ZA201000314B - 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2C antagonists for use in the treatment of peripheric and central nervous system diseases - Google Patents

2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2C antagonists for use in the treatment of peripheric and central nervous system diseases

Info

Publication number: ZA201000314B
Authority: ZA; South Africa
Prior art keywords: peripheric; dihydrobenzo; dioxin; treatment; nervous system
Prior art date: 2007-07-20

Application number

ZA201000314A

Other languages

English (en)

Inventor

Belle David Din

Patrik Holm

Arto Karljalainen

Arto Tolvanen

Gerd Wohlfahrt

Petteri Rummakko

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-20

Filing date

2010-01-15

Publication date

2010-10-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39884455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201000314(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-01-15 Application filed by Orion Corp filed Critical Orion Corp

2010-10-27 Publication of ZA201000314B publication Critical patent/ZA201000314B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA201000314A 2007-07-20 2010-01-15 2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2C antagonists for use in the treatment of peripheric and central nervous system diseases ZA201000314B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US95098307P	2007-07-20	2007-07-20

Publications (1)

Publication Number	Publication Date
ZA201000314B true ZA201000314B (en)	2010-10-27

Family

ID=39884455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA201000314A ZA201000314B (en)	2007-07-20	2010-01-15	2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2C antagonists for use in the treatment of peripheric and central nervous system diseases

Country Status (31)

Country	Link
US (3)	US8492549B2 (xx)
EP (1)	EP2176252B1 (xx)
JP (1)	JP5460590B2 (xx)
KR (1)	KR101535059B1 (xx)
CN (1)	CN101842369B (xx)
AR (1)	AR069271A1 (xx)
AU (1)	AU2008278924B2 (xx)
BR (1)	BRPI0814529B8 (xx)
CA (1)	CA2693804C (xx)
CL (1)	CL2008002114A1 (xx)
CO (1)	CO6331473A2 (xx)
CY (1)	CY1115789T1 (xx)
DK (1)	DK2176252T3 (xx)
EA (1)	EA017554B1 (xx)
ES (1)	ES2502215T3 (xx)
GE (1)	GEP20125538B (xx)
HR (1)	HRP20141156T1 (xx)
IL (1)	IL202964A (xx)
MA (1)	MA31521B1 (xx)
MY (1)	MY153872A (xx)
NZ (1)	NZ582432A (xx)
PE (1)	PE20090890A1 (xx)
PL (1)	PL2176252T3 (xx)
PT (1)	PT2176252E (xx)
RS (1)	RS53571B1 (xx)
SI (1)	SI2176252T1 (xx)
TN (1)	TN2010000029A1 (xx)
TW (1)	TWI457122B (xx)
UA (1)	UA100695C2 (xx)
WO (1)	WO2009013390A1 (xx)
ZA (1)	ZA201000314B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI457122B (zh)	2007-07-20	2014-10-21	Orion Corp	作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
JP2011519839A (ja) *	2008-04-29	2011-07-14	エヌエスエイビー、フィリアルアヴノイロサーチスウェーデンエービー、スヴェーリエ	ドーパミン神経伝達のモジュレーター
JP5514804B2 (ja) *	2008-04-29	2014-06-04	エヌエスエイビー、フィリアルアヴノイロサーチスウェーデンエービー、スヴェーリエ	ドーパミン神経伝達のモジュレーター
WO2009133110A1 (en)	2008-04-29	2009-11-05	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Modulators of dopamine neurotransmission
TW201024282A (en) *	2008-11-20	2010-07-01	Orion Corp	New pharmaceutical compounds
US20130267699A1 (en)	2011-06-24	2013-10-10	California Institute Of Technology	Quaternary heteroatom containing compounds
US8822679B2 (en) *	2011-06-24	2014-09-02	California Institute Of Technology	Quaternary heteroatom containing compounds
US9518034B2 (en)	2013-10-14	2016-12-13	California Institute Of Technology	Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof
US10421696B2 (en)	2014-12-18	2019-09-24	California Institute Of Technology	Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
CN105985389B (zh) *	2015-03-06	2019-03-19	北京大学	苯乙醇苷类似物及其合成方法和应用
US10106479B2 (en)	2015-03-27	2018-10-23	California Institute Of Technology	Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst
TWI704145B (zh) *	2015-06-05	2020-09-11	芬蘭商奧利安公司	新醫藥化合物
EP3426391A4 (en)	2016-03-11	2019-08-28	California Institute of Technology	COMPOSITIONS AND METHODS FOR ACYLATING LACTAMEN
US20190152992A1 (en)	2016-06-29	2019-05-23	Orion Corporation	Benzodioxane derivatives and their pharmaceutical use
CA3055215A1 (en) *	2017-03-12	2018-09-20	Xiaodong Wang	Polycyclic amines as opioid receptor modulators
US10358422B2 (en)	2017-11-01	2019-07-23	California Institute Of Technology	Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
GB201801130D0 (en)	2018-01-24	2018-03-07	Univ Oxford Innovation Ltd	Compounds
CN112714647A (zh) *	2018-09-25	2021-04-27	拜耳公司	用于治疗睡眠呼吸中止的α2-肾上腺素受体亚型C(α-2C)拮抗剂
EP3699173A1 (en)	2018-10-18	2020-08-26	California Institute of Technology	Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same
WO2023131640A1 (en)	2022-01-07	2023-07-13	Bayer Aktiengesellschaft	α2-ADRENOCEPTOR SUBTYPE C ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA
KR102776660B1 (ko) *	2022-01-25	2025-03-04	재단법인 한국파스퇴르연구소	벤조다이옥세인 유도체 화합물 및 이의 의약 용도

