[go: up one dir, main page]

ZA897020B - Derivatives of human/bovine basic fibroblast growth factor - Google Patents

Derivatives of human/bovine basic fibroblast growth factor

Info

Publication number
ZA897020B
ZA897020B ZA897020A ZA897020A ZA897020B ZA 897020 B ZA897020 B ZA 897020B ZA 897020 A ZA897020 A ZA 897020A ZA 897020 A ZA897020 A ZA 897020A ZA 897020 B ZA897020 B ZA 897020B
Authority
ZA
South Africa
Prior art keywords
derivatives
human
bfgf
growth factor
fibroblast growth
Prior art date
Application number
ZA897020A
Other languages
English (en)
Inventor
Laura Bergonzoni
Bergonzoni Laura
Antonella Isacchi
Isacchi Antonella
Paolo Sarmientos
Sarmientos Paolo
Gilles Gauet
Gauet Gilles
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of ZA897020B publication Critical patent/ZA897020B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Eye Examination Apparatus (AREA)
ZA897020A 1988-09-16 1989-09-14 Derivatives of human/bovine basic fibroblast growth factor ZA897020B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888821795A GB8821795D0 (en) 1988-09-16 1988-09-16 New derivatives of human/bovine basic fibroplast growth factor

Publications (1)

Publication Number Publication Date
ZA897020B true ZA897020B (en) 1990-08-29

Family

ID=10643728

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA897020A ZA897020B (en) 1988-09-16 1989-09-14 Derivatives of human/bovine basic fibroblast growth factor

Country Status (21)

Country Link
EP (2) EP0396664A1 (xx)
JP (1) JP2888575B2 (xx)
KR (1) KR900702027A (xx)
CN (1) CN1041181A (xx)
AT (1) ATE98693T1 (xx)
AU (1) AU620925B2 (xx)
CA (1) CA1340834C (xx)
DE (1) DE68911461T2 (xx)
DK (1) DK120290A (xx)
ES (1) ES2061855T3 (xx)
FI (1) FI902391A0 (xx)
GB (1) GB8821795D0 (xx)
HU (1) HUT53937A (xx)
IL (1) IL91615A0 (xx)
MY (1) MY104910A (xx)
NO (1) NO902176L (xx)
NZ (1) NZ230621A (xx)
PT (1) PT91719B (xx)
WO (1) WO1990002800A1 (xx)
YU (1) YU179489A (xx)
ZA (1) ZA897020B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
US5478804A (en) * 1990-09-19 1995-12-26 The Salk Institute For Biological Studies Treatment of tumorigenic pathophysiological conditions with FGF-cytoxic conjugates
JP3135138B2 (ja) * 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
US6833354B1 (en) 1990-12-19 2004-12-21 Kaken Pharmaceutical Co., Ltd. Agent for the treatment of bone diseases
DE69205466T2 (de) * 1991-03-21 1996-05-30 Procter & Gamble Mittel zur Kontrolle von Hautfalten, die die Arg-Ser-Arg-Lys-Sequenzen enthalten.
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 ｂＦＧＦムテインおよびその製造法
TW275068B (xx) * 1993-09-24 1996-05-01 American Cyanamid Co
AUPO247496A0 (en) 1996-09-23 1996-10-17 Resmed Limited Assisted ventilation to match patient respiratory need
US6214795B1 (en) * 1996-11-12 2001-04-10 Praecis Pharmaceuticals, Inc. Peptide compounds useful for modulating FGF receptor activity
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
FR2780416B1 (fr) * 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
CA2381780C (en) 1999-08-13 2015-03-10 Chiron Corporation Dose of an angiogenic factor and method of administering to improve myocardial blood flow
AU2376000A (en) * 1999-12-22 2001-07-03 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor
CN100357443C (zh) 2000-11-27 2007-12-26 株式会社载体研究所 编码血管生成基因的副粘病毒载体及其应用
US8772460B2 (en) * 2011-12-16 2014-07-08 Wisconsin Alumni Research Foundation Thermostable FGF-2 mutant having enhanced stability
CN106957359B (zh) * 2016-08-31 2020-04-24 黄志锋 Fgf1突变体及其医药应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81839A0 (en) * 1986-03-14 1987-10-20 Takeda Chemical Industries Ltd Polypeptide,dna and its use
WO1988005465A1 (en) * 1987-01-16 1988-07-28 Amgen Inc. Production of fibroblast growth factor
JP2526965B2 (ja) * 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途
EP0298723A1 (en) * 1987-07-07 1989-01-11 California Biotechnology, Inc. Recombinant fibroblast growth factors
EP0326907A1 (en) * 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA and its use

