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ZA911153B - Process for the preparation of oxetanones - Google Patents

Process for the preparation of oxetanones

Info

Publication number
ZA911153B
ZA911153B ZA911153A ZA911153A ZA911153B ZA 911153 B ZA911153 B ZA 911153B ZA 911153 A ZA911153 A ZA 911153A ZA 911153 A ZA911153 A ZA 911153A ZA 911153 B ZA911153 B ZA 911153B
Authority
ZA
South Africa
Prior art keywords
oxetanones
preparation
beta
novel
lactones
Prior art date
Application number
ZA911153A
Other languages
English (en)
Inventor
Martin Karpf
Karpf Martin
Ulrich Zutter
Zutter Ulrich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA911153B publication Critical patent/ZA911153B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Treatment Of Steel (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA911153A 1990-02-23 1991-02-15 Process for the preparation of oxetanones ZA911153B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH58990 1990-02-23
CH392590 1990-12-12

Publications (1)

Publication Number Publication Date
ZA911153B true ZA911153B (en) 1991-11-27

Family

ID=25685045

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA911153A ZA911153B (en) 1990-02-23 1991-02-15 Process for the preparation of oxetanones

Country Status (18)

Country Link
US (2) US5245056A (xx)
EP (1) EP0443449B1 (xx)
JP (1) JP2912463B2 (xx)
KR (2) KR0183034B1 (xx)
AT (1) ATE153332T1 (xx)
AU (1) AU644846B2 (xx)
CA (1) CA2035972C (xx)
DE (1) DE59108707D1 (xx)
DK (1) DK0443449T3 (xx)
ES (1) ES2103751T3 (xx)
FI (1) FI115458B (xx)
GR (1) GR3024420T3 (xx)
HU (1) HU208686B (xx)
IE (1) IE910608A1 (xx)
NO (1) NO178764C (xx)
NZ (1) NZ237132A (xx)
PT (1) PT96857B (xx)
ZA (1) ZA911153B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5412110A (en) * 1992-07-06 1995-05-02 Chemie Linz Gesellschaft M.B.H. Enzymatic process to separate racemic mixtures of delta valerolactones

