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UA106873C2 - COMPOUNDS OF SUBSTITUTED DIAZEPANES AS ANXAGONES OF OREXIN RECEPTORS - Google Patents

COMPOUNDS OF SUBSTITUTED DIAZEPANES AS ANXAGONES OF OREXIN RECEPTORS

Info

Publication number
UA106873C2
UA106873C2 UAA201015209A UAA201015209A UA106873C2 UA 106873 C2 UA106873 C2 UA 106873C2 UA A201015209 A UAA201015209 A UA A201015209A UA A201015209 A UAA201015209 A UA A201015209A UA 106873 C2 UA106873 C2 UA 106873C2
Authority
UA
Ukraine
Prior art keywords
compounds
substituted
anxagones
diazepanes
orexin receptors
Prior art date
Application number
UAA201015209A
Other languages
Ukrainian (uk)
Inventor
Джеффрі М. Бергман
Майкл Дж. Бреслін
Пол Дж. Коулман
Крістофер Д. Кокс
Сваті П. Мерсер
Ентоні Дж. Рокер
Original Assignee
Мерк Шарп Енд Доме Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Шарп Енд Доме Корп. filed Critical Мерк Шарп Енд Доме Корп.
Publication of UA106873C2 publication Critical patent/UA106873C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Даний винахід направлений на сполуки заміщеного діазепану, які є антагоністами орексинових рецепторів і які придатні для лікування або профілактики неврологічних і психіатричних розладів і захворювань, в які залучені орексинові рецептори.Також винахід направлений на фармацевтичні композиції, що містять дані сполуки, і на застосування вказаних сполук і композицій для профілактики або лікування таких захворювань, в які залучені орексинові рецептори.The present invention is directed to compounds of substituted diazepane, which are orexin receptor antagonists and which are suitable for the treatment or prevention of neurological and psychiatric disorders and diseases involving orexin receptors. and compositions for the prevention or treatment of diseases involving orexin receptors.

UAA201015209A 2006-12-01 2007-11-30 COMPOUNDS OF SUBSTITUTED DIAZEPANES AS ANXAGONES OF OREXIN RECEPTORS UA106873C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87239306P 2006-12-01 2006-12-01

Publications (1)

Publication Number Publication Date
UA106873C2 true UA106873C2 (en) 2014-10-27

Family

ID=41522310

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201015209A UA106873C2 (en) 2006-12-01 2007-11-30 COMPOUNDS OF SUBSTITUTED DIAZEPANES AS ANXAGONES OF OREXIN RECEPTORS
UAA200906864A UA100974C2 (en) 2006-12-01 2007-11-30 Substituted diazepan compounds as orexin receptor antagonists

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA200906864A UA100974C2 (en) 2006-12-01 2007-11-30 Substituted diazepan compounds as orexin receptor antagonists

Country Status (4)

Country Link
CN (1) CN101627028B (en)
HN (1) HN2009001067A (en)
UA (2) UA106873C2 (en)
ZA (1) ZA200903334B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150097486A (en) * 2012-11-12 2015-08-26 닥터 레디스 레보러터리즈 리미티드 Polymorphic forms of suvorexant
CN103012293A (en) * 2012-12-13 2013-04-03 同济大学 Synthetic method for anti-sleeplessness medicine MK-4305 intermediate
CN103923068B (en) * 2014-02-13 2016-09-07 武汉珈瑜科技有限公司 For compound preparing suvorexant and preparation method thereof
CN105377840B (en) * 2014-05-28 2017-12-22 杭州普晒医药科技有限公司 The salt and its crystal formation and amorphous article of a kind of diazepan compounds
US10030010B2 (en) * 2014-08-04 2018-07-24 Sandoz Ag Route of synthesis for the preparation of suvorexant
CN105461699B (en) * 2014-09-25 2019-07-09 广东东阳光药业有限公司 Substituted heterocyclic compound and its application method and purposes
CN104327061A (en) * 2014-10-19 2015-02-04 湖南华腾制药有限公司 Preparation method of bromobenzo[d]oxazole derivative
CN104649983B (en) * 2014-12-23 2018-01-23 广东东阳光药业有限公司 A kind of sour preparation method
US10196383B2 (en) * 2015-07-17 2019-02-05 Sunshine Lake Pharma Co., Ltd. Substituted quinazoline compounds and preparation and uses thereof
AU2016360245B2 (en) * 2015-11-23 2020-07-09 Sunshine Lake Pharma Co., Ltd. Octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof
CN106916149A (en) * 2015-12-25 2017-07-04 上海奥博生物医药技术有限公司 A kind of method for preparing Su Woleisheng
CN107021964A (en) * 2016-02-01 2017-08-08 广东东阳光药业有限公司 7-naphthyridine derivatives and application thereof
CN105949203B (en) * 2016-05-24 2018-07-13 广东东阳光药业有限公司 Octahydro pyrrolo- [3,4-c] azole derivatives and its application method and purposes
CN106866632A (en) * 2017-01-19 2017-06-20 成都美域高制药有限公司 A kind of method for preparing Suvorexant intermediates and the like
CN109942563A (en) * 2017-12-21 2019-06-28 上海医药工业研究院 A kind of preparation method of Su Woleisheng midbody compound
KR20220016918A (en) * 2019-06-04 2022-02-10 하거 바이오사이언시즈, 엘엘씨 Imidazolo derivatives, compositions and methods as orexin antagonists
CN111943945B (en) * 2020-09-03 2022-07-12 上海应用技术大学 Suvorexant intermediate and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4966691A (en) * 1972-10-30 1974-06-27
WO1996016946A1 (en) * 1994-11-25 1996-06-06 Nippon Chemiphar Co., Ltd. Quinazoline derivative
CN100522171C (en) * 2003-09-09 2009-08-05 弗·哈夫曼-拉罗切有限公司 1-Benzoylpiperazine derivatives as glycine uptake inhibitors for the treatment of psychosis

Also Published As

Publication number Publication date
CN101627028B (en) 2013-03-27
HN2009001067A (en) 2011-05-11
ZA200903334B (en) 2010-04-28
CN101627028A (en) 2010-01-13
UA100974C2 (en) 2013-02-25

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