy-5-(α-cyklopropylokarbonylo-2-fluorobenzylo)-4,5,6,7-tetrahydrotieno[3,2-c]pirydyny i sposób jego otrzymywania
EP2481396A4 (en) 2009-09-21 2014-03-05 Jw Pharmaceutical Corp OXALIPLATIN NANOPARTICLES AND MANUFACTURING METHOD THEREFOR
WO2011101865A2 (en) 2010-02-19 2011-08-25 Cadila Healthcare Limited Stable pharmaceutical compositions of clopidogrel for parenteral delivery
ES2715551T3 (es) * 2010-05-12 2019-06-04 The Medicines Company San Diego Llc Composiciones de tetraciclina
US8861919B2 (en) 2011-02-16 2014-10-14 Tyco Electronics Corporation Fiber optic closure
PL2696848T3 (pl) 2011-04-15 2020-12-28 Janssen Pharmaceutica N.V. Liofilizowane nanozawiesiny leków
CN103230371B (zh) * 2012-05-18 2014-07-23 湖北一半天制药有限公司 注射用奥沙利铂冻干制剂的制备方法
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
CN106706785B (zh) * 2016-12-23 2019-02-26 东药集团沈阳施德药业有限公司 一种采用高效液相色谱检测厄贝沙坦氢氯噻嗪片中有关物质的方法
US10149857B2 (en) 2017-03-09 2018-12-11 Ampac Fine Chemicals Llc Lyophilized cyclophosphamide composition and methods of preparation thereof
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations
JOP20200134A1 (ar) * 2017-12-07 2022-10-30 Reven Llc تركيبات وطرق لمعالجة حالات أيضية
US20230059869A1 (en) 2021-08-03 2023-02-23 Liqmeds Worldwide Limited Oral pharmaceutical solution of clopidogrel
CN114533683B (zh) * 2021-12-23 2023-08-01 李宏 一种注射用腺苷钴胺冻干制剂组合物及其制备方法
TW202339745A (zh) 2022-01-28 2023-10-16 大陸商上海柯君醫藥科技有限公司 抗血小板藥物的藥物組合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS532931B2 (xx) * 1973-12-05 1978-02-01
GB2021581B (en) * 1978-05-17 1982-10-20 Wellcome Found Stabilisation of pgl derivatives
US4537883A (en) * 1982-11-12 1985-08-27 Mead Johnson & Company Lyophilized cyclophosphamide
US4730007A (en) * 1985-09-04 1988-03-08 Seymour Ehrenpreis Novel analgesic compositions
FR2600252A1 (fr) * 1986-06-19 1987-12-24 Inst Nat Sante Rech Med Medicament et composition medicamenteuse pour le traitement de maladies infectieuses dues aux virus, ainsi que pour le traitement des tumeurs
JPH0296536A (ja) * 1988-09-29 1990-04-09 Green Cross Corp:The プラスミノゲン乾燥製剤
CA2013474C (en) * 1989-04-20 2000-01-18 Pharmacia Inc. Cyclophosphamide - alanine lyophilizates
US5558880A (en) 1989-12-22 1996-09-24 Janssen Pharmaceutica Inc. Pharmaceutical and other dosage forms
IL105553A (en) * 1992-05-06 1998-01-04 Janssen Pharmaceutica Inc Solid dosage form comprising a porous network of matrix forming material which disperses rapidly in water
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
FR2719479B1 (fr) * 1994-05-04 1996-07-26 Sanofi Elf Formulation stable lyophilisée comprenant une protéine: kit de dosage.

Also Published As

Publication number Publication date
EP0858325B1 (fr) 2002-07-31
CA2234140C (fr) 2004-10-26
IS4729A (is) 1998-04-29
KR100367752B1 (ko) 2003-03-15
RU2163801C2 (ru) 2001-03-10
AU713383B2 (en) 1999-12-02
IL124214A (en) 2001-01-28
NZ321616A (en) 1999-04-29
NO981967D0 (no) 1998-04-30
TR199800782T2 (xx) 1998-09-21
ES2180805T3 (es) 2003-02-16
SK283031B6 (sk) 2003-02-04
HK1015697A1 (en) 1999-10-22
JPH11507945A (ja) 1999-07-13
MX9803344A (es) 1998-09-30
EE04293B1 (et) 2004-06-15
MY116578A (en) 2004-02-28
IS1967B (is) 2004-12-15
WO1997017064A1 (fr) 1997-05-15
AU7499096A (en) 1997-05-29
KR19990067325A (ko) 1999-08-16
PT858325E (pt) 2002-12-31
DE69622735T2 (de) 2003-04-03
AR004255A1 (es) 1998-11-04
EP0858325A1 (fr) 1998-08-19
PL186284B1 (pl) 2003-12-31
FR2740686A1 (fr) 1997-05-09
US6284277B1 (en) 2001-09-04
CN1124844C (zh) 2003-10-22
NO322582B1 (no) 2006-10-30
CN1203527A (zh) 1998-12-30
UA60297C2 (uk) 2003-10-15
JP3357376B2 (ja) 2002-12-16
CZ123198A3 (cs) 1998-07-15
CZ287178B6 (en) 2000-10-11
DK0858325T3 (da) 2002-11-25
SK52598A3 (en) 1998-10-07
CA2234140A1 (fr) 1997-05-15
FR2740686B1 (fr) 1998-01-16
BR9611367A (pt) 1999-02-23
ATE221374T1 (de) 2002-08-15
EE9800123A (et) 1998-10-15
DE69622735D1 (de) 2002-09-05
PL326451A1 (en) 1998-09-28
TW442295B (en) 2001-06-23
NO981967L (no) 1998-06-30

Similar Documents

Publication Publication Date Title
ZA969176B (en) Stable freeze-dried pharmaceutical formulation.
ZA967745B (en) Pharmaceutical formulations.
ZA969722B (en) Pharmaceutical formulations.
GB9519363D0 (en) Pharmaceutical formulation
CY2359B1 (en) Pharmaceutical formulation.
ZA965190B (en) Pharmaceutical composition.
ZA967034B (en) Pharmaceutical compositions.
EP0841901A4 (en) POLYMIC MEDICAL TOOL MOLLATIONS
EP0645136A3 (en) Pharmaceutical preparation of the type: physiologically active substance with sustained release.
GB9407386D0 (en) Pharmaceutical formulation
GB9402203D0 (en) Pharmaceutical formulation
ZA982872B (en) Pharmaceutical formulation
ZA968081B (en) Pharmaceutical composition.
GB9405856D0 (en) Pharmaceutical formulation
GB9416599D0 (en) Pharmaceutical formulation
GB9523566D0 (en) Pharmaceutical formulation
ZA96526B (en) Novel pharmaceutical formulation
GB9709739D0 (en) Pharmaceutical formulation
ZA96392B (en) Pharmaceutical formulations
HUP9900016A3 (en) Stable freeze-dried pharmaceutical formulation
AU5049098A (en) Pharmaceutical formulation
SI0858325T1 (en) Stable freeze-dried pharmaceutical formulation
ZA9710675B (en) Pharmaceutical formulation.
ZA976795B (en) Pharmaceutical formulation.
GB9500978D0 (en) Pharmaceutical formulations