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274143A (en) * 1991-07-23 1993-12-28 Hoffmann-La Roche Inc. Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
DE4225817A1 (de) * 1992-08-05 1994-02-10 Chemie Linz Deutschland Enzymatisches Verfahren zur Trennung racemischer Gemische von delta-Valerolactonen
US5481008A (en) * 1993-09-13 1996-01-02 Hoffmann-La Roche Inc. Process for the preparation of optically active compounds
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
NZ336755A (en) * 1997-02-05 2001-06-29 F Use of gastrointestinal lipase inhibitors in particular tetrahydrolipstatin (orlistat)
WO1999014210A1 (en) * 1997-09-15 1999-03-25 Warner-Lambert Company Process for the preparation of substituted 5,6-dihydro-2h-pyran-2-ones
US7124221B1 (en) 1999-10-19 2006-10-17 Rambus Inc. Low latency multi-level communication interface
US6545165B1 (en) * 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6552204B1 (en) * 2000-02-04 2003-04-22 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
JP4772264B2 (ja) * 2000-07-28 2011-09-14 エフ．ホフマン−ラ ロシュ アーゲー リパーゼ阻害物質の新規用途
AU2002212120B2 (en) 2000-08-09 2006-05-11 Cheplapharm Arzneimittel Gmbh Lipase inhibitors for the treatment of dyspepsia
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
CA2422698C (en) 2000-10-16 2009-12-15 F. Hoffmann-La Roche Ag Indoline derivatives and their use as 5-ht2 receptor ligands
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
KR100539143B1 (ko) 2000-12-27 2005-12-26 에프. 호프만-라 로슈 아게 인돌 유도체 및 그의 5-ｈｔ2ｂ 및 5-ｈｔ2ｃ 수용체리간드로서의 용도
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
JP2005516011A (ja) * 2001-12-13 2005-06-02 ランバクシー ラボラトリーズ リミテッド 結晶二水化セフニディールカリウム
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
CN100383124C (zh) 2002-02-04 2008-04-23 霍夫曼-拉罗奇有限公司 作为npy拮抗剂的喹啉衍生物
RU2004129285A (ru) 2002-02-28 2005-10-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные тиазола в качестве антагонистов рецептора npy
US7728153B2 (en) * 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
WO2003088975A1 (en) * 2002-04-17 2003-10-30 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
RU2296757C2 (ru) 2002-07-05 2007-04-10 Ф.Хоффманн-Ля Рош Аг Производные хиназолина
US8861667B1 (en) 2002-07-12 2014-10-14 Rambus Inc. Clock data recovery circuit with equalizer clock calibration
CN100381429C (zh) 2002-08-07 2008-04-16 霍夫曼-拉罗奇有限公司 噻唑衍生物
RU2296759C2 (ru) 2002-09-12 2007-04-10 Ф.Хоффманн-Ля Рош Аг N-замещенные 1н-индол-5-пропионовые кислоты, фармацевтическая композиция, содержащая эти соединения, и их применение (варианты)
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
ES2312819T3 (es) 2002-11-25 2009-03-01 F. Hoffmann-La Roche Ag Derivados de indolilo.
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
CN100422179C (zh) * 2003-08-12 2008-10-01 霍夫曼-拉罗奇有限公司 2-氨基-5-苯甲酰基噻唑npy拮抗剂
CA2533464A1 (en) * 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Thiazole derivatives as npy antagonists
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
JP2008540368A (ja) * 2005-05-03 2008-11-20 エフ．ホフマン−ラ ロシュ アーゲー ５−ｈｔ２リガンドとしての四環式アザピラジノインドリン
ATE430744T1 (de) 2005-08-18 2009-05-15 Hoffmann La Roche Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
BRPI0619266A2 (pt) 2005-11-30 2011-09-27 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, obesidade, diabetes do tipo ii e seu uso
CA2630270A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 5-substituted indole-2-carboxamide derivatives
KR101124156B1 (ko) 2005-11-30 2012-03-23 에프. 호프만-라 로슈 아게 1,5-치환된 인돌-2-일 아마이드 유도체
AU2006324089A1 (en) 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Tricyclic amide derivatives useful for treating obesity
KR20080068127A (ko) 2005-12-15 2008-07-22 에프. 호프만-라 로슈 아게 피롤로[2,3-ｃ]피리딘 유도체
CN101331131A (zh) 2005-12-16 2008-12-24 霍夫曼-拉罗奇有限公司 用作H3受体调节剂的吡咯并[2,3-b]吡啶衍生物
JP2009523150A (ja) * 2006-01-13 2009-06-18 エフ．ホフマン−ラ ロシュ アーゲー シクロヘキシルピペラジニルメタノン誘導体及びｈ３受容体調節剤としてのそれらの使用
CN101370779B (zh) * 2006-01-23 2011-07-20 霍夫曼-拉罗奇有限公司 具有h3受体活性的环己基磺酰胺衍生物
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
CN101448820A (zh) 2006-05-30 2009-06-03 霍夫曼-拉罗奇有限公司 哌啶基嘧啶衍生物
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
CN101348475B (zh) * 2007-07-20 2011-03-30 重庆人本药物研究院 一种奥利司他合成方法、中间体化合物及其制备方法
CN101796043A (zh) * 2007-07-25 2010-08-04 霍夫曼-拉罗奇有限公司 苯并呋喃-和苯并[b]噻吩-2-羧酸酰胺衍生物及其作为阻胺3受体调节剂的应用
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
US9243040B2 (en) 2010-11-30 2016-01-26 The Board Of Trustees Of The University Of Illinois Stable helical ionic polypeptides
CN103588735A (zh) * 2013-11-13 2014-02-19 大连九信生物化工科技有限公司 一种奥利司他的结晶提纯方法
FR3017878B1 (fr) * 2014-02-27 2017-12-08 Charabot Procede de production de lactones a partir d'une souche d'aureobasidium pullulans
WO2018140613A1 (en) 2017-01-25 2018-08-02 The Board Of Trustees Of The University Of Illinois Conformation switchable antimicrobial peptides and methods of using the same
CN112625009A (zh) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 一种奥利司他关键中间体的精制方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3457193A (en) * 1965-06-30 1969-07-22 Union Carbide Corp Epoxyoxacyclobutanes and polymers thereof
DE2400429A1 (de) * 1974-01-05 1975-07-17 Basf Ag Verfahren zur herstellung von 4-ketotetrahydro-alpha-pyronen
US4395561A (en) * 1982-05-14 1983-07-26 The United States Of America As Represented By The Secretary Of The Navy Synthesis of 3-hydroxyoxetane
CA1328881C (en) * 1984-12-21 1994-04-26 Pierre Barbier Process for the manufacture of oxetanones
CA1270837A (en) * 1984-12-21 1990-06-26 Hoffmann-La Roche Limited Oxetanones
EP0365539A4 (en) * 1987-06-17 1990-12-05 Australian Commercial Research & Development Limited Human leucocyte elastase inhibitor compounds
HU202851B (en) * 1988-04-04 1991-04-29 Sandoz Ag Herbicidal or acaricidal compositions and process for producing the active ingredient aryldione derivatives
US5149835A (en) * 1989-04-27 1992-09-22 University Of New Mexico Substituted mevalonolactones, and methods for stereoselective preparation thereof and desmethyl homologues thereof
US5036008A (en) * 1989-07-12 1991-07-30 Bristol-Myers Company Antitumor antibiotic BU-3285T
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
IL97148A (en) * 1990-02-26 1996-11-14 Hoffmann La Roche Oxetanones a process for their manufacture and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5412110A (en) * 1992-07-06 1995-05-02 Chemie Linz Gesellschaft M.B.H. Enzymatic process to separate racemic mixtures of delta valerolactones

Also Published As

Publication number Publication date
FI910857L (fi) 1991-08-24
IE910608A1 (en) 1991-08-28
GR3024420T3 (en) 1997-11-28
US5399720A (en) 1995-03-21
KR100191365B1 (ko) 1999-06-15
HUT56558A (en) 1991-09-30
NO178764C (no) 1996-05-29
ATE153332T1 (de) 1997-06-15
KR0183034B1 (ko) 1999-05-01
DK0443449T3 (da) 1997-11-24
NO910712D0 (no) 1991-02-22
NZ237132A (en) 1993-04-28
NO178764B (no) 1996-02-19
US5245056A (en) 1993-09-14
FI910857A0 (fi) 1991-02-22
AU7116691A (en) 1991-08-29
FI115458B (fi) 2005-05-13
CA2035972A1 (en) 1991-08-24
EP0443449A2 (de) 1991-08-28
HU208686B (en) 1993-12-28
KR910021393A (ko) 1991-12-20
EP0443449B1 (de) 1997-05-21
AU644846B2 (en) 1993-12-23
PT96857B (pt) 1998-07-31
DE59108707D1 (de) 1997-06-26
ES2103751T3 (es) 1997-10-01
EP0443449A3 (en) 1991-12-04
PT96857A (pt) 1991-10-31
JPH04211675A (ja) 1992-08-03
JP2912463B2 (ja) 1999-06-28
NO910712L (no) 1991-08-26
CA2035972C (en) 2006-07-11

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