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PT96857A - Processo para a preparacao de oxetanonas - Google Patents

Processo para a preparacao de oxetanonas

Info

Publication number
PT96857A
PT96857A PT96857A PT9685791A PT96857A PT 96857 A PT96857 A PT 96857A PT 96857 A PT96857 A PT 96857A PT 9685791 A PT9685791 A PT 9685791A PT 96857 A PT96857 A PT 96857A
Authority
PT
Portugal
Prior art keywords
oxetanones
preparation
beta
novel
lactones
Prior art date
Application number
PT96857A
Other languages
English (en)
Other versions
PT96857B (pt
Inventor
Martin Karpf
Ulrich Zutter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT96857A publication Critical patent/PT96857A/pt
Publication of PT96857B publication Critical patent/PT96857B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Treatment Of Steel (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT96857A 1990-02-23 1991-02-22 Processo para a preparacao de oxetanonas PT96857B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH58990 1990-02-23
CH392590 1990-12-12

Publications (2)

Publication Number Publication Date
PT96857A true PT96857A (pt) 1991-10-31
PT96857B PT96857B (pt) 1998-07-31

Family

ID=25685045

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96857A PT96857B (pt) 1990-02-23 1991-02-22 Processo para a preparacao de oxetanonas

Country Status (18)

Country Link
US (2) US5245056A (pt)
EP (1) EP0443449B1 (pt)
JP (1) JP2912463B2 (pt)
KR (2) KR0183034B1 (pt)
AT (1) ATE153332T1 (pt)
AU (1) AU644846B2 (pt)
CA (1) CA2035972C (pt)
DE (1) DE59108707D1 (pt)
DK (1) DK0443449T3 (pt)
ES (1) ES2103751T3 (pt)
FI (1) FI115458B (pt)
GR (1) GR3024420T3 (pt)
HU (1) HU208686B (pt)
IE (1) IE910608A1 (pt)
NO (1) NO178764C (pt)
NZ (1) NZ237132A (pt)
PT (1) PT96857B (pt)
ZA (1) ZA911153B (pt)

