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ZA938978B - Catechol diethers as selective pde iv inhibitors - Google Patents

Catechol diethers as selective pde iv inhibitors

Info

Publication number
ZA938978B
ZA938978B ZA938978A ZA938978A ZA938978B ZA 938978 B ZA938978 B ZA 938978B ZA 938978 A ZA938978 A ZA 938978A ZA 938978 A ZA938978 A ZA 938978A ZA 938978 B ZA938978 B ZA 938978B
Authority
ZA
South Africa
Prior art keywords
inhibitors
compounds
selective pde
relates
pde
Prior art date
Application number
ZA938978A
Other languages
English (en)
Inventor
Allen J Duplantier
James F Eggler
Anthony Marfat
Hiroko Masamune
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA938978B publication Critical patent/ZA938978B/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
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    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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ZA938978A 1992-12-02 1993-12-01 Catechol diethers as selective pde iv inhibitors ZA938978B (en)

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JP3100984B2 (ja) 2000-10-23
FI935379A7 (fi) 1994-06-03
IL107758A0 (en) 1994-02-27
CA2400368A1 (fr) 1994-06-09
CA2150812A1 (fr) 1994-06-09
HU9303423D0 (en) 1994-04-28
DE69332762D1 (de) 2003-04-17
PT672031E (pt) 2003-06-30
FI935379A0 (fi) 1993-12-01
CZ141795A3 (en) 1995-11-15
CN1094028A (zh) 1994-10-26
RU95113454A (ru) 1997-06-10
ATE234270T1 (de) 2003-03-15
ES2192192T3 (es) 2003-10-01
KR950704228A (ko) 1995-11-17
BR9307570A (pt) 1999-05-25
WO1994012461A1 (fr) 1994-06-09
NO952178D0 (no) 1995-06-01
DE69332762T2 (de) 2003-08-14
AU673569B2 (en) 1996-11-14
HUT65928A (en) 1994-07-28
EP0672031B1 (fr) 2003-03-12
NO952178L (no) 1995-08-01
CA2150812C (fr) 2002-12-24
DK0672031T3 (da) 2003-06-10
JPH08501318A (ja) 1996-02-13
NZ257955A (en) 1996-05-28
IL107758A (en) 1997-11-20
AU5539694A (en) 1994-06-22
FI935379L (fi) 1994-06-03
PL309257A1 (en) 1995-10-02
EP0672031A1 (fr) 1995-09-20

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