Also Published As

Publication number Publication date
DE68911461T2 (de) 1994-05-19
AU4317189A (en) 1990-04-02
EP0363675B1 (en) 1993-12-15
NO902176D0 (no) 1990-05-15
DK120290A (da) 1990-07-16
NZ230621A (en) 1992-06-25
PT91719A (pt) 1990-03-30
NO902176L (no) 1990-07-13
WO1990002800A1 (en) 1990-03-22
MY104910A (en) 1994-06-30
JP2888575B2 (ja) 1999-05-10
EP0396664A1 (en) 1990-11-14
FI902391A7 (fi) 1990-05-14
YU179489A (en) 1991-10-31
ATE98693T1 (de) 1994-01-15
AU620925B2 (en) 1992-02-27
PT91719B (pt) 1995-05-31
HU895573D0 (en) 1990-11-28
DE68911461D1 (de) 1994-01-27
KR900702027A (ko) 1990-12-05
FI902391A0 (fi) 1990-05-14
DK120290D0 (da) 1990-05-15
CA1340834C (en) 1999-11-30
JPH03501855A (ja) 1991-04-25
GB8821795D0 (en) 1988-10-19
EP0363675A1 (en) 1990-04-18
HUT53937A (en) 1990-12-28
IL91615A0 (en) 1990-04-29
ES2061855T3 (es) 1994-12-16
CN1041181A (zh) 1990-04-11

Similar Documents

Publication Publication Date Title
IL91615A0 (en) Derivatives of human/bovine basic fibroblast growth factor
PL322945A1 (en) Novel protein and method of obtaining same
GR3020517T3 (en) Human erythropoietin muteins, their production and their use
EP0458959A4 (en) Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof
SG49097A1 (en) Nucleotide sequences coding for a protein with urease activity
GB8727045D0 (en) Immunoglobulin e competitor
IL92669A (en) TGF beta 1/beta 2: a chimeric transforming growth factor-beta
DK38889D0 (da) Onkogen-indkodet polypeptid med vaekstfaktoraktivitet
EP0276778A3 (en) High level expression in e. coli of soluble mature hil-1beta and derivatives with altered biological activity
EP0315118A3 (en) Dna coding for endothelin and use thereof
HUT62327A (en) Process for producing somatotropins modified in their alfa-helix 1 region and their combination with other mutants
HUT44609A (en) Process for preparing new polypeptides
DE69115270D1 (de) Protein mit fibroblasten-wachstumsfaktor-rezeptoraktivität.
AU1321988A (en) The cloning of malaria-specific dna sequences: isolation of the gene for the 140 kd protein
DE68927009D1 (de) EXPRESSION UND PROZESSIERUNG VON ACETYLIERTEN FGFs IN HEFEN
AU637589B2 (en) Ancrod proteins, their production and use
IL78278A0 (en) Process for the production of polypeptides,dna sequence encoding desired polypeptide human somatomedin c polypeptide and recombinant dna molecules
ATE130872T1 (de) Ancrod ähnliche proteine, ihre herstellung und verwendung.
Bergonzoni et al. Deletion mutant of basic fibroblast growth factor and production thereof