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2056046A (en)	1933-05-19	1936-09-29	Rhone Poulenc Sa	Manufacture of bases derived from benz-dioxane
US3635982A (en)	1969-04-08	1972-01-18	American Home Prod	Amino-substituted-quinoxalinyloxazolidines and -oxazines
GB1411531A (en)	1972-10-24	1975-10-29	Lafon Labor	Amino derivatives of 1,4-benzodioxan
JPS5163193A (ja) *	1974-11-26	1976-06-01	Yoshitomi Pharmaceutical	Tetorahidoropirazoropirijinkagobutsuno seizoho
US4039676A (en)	1975-06-23	1977-08-02	Ciba-Geigy Corporation	2-piperidinoalkyl-1,4-benzodioxans
US4329348A (en) *	1979-02-26	1982-05-11	Ciba-Geigy Corporation	N-Oxacyclic-alkylpiperidines as psychostimulants
HU181575B (en)	1980-10-03	1983-10-28	Richter Gedeon Vegyeszet	Process for preparing 3-chloro-propyl-malonic acid ester and cyano-acetic acid ester derivatives
FR2525600A1 (fr) *	1982-04-21	1983-10-28	Bouchara Emile	Nouvelles carboxamidoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
GB2167408B (en)	1984-11-23	1988-05-25	Farmos Oy	Substituted imidazole derivatives and their preparation and use
DD250930A1 (de)	1986-06-08	1987-10-28	Isis Chemie Zwickau Veb	Verfahren zur herstellung neuer tetrahydroisochinolinderivate
US4957928A (en) *	1986-06-26	1990-09-18	Ciba-Geigy Corporation	Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
WO1990002122A1 (en)	1988-08-16	1990-03-08	E.I. Du Pont De Nemours And Company	Fungicidal benzodioxane amine derivatives
JPH06507392A (ja)	1991-02-26	1994-08-25	エイアールシー　１，インコーポレイテッド	交感神経性の持続性疼痛の治療のための組成物および方法
GB9318431D0 (en) *	1993-09-06	1993-10-20	Boots Co Plc	Therapeutic agents
GB9514380D0 (en)	1995-07-13	1995-09-13	Knoll Ag	Therapeutic agents
FR2744451B1 (fr)	1996-02-01	1998-04-24	Pf Medicament	Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique
IL132170A0 (en)	1997-05-06	2001-03-19	Novo Nordisk As	Novel heterocyclic compounds
US5902807A (en)	1997-05-12	1999-05-11	Antti Haapalinna	Method for the treatment of mental illness in mammals and a composition therefor
CN1284066A (zh)	1997-12-04	2001-02-14	阿勒根销售公司	对α2B或2B/2C肾上腺素能受体具有激动剂样活性的取代咪唑衍生物
FI20000480A0 (fi)	2000-03-01	2000-03-01	Orion Yhtymae Oyj	Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina
JP2004509103A (ja) *	2000-09-11	2004-03-25	セプレイコー　インコーポレイテッド	モノアミン受容体及び輸送体のリガンドならびにその使用方法
EA008537B1 (ru)	2002-04-03	2007-06-29	Орион Корпорейшн	Полициклические соединения как эффективные антагонисты альфа2-адренорецептора
WO2004067513A1 (en)	2003-01-27	2004-08-12	Oy Juvantia Pharma Ltd	Antagonists for alpha-2 adrenoceptors
TWI457122B (zh)	2007-07-20	2014-10-21	Orion Corp	作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
JP5163193B2 (ja)	2008-03-13	2013-03-13	セイコーエプソン株式会社	プリンタシステム及びプリンタシステムにおける制御方法

