ZA806528B - 6,7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticals - Google Patents
6,7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticalsInfo
- Publication number
- ZA806528B ZA806528B ZA00806528A ZA806528A ZA806528B ZA 806528 B ZA806528 B ZA 806528B ZA 00806528 A ZA00806528 A ZA 00806528A ZA 806528 A ZA806528 A ZA 806528A ZA 806528 B ZA806528 B ZA 806528B
- Authority
- ZA
- South Africa
- Prior art keywords
- derivatives
- hydrogen
- pharmaceuticals
- processes
- production
- Prior art date
Links
- NSLKFRGZLUIUKO-QWRGUYRKSA-N 6,7-benzomorphan Chemical class C1C2=CC=CC=C2[C@H]2CCN[C@@H]1C2 NSLKFRGZLUIUKO-QWRGUYRKSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000005452 alkenyloxyalkyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000006213 aryl hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001592 luteinising effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7907800A NL7907800A (nl) | 1979-10-23 | 1979-10-23 | Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA806528B true ZA806528B (en) | 1982-06-30 |
Family
ID=19834064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00806528A ZA806528B (en) | 1979-10-23 | 1980-10-23 | 6,7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticals |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4425353A (xx) |
| EP (1) | EP0028717B1 (xx) |
| JP (1) | JPS5686164A (xx) |
| AT (1) | ATE8990T1 (xx) |
| AU (1) | AU539310B2 (xx) |
| CA (1) | CA1155840A (xx) |
| DE (1) | DE3068961D1 (xx) |
| DK (1) | DK435380A (xx) |
| ES (1) | ES496167A0 (xx) |
| FI (1) | FI67373C (xx) |
| IE (1) | IE50667B1 (xx) |
| IL (1) | IL61324A (xx) |
| MY (1) | MY8700184A (xx) |
| NL (1) | NL7907800A (xx) |
| NZ (1) | NZ195329A (xx) |
| PT (1) | PT71949B (xx) |
| ZA (1) | ZA806528B (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4579950A (en) * | 1982-08-20 | 1986-04-01 | Hoechst-Roussel Pharmaceuticals Inc. | Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine] compounds |
| JPH01102077A (ja) * | 1987-09-24 | 1989-04-19 | Hoechst Roussel Pharmaceut Inc | ２，６‐メタノピロロ‐３‐ベンズアゾジン類 |
| DE4121821A1 (de) * | 1991-07-02 | 1993-01-14 | Boehringer Ingelheim Kg | Neue benzomorphane und ihre verwendung als arzneimittel |
| DE19528472A1 (de) * | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan |
| AU9621598A (en) | 1997-10-20 | 1999-05-10 | Novo Nordisk A/S | Luteinising hormone antagonists useful for treatment of estrogen deficiencies, or as a contraceptive |
| US6136980A (en) * | 1998-05-01 | 2000-10-24 | Boehringer Ingelheim Kg | Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane |
| EP1225901A2 (en) * | 1999-09-21 | 2002-07-31 | Emory University | Uses and compositions for treating platelet-related disorders using anagrelide |
| US6495694B2 (en) * | 2000-06-16 | 2002-12-17 | Boehringer Ingelheim Pharma Kg | Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer |
| CA2870605A1 (en) | 2012-05-11 | 2013-11-14 | Purdue Pharma L.P. | Benzomorphan compounds as opioid receptors modulators |
| US10138207B2 (en) | 2012-11-09 | 2018-11-27 | Purdue Pharma, L.P. | Benzomorphan analogs and the use thereof |
| EP2951160B1 (en) | 2013-01-31 | 2019-04-24 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
| WO2015171553A1 (en) | 2014-05-06 | 2015-11-12 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130089C (xx) | 1963-11-07 | |||
| US4087532A (en) | 1974-03-09 | 1978-05-02 | Boehringer Ingelheim Gmbh | Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof |
| GB1513961A (en) * | 1975-02-25 | 1978-06-14 | Acf Chemiefarma Nv | 6,7-benzomorphans method for their preparation and intermediates |
| DE2716687A1 (de) | 1977-04-15 | 1978-10-19 | Boehringer Sohn Ingelheim | 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel |
| US4202897A (en) * | 1977-07-25 | 1980-05-13 | Sandoz, Inc. | Prolactin secretion inhibitors |
| IT8049377A0 (it) | 1979-08-03 | 1980-07-30 | Sandoz Ag | Medicamento a base di composti triciclici per inibire la secrezione dell'ormone luteinizzante(caso 1005224) |
-
1979
- 1979-10-23 NL NL7907800A patent/NL7907800A/nl not_active Application Discontinuation
-
1980
- 1980-10-13 EP EP80106213A patent/EP0028717B1/en not_active Expired
- 1980-10-13 AT AT80106213T patent/ATE8990T1/de active
- 1980-10-13 DE DE8080106213T patent/DE3068961D1/de not_active Expired
- 1980-10-14 DK DK435380A patent/DK435380A/da not_active Application Discontinuation
- 1980-10-14 FI FI803237A patent/FI67373C/fi not_active IP Right Cessation
- 1980-10-21 CA CA000362879A patent/CA1155840A/en not_active Expired
- 1980-10-21 NZ NZ195329A patent/NZ195329A/en unknown
- 1980-10-21 AU AU63540/80A patent/AU539310B2/en not_active Ceased
- 1980-10-21 IL IL61324A patent/IL61324A/xx unknown
- 1980-10-22 IE IE2188/80A patent/IE50667B1/en unknown
- 1980-10-22 ES ES496167A patent/ES496167A0/es active Granted
- 1980-10-22 JP JP14887180A patent/JPS5686164A/ja active Pending
- 1980-10-22 PT PT71949A patent/PT71949B/pt unknown
- 1980-10-23 ZA ZA00806528A patent/ZA806528B/xx unknown
-
1981
- 1981-07-13 US US06/282,799 patent/US4425353A/en not_active Expired - Fee Related
- 1981-07-13 US US06/283,084 patent/US4406904A/en not_active Expired - Fee Related
-
1987
- 1987-12-30 MY MY184/87A patent/MY8700184A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1155840A (en) | 1983-10-25 |
| IL61324A0 (en) | 1980-12-31 |
| AU6354080A (en) | 1981-04-30 |
| FI67373C (fi) | 1985-03-11 |
| US4425353A (en) | 1984-01-10 |
| EP0028717A1 (en) | 1981-05-20 |
| IL61324A (en) | 1985-03-31 |
| MY8700184A (en) | 1987-12-31 |
| FI67373B (fi) | 1984-11-30 |
| PT71949B (en) | 1981-12-17 |
| DK435380A (da) | 1981-04-24 |
| AU539310B2 (en) | 1984-09-20 |
| NL7907800A (nl) | 1981-04-27 |
| ES8106894A1 (es) | 1981-09-16 |
| FI803237L (fi) | 1981-04-24 |
| NZ195329A (en) | 1984-05-31 |
| IE50667B1 (en) | 1986-06-11 |
| EP0028717B1 (en) | 1984-08-15 |
| PT71949A (en) | 1981-08-19 |
| DE3068961D1 (en) | 1984-09-20 |
| ATE8990T1 (de) | 1984-09-15 |
| US4406904A (en) | 1983-09-27 |
| JPS5686164A (en) | 1981-07-13 |
| IE802188L (en) | 1981-04-23 |
| ES496167A0 (es) | 1981-09-16 |
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