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US6545165B1 (en) 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
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DE60133470T2 (de) 2000-08-09 2009-05-07 F. Hoffmann-La Roche Ag Lipase inhibitoren zur behandlung von dyspepsia
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
AR038762A1 (es) 2000-10-16 2005-01-26 Hoffmann La Roche Derivados de indolina, un proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion y el uso de dichos derivados para la fabricacion de un medicamento
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
US6610685B2 (en) 2000-12-27 2003-08-26 Hoffmann-La Roche Inc. Fused indole derivatives
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
AU2002347539A1 (en) * 2001-12-13 2003-06-23 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
JP4216196B2 (ja) 2002-02-04 2009-01-28 エフ．ホフマン−ラ ロシュ アーゲー Ｎｐｙアンタゴニストとしてのキノリン誘導体
ATE373654T1 (de) 2002-02-28 2007-10-15 Hoffmann La Roche Thiazolderivate als npy-rezeptorantagonisten
AU2003226370A1 (en) * 2002-04-17 2003-11-03 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
US7728153B2 (en) 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
BR0312461A (pt) 2002-07-05 2005-04-26 Hoffmann La Roche Compostos, processo para a preparação de um composto, composição farmacêutica que compreende o mesmo, sua utilização e métodos para tratamento e profilaxia
US8861667B1 (en) 2002-07-12 2014-10-14 Rambus Inc. Clock data recovery circuit with equalizer clock calibration
AU2003253364B2 (en) 2002-08-07 2007-06-07 F. Hoffmann-La Roche Ag Thiazole derivatives
ES2275105T3 (es) 2002-09-12 2007-06-01 F. Hoffmann-La Roche Ag Compuestos de acido 1-h-indol-5-propionico n-sustituidos como agonistas ppar utiles para el tratamiento de diabetes.
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
PL377320A1 (pl) 2002-11-25 2006-01-23 F. Hoffmann-La Roche Ag Pochodne indolilowe
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
WO2005014592A1 (en) * 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag 2-amino-5-benzoylthiazole npy antagonists
EP1656374B1 (en) * 2003-08-12 2009-03-11 F. Hoffmann-La Roche Ag Thiazole derivatives as npy antagonists
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
EP1888585B1 (en) * 2005-05-03 2011-06-29 F. Hoffmann-La Roche AG Tetracyclic azapyrazinoindolines as 5-ht2 ligands
EP1945635B1 (en) 2005-08-18 2009-05-06 F.Hoffmann-La Roche Ag Thiazolyl piperidine derivatives useful as h3 receptor modulators
BRPI0619268A2 (pt) 2005-11-30 2011-09-20 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal
CN101316838B (zh) 2005-11-30 2013-01-30 霍夫曼-拉罗奇有限公司 用作h3调节剂的1,1-二氧代-硫代吗啉基吲哚基甲酮衍生物
ES2342979T3 (es) 2005-11-30 2010-07-20 F. Hoffmann-La Roche Ag Derivados de indol-2-carboxamida sustituidos en 5.
EP1960401B1 (en) 2005-12-09 2009-11-11 F.Hoffmann-La Roche Ag Tricyclic amide derivatives useful for treating obesity
ATE449776T1 (de) 2005-12-15 2009-12-15 Hoffmann La Roche Pyrroloä2,3-cüpyridinderivate
AU2006326067A1 (en) 2005-12-16 2007-06-21 F. Hoffmann-La Roche Ag Pyrrolo [2 , 3-b] pyridine derivatives as H3 receptor modulators
EP1976840A1 (en) * 2006-01-13 2008-10-08 F.Hoffmann-La Roche Ag Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators
KR101047274B1 (ko) * 2006-01-23 2011-07-06 에프. 호프만-라 로슈 아게 Ｈ3 수용체 활성을 갖는 사이클로헥실 설폰아마이드 유도체
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
WO2007137955A1 (en) 2006-05-30 2007-12-06 F. Hoffmann-La Roche Ag Piperidinyl pyrimidine derivatives
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
CN101348475B (zh) * 2007-07-20 2011-03-30 重庆人本药物研究院 一种奥利司他合成方法、中间体化合物及其制备方法
US7534788B2 (en) * 2007-07-25 2009-05-19 Hoffmann-La Roche Inc. Benzofuran and benzothiophene-2-carboxylic acid amide derivatives
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
WO2012075147A2 (en) * 2010-11-30 2012-06-07 Board Of Trustees Of The University Of Illinois Stable helical ionic polypeptides
CN103588735A (zh) * 2013-11-13 2014-02-19 大连九信生物化工科技有限公司 一种奥利司他的结晶提纯方法
FR3017878B1 (fr) * 2014-02-27 2017-12-08 Charabot Procede de production de lactones a partir d'une souche d'aureobasidium pullulans
WO2018140613A1 (en) 2017-01-25 2018-08-02 The Board Of Trustees Of The University Of Illinois Conformation switchable antimicrobial peptides and methods of using the same
CN112625009A (zh) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 一种奥利司他关键中间体的精制方法

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Also Published As

Publication number Publication date
FI115458B (fi) 2005-05-13
ZA911153B (en) 1991-11-27
HUT56558A (en) 1991-09-30
FI910857A0 (fi) 1991-02-22
EP0443449A2 (de) 1991-08-28
CA2035972C (en) 2006-07-11
JPH04211675A (ja) 1992-08-03
NO178764C (no) 1996-05-29
NO910712L (no) 1991-08-26
US5245056A (en) 1993-09-14
DE59108707D1 (de) 1997-06-26
NO910712D0 (no) 1991-02-22
HU208686B (en) 1993-12-28
EP0443449B1 (de) 1997-05-21
FI910857L (fi) 1991-08-24
JP2912463B2 (ja) 1999-06-28
KR910021393A (ko) 1991-12-20
CA2035972A1 (en) 1991-08-24
US5399720A (en) 1995-03-21
PT96857B (pt) 1998-07-31
EP0443449A3 (en) 1991-12-04
ES2103751T3 (es) 1997-10-01
KR0183034B1 (ko) 1999-05-01
NZ237132A (en) 1993-04-28
AU644846B2 (en) 1993-12-23
KR100191365B1 (ko) 1999-06-15
ATE153332T1 (de) 1997-06-15
AU7116691A (en) 1991-08-29
DK0443449T3 (da) 1997-11-24
NO178764B (no) 1996-02-19
GR3024420T3 (en) 1997-11-28
IE910608A1 (en) 1991-08-28

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