2008
- 2008-07-02 TW TW097124840A patent/TWI457122B/zh active
- 2008-07-17 AR ARP080103087A patent/AR069271A1/es active IP Right Grant
- 2008-07-17 PE PE2008001216A patent/PE20090890A1/es active IP Right Grant
- 2008-07-17 CL CL2008002114A patent/CL2008002114A1/es unknown
- 2008-07-18 NZ NZ582432A patent/NZ582432A/en unknown
- 2008-07-18 US US12/668,918 patent/US8492549B2/en active Active
- 2008-07-18 EP EP08787689.2A patent/EP2176252B1/en active Active
- 2008-07-18 ES ES08787689.2T patent/ES2502215T3/es active Active
- 2008-07-18 JP JP2010516529A patent/JP5460590B2/ja active Active
- 2008-07-18 CN CN200880025445.8A patent/CN101842369B/zh active Active
- 2008-07-18 CA CA2693804A patent/CA2693804C/en active Active
- 2008-07-18 GE GEAP200811693A patent/GEP20125538B/en unknown
- 2008-07-18 UA UAA201001749A patent/UA100695C2/ru unknown
- 2008-07-18 BR BRPI0814529A patent/BRPI0814529B8/pt active IP Right Grant
- 2008-07-18 DK DK08787689.2T patent/DK2176252T3/en active
- 2008-07-18 KR KR1020107003606A patent/KR101535059B1/ko active Active
- 2008-07-18 WO PCT/FI2008/000090 patent/WO2009013390A1/en not_active Ceased
- 2008-07-18 SI SI200831313T patent/SI2176252T1/sl unknown
- 2008-07-18 EA EA201070169A patent/EA017554B1/ru not_active IP Right Cessation
- 2008-07-18 HR HRP20141156AT patent/HRP20141156T1/hr unknown
- 2008-07-18 MY MYPI2010000086A patent/MY153872A/en unknown
- 2008-07-18 RS RSP20140510 patent/RS53571B1/sr unknown
- 2008-07-18 PT PT87876892T patent/PT2176252E/pt unknown
- 2008-07-18 AU AU2008278924A patent/AU2008278924B2/en active Active
- 2008-07-18 PL PL08787689T patent/PL2176252T3/pl unknown
2009
- 2009-12-24 IL IL202964A patent/IL202964A/en active IP Right Grant
2010
- 2010-01-15 TN TNP2010000029A patent/TN2010000029A1/fr unknown
- 2010-01-15 ZA ZA201000314A patent/ZA201000314B/xx unknown
- 2010-01-15 MA MA32515A patent/MA31521B1/fr unknown
- 2010-01-19 CO CO10004690A patent/CO6331473A2/es active IP Right Grant
2013
- 2013-06-14 US US13/917,745 patent/US8697723B2/en active Active
2014
- 2014-02-27 US US14/192,131 patent/US8809536B2/en active Active
- 2014-11-26 CY CY20141100982T patent/CY1115789T1/el unknown

Also Published As

Publication number	Publication date
JP2010534197A (ja)	2010-11-04
CN101842369B (zh)	2014-01-22
EP2176252B1 (en)	2014-09-03
MY153872A (en)	2015-03-31
US8697723B2 (en)	2014-04-15
RS53571B1 (sr)	2015-02-27
MA31521B1 (fr)	2010-07-01
US20120035210A9 (en)	2012-02-09
PT2176252E (pt)	2014-12-03
EA017554B1 (ru)	2013-01-30
CY1115789T1 (el)	2017-01-25
BRPI0814529B1 (pt)	2019-09-17
GEP20125538B (en)	2012-05-25
PL2176252T3 (pl)	2015-04-30
BRPI0814529A2 (pt)	2015-01-27
US20130281486A1 (en)	2013-10-24
CA2693804A1 (en)	2009-01-29
AR069271A1 (es)	2010-01-13
AU2008278924A1 (en)	2009-01-29
AU2008278924B2 (en)	2013-09-26
DK2176252T3 (en)	2014-12-08
CL2008002114A1 (es)	2009-04-03
NZ582432A (en)	2012-03-30
TW200908961A (en)	2009-03-01
HRP20141156T1 (hr)	2015-01-16
US20140179926A1 (en)	2014-06-26
KR20100044220A (ko)	2010-04-29
SI2176252T1 (sl)	2014-12-31
TN2010000029A1 (en)	2011-09-26
UA100695C2 (ru)	2013-01-25
EP2176252A1 (en)	2010-04-21
HK1148530A1 (en)	2011-09-09
CA2693804C (en)	2015-11-24
US8809536B2 (en)	2014-08-19
JP5460590B2 (ja)	2014-04-02
ES2502215T3 (es)	2014-10-03
IL202964A (en)	2013-12-31
US8492549B2 (en)	2013-07-23
CO6331473A2 (es)	2011-10-20
BRPI0814529B8 (pt)	2021-05-25
US20100216836A1 (en)	2010-08-26
KR101535059B1 (ko)	2015-07-24
CN101842369A (zh)	2010-09-22
PE20090890A1 (es)	2009-07-08
TWI457122B (zh)	2014-10-21
WO2009013390A1 (en)	2009-01-29
EA201070169A1 (ru)	2010-06-30

Publication	Publication Date	Title
ZA201000314B (en)	2010-10-27	2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2C antagonists for use in the treatment of peripheric and central nervous system diseases
IL216967B (en)	2018-06-28	The history of 17-hydroxy-17-pentafluoroethyl-astra-9,4 (10)-diene-11-aryl and their use for the treatment of